The network for 'negative regulation of cell adhesion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell adhesion

Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.

NameDescriptionProbabilityFunc Analog Organism
BCAR1breast cancer anti-estrogen resistance 10.999
EGFRepidermal growth factor receptor0.986
PTPN1protein tyrosine phosphatase, non-receptor type 10.975
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.973
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.966
JAG1jagged 10.956
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.943
TEKTEK tyrosine kinase, endothelial0.942
IL1R1interleukin 1 receptor, type I0.922
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.903
NRP1neuropilin 10.903
SHC1SHC (Src homology 2 domain containing) transforming protein 10.834
TGFB1transforming growth factor, beta 10.808
C1QAcomplement component 1, q subcomponent, A chain0.805
BMPR1Abone morphogenetic protein receptor, type IA0.790
FN1fibronectin 10.768
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.745
PTK2PTK2 protein tyrosine kinase 20.738
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.724
BMP2bone morphogenetic protein 20.721
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.713
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.673
ENGendoglin0.653
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.641
LAMC1laminin, gamma 1 (formerly LAMB2)0.604
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.599
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.594
SEMA4Asema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A0.573
IGFBP3insulin-like growth factor binding protein 30.556
EZRezrin0.553
METmet proto-oncogene (hepatocyte growth factor receptor)0.526
PTPN11protein tyrosine phosphatase, non-receptor type 110.517
FSTL1follistatin-like 10.496
PLATplasminogen activator, tissue0.485
CD44CD44 molecule (Indian blood group)0.471
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.460
SOCS3suppressor of cytokine signaling 30.459
FHL2four and a half LIM domains 20.454
CD63CD63 molecule0.434
COL5A1collagen, type V, alpha 10.421
FKBP1AFK506 binding protein 1A, 12kDa0.410
INADLInaD-like (Drosophila)0.397
PLAURplasminogen activator, urokinase receptor0.395
THBS1thrombospondin 10.388
SMAD7SMAD family member 70.369
FZD1frizzled homolog 1 (Drosophila)0.366
C1QCcomplement component 1, q subcomponent, C chain0.364
FGAfibrinogen alpha chain0.355
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.350
LCKlymphocyte-specific protein tyrosine kinase0.344
ARandrogen receptor0.337
NCOA1nuclear receptor coactivator 10.300
APPamyloid beta (A4) precursor protein0.284
HOXB5homeobox B50.275
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.262
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.249
ABI2abl-interactor 20.244
PTPN12protein tyrosine phosphatase, non-receptor type 120.239
RXRAretinoid X receptor, alpha0.236
PTPRJprotein tyrosine phosphatase, receptor type, J0.233
GRB2growth factor receptor-bound protein 20.227
BBS10Bardet-Biedl syndrome 100.226
TNCtenascin C0.218
FNDC3Bfibronectin type III domain containing 3B0.218
HDAC6histone deacetylase 60.217
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.213
TIMP2TIMP metallopeptidase inhibitor 20.212
HOXA10homeobox A100.210
COL4A1collagen, type IV, alpha 10.209
GAB1GRB2-associated binding protein 10.209
NOTCH1notch 10.208
DSG2desmoglein 20.203
PLXND1plexin D10.200
TGFB3transforming growth factor, beta 30.197
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.191
PCYT2phosphate cytidylyltransferase 2, ethanolamine0.187
C1QBcomplement component 1, q subcomponent, B chain0.183
A2Malpha-2-macroglobulin0.183
COL4A2collagen, type IV, alpha 20.181
SDC2syndecan 20.180
COL1A1collagen, type I, alpha 10.176
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.173
SFRP1secreted frizzled-related protein 10.168
ILKintegrin-linked kinase0.166
MUC1mucin 1, cell surface associated0.161
THBS2thrombospondin 20.159
COL1A2collagen, type I, alpha 20.159
PLAUplasminogen activator, urokinase0.158
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.154
MAPK1mitogen-activated protein kinase 10.154
DSPdesmoplakin0.152
IGFBP5insulin-like growth factor binding protein 50.148
ESR1estrogen receptor 10.147
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.146
CDCP1CUB domain containing protein 10.144
WNT5Awingless-type MMTV integration site family, member 5A0.143
COL7A1collagen, type VII, alpha 10.142
DLG1discs, large homolog 1 (Drosophila)0.142
LPXNleupaxin0.142
HOXA5homeobox A50.141
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cdh1cadherin 1, epithelial0.590
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.539
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.382
gna13bguanine nucleotide binding protein (G protein), alpha 13b0.309
gna12guanine nucleotide binding protein (G protein) alpha 120.260
bmp4bone morphogenetic protein 40.240
trpv4transient receptor potential cation channel, subfamily V, member 40.210
nf1aneurofibromin 1a0.149
spry4sprouty (Drosophila) homolog 40.143
plxnd1plexin D10.142
gna11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)0.122
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.118
kdrlkinase insert domain receptor like0.114
wnt5bwingless-type MMTV integration site family, member 5b0.104
hlxb9lbhomeo box HB9 like b0.100
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.087
gnai2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.086
spns2spinster homolog 2 (Drosophila)0.084
fetubfetuin B0.082
msxcmuscle segment homeobox C0.076
col5a1procollagen, type V, alpha 10.075
sox10SRY-box containing gene 100.073
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.072
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.070
bmpr1aabone morphogenetic protein receptor, type 1aa0.067
nrp1aneuropilin 1a0.065
lmo4aLIM domain only 4a0.063
grhl1grainyhead-like 1 (Drosophila)0.061
bmp2bbone morphogenetic protein 2b0.060
fgafibrinogen alpha chain0.054
epas1bendothelial PAS domain protein 1b0.053
fbn2bfibrillin 2b0.050
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.049
col12a1collagen, type XII, alpha 10.047
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.047
lmx1b.1LIM homeobox transcription factor 1, beta 10.041
snai1asnail homolog 1a (Drosophila)0.038
tac1tachykinin 10.037
axin1axin 10.037
fzd7bfrizzled homolog 7b0.036
plce1phospholipase C, epsilon 10.036
emp2epithelial membrane protein 20.035
zgc:101761zgc:1017610.033
ambplalpha-1-microglobulin/bikunin precursor, like0.033
zgc:123178zgc:1231780.032
fras1Fraser syndrome 10.029
uoxurate oxidase0.028
rarabretinoic acid receptor, alpha b0.028
cnn2calponin 20.028
kirrel3lkin of IRRE like 3 like0.027
nrarpanotch-regulated ankyrin repeat protein a0.027
wtipWilms tumor 1 interacting protein0.027
rargaretinoic acid receptor gamma a0.027
ccm2cerebral cavernous malformation 20.027
zgc:85866zgc:858660.027
tie1endothelium-specific receptor tyrosine kinase 10.027
gnasGNAS complex locus0.026
vegfcvascular endothelial growth factor c0.026
irx3airoquois homeobox protein 3a0.025
chdchordin0.024
col1a2collagen, type I, alpha 20.024
sept6septin 60.023
llgl2lethal giant larvae homolog 2 (Drosophila)0.022
bnc2basonuclin 20.022
gnai3guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 30.020
hsp47heat shock protein 470.020
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.020
apomapolipoprotein M0.019
rasl11bRAS-like, family 11, member B0.019
itih2inter-alpha (globulin) inhibitor H20.019
scn8aasodium channel, voltage-gated, type VIII, alpha a0.019
slc25a22solute carrier family 25 (mitochondrial carrier: glutamate), member 220.018
nsa2NSA2 ribosome biogenesis homolog (S. cerevisiae)0.018
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.017
postnperiostin, osteoblast specific factor0.017
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.017
ptpraprotein tyrosine phosphatase, receptor type, A0.017
egr1early growth response 10.017
tp63tumor protein p630.017
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.017
zgc:193613zgc:1936130.016
gnaiaguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a0.016
mapk1mitogen-activated protein kinase 10.016
si:dkey-261h17.1si:dkey-261h17.10.016
c9complement component 90.016
wlswntless homolog (Drosophila)0.016
psen1presenilin 10.015
zgc:100942zgc:1009420.015
xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.015
ppp3cbprotein phosphatase 3, catalytic subunit, beta isozyme0.015
styk1serine/threonine/tyrosine kinase 10.015
osr1odd-skipped related 1 (Drosophila)0.014
qkquaking0.014
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.014
bmp3bone morphogenetic protein 30.014
nf1bneurofibromin 1b0.014
dab1bdisabled homolog 1b (Drosophila)0.014
f11rF11 receptor0.014
si:dkey-204a24.2si:dkey-204a24.20.014
her1hairy-related 10.013
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.195
panpangolin0.115
uspultraspiracle0.103
l(2)gllethal (2) giant larvae0.095
Ras85DRas oncogene at 85D0.094
LIMK1LIM-kinase10.090
wgwingless0.089
EcREcdysone receptor0.056
McrMacroglobulin complement-related0.054
rhorhomboid0.052
wunwunen0.044
Akt1CG4006 gene product from transcript CG4006-RA0.042
drkdownstream of receptor kinase0.040
babobaboon0.038
shgshotgun0.037
dppdecapentaplegic0.036
EgfrEpidermal growth factor receptor0.036
edechinoid0.034
CblCG7037 gene product from transcript CG7037-RB0.034
staistathmin0.032
shishibire0.030
taitaiman0.029
ttktramtrack0.029
pckpickel0.028
par-1CG8201 gene product from transcript CG8201-RA0.028
hhhedgehog0.027
pntpointed0.027
plexAplexin A0.027
mavmaverick0.026
myoglianinCG1838 gene product from transcript CG1838-RD0.025
NNotch0.024
Src64BSrc oncogene at 64B0.020
spispitz0.019
Stat92ESignal-transducer and activator of transcription protein at 92E0.018
Src42ASrc oncogene at 42A0.017
Mmp1Matrix metalloproteinase 10.016
gtgiant0.015
ftz-f1ftz transcription factor 10.015
CaMKIICalcium/calmodulin-dependent protein kinase II0.015
crbcrumbs0.014
chicoCG5686 gene product from transcript CG5686-RB0.014
witwishful thinking0.014
CG1021CG1021 gene product from transcript CG1021-RE0.013
gcmglial cells missing0.013
CG3797CG3797 gene product from transcript CG3797-RA0.012
rstroughest0.012
argosCG4531 gene product from transcript CG4531-RA0.011
seiseizure0.011
LLobe0.011
CG32810CG32810 gene product from transcript CG32810-RB0.011
NFATNFAT homolog0.011
G-oalpha47AG protein oalpha 47A0.011
easeasily shocked0.011
TlToll0.011
drlderailed0.010
ContContactin0.010
FhosCG42610 gene product from transcript CG42610-RC0.010
Nrx-IVNeurexin IV0.010
Tao-1CG14217 gene product from transcript CG14217-RF0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.964
Trp53transformation related protein 530.922
Dlg1discs, large homolog 1 (Drosophila)0.704
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.703
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.685
Thbs1thrombospondin 10.668
Nos3nitric oxide synthase 3, endothelial cell0.654
Col1a1collagen, type I, alpha 10.579
Itgb1integrin beta 1 (fibronectin receptor beta)0.568
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.555
Snai1snail homolog 1 (Drosophila)0.519
Nid1nidogen 10.517
Ptk2PTK2 protein tyrosine kinase 20.508
Bgnbiglycan0.482
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.468
Col5a1collagen, type V, alpha 10.467
Col3a1collagen, type III, alpha 10.440
Ptenphosphatase and tensin homolog0.423
Mmp2matrix metallopeptidase 20.369
Tgfb2transforming growth factor, beta 20.355
Fbn1fibrillin 10.338
Wnt5awingless-related MMTV integration site 5A0.336
Thbs2thrombospondin 20.335
Postnperiostin, osteoblast specific factor0.313
Col8a1collagen, type VIII, alpha 10.302
Col5a2collagen, type V, alpha 20.296
Tnctenascin C0.275
Gli3GLI-Kruppel family member GLI30.274
Flt4FMS-like tyrosine kinase 40.272
Col4a4collagen, type IV, alpha 40.259
Col6a3collagen, type VI, alpha 30.257
Tgfbr2transforming growth factor, beta receptor II0.247
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.235
Smad4MAD homolog 4 (Drosophila)0.224
Col6a1collagen, type VI, alpha 10.223
Ddr2discoidin domain receptor family, member 20.223
Acvr1activin A receptor, type 10.222
Mrc2mannose receptor, C type 20.210
Fstl1follistatin-like 10.209
Nf1neurofibromatosis 10.208
Nos1nitric oxide synthase 1, neuronal0.201
Wisp1WNT1 inducible signaling pathway protein 10.191
Twsg1twisted gastrulation homolog 1 (Drosophila)0.182
Efnb2ephrin B20.181
Fzd8frizzled homolog 8 (Drosophila)0.180
Col6a2collagen, type VI, alpha 20.171
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.171
Lama4laminin, alpha 40.170
Gopcgolgi associated PDZ and coiled-coil motif containing0.169
Pcolceprocollagen C-endopeptidase enhancer protein0.162
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.154
Nphs2nephrosis 2 homolog, podocin (human)0.148
FynFyn proto-oncogene0.144
Prrx2paired related homeobox 20.139
Fbln2fibulin 20.138
Csf1colony stimulating factor 1 (macrophage)0.137
Col12a1collagen, type XII, alpha 10.136
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.132
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.130
Elnelastin0.127
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.126
Hif1ahypoxia inducible factor 1, alpha subunit0.125
Col1a2collagen, type I, alpha 20.118
Ctskcathepsin K0.117
Lama5laminin, alpha 50.117
Engendoglin0.116
Creb3l1cAMP responsive element binding protein 3-like 10.116
Sox9SRY-box containing gene 90.115
Smad1MAD homolog 1 (Drosophila)0.114
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.114
Hes1hairy and enhancer of split 1 (Drosophila)0.112
Apcadenomatosis polyposis coli0.111
Lhx1LIM homeobox protein 10.111
Col4a5collagen, type IV, alpha 50.110
Gsk3bglycogen synthase kinase 3 beta0.109
Thbdthrombomodulin0.106
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.105
Loxlysyl oxidase0.103
Zfhx3zinc finger homeobox 30.101
Ntf3neurotrophin 30.097
Col11a1collagen, type XI, alpha 10.093
Rargretinoic acid receptor, gamma0.091
Fgf7fibroblast growth factor 70.091
Twist1twist homolog 1 (Drosophila)0.090
Bmp4bone morphogenetic protein 40.089
Angptl2angiopoietin-like 20.088
Aebp1AE binding protein 10.087
Notch2Notch gene homolog 2 (Drosophila)0.087
Fndc1fibronectin type III domain containing 10.086
Smad3MAD homolog 3 (Drosophila)0.085
Loxl1lysyl oxidase-like 10.084
Foxf1aforkhead box F1a0.084
Sox4SRY-box containing gene 40.082
Ceacam16carcinoembryonic antigen-related cell adhesion molecule 160.082
Kitlkit ligand0.081
Phldb2pleckstrin homology-like domain, family B, member 20.081
Emp2epithelial membrane protein 20.081
Fkbp10FK506 binding protein 100.080
Pdgfbplatelet derived growth factor, B polypeptide0.080
Ptpn11protein tyrosine phosphatase, non-receptor type 110.080
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism