The network for 'response to estrogen' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to estrogen

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
EGFRepidermal growth factor receptor1.000
TP53tumor protein p531.000
CAV1caveolin 1, caveolae protein, 22kDa0.998
ARandrogen receptor0.986
NCOA6nuclear receptor coactivator 60.979
PTPN1protein tyrosine phosphatase, non-receptor type 10.975
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.943
CREBBPCREB binding protein0.935
NCOA1nuclear receptor coactivator 10.906
MDM2Mdm2 p53 binding protein homolog (mouse)0.894
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.894
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.888
GSTM1glutathione S-transferase mu 10.876
WDR5WD repeat domain 50.858
CASP3caspase 3, apoptosis-related cysteine peptidase0.702
GSTM2glutathione S-transferase mu 2 (muscle)0.680
HSPB1heat shock 27kDa protein 10.677
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.674
SOCS1suppressor of cytokine signaling 10.626
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.626
NRP1neuropilin 10.594
EPORerythropoietin receptor0.577
THBS1thrombospondin 10.564
HNF4Ahepatocyte nuclear factor 4, alpha0.558
AKR1C1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.557
BCAR1breast cancer anti-estrogen resistance 10.556
RXRAretinoid X receptor, alpha0.546
AKR1C2aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)0.544
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.536
JAK2Janus kinase 20.523
SP1Sp1 transcription factor0.468
BRCA1breast cancer 1, early onset0.459
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.457
CCND1cyclin D10.454
TBX5T-box 50.447
SMAD2SMAD family member 20.427
KRT6Bkeratin 6B0.423
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.409
NCOA2nuclear receptor coactivator 20.404
FAM46Afamily with sequence similarity 46, member A0.387
HDAC1histone deacetylase 10.375
UHRF1ubiquitin-like with PHD and ring finger domains 10.372
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.355
HDAC3histone deacetylase 30.347
NCOA3nuclear receptor coactivator 30.343
APAF1apoptotic peptidase activating factor 10.331
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.327
CXCL2chemokine (C-X-C motif) ligand 20.324
POU5F1POU class 5 homeobox 10.318
MAPK14mitogen-activated protein kinase 140.312
RBBP5retinoblastoma binding protein 50.312
STAT5Asignal transducer and activator of transcription 5A0.308
FGFR2fibroblast growth factor receptor 20.307
CDK2cyclin-dependent kinase 20.261
NRIP1nuclear receptor interacting protein 10.253
IL8interleukin 80.247
SLMAPsarcolemma associated protein0.244
AKR1C3aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)0.225
CCL20chemokine (C-C motif) ligand 200.223
GSTM4glutathione S-transferase mu 40.216
ESR2estrogen receptor 2 (ER beta)0.213
INSRinsulin receptor0.213
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.211
CCND3cyclin D30.207
CRHR1corticotropin releasing hormone receptor 10.207
SYKspleen tyrosine kinase0.206
EP300E1A binding protein p3000.202
RB1retinoblastoma 10.202
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.199
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.199
TRADDTNFRSF1A-associated via death domain0.198
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.194
SRFserum response factor (c-fos serum response element-binding transcription factor)0.188
PAXIP1PAX interacting (with transcription-activation domain) protein 10.182
RARAretinoic acid receptor, alpha0.175
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.172
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.171
NR0B2nuclear receptor subfamily 0, group B, member 20.170
FASFas (TNF receptor superfamily, member 6)0.168
CYR61cysteine-rich, angiogenic inducer, 610.162
MUC1mucin 1, cell surface associated0.157
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.155
PTK2PTK2 protein tyrosine kinase 20.155
PDIA3protein disulfide isomerase family A, member 30.151
STAT1signal transducer and activator of transcription 1, 91kDa0.151
XIAPX-linked inhibitor of apoptosis0.150
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.150
TEKTEK tyrosine kinase, endothelial0.149
CRHcorticotropin releasing hormone0.148
UHRF2ubiquitin-like with PHD and ring finger domains 20.148
IL12RB2interleukin 12 receptor, beta 20.146
GH1growth hormone 10.143
RUNX1runt-related transcription factor 10.140
IL1R1interleukin 1 receptor, type I0.136
CXCL3chemokine (C-X-C motif) ligand 30.136
NR4A1nuclear receptor subfamily 4, group A, member 10.134
ANGPT2angiopoietin 20.133
PGRprogesterone receptor0.132
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pcnaproliferating cell nuclear antigen0.585
vtg3vitellogenin 3, phosvitinless0.315
spry4sprouty (Drosophila) homolog 40.285
aldobaldolase b, fructose-bisphosphate0.218
esr1estrogen receptor 10.217
ghrbgrowth hormone receptor b0.194
vcanaversican a0.171
ptprn2protein tyrosine phosphatase, receptor type, N polypeptide 20.153
junjun proto-oncogene0.133
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.130
cx43connexin 430.125
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.124
ssr4signal sequence receptor, delta0.121
wnt10awingless-type MMTV integration site family, member 10a0.117
hdlbphigh density lipoprotein-binding protein (vigilin)0.115
socs3asuppressor of cytokine signaling 3a0.114
her6hairy-related 60.112
ddcdopa decarboxylase0.109
fabp11afatty acid binding protein 11a0.109
krit1KRIT1, ankyrin repeat containing0.108
hspa5heat shock protein 50.106
atf3activating transcription factor 30.104
rbp4retinol binding protein 4, plasma0.103
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.101
trpm7transient receptor potential cation channel, subfamily M, member 70.099
mkrn2makorin, ring finger protein, 20.099
arandrogen receptor0.094
id1inhibitor of DNA binding 10.094
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.085
gamtguanidinoacetate N-methyltransferase0.085
fgf3fibroblast growth factor 30.083
serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.080
rasl11bRAS-like, family 11, member B0.080
tram1translocating chain-associating membrane protein 10.080
vasavasa homolog0.079
kdelr2lKDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2, like0.078
ssr2signal sequence receptor, beta0.077
shhasonic hedgehog a0.075
bmp2bbone morphogenetic protein 2b0.075
LOC799612prolactin 20.072
ghragrowth hormone receptor a0.070
mcoln1mucolipin 10.069
rspo1R-spondin homolog (Xenopus laevis)0.068
cyp11a1cytochrome P450, subfamily XIA, polypeptide 10.068
prox1prospero-related homeobox gene 10.067
col5a2lcollagen, type V, alpha 2-like0.066
col1a2collagen, type I, alpha 20.063
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.062
nrg2aneuregulin 2a0.061
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.061
vtg1vitellogenin 10.059
cx35connexin 350.059
vdravitamin D receptor a0.058
xbp1X-box binding protein 10.057
crabp2acellular retinoic acid binding protein 2, a0.055
c3ccomplement component c3c0.054
csadcysteine sulfinic acid decarboxylase0.054
sox32SRY-box containing gene 320.054
fosl2fos-like antigen 20.052
wnt2bawingless-type MMTV integration site family, member 2Ba0.051
col12a1collagen, type XII, alpha 10.051
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.050
trim71tripartite motif-containing 710.049
prom1bprominin 1 b0.049
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.048
tie1endothelium-specific receptor tyrosine kinase 10.047
foxa2forkhead box A20.047
mtnr1bamelatonin receptor type 1B a0.046
junbljun B proto-oncogene, like0.045
anxa2aannexin A2a0.045
sec61al1Sec61 alpha like 10.044
aplnraapelin receptor a0.044
anxa11aannexin A11a0.043
efnb2aephrin B2a0.043
flt4fms-related tyrosine kinase 40.042
col5a1procollagen, type V, alpha 10.041
sgk1serum/glucocorticoid regulated kinase 10.041
wnt2wingless-type MMTV integration site family member 20.041
insrainsulin receptor a0.040
sema3dsemaphorin 3d0.040
esr2bestrogen receptor 2b0.040
fggfibrinogen, gamma polypeptide0.040
lmo7aLIM domain only 7a0.039
igfbp1ainsulin-like growth factor binding protein 1a0.039
slc6a4asolute carrier family 6 (neurotransmitter transporter, serotonin), member 4A0.039
barhl1.1BarH-like 1.10.038
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.038
duoxdual oxidase0.038
cfbcomplement factor B0.038
dlx4adistal-less homeobox gene 4a0.038
shbgsex hormone binding globulin0.037
ucp1uncoupling protein 10.037
vtnbvitronectin b0.037
ptprfprotein tyrosine phosphatase, receptor type, F0.036
ccng1cyclin G10.036
nlgn2bneuroligin 2b0.035
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor0.898
Apoeapolipoprotein E0.605
Esr1estrogen receptor 1 (alpha)0.535
Nos3nitric oxide synthase 3, endothelial cell0.521
Stat3signal transducer and activator of transcription 30.498
Bglapbone gamma carboxyglutamate protein0.493
Tgfbr2transforming growth factor, beta receptor II0.461
Ptpn11protein tyrosine phosphatase, non-receptor type 110.429
Cav1caveolin 1, caveolae protein0.422
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.328
Csf1colony stimulating factor 1 (macrophage)0.317
Ppargperoxisome proliferator activated receptor gamma0.312
Shhsonic hedgehog0.305
Col1a1collagen, type I, alpha 10.298
Bmp4bone morphogenetic protein 40.291
Ptgs2prostaglandin-endoperoxide synthase 20.273
Trp53transformation related protein 530.251
Stat5asignal transducer and activator of transcription 5A0.239
Arandrogen receptor0.228
Nos1nitric oxide synthase 1, neuronal0.224
Cdk4cyclin-dependent kinase 40.200
Foxp3forkhead box P30.183
Rbbp5retinoblastoma binding protein 50.168
Ptenphosphatase and tensin homolog0.166
Nos2nitric oxide synthase 2, inducible0.149
Egfrepidermal growth factor receptor0.144
Ccl2chemokine (C-C motif) ligand 20.143
Pgrprogesterone receptor0.137
Fbn1fibrillin 10.135
Nr3c1nuclear receptor subfamily 3, group C, member 10.133
Il10interleukin 100.133
Cdk6cyclin-dependent kinase 60.125
Adam17a disintegrin and metallopeptidase domain 170.125
Rxraretinoid X receptor alpha0.121
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.115
Fgfr3fibroblast growth factor receptor 30.108
Gpc3glypican 30.107
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.106
Ezh2enhancer of zeste homolog 2 (Drosophila)0.105
Ldlrlow density lipoprotein receptor0.104
Gpr50G-protein-coupled receptor 500.103
Cdk2cyclin-dependent kinase 20.102
Cdkn1bcyclin-dependent kinase inhibitor 1B0.099
Mmp2matrix metallopeptidase 20.092
Slc12a1solute carrier family 12, member 10.090
Tal1T-cell acute lymphocytic leukemia 10.090
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.084
Ash2lash2 (absent, small, or homeotic)-like (Drosophila)0.083
Sfrp2secreted frizzled-related protein 20.079
CrebbpCREB binding protein0.079
Foxa2forkhead box A20.078
Wdr5WD repeat domain 50.078
Inhbainhibin beta-A0.075
Il6stinterleukin 6 signal transducer0.075
Gata6GATA binding protein 60.075
Il1r1interleukin 1 receptor, type I0.074
Fgfr2fibroblast growth factor receptor 20.074
Notch2Notch gene homolog 2 (Drosophila)0.073
Kiss1KiSS-1 metastasis-suppressor0.072
Agtr2angiotensin II receptor, type 20.071
Loxlysyl oxidase0.070
Ep400E1A binding protein p4000.070
Pthlhparathyroid hormone-like peptide0.069
Dkk1dickkopf homolog 1 (Xenopus laevis)0.069
Dmap1DNA methyltransferase 1-associated protein 10.068
Tlr4toll-like receptor 40.068
Cd44CD44 antigen0.067
Myod1myogenic differentiation 10.067
Socs1suppressor of cytokine signaling 10.066
Vegfavascular endothelial growth factor A0.063
Drd2dopamine receptor D20.063
Il6interleukin 60.062
Fgf8fibroblast growth factor 80.061
Snai1snail homolog 1 (Drosophila)0.061
Lmnalamin A0.061
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.059
Amhr2anti-Mullerian hormone type 2 receptor0.058
Bdkrb2bradykinin receptor, beta 20.058
Fgf10fibroblast growth factor 100.058
Pax3paired box gene 30.057
Gdnfglial cell line derived neurotrophic factor0.056
Npy1rneuropeptide Y receptor Y10.056
Sftpcsurfactant associated protein C0.054
Grb10growth factor receptor bound protein 100.054
Fgfr4fibroblast growth factor receptor 40.054
Twist2twist homolog 2 (Drosophila)0.053
ND6NADH dehydrogenase subunit 60.053
Stat6signal transducer and activator of transcription 60.052
Sfrp1secreted frizzled-related protein 10.052
Ctnnb1catenin (cadherin associated protein), beta 10.051
Dhhdesert hedgehog0.050
Smad3MAD homolog 3 (Drosophila)0.050
Dmddystrophin, muscular dystrophy0.049
Tgfb2transforming growth factor, beta 20.049
Tpi1triosephosphate isomerase 10.049
Sim1single-minded homolog 1 (Drosophila)0.048
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Pzppregnancy-zone protein0.932
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.913
Bcl2B-cell CLL/lymphoma 20.880
Mmp10matrix metallopeptidase 100.826
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.823
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.811
Col1a1collagen, type I, alpha 10.750
Htr65-hydroxytryptamine (serotonin) receptor 60.734
Aqp8aquaporin 80.733
Agtr1aangiotensin II receptor, type 1a0.706
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.682
Il12binterleukin 12B0.643
Slc22a7solute carrier family 22 (organic anion transporter), member 70.623
Nos1nitric oxide synthase 1, neuronal0.615
Acsm2acyl-CoA synthetase medium-chain family member 20.613
Jak2Janus kinase 20.610
Gstm1glutathione S-transferase mu 10.599
Nr5a2nuclear receptor subfamily 5, group A, member 20.581
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.581
Anxa5annexin A50.571
Reg3gregenerating islet-derived 3 gamma0.568
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.566
Pparaperoxisome proliferator activated receptor alpha0.552
Cd14CD14 molecule0.550
Cyp2c12cytochrome P450, family 2, subfamily c, polypeptide 120.549
Prdx2peroxiredoxin 20.549
Pla2g2cphospholipase A2, group IIC0.547
Vipvasoactive intestinal peptide0.546
Cgm4carcinoembryonic antigen gene family 40.538
Ccl2chemokine (C-C motif) ligand 20.502
Edn1endothelin 10.502
Il8rbinterleukin 8 receptor, beta0.501
Apcsamyloid P component, serum0.496
Anxa2annexin A20.495
Sellselectin L0.492
LOC60591calcium-activated potassium channel beta subunit0.484
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.482
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.477
S1pr2sphingosine-1-phosphate receptor 20.476
Il1rninterleukin 1 receptor antagonist0.457
Gpr1G protein-coupled receptor 10.454
Cgaglycoprotein hormones, alpha polypeptide0.452
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.451
Muskmuscle, skeletal, receptor tyrosine kinase0.448
Cpb1carboxypeptidase B1 (tissue)0.448
Trhrthyrotropin releasing hormone receptor0.447
Bdkrb1bradykinin receptor B10.445
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.442
NrarpNotch-regulated ankyrin repeat protein0.441
Fbp1fructose-1,6-bisphosphatase 10.437
Olr1078olfactory receptor 10780.435
Galr2galanin receptor 20.434
Atxn1ataxin 10.433
Mmp3matrix metallopeptidase 30.429
Gja6gap junction protein, alpha 60.428
Aldobaldolase B, fructose-bisphosphate0.426
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.426
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.426
Gng7guanine nucleotide binding protein (G protein), gamma 70.425
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.424
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.419
Ctsjcathepsin J0.416
Tgm1transglutaminase 1, K polypeptide0.413
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.412
Fgf16fibroblast growth factor 160.411
Col10a1collagen, type X, alpha 10.409
Testintestin gene0.404
Slco2b1solute carrier organic anion transporter family, member 2b10.404
RatNP-3bdefensin RatNP-3 precursor0.404
Trim66tripartite motif-containing 660.402
Tacr2tachykinin receptor 20.401
Chrm1cholinergic receptor, muscarinic 10.396
Has2hyaluronan synthase 20.393
Gja1gap junction protein, alpha 10.385
Procprotein C0.385
Ceacam3carcinoembryonic antigen-related cell adhesion molecule 30.384
Flt1FMS-related tyrosine kinase 10.381
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.379
Slco2a1solute carrier organic anion transporter family, member 2a10.378
Hsd17b3hydroxysteroid (17-beta) dehydrogenase 30.377
Zic1Zic family member 1 (odd-paired homolog, Drosophila)0.374
Stat6signal transducer and activator of transcription 60.373
F9coagulation factor IX0.372
Hsd17b2hydroxysteroid (17-beta) dehydrogenase 20.369
Mamdc4MAM domain containing 40.367
Gpr83G protein-coupled receptor 830.355
RGD1564664similar to LOC387763 protein0.354
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.354
Col1a2collagen, type I, alpha 20.352
Nr1h4nuclear receptor subfamily 1, group H, member 40.352
Mifmacrophage migration inhibitory factor0.352
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.348
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.346
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.344
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism