The network for 'release of cytochrome c from mitochondria' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

release of cytochrome c from mitochondria

The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1.000
BADBCL2-associated agonist of cell death1.000
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
BCL2L11BCL2-like 11 (apoptosis facilitator)1.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
BCL2L1BCL2-like 11.000
BAXBCL2-associated X protein0.999
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.998
BIDBH3 interacting domain death agonist0.995
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.987
CFLARCASP8 and FADD-like apoptosis regulator0.951
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.918
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.908
BECN1beclin 1, autophagy related0.876
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.783
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.765
BAK1BCL2-antagonist/killer 10.760
CASP10caspase 10, apoptosis-related cysteine peptidase0.741
TP53BP2tumor protein p53 binding protein, 20.686
MAPK8mitogen-activated protein kinase 80.661
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.658
FASFas (TNF receptor superfamily, member 6)0.650
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.623
XIAPX-linked inhibitor of apoptosis0.621
FADDFas (TNFRSF6)-associated via death domain0.555
MDM4Mdm4 p53 binding protein homolog (mouse)0.540
CASP9caspase 9, apoptosis-related cysteine peptidase0.509
ZNF746zinc finger protein 7460.475
MAP2K4mitogen-activated protein kinase kinase 40.473
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.458
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.449
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.447
BCAP31B-cell receptor-associated protein 310.418
BBC3BCL2 binding component 30.346
CASP3caspase 3, apoptosis-related cysteine peptidase0.325
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.308
PDZD11PDZ domain containing 110.308
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.255
FKBP8FK506 binding protein 8, 38kDa0.246
VDAC2voltage-dependent anion channel 20.243
MAPK1mitogen-activated protein kinase 10.200
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.194
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.192
BIKBCL2-interacting killer (apoptosis-inducing)0.176
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.172
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.162
NLRC4NLR family, CARD domain containing 40.147
APAF1apoptotic peptidase activating factor 10.133
RIPK2receptor-interacting serine-threonine kinase 20.119
WWOXWW domain containing oxidoreductase0.114
FBXO7F-box protein 70.113
METmet proto-oncogene (hepatocyte growth factor receptor)0.110
BIRC2baculoviral IAP repeat containing 20.108
KRT5keratin 50.102
MAP3K1mitogen-activated protein kinase kinase kinase 10.095
MAPK14mitogen-activated protein kinase 140.094
AP2S1adaptor-related protein complex 2, sigma 1 subunit0.091
HDAC4histone deacetylase 40.091
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.086
AMBRA1autophagy/beclin-1 regulator 10.083
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.081
ZFYVE1zinc finger, FYVE domain containing 10.078
MEFVMediterranean fever0.076
CDC25Bcell division cycle 25 homolog B (S. pombe)0.074
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.074
ENO1enolase 1, (alpha)0.066
MDM2Mdm2 p53 binding protein homolog (mouse)0.066
GPX4glutathione peroxidase 4 (phospholipid hydroperoxidase)0.065
MAGEH1melanoma antigen family H, 10.064
IFI44Linterferon-induced protein 44-like0.063
TSPOtranslocator protein (18kDa)0.061
NR4A1nuclear receptor subfamily 4, group A, member 10.058
CASP7caspase 7, apoptosis-related cysteine peptidase0.058
PLATplasminogen activator, tissue0.055
LRRK2leucine-rich repeat kinase 20.054
ACTBactin, beta0.054
S100A6S100 calcium binding protein A60.053
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.051
CABLES1Cdk5 and Abl enzyme substrate 10.050
HIST2H3Chistone cluster 2, H3c0.050
VDAC1voltage-dependent anion channel 10.049
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.049
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.049
SFNstratifin0.045
HUWE1HECT, UBA and WWE domain containing 10.044
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.043
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.042
MRPS12mitochondrial ribosomal protein S120.042
PAFAH1B2platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)0.041
FOSL1FOS-like antigen 10.039
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.039
FLNAfilamin A, alpha0.038
TAGLN2transgelin 20.037
ISG15ISG15 ubiquitin-like modifier0.037
SATB2SATB homeobox 20.036
TMEM11transmembrane protein 110.036
SPNS1spinster homolog 1 (Drosophila)0.036
FASLGFas ligand (TNF superfamily, member 6)0.036
RNF144Bring finger protein 144B0.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Bcl2l11BCL2-like 11 (apoptosis facilitator)1.000
Bcl2B-cell leukemia/lymphoma 21.000
BaxBCL2-associated X protein1.000
Vhlvon Hippel-Lindau tumor suppressor0.999
Ptenphosphatase and tensin homolog0.992
Mapk8mitogen-activated protein kinase 80.988
Gbp5guanylate binding protein 50.985
Casp1caspase 10.984
Itgb1integrin beta 1 (fibronectin receptor beta)0.967
Mcl1myeloid cell leukemia sequence 10.964
Kitkit oncogene0.942
Ighimmunoglobulin heavy chain complex0.932
Rxraretinoid X receptor alpha0.929
Aim2absent in melanoma 20.887
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.797
FasFas (TNF receptor superfamily member 6)0.765
Egfrepidermal growth factor receptor0.762
Lmnalamin A0.751
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.722
Casp4caspase 4, apoptosis-related cysteine peptidase0.699
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.691
Lmnb1lamin B10.676
FosFBJ osteosarcoma oncogene0.668
Vegfavascular endothelial growth factor A0.664
Leprleptin receptor0.646
Notch2Notch gene homolog 2 (Drosophila)0.633
Ppargperoxisome proliferator activated receptor gamma0.616
Ptpn11protein tyrosine phosphatase, non-receptor type 110.593
Igf1rinsulin-like growth factor I receptor0.592
Cd151CD151 antigen0.581
Casp3caspase 30.553
PycardPYD and CARD domain containing0.514
Smn1survival motor neuron 10.495
Akt1thymoma viral proto-oncogene 10.487
Mdm4transformed mouse 3T3 cell double minute 40.480
Smad3MAD homolog 3 (Drosophila)0.449
Nos3nitric oxide synthase 3, endothelial cell0.437
Insrinsulin receptor0.436
Acot13acyl-CoA thioesterase 130.425
Bak1BCL2-antagonist/killer 10.425
Tlr4toll-like receptor 40.424
Rbl1retinoblastoma-like 1 (p107)0.396
Lystlysosomal trafficking regulator0.378
Grb10growth factor receptor bound protein 100.375
Slc31a1solute carrier family 31, member 10.370
Apoeapolipoprotein E0.368
Adam17a disintegrin and metallopeptidase domain 170.367
SkilSKI-like0.358
Tnfaip3tumor necrosis factor, alpha-induced protein 30.347
Dusp1dual specificity phosphatase 10.339
Esr1estrogen receptor 1 (alpha)0.333
Mfn2mitofusin 20.319
Nphs2nephrosis 2 homolog, podocin (human)0.303
Fbn1fibrillin 10.301
Prkciprotein kinase C, iota0.301
Rararetinoic acid receptor, alpha0.285
Lmnb2lamin B20.240
WrnWerner syndrome homolog (human)0.240
Tmpothymopoietin0.236
Itga3integrin alpha 30.225
Bcl2l1BCL2-like 10.220
Ikzf1IKAROS family zinc finger 10.217
Mdm2transformed mouse 3T3 cell double minute 20.197
Mapk14mitogen-activated protein kinase 140.191
Lama5laminin, alpha 50.187
Stim2stromal interaction molecule 20.185
Fgfr2fibroblast growth factor receptor 20.180
Il18interleukin 180.174
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.173
Hif1ahypoxia inducible factor 1, alpha subunit0.172
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.165
Ins2insulin II0.150
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.138
Ctnnb1catenin (cadherin associated protein), beta 10.135
Atf3activating transcription factor 30.132
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.129
Mtormechanistic target of rapamycin (serine/threonine kinase)0.128
Loxlysyl oxidase0.127
BidBH3 interacting domain death agonist0.126
Becn1beclin 1, autophagy related0.122
Tgfbr1transforming growth factor, beta receptor I0.116
Igf2rinsulin-like growth factor 2 receptor0.111
Ldb3LIM domain binding 30.109
Emx1empty spiracles homolog 1 (Drosophila)0.107
Cyldcylindromatosis (turban tumor syndrome)0.106
Rb1retinoblastoma 10.105
Thrbthyroid hormone receptor beta0.103
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.102
Atf2activating transcription factor 20.100
Apaf1apoptotic peptidase activating factor 10.099
Usp9xubiquitin specific peptidase 9, X chromosome0.098
Ptgs2prostaglandin-endoperoxide synthase 20.094
Lyz2lysozyme 20.093
Pthlhparathyroid hormone-like peptide0.090
L1camL1 cell adhesion molecule0.089
1810020D17RikRIKEN cDNA 1810020D17 gene0.087
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.085
Casp7caspase 70.084
BlnkB-cell linker0.084
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.435
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.387
Rnf4ring finger protein 40.197
Ccnd3cyclin D30.113
Top2btopoisomerase (DNA) II beta0.104
NsfN-ethylmaleimide-sensitive factor0.073
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.059
Tfrctransferrin receptor0.059
Usf2upstream transcription factor 2, c-fos interacting0.056
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.052
Agtr1aangiotensin II receptor, type 1a0.047
Adam10ADAM metallopeptidase domain 100.042
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.041
Syt4synaptotagmin IV0.040
Apcadenomatous polyposis coli0.040
Dnm1ldynamin 1-like0.037
FosFBJ osteosarcoma oncogene0.034
Flt1FMS-related tyrosine kinase 10.033
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.031
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.030
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.029
Adrbk1adrenergic, beta, receptor kinase 10.028
Dctn4dynactin 40.028
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.026
Akap1A kinase (PRKA) anchor protein 10.024
Map2k4mitogen activated protein kinase kinase 40.021
Mapk9mitogen-activated protein kinase 90.021
Mrps2mitochondrial ribosomal protein S20.019
Ap2b1adaptor-related protein complex 2, beta 1 subunit0.019
Zfp260zinc finger protein 2600.018
LOC687711similar to small nuclear ribonucleoprotein D30.018
Mybl2myeloblastosis oncogene-like 20.017
Aph1aanterior pharynx defective 1 homolog A (C. elegans)0.017
Mapk7mitogen-activated protein kinase 70.017
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.017
Cyb5r1cytochrome b5 reductase 10.016
Creb1cAMP responsive element binding protein 10.016
Matkmegakaryocyte-associated tyrosine kinase0.015
Cdk4cyclin-dependent kinase 40.015
Taok1TAO kinase 10.015
Dll3delta-like 3 (Drosophila)0.015
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.015
Mapk8mitogen-activated protein kinase 80.015
Vegfavascular endothelial growth factor A0.014
Gnai1guanine nucleotide binding protein (G protein), alpha inhibiting 10.014
Coro1bcoronin, actin-binding protein, 1B0.014
Trim23tripartite motif-containing 230.013
Tagln3transgelin 30.013
Klf6Kruppel-like factor 60.013
Snap25synaptosomal-associated protein 250.013
Myo1bmyosin Ib0.013
Amphamphiphysin0.013
Arl5aADP-ribosylation factor-like 5A0.013
Pdp1pyruvate dehyrogenase phosphatase catalytic subunit 10.013
Uchl1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.012
Tubb5tubulin, beta 50.012
Tgfb1transforming growth factor, beta 10.012
Doc2bdouble C2-like domains, beta0.012
Cishcytokine inducible SH2-containing protein0.012
Lin7clin-7 homolog C (C. elegans)0.012
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.012
Ckmt1creatine kinase, mitochondrial 10.012
Ppatphosphoribosyl pyrophosphate amidotransferase0.011
Vsnl1visinin-like 10.011
Notch4Notch homolog 4 (Drosophila)0.011
Sdc3syndecan 30.011
Prmt1protein arginine methyltransferase 10.011
Lystlysosomal trafficking regulator0.011
Stat6signal transducer and activator of transcription 60.011
Nckap1NCK-associated protein 10.010
Sstsomatostatin0.010
Dusp1dual specificity phosphatase 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism