The network for 'epithelial to mesenchymal transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epithelial to mesenchymal transition

A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

NameDescriptionProbabilityFunc Analog Organism
SMAD3SMAD family member 30.999
SMAD7SMAD family member 70.987
SMAD2SMAD family member 20.986
SMAD4SMAD family member 40.986
SMAD1SMAD family member 10.976
JAG1jagged 10.948
SMURF2SMAD specific E3 ubiquitin protein ligase 20.931
NOTCH1notch 10.915
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.898
COL1A1collagen, type I, alpha 10.869
FHL2four and a half LIM domains 20.861
ARandrogen receptor0.835
BMPR1Abone morphogenetic protein receptor, type IA0.825
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.773
SKILSKI-like oncogene0.758
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.756
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.726
TP53tumor protein p530.715
TGFB1transforming growth factor, beta 10.693
FSTL1follistatin-like 10.668
GSK3Bglycogen synthase kinase 3 beta0.623
TGFB3transforming growth factor, beta 30.618
COL6A1collagen, type VI, alpha 10.604
SMAD9SMAD family member 90.536
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.527
FKBP1AFK506 binding protein 1A, 12kDa0.526
AXIN1axin 10.483
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.477
NCK2NCK adaptor protein 20.463
YAP1Yes-associated protein 10.450
BMP2bone morphogenetic protein 20.449
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.425
TGFBR1transforming growth factor, beta receptor 10.418
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.406
CREBBPCREB binding protein0.386
CXXC5CXXC finger protein 50.371
DDR2discoidin domain receptor tyrosine kinase 20.367
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.322
EP300E1A binding protein p3000.315
FGF1fibroblast growth factor 1 (acidic)0.311
SMURF1SMAD specific E3 ubiquitin protein ligase 10.299
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.296
PTK2PTK2 protein tyrosine kinase 20.288
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.287
BCAR1breast cancer anti-estrogen resistance 10.286
COL4A1collagen, type IV, alpha 10.282
SMAD6SMAD family member 60.280
COL1A2collagen, type I, alpha 20.278
TBX5T-box 50.257
COL4A2collagen, type IV, alpha 20.242
FN1fibronectin 10.240
GATA4GATA binding protein 40.236
SP1Sp1 transcription factor0.235
NOTCH3notch 30.234
FZD1frizzled homolog 1 (Drosophila)0.221
HDAC1histone deacetylase 10.218
SETD8SET domain containing (lysine methyltransferase) 80.207
COL5A1collagen, type V, alpha 10.207
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.205
SMN1survival of motor neuron 1, telomeric0.205
MAP3K5mitogen-activated protein kinase kinase kinase 50.197
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.196
ENGendoglin0.194
QKIquaking homolog, KH domain RNA binding (mouse)0.191
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.179
POU5F1POU class 5 homeobox 10.174
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.171
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.170
PAPPApregnancy-associated plasma protein A, pappalysin 10.153
FOXF2forkhead box F20.150
IMMTinner membrane protein, mitochondrial0.143
FGF10fibroblast growth factor 100.140
FGF3fibroblast growth factor 30.134
MSX1msh homeobox 10.133
RUNX1runt-related transcription factor 10.130
PAX8paired box 80.129
SIRT1sirtuin 10.127
FOXA2forkhead box A20.125
LOXlysyl oxidase0.121
MAGEA2melanoma antigen family A, 20.121
BGNbiglycan0.120
BMP7bone morphogenetic protein 70.120
GATA2GATA binding protein 20.116
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.113
WDYHV1WDYHV motif containing 10.112
PMLpromyelocytic leukemia0.102
LPXNleupaxin0.099
FGF8fibroblast growth factor 8 (androgen-induced)0.099
CTNNBIP1catenin, beta interacting protein 10.091
COL5A2collagen, type V, alpha 20.088
HEY1hairy/enhancer-of-split related with YRPW motif 10.088
WNT3Awingless-type MMTV integration site family, member 3A0.087
POSTNperiostin, osteoblast specific factor0.086
FOXF1forkhead box F10.085
HIPK2homeodomain interacting protein kinase 20.085
PDX1pancreatic and duodenal homeobox 10.084
SKIv-ski sarcoma viral oncogene homolog (avian)0.083
HIC1hypermethylated in cancer 10.082
SOX1SRY (sex determining region Y)-box 10.082
WNT1wingless-type MMTV integration site family, member 10.081
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.944
aldh1a2aldehyde dehydrogenase 1 family, member A20.804
cdh2cadherin 2, neuronal0.763
shhasonic hedgehog a0.707
dlcdeltaC0.653
sox10SRY-box containing gene 100.642
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.623
bmp2bbone morphogenetic protein 2b0.517
tgfb3transforming growth factor, beta 30.443
dlddeltaD0.417
has2hyaluronan synthase 20.410
hey1hairy/enhancer-of-split related with YRPW motif 10.388
wnt5bwingless-type MMTV integration site family, member 5b0.346
fn1fibronectin 10.344
dctdopachrome tautomerase0.320
eya1eyes absent homolog 10.319
lmo4aLIM domain only 4a0.303
tgfbitransforming growth factor, beta-induced0.289
fgf10afibroblast growth factor 10a0.274
alcamaactivated leukocyte cell adhesion molecule a0.258
col1a2collagen, type I, alpha 20.250
gli1GLI-Kruppel family member 10.246
osr1odd-skipped related 1 (Drosophila)0.227
nrarpanotch-regulated ankyrin repeat protein a0.227
rargaretinoic acid receptor gamma a0.226
pax9paired box gene 90.217
foxd3forkhead box D30.217
bmp4bone morphogenetic protein 40.212
msxcmuscle segment homeobox C0.191
mmp2matrix metalloproteinase 20.182
igf1rbinsulin-like growth factor 1b receptor0.173
foxa3forkhead box A30.160
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.157
lef1lymphocyte enhancer binding factor 10.154
notch3notch homolog 30.152
osr2odd-skipped related 2 (Drosophila)0.148
dlx2adistal-less homeobox gene 2a0.141
hoxc8ahomeo box C8a0.136
tfap2atranscription factor AP-2 alpha0.133
wnt11wingless-type MMTV integration site family, member 110.132
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.125
her1hairy-related 10.125
mitfamicrophthalmia-associated transcription factor a0.123
crabp2acellular retinoic acid binding protein 2, a0.121
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.118
gscgoosecoid0.117
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.111
tcf7transcription factor 7 (T-cell specific, HMG-box)0.103
twist3twist30.101
chdchordin0.100
edn1endothelin 10.099
robo3roundabout homolog 30.098
lft2lefty20.097
spry4sprouty (Drosophila) homolog 40.095
gro1groucho 10.086
gdf6agrowth differentiation factor 6a0.082
myl7myosin, light polypeptide 7, regulatory0.081
msxdmuscle segment homeobox D0.077
id3inhibitor of DNA binding 30.076
dcndecorin0.076
nkx2.5NK2 transcription factor related 50.075
col5a2lcollagen, type V, alpha 2-like0.073
lhx5LIM homeobox 50.072
spns2spinster homolog 2 (Drosophila)0.072
mibmind bomb0.070
vcanbversican b0.068
pcdh8protocadherin 80.067
sox19aSRY-box containing gene 19a0.067
fgf8afibroblast growth factor 8 a0.067
hapln1ahyaluronan and proteoglycan link protein 1a0.067
col5a1procollagen, type V, alpha 10.067
ripply1ripply10.066
tbx18T-box 180.066
wnt11rwingless-type MMTV integration site family, member 11, related0.065
irx3airoquois homeobox protein 3a0.064
pkd2polycystic kidney disease 20.064
lfnglunatic fringe homolog0.063
ndr2nodal-related 20.063
gli2aGLI-Kruppel family member GLI2a0.062
rbfox2RNA binding protein, fox-1 homolog (C. elegans) 20.061
raraaretinoic acid receptor, alpha a0.061
pdgfrlplatelet-derived growth factor receptor-like0.060
cxcr4achemokine (C-X-C motif) receptor 4a0.060
cdx4caudal type homeo box transcription factor 40.059
tbx22T-box 220.059
cdh1cadherin 1, epithelial0.059
vsx1visual system homeobox 1 homolog, chx10-like0.058
fzd10frizzled homolog 100.058
rarabretinoic acid receptor, alpha b0.058
shhbsonic hedgehog b0.057
nkx3.2NK3 homeobox 20.056
nog3noggin 30.056
tbx6T-box gene 60.056
lhx2bLIM homeobox 2b0.054
fzd5frizzled homolog 50.054
plod1aprocollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a0.052
col1a1acollagen, type I, alpha 1a0.052
sox3SRY-box containing gene 30.051
tbx16T-box gene 160.050
tgfb2transforming growth factor, beta 20.049
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
EgfrEpidermal growth factor receptor0.026
bazbazooka0.023
wgwingless0.021
MadMothers against dpp0.015
hhhedgehog0.014
dshdishevelled0.014
stumpsCG31317 gene product from transcript CG31317-RC0.013
NNotch0.013
bnlbranchless0.013
Cg25CCollagen type IV0.012
cicubitus interruptus0.012
AxnAxin0.012
tkvthickveins0.012
ecdecdysoneless0.012
kibrakibra ortholog0.011
ftz-f1ftz transcription factor 10.011
shnschnurri0.011
CG11347CG11347 gene product from transcript CG11347-RE0.011
pr-set7CG3307 gene product from transcript CG3307-RC0.011
panpangolin0.011
ash2absent, small, or homeotic discs 20.011
CG9705CG9705 gene product from transcript CG9705-RA0.011
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.011
tlltailless0.010
babobaboon0.010
RelRelish0.010
wdbwiderborst0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Tgfb2transforming growth factor, beta 21.000
Gli3GLI-Kruppel family member GLI30.999
Ctnnb1catenin (cadherin associated protein), beta 10.996
Efnb2ephrin B20.996
Fgfr2fibroblast growth factor receptor 20.994
Sox2SRY-box containing gene 20.992
Foxc1forkhead box C10.988
Runx2runt related transcription factor 20.987
Hand1heart and neural crest derivatives expressed transcript 10.987
Otx2orthodenticle homolog 2 (Drosophila)0.986
Bmp4bone morphogenetic protein 40.985
Pax2paired box gene 20.984
Pax3paired box gene 30.978
Prrx1paired related homeobox 10.978
Nodalnodal0.972
Msx1homeobox, msh-like 10.966
Lef1lymphoid enhancer binding factor 10.963
Rargretinoic acid receptor, gamma0.959
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.946
Alx4aristaless-like homeobox 40.945
Tbx3T-box 30.941
Notch1Notch gene homolog 1 (Drosophila)0.934
Msx2homeobox, msh-like 20.931
Gli2GLI-Kruppel family member GLI20.931
Snai1snail homolog 1 (Drosophila)0.922
Dlx5distal-less homeobox 50.921
Jag1jagged 10.918
Hoxa1homeobox A10.899
Foxa2forkhead box A20.894
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.893
Fgf8fibroblast growth factor 80.879
Pitx2paired-like homeodomain transcription factor 20.872
Gata4GATA binding protein 40.870
Pax6paired box gene 60.867
Fgfr1fibroblast growth factor receptor 10.849
Smad6MAD homolog 6 (Drosophila)0.846
Ror2receptor tyrosine kinase-like orphan receptor 20.845
Nognoggin0.827
Hey2hairy/enhancer-of-split related with YRPW motif 20.801
Gdnfglial cell line derived neurotrophic factor0.784
Crb2crumbs homolog 2 (Drosophila)0.779
Tcfap2atranscription factor AP-2, alpha0.779
Hes1hairy and enhancer of split 1 (Drosophila)0.777
Prrx2paired related homeobox 20.762
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.756
Gata6GATA binding protein 60.754
Sox9SRY-box containing gene 90.751
Ntf3neurotrophin 30.747
Bmp7bone morphogenetic protein 70.731
Col2a1collagen, type II, alpha 10.729
Pitx1paired-like homeodomain transcription factor 10.695
Hand2heart and neural crest derivatives expressed transcript 20.672
Lhx1LIM homeobox protein 10.665
Zeb1zinc finger E-box binding homeobox 10.665
Smosmoothened homolog (Drosophila)0.647
Hoxd13homeobox D130.645
Tlx3T-cell leukemia, homeobox 30.639
Lmx1aLIM homeobox transcription factor 1 alpha0.635
Eya1eyes absent 1 homolog (Drosophila)0.624
Smad4MAD homolog 4 (Drosophila)0.619
Col1a1collagen, type I, alpha 10.616
Ascl1achaete-scute complex homolog 1 (Drosophila)0.614
Emx1empty spiracles homolog 1 (Drosophila)0.614
Pou3f3POU domain, class 3, transcription factor 30.602
Efnb1ephrin B10.586
En1engrailed 10.577
Apcadenomatosis polyposis coli0.573
Lrp6low density lipoprotein receptor-related protein 60.571
Fgf10fibroblast growth factor 100.565
Pou5f1POU domain, class 5, transcription factor 10.562
Pthlhparathyroid hormone-like peptide0.537
Axin1axin 10.533
Foxf1aforkhead box F1a0.516
Twist2twist homolog 2 (Drosophila)0.512
Neurod1neurogenic differentiation 10.511
Hes5hairy and enhancer of split 5 (Drosophila)0.505
Foxc2forkhead box C20.495
Foxg1forkhead box G10.489
Wnt3awingless-related MMTV integration site 3A0.474
Hoxb1homeobox B10.471
Hif1ahypoxia inducible factor 1, alpha subunit0.470
Otx1orthodenticle homolog 1 (Drosophila)0.466
Pax9paired box gene 90.464
Rspo2R-spondin 2 homolog (Xenopus laevis)0.454
Hspg2perlecan (heparan sulfate proteoglycan 2)0.445
Zic3zinc finger protein of the cerebellum 30.437
Ephb3Eph receptor B30.432
Ephb2Eph receptor B20.429
Foxh1forkhead box H10.417
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.410
Dll4delta-like 4 (Drosophila)0.402
Gas1growth arrest specific 10.400
Bmp2bone morphogenetic protein 20.391
Gbx2gastrulation brain homeobox 20.378
Tgfbr2transforming growth factor, beta receptor II0.376
Rarbretinoic acid receptor, beta0.372
Wnt6wingless-related MMTV integration site 60.365
Atoh7atonal homolog 7 (Drosophila)0.363
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.359
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism