The network for 'cell substrate junction assembly' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell substrate junction assembly

The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.

NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.997
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.983
PTK2PTK2 protein tyrosine kinase 20.950
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.940
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.917
MDM2Mdm2 p53 binding protein homolog (mouse)0.883
EGFRepidermal growth factor receptor0.882
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.843
S100BS100 calcium binding protein B0.832
VEGFAvascular endothelial growth factor A0.808
FN1fibronectin 10.788
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.773
NCK2NCK adaptor protein 20.734
BCAR1breast cancer anti-estrogen resistance 10.708
FYNFYN oncogene related to SRC, FGR, YES0.642
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.610
FLNAfilamin A, alpha0.579
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.536
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.495
S100A8S100 calcium binding protein A80.451
S100A6S100 calcium binding protein A60.448
S100A9S100 calcium binding protein A90.447
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.445
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.408
S100A1S100 calcium binding protein A10.402
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.383
ENGendoglin0.382
HNRNPKheterogeneous nuclear ribonucleoprotein K0.363
NRP1neuropilin 10.353
CAV1caveolin 1, caveolae protein, 22kDa0.334
PDIA3protein disulfide isomerase family A, member 30.314
PXNpaxillin0.295
EPHA2EPH receptor A20.291
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.262
ZYXzyxin0.245
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.242
PLECplectin0.225
PDCD6IPprogrammed cell death 6 interacting protein0.224
S100A4S100 calcium binding protein A40.224
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.221
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.216
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.212
TGFB1transforming growth factor, beta 10.211
BMP2bone morphogenetic protein 20.207
PTPN1protein tyrosine phosphatase, non-receptor type 10.195
TJP1tight junction protein 1 (zona occludens 1)0.193
SFNstratifin0.182
ANGPT2angiopoietin 20.179
RASA1RAS p21 protein activator (GTPase activating protein) 10.174
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.164
GRB7growth factor receptor-bound protein 70.163
ITGB4integrin, beta 40.150
CDH5cadherin 5, type 2 (vascular endothelium)0.148
SMAD2SMAD family member 20.144
MEOX2mesenchyme homeobox 20.131
EPHA7EPH receptor A70.131
FKBP1AFK506 binding protein 1A, 12kDa0.129
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.126
EFNA1ephrin-A10.123
GHRgrowth hormone receptor0.122
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.110
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.109
TRIP6thyroid hormone receptor interactor 60.107
PLCG1phospholipase C, gamma 10.104
CAPGcapping protein (actin filament), gelsolin-like0.100
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.099
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.096
PTPRBprotein tyrosine phosphatase, receptor type, B0.093
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.092
SMAD7SMAD family member 70.092
GRB2growth factor receptor-bound protein 20.090
SOX10SRY (sex determining region Y)-box 100.084
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.083
TCF4transcription factor 40.078
ZNF746zinc finger protein 7460.076
QKIquaking homolog, KH domain RNA binding (mouse)0.076
PRKG1protein kinase, cGMP-dependent, type I0.074
TEKTEK tyrosine kinase, endothelial0.071
METmet proto-oncogene (hepatocyte growth factor receptor)0.071
PTPN23protein tyrosine phosphatase, non-receptor type 230.068
ITGA6integrin, alpha 60.068
PDGFAplatelet-derived growth factor alpha polypeptide0.067
GRB10growth factor receptor-bound protein 100.064
S100A2S100 calcium binding protein A20.064
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.063
PVRL3poliovirus receptor-related 30.063
CALD1caldesmon 10.061
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.058
BMP1bone morphogenetic protein 10.058
PTRFpolymerase I and transcript release factor0.058
ATF7IPactivating transcription factor 7 interacting protein0.057
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.056
S100A11S100 calcium binding protein A110.055
LDLRlow density lipoprotein receptor0.055
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.054
LMNAlamin A/C0.054
KITLGKIT ligand0.053
PDGFCplatelet derived growth factor C0.053
GDF5growth differentiation factor 50.049
ACVR1activin A receptor, type I0.049
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pat-2Protein PAT-20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gpm6aaglycoprotein M6Aa0.384
pdia3protein disulfide isomerase family A, member 30.326
vegfaavascular endothelial growth factor Aa0.199
sh3gl1bSH3-domain GRB2-like 1b0.167
bactin1bactin10.156
krt8keratin 80.135
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.131
egr1early growth response 10.125
hsp90b1heat shock protein 90, beta (grp94), member 10.122
myf5myogenic factor 50.119
calrlcalreticulin like0.113
cnn2calponin 20.108
fbn2bfibrillin 2b0.099
tpm4tropomyosin 40.097
lamb1alaminin, beta 1a0.092
gro1groucho 10.090
hyou1hypoxia up-regulated 10.088
dnajc3DnaJ (Hsp40) homolog, subfamily C, member 30.086
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.084
si:dkey-76k16.7si:dkey-76k16.70.082
sfrs3bsplicing factor, arginine/serine-rich 3b0.080
osr1odd-skipped related 1 (Drosophila)0.074
pfn1profilin 10.072
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.070
kdrlkinase insert domain receptor like0.070
hs3st3b1aheparan sulfate (glucosamine) 3-O-sulfotransferase 3B1a0.067
calrcalreticulin and calreticulin0.065
hcfc1ahost cell factor C1a0.064
tagln2transgelin 20.063
hspa5heat shock protein 50.063
adam8aa disintegrin and metalloproteinase domain 8a0.061
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.059
pdia4protein disulfide isomerase associated 40.057
hnrnpmheterogeneous nuclear ribonucleoprotein M0.057
ntn2netrin 20.056
pdlim1PDZ and LIM domain 1 (elfin)0.056
lgi1bleucine-rich, glioma inactivated 1b0.055
calcrlacalcitonin receptor-like a0.055
pdip5protein disulfide isomerase-related protein (provisional)0.054
ptch2patched 20.054
fstl1bfollistatin-like 1b0.053
manfmesencephalic astrocyte-derived neurotrophic factor0.052
pdia5protein disulfide isomerase family A, member 50.052
itgavintegrin, alpha V0.051
mapk1mitogen-activated protein kinase 10.051
crip2cysteine-rich protein 20.050
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.049
rab11fip4aRAB11 family interacting protein 4 (class II) a0.049
itgb1bintegrin, beta 1b0.049
emilin1aelastin microfibril interfacer 1a0.049
sept6septin 60.047
gatsl2GATS protein-like 20.046
crb2bcrumbs homolog 2b0.046
hspg2heparan sulfate proteoglycan 20.045
copb2coatomer protein complex, subunit beta 20.045
calrl2calreticulin, like 20.044
sheSrc homology 2 domain containing E0.044
plod3procollagen-lysine, 2-oxoglutarate 5-dioxygenase 30.044
chrna6cholinergic receptor, nicotinic, alpha 60.043
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.043
rbpms2RNA binding protein with multiple splicing 20.043
trpm7transient receptor potential cation channel, subfamily M, member 70.042
mapk15mitogen-activated protein kinase 150.042
efnb2aephrin B2a0.042
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.041
zgc:100829zgc:1008290.040
angpt1angiopoietin 10.039
uba1ubiquitin-like modifier activating enzyme 10.039
hnrnph1lheterogeneous nuclear ribonucleoprotein H1, like0.039
mtmr8myotubularin related protein 80.039
snai2snail homolog 2 (Drosophila)0.039
pdlim4PDZ and LIM domain 40.039
mespamesoderm posterior a0.038
LOC100151531zinc finger protein Gfi-1b-like0.038
icnictacalcin0.038
podxlpodocalyxin-like0.038
si:ch211-51m24.3si:ch211-51m24.30.038
crb2acrumbs homolog 2a0.037
LOC100149834cdc2-related kinase, arginine/serine-rich-like0.037
gdf6agrowth differentiation factor 6a0.037
bcambasal cell adhesion molecule (Lutheran blood group)0.037
limk1LIM domain kinase 10.037
ptgs1prostaglandin-endoperoxide synthase 10.037
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.036
dnajb11DnaJ (Hsp40) homolog, subfamily B, member 110.036
wnt3awingless-type MMTV integration site family, member 3A0.036
LOC100537975thyroid receptor-interacting protein 11-like0.036
dpysl5bdihydropyrimidinase-like 5b0.036
pqbp1lpolyglutamine binding protein 1-like0.036
etv2ets variant gene 20.036
hnrplheterogeneous nuclear ribonucleoprotein L0.035
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.035
dag1dystroglycan 10.035
ddx5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.035
zgc:77262zgc:772620.035
top2btopoisomerase (DNA) II beta0.035
slc4a2asolute carrier family 4, anion exchanger, member 2a0.034
bmp1abone morphogenetic protein 1a0.034
msnamoesin a0.034
nrp1bneuropilin 1b0.034
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Engendoglin0.847
Pxnpaxillin0.844
Trp53transformation related protein 530.731
Bcl2B-cell leukemia/lymphoma 20.715
Lama5laminin, alpha 50.664
Itgb1integrin beta 1 (fibronectin receptor beta)0.620
Col4a2collagen, type IV, alpha 20.595
Apcadenomatosis polyposis coli0.592
Ptk2PTK2 protein tyrosine kinase 20.527
Lamc1laminin, gamma 10.456
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.370
Ptprbprotein tyrosine phosphatase, receptor type, B0.301
Itga3integrin alpha 30.288
Wt1Wilms tumor 1 homolog0.288
Fgfr2fibroblast growth factor receptor 20.273
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.246
Col4a3collagen, type IV, alpha 30.245
Cd151CD151 antigen0.213
Vclvinculin0.213
Flt4FMS-like tyrosine kinase 40.198
Nid1nidogen 10.173
Hspg2perlecan (heparan sulfate proteoglycan 2)0.167
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.148
Pax8paired box gene 80.148
Rargretinoic acid receptor, gamma0.141
Tenc1tensin like C1 domain-containing phosphatase0.137
Itgb3integrin beta 30.131
Gdnfglial cell line derived neurotrophic factor0.126
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.125
Rbms1RNA binding motif, single stranded interacting protein 10.106
Ctnnb1catenin (cadherin associated protein), beta 10.105
Dlg1discs, large homolog 1 (Drosophila)0.103
Parvaparvin, alpha0.094
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.093
Plecplectin0.092
Wwtr1WW domain containing transcription regulator 10.091
Notch2Notch gene homolog 2 (Drosophila)0.090
Vegfavascular endothelial growth factor A0.090
Appamyloid beta (A4) precursor protein0.088
Mta2metastasis-associated gene family, member 20.083
Retret proto-oncogene0.081
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.081
Ptgs2prostaglandin-endoperoxide synthase 20.078
Lhx1LIM homeobox protein 10.075
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.070
Desdesmin0.069
Spnb2spectrin beta 20.060
Flnafilamin, alpha0.056
Leprleptin receptor0.055
Rxraretinoid X receptor alpha0.055
Fgfr1fibroblast growth factor receptor 10.055
Tnks1bp1tankyrase 1 binding protein 10.054
Itga5integrin alpha 5 (fibronectin receptor alpha)0.053
Rararetinoic acid receptor, alpha0.052
Rac1RAS-related C3 botulinum substrate 10.049
Bcar1breast cancer anti-estrogen resistance 10.048
Fzd4frizzled homolog 4 (Drosophila)0.048
Lrp5low density lipoprotein receptor-related protein 50.048
Amotl2angiomotin-like 20.046
LppLIM domain containing preferred translocation partner in lipoma0.046
Sorbs3sorbin and SH3 domain containing 30.045
Porcnporcupine homolog (Drosophila)0.045
Fuzfuzzy homolog (Drosophila)0.044
Srsf6serine/arginine-rich splicing factor 60.044
Tmod3tropomodulin 30.044
Hnrnpdheterogeneous nuclear ribonucleoprotein D0.042
Cd97CD97 antigen0.042
Emx2empty spiracles homolog 2 (Drosophila)0.041
Gab1growth factor receptor bound protein 2-associated protein 10.041
Wasf2WAS protein family, member 20.040
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.039
Tcfcp2l1transcription factor CP2-like 10.039
Aebp1AE binding protein 10.038
Lama4laminin, alpha 40.037
Fermt2fermitin family homolog 2 (Drosophila)0.036
Ptp4a2protein tyrosine phosphatase 4a20.036
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.035
Smad4MAD homolog 4 (Drosophila)0.035
Ptpn13protein tyrosine phosphatase, non-receptor type 130.034
Lamb1laminin B10.034
Cyr61cysteine rich protein 610.034
Zyxzyxin0.034
Nos3nitric oxide synthase 3, endothelial cell0.033
Tpm4tropomyosin 40.033
Gpc3glypican 30.033
Selpselectin, platelet0.033
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.032
Mta1metastasis associated 10.032
Capn2calpain 20.032
Eltd1EGF, latrophilin seven transmembrane domain containing 10.032
Pvrl2poliovirus receptor-related 20.032
Rhbdf1rhomboid family 1 (Drosophila)0.032
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.032
Tgfbr3transforming growth factor, beta receptor III0.032
Nf1neurofibromatosis 10.032
Trp63transformation related protein 630.031
Fgf2fibroblast growth factor 20.031
Emp2epithelial membrane protein 20.031
Wnt4wingless-related MMTV integration site 40.031
AhnakAHNAK nucleoprotein (desmoyokin)0.031
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Lamc1laminin, gamma 10.021
Dchs1dachsous 1 (Drosophila)0.012
Myo1bmyosin Ib0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism