The network for 'striated muscle myosin thick filament assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

striated muscle myosin thick filament assembly

The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in striated muscle.

NameDescriptionProbabilityFunc Analog Organism
FN1fibronectin 10.502
TRIM63tripartite motif containing 630.496
ILKintegrin-linked kinase0.451
FLNAfilamin A, alpha0.365
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.353
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.329
PGK1phosphoglycerate kinase 10.324
SF3B4splicing factor 3b, subunit 4, 49kDa0.305
GEMIN7gem (nuclear organelle) associated protein 70.285
ARHGAP1Rho GTPase activating protein 10.275
HAP1huntingtin-associated protein 10.254
CDT1chromatin licensing and DNA replication factor 10.234
ATG5ATG5 autophagy related 5 homolog (S. cerevisiae)0.227
ALDOAaldolase A, fructose-bisphosphate0.191
GPIglucose-6-phosphate isomerase0.178
TCF4transcription factor 40.175
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.154
ACTN4actinin, alpha 40.132
FKBP4FK506 binding protein 4, 59kDa0.125
MYH9myosin, heavy chain 9, non-muscle0.123
ENO1enolase 1, (alpha)0.123
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.121
ACTN1actinin, alpha 10.121
ANK1ankyrin 1, erythrocytic0.118
PKM2pyruvate kinase, muscle0.113
TNNC1troponin C type 1 (slow)0.104
ZNF830zinc finger protein 8300.102
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.099
DHCR77-dehydrocholesterol reductase0.096
HDAC4histone deacetylase 40.091
TAGLN2transgelin 20.089
STRAPserine/threonine kinase receptor associated protein0.087
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.084
TUBB3tubulin, beta 30.084
FADS2fatty acid desaturase 20.083
PPP5Cprotein phosphatase 5, catalytic subunit0.079
TK1thymidine kinase 1, soluble0.073
CD44CD44 molecule (Indian blood group)0.073
NDUFS7NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)0.072
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.071
UBAP2Lubiquitin associated protein 2-like0.068
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.068
LDHAlactate dehydrogenase A0.067
SF1splicing factor 10.065
GAPDHglyceraldehyde-3-phosphate dehydrogenase0.065
PTBP1polypyrimidine tract binding protein 10.065
AHSA1AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)0.063
CALD1caldesmon 10.061
RHOGras homolog gene family, member G (rho G)0.059
CFL1cofilin 1 (non-muscle)0.058
FLNBfilamin B, beta0.055
TPM4tropomyosin 40.055
PARVAparvin, alpha0.054
SCDstearoyl-CoA desaturase (delta-9-desaturase)0.051
MYL9myosin, light chain 9, regulatory0.051
TUBB6tubulin, beta 60.051
TUBB2Ctubulin, beta 2C0.050
TRIM28tripartite motif containing 280.050
EWSR1Ewing sarcoma breakpoint region 10.049
UBAP2ubiquitin associated protein 20.048
ATG7ATG7 autophagy related 7 homolog (S. cerevisiae)0.048
SF3A1splicing factor 3a, subunit 1, 120kDa0.047
UBE2R2ubiquitin-conjugating enzyme E2R 20.046
SEC24DSEC24 family, member D (S. cerevisiae)0.046
PRRC2Aproline-rich coiled-coil 2A0.046
TPM1tropomyosin 1 (alpha)0.045
MCM10minichromosome maintenance complex component 100.045
ACTBactin, beta0.045
CCND1cyclin D10.044
ACTN2actinin, alpha 20.044
ATG16L1ATG16 autophagy related 16-like 1 (S. cerevisiae)0.044
JUPjunction plakoglobin0.044
DAZAP1DAZ associated protein 10.043
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.042
HSPH1heat shock 105kDa/110kDa protein 10.042
PARVBparvin, beta0.042
PRPF8PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)0.041
CDK2cyclin-dependent kinase 20.041
YIPF5Yip1 domain family, member 50.041
SUGT1SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)0.041
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.040
RICTORRPTOR independent companion of MTOR, complex 20.040
CAPN3calpain 3, (p94)0.039
NUP62nucleoporin 62kDa0.039
RCC2regulator of chromosome condensation 20.039
TPI1triosephosphate isomerase 10.039
BAK1BCL2-antagonist/killer 10.038
TGS1trimethylguanosine synthase 10.038
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.037
TOMM70Atranslocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)0.037
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.037
FUSfused in sarcoma0.037
SF3B3splicing factor 3b, subunit 3, 130kDa0.037
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
F39G3.5Protein F39G3.50.161
his-46Protein HIS-460.156
pat-4Protein PAT-40.137
unc-15Protein UNC-150.133
his-64Protein HIS-640.130
pat-2Protein PAT-20.118
act-4Protein ACT-40.117
his-1Protein HIS-10.115
twk-18Protein TWK-180.105
myo-3Protein MYO-30.102
deb-1Protein DEB-10.102
ketn-1Protein KETN-10.102
act-2Protein ACT-20.101
unc-112Protein UNC-1120.101
mup-2Protein MUP-20.099
ZK856.7Protein ZK856.70.099
his-5Protein HIS-50.098
CELE_Y95D11A.1Protein Y95D11A.10.095
ifa-1Protein IFA-10.095
vab-3Protein VAB-30.094
lev-11Protein LEV-110.093
let-363Protein LET-3630.090
mig-6Protein MIG-60.090
T28B4.1Protein T28B4.10.088
tag-232Protein TAG-2320.087
nhr-2Protein NHR-20.084
hrdl-1Protein HRDL-10.083
ttm-4Protein TTM-40.082
gei-4Protein GEI-40.082
C46A5.6Protein C46A5.60.081
CELE_Y51A2D.14Protein Y51A2D.140.078
set-18Protein SET-180.077
CELE_M03A8.3Protein M03A8.30.077
cmd-1Protein CMD-10.076
lam-2Protein LAM-20.075
his-31Protein HIS-310.074
col-34Protein COL-340.074
cam-1Protein CAM-10.074
inx-15Protein INX-150.074
zer-1Protein ZER-10.073
hipr-1Protein HIPR-10.072
dnj-12Protein DNJ-120.072
ZK54.1Protein ZK54.10.070
glc-4Protein GLC-40.069
his-50Protein HIS-500.069
unc-89Protein UNC-890.069
pfn-3Protein PFN-30.068
cysl-1Protein CYSL-10.068
mec-2Protein MEC-20.067
unc-7Protein UNC-70.067
ifb-2Protein IFB-20.067
lec-3Protein LEC-30.067
C06G3.6Protein C06G3.60.067
cnd-1Protein CND-10.066
gst-7Protein GST-70.066
wrk-1Protein WRK-10.065
CELE_F18A11.3Protein F18A11.30.064
unc-36Protein UNC-360.064
ajm-1Protein AJM-10.063
unc-43Protein UNC-430.063
snf-1Protein SNF-10.063
egl-27Protein EGL-270.062
flt-1Protein FLT-10.062
CELE_M03D4.4Protein M03D4.40.062
gst-20Protein GST-200.062
inx-5Protein INX-50.061
H36L18.2Protein H36L18.20.061
col-180Protein COL-1800.061
che-3Protein CHE-30.061
F54E4.3Protein F54E4.30.061
mrpl-10Protein MRPL-100.061
T19D12.4Protein T19D12.40.061
CELE_ZC204.12Protein ZC204.120.060
his-38Protein HIS-380.060
tag-345Protein TAG-3450.060
eat-18Protein EAT-180.060
C44C1.1Protein C44C1.10.059
dur-1Protein DUR-10.059
col-142Protein COL-1420.059
pat-10Protein PAT-100.059
unc-44Protein UNC-440.059
Y110A7A.6Protein Y110A7A.60.058
atp-5Protein ATP-50.058
pdl-1Protein PDL-10.058
inx-4Protein INX-40.057
T20D3.5Protein T20D3.50.057
nhr-111Protein NHR-1110.057
fog-2Protein FOG-20.056
epi-1Protein EPI-10.056
unc-87Protein UNC-870.056
unc-82Protein UNC-820.056
CELE_W02D7.5Protein W02D7.50.055
evl-20Protein EVL-200.055
act-5Protein ACT-50.055
B0041.5Protein B0041.50.055
inx-8Protein INX-80.054
ubr-1Protein UBR-10.054
C32D5.3Protein C32D5.30.054
F01F1.11Protein F01F1.110.054
dig-1Protein DIG-10.054
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
smyd1bSET and MYND domain containing 1b0.997
mef2cbmyocyte enhancer factor 2cb0.977
smyhc2slow myosin heavy chain 20.962
mef2camyocyte enhancer factor 2ca0.807
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.771
tnni1altroponin I, skeletal, slow like0.693
tnni1btroponin I, skeletal, slow b0.628
unc45bunc-45 homolog B (C. elegans)0.625
tnni2a.4troponin I, skeletal, fast 2a.40.610
flncbfilamin C, gamma b (actin binding protein 280)0.553
ttnatitin a0.462
six1bsine oculis homeobox homolog 1b0.442
hsp90a.1heat shock protein 90-alpha 10.429
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.415
eno3enolase 3, (beta, muscle)0.307
myhc4myosin heavy chain 40.303
myhz2myosin, heavy polypeptide 2, fast muscle specific0.271
smyhc1slow myosin heavy chain 10.249
smyhc1lslow myosin heavy chain 1, like0.248
smyd1aSET and MYND domain containing 1a0.243
tnnc1btroponin C type 1b (slow)0.196
tnnt3btroponin T3b, skeletal, fast0.180
pgk1phosphoglycerate kinase 10.165
aldocbaldolase C, fructose-bisphosphate, b0.164
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.122
bc2putative breast adenocarcinoma marker0.111
smyd2bSET and MYND domain containing 2b0.077
myod1myogenic differentiation 10.062
vmhcventricular myosin heavy chain0.062
myhz1.1myosin, heavy polypeptide 1.1, skeletal muscle0.062
tpi1btriosephosphate isomerase 1b0.059
ldhalactate dehydrogenase A40.059
eno1enolase 1, (alpha)0.052
actn3aactinin alpha 3a0.051
tnnt2atroponin T2a, cardiac0.045
sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.045
got2bglutamic-oxaloacetic transaminase 2b, mitochondrial (aspartate aminotransferase 2)0.045
gpiaglucose phosphate isomerase a0.045
desmadesmin a0.043
ryr1bryanodine receptor 1b (skeletal)0.043
cacnb1calcium channel, voltage-dependent, beta 1 subunit0.043
xirp1xin actin-binding repeat containing 10.040
spock3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 30.038
mylz2myosin, light polypeptide 2, skeletal muscle0.037
plxna3plexin A30.028
lamb2laminin, beta 2 (laminin S)0.028
ldhbalactate dehydrogenase Ba0.026
ckmacreatine kinase, muscle a0.026
pkm2apyruvate kinase, muscle, a0.026
efna1bephrin A1b0.022
stac3SH3 and cysteine rich domain 30.022
calm1acalmodulin 1a0.022
actn3bactinin alpha 3b0.020
tnnc2troponin C type 2 (fast)0.019
hmcn1hemicentin 10.019
dmrt2bdoublesex and mab-3 related transcription factor 2b0.019
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.018
chmp5chromatin modifying protein 50.017
muskmuscle, skeletal, receptor tyrosine kinase0.017
pygmbphosphorylase, glycogen (muscle) b0.017
mstnamyostatin a0.017
chrndcholinergic receptor, nicotinic, delta polypeptide0.017
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.016
aldoaaaldolase a, fructose-bisphosphate, a0.016
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.015
krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.015
pobpartial optokinetic response b0.014
nup93nucleoporin 930.014
ppargperoxisome proliferator activated receptor gamma0.014
tnnt1troponin T1, skeletal, slow0.014
fabp3fatty acid binding protein 3, muscle and heart0.014
kbpkif1-binding protein0.014
rap1bRAS related protein 1b0.013
tnnt3atroponin T3a, skeletal, fast0.013
nme2b.2non-metastatic cells 2b.2, protein (NM23B) expressed in0.013
pahphenylalanine hydroxylase0.013
pdlim7PDZ and LIM domain 70.013
eif5aeukaryotic translation initiation factor 5A0.012
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.011
actn2actinin, alpha 20.011
fabp11afatty acid binding protein 11a0.011
gle1GLE1 RNA export mediator homolog (yeast)0.011
smyhc3slow myosin heavy chain 30.010
vgll2bvestigial like 2b0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Actnalpha actinin0.902
Tm2Tropomyosin 20.862
wupAwings up A0.845
Ca-P60ACalcium ATPase at 60A0.689
Zasp66Z band alternatively spliced PDZ-motif protein 660.675
Zasp52Z band alternatively spliced PDZ-motif protein 520.633
AtpalphaNa pump alpha subunit0.517
Act88FActin 88F0.352
l(1)10Bblethal (1) 10Bb0.307
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.264
stmAstambha A0.253
rheaCG6831 gene product from transcript CG6831-RA0.239
Mlc2Myosin light chain 20.227
GpdhGlycerol 3 phosphate dehydrogenase0.183
coroCG9446 gene product from transcript CG9446-RC0.172
Mef2Myocyte enhancer factor 20.167
CG4866CG4866 gene product from transcript CG4866-RB0.147
Trxr-1Thioredoxin reductase-10.127
AcslAcyl-CoA synthetase long-chain0.125
shotshort stop0.114
Rya-r44FRyanodine receptor 44F0.114
howheld out wings0.108
Mlc1Myosin alkali light chain 10.108
CG11299CG11299 gene product from transcript CG11299-RA0.100
beta-Specbeta Spectrin0.098
CanB2Calcineurin B20.095
MicalMolecule interacting with CasL0.092
Gpo-1Glycerophosphate oxidase-10.089
Cf2Chorion factor 20.083
salssarcomere length short0.079
ArgkArginine kinase0.079
eIF-4EEukaryotic initiation factor 4E0.078
me31Bmaternal expression at 31B0.077
Cg25CCollagen type IV0.074
Rac1CG2248 gene product from transcript CG2248-RA0.067
Act57BActin 57B0.062
Atg1Autophagy-specific gene 10.058
DAAMDishevelled Associated Activator of Morphogenesis0.056
sesBstress-sensitive B0.056
RalaRas-related protein0.054
CG11583CG11583 gene product from transcript CG11583-RA0.053
eRF1eukaryotic release factor 10.053
LamCLamin C0.051
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.051
CG5214CG5214 gene product from transcript CG5214-RA0.050
KhcKinesin heavy chain0.049
ChcClathrin heavy chain0.048
Tom34Translocase of outer membrane 340.047
FhosCG42610 gene product from transcript CG42610-RC0.045
ImpL3Ecdysone-inducible gene L30.044
Mlp84BMuscle LIM protein at 84B0.042
CG1542CG1542 gene product from transcript CG1542-RA0.042
mbcmyoblast city0.041
CG1234CG1234 gene product from transcript CG1234-RA0.041
lqfliquid facets0.041
Mp20Muscle protein 200.041
Gapdh1Glyceraldehyde 3 phosphate dehydrogenase 10.041
PgkPhosphoglycerate kinase0.040
Syt4Synaptotagmin 40.040
Uch-L3Ubiquitin C-terminal hydrolase0.039
Vha68-2CG3762 gene product from transcript CG3762-RA0.039
Vap-33-1CG5014 gene product from transcript CG5014-RB0.038
TER94CG2331 gene product from transcript CG2331-RA0.038
Eip75BEcdysone-induced protein 75B0.038
Eb1CG3265 gene product from transcript CG3265-RF0.037
Pink1PTEN-induced putative kinase 10.037
snRNP-U1-70Ksmall ribonucleoprotein particle U1 subunit 70K0.037
CG13124CG13124 gene product from transcript CG13124-RE0.035
Surf6Surfeit 60.035
CG5177CG5177 gene product from transcript CG5177-RA0.034
TpnC73FTroponin C at 73F0.033
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.983
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.973
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.967
Hrchistidine rich calcium binding protein0.913
Wdr1WD repeat domain 10.913
Ilkintegrin linked kinase0.903
Itgb1integrin beta 1 (fibronectin receptor beta)0.872
TapbpTAP binding protein0.833
Aldoaaldolase A, fructose-bisphosphate0.822
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.807
Ldb3LIM domain binding 30.793
Tnni2troponin I, skeletal, fast 20.790
Actn2actinin alpha 20.782
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.778
Hspa8heat shock protein 80.770
Gpi1glucose phosphate isomerase 10.759
Hsph1heat shock 105kDa/110kDa protein 10.732
Gm5506predicted gene 55060.694
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.674
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.670
Ckmcreatine kinase, muscle0.615
Myom1myomesin 10.551
Parvaparvin, alpha0.539
Hdac4histone deacetylase 40.537
Tnnc2troponin C2, fast0.520
Vegfavascular endothelial growth factor A0.487
Csrp3cysteine and glycine-rich protein 30.470
Tnnc1troponin C, cardiac/slow skeletal0.452
Ldhalactate dehydrogenase A0.451
Acta1actin, alpha 1, skeletal muscle0.441
Iqcb1IQ calmodulin-binding motif containing 10.427
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.425
Nrapnebulin-related anchoring protein0.417
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.400
Tcte3t-complex-associated testis expressed 30.395
Tnnt3troponin T3, skeletal, fast0.392
Actc1actin, alpha, cardiac muscle 10.388
Myl3myosin, light polypeptide 30.362
Pgk1phosphoglycerate kinase 10.352
Actn3actinin alpha 30.345
Chrm2cholinergic receptor, muscarinic 2, cardiac0.335
Capzbcapping protein (actin filament) muscle Z-line, beta0.316
Pgam2phosphoglycerate mutase 20.310
Myh7myosin, heavy polypeptide 7, cardiac muscle, beta0.296
Vaspvasodilator-stimulated phosphoprotein0.290
Lims1LIM and senescent cell antigen-like domains 10.275
Gja1gap junction protein, alpha 10.266
Laptm5lysosomal-associated protein transmembrane 50.261
Tnnt2troponin T2, cardiac0.260
Myh9myosin, heavy polypeptide 9, non-muscle0.260
Hdac5histone deacetylase 50.256
Cox8bcytochrome c oxidase, subunit VIIIb0.251
Myom2myomesin 20.249
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.243
Cav3caveolin 30.237
Csrp1cysteine and glycine-rich protein 10.232
Pdlim3PDZ and LIM domain 30.226
Itgb1bp2integrin beta 1 binding protein 20.225
Actn4actinin alpha 40.224
Ckmt2creatine kinase, mitochondrial 20.224
Cd151CD151 antigen0.224
Hmha1histocompatibility (minor) HA-10.219
Casq2calsequestrin 20.213
Rac1RAS-related C3 botulinum substrate 10.212
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.207
Myl1myosin, light polypeptide 10.187
Cnn1calponin 10.185
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.184
Tnnt1troponin T1, skeletal, slow0.183
Map3k5mitogen-activated protein kinase kinase kinase 50.183
Ahi1Abelson helper integration site 10.175
Xirp1xin actin-binding repeat containing 10.174
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.170
Eno1enolase 1, alpha non-neuron0.168
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.164
Serbp1serpine1 mRNA binding protein 10.163
Srpk3serine/arginine-rich protein specific kinase 30.163
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.163
Hspa5heat shock protein 50.163
Cltcclathrin, heavy polypeptide (Hc)0.159
Hspb2heat shock protein 20.158
Eef1a2eukaryotic translation elongation factor 1 alpha 20.157
Itga3integrin alpha 30.157
Lmnalamin A0.156
NsfN-ethylmaleimide sensitive fusion protein0.156
Pygmmuscle glycogen phosphorylase0.154
Tagln2transgelin 20.153
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.151
Nphp1nephronophthisis 1 (juvenile) homolog (human)0.143
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.142
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.139
Stip1stress-induced phosphoprotein 10.138
Arpc4actin related protein 2/3 complex, subunit 40.138
Ptprqprotein tyrosine phosphatase, receptor type, Q0.137
Pfklphosphofructokinase, liver, B-type0.136
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism