The network for 'negative regulation of kidney development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of kidney development

Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.

NameDescriptionProbabilityFunc Analog Organism
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.999
BMPR1Bbone morphogenetic protein receptor, type IB0.998
FSTL1follistatin-like 10.955
DVL3dishevelled, dsh homolog 3 (Drosophila)0.897
BMPR1Abone morphogenetic protein receptor, type IA0.867
NKX2-1NK2 homeobox 10.850
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.696
CLDN7claudin 70.651
CLDN1claudin 10.466
BMP2bone morphogenetic protein 20.465
ZNF205zinc finger protein 2050.452
CLDN4claudin 40.444
COL2A1collagen, type II, alpha 10.399
BMP4bone morphogenetic protein 40.276
ZFYVE9zinc finger, FYVE domain containing 90.206
BBS1Bardet-Biedl syndrome 10.174
HNF1AHNF1 homeobox A0.152
BBS4Bardet-Biedl syndrome 40.150
TAL1T-cell acute lymphocytic leukemia 10.141
TAOK1TAO kinase 10.138
MDFIMyoD family inhibitor0.132
SIM2single-minded homolog 2 (Drosophila)0.123
FGF4fibroblast growth factor 40.122
FOXF1forkhead box F10.106
EYA2eyes absent homolog 2 (Drosophila)0.099
CDH16cadherin 16, KSP-cadherin0.093
EYA1eyes absent homolog 1 (Drosophila)0.090
DVL1dishevelled, dsh homolog 1 (Drosophila)0.076
WNT7Awingless-type MMTV integration site family, member 7A0.073
NPM3nucleophosmin/nucleoplasmin 30.072
TGFB1transforming growth factor, beta 10.064
TGFB2transforming growth factor, beta 20.062
HMGA2high mobility group AT-hook 20.059
PITX2paired-like homeodomain 20.057
FOXF2forkhead box F20.051
FOXA2forkhead box A20.049
FOXJ1forkhead box J10.047
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.047
OVOL1ovo-like 1(Drosophila)0.046
ALX4ALX homeobox 40.045
HNF4Ahepatocyte nuclear factor 4, alpha0.044
HOXA11homeobox A110.044
SLC22A2solute carrier family 22 (organic cation transporter), member 20.043
HAND1heart and neural crest derivatives expressed 10.042
CCDC85Bcoiled-coil domain containing 85B0.042
PAX7paired box 70.040
AQP2aquaporin 2 (collecting duct)0.039
WNT1wingless-type MMTV integration site family, member 10.038
CALCAcalcitonin-related polypeptide alpha0.037
HOXC8homeobox C80.036
DLX4distal-less homeobox 40.036
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.036
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.035
GDNFglial cell derived neurotrophic factor0.035
PYYpeptide YY0.033
ALDOBaldolase B, fructose-bisphosphate0.033
GAS1growth arrest-specific 10.033
LHX1LIM homeobox 10.032
CDH3cadherin 3, type 1, P-cadherin (placental)0.032
PTGISprostaglandin I2 (prostacyclin) synthase0.032
HOXD11homeobox D110.032
FOXE1forkhead box E1 (thyroid transcription factor 2)0.032
HOXB9homeobox B90.031
HOXD10homeobox D100.030
NKX3-2NK3 homeobox 20.030
INHBBinhibin, beta B0.030
SOD3superoxide dismutase 3, extracellular0.030
CDH6cadherin 6, type 2, K-cadherin (fetal kidney)0.029
WT1Wilms tumor 10.029
SOX2SRY (sex determining region Y)-box 20.029
CEP164centrosomal protein 164kDa0.028
LBX1ladybird homeobox 10.028
SIX2SIX homeobox 20.028
SOSTDC1sclerostin domain containing 10.028
RAB3IL1RAB3A interacting protein (rabin3)-like 10.027
KLHL35kelch-like 35 (Drosophila)0.027
HS3ST3A1heparan sulfate (glucosamine) 3-O-sulfotransferase 3A10.027
BMP8Bbone morphogenetic protein 8b0.026
ONECUT2one cut homeobox 20.026
WNT11wingless-type MMTV integration site family, member 110.026
THBS2thrombospondin 20.026
FZD10frizzled homolog 10 (Drosophila)0.026
HES2hairy and enhancer of split 2 (Drosophila)0.026
LMX1BLIM homeobox transcription factor 1, beta0.026
REG1Bregenerating islet-derived 1 beta0.025
FZD8frizzled homolog 8 (Drosophila)0.025
GALR2galanin receptor 20.025
SCUBE3signal peptide, CUB domain, EGF-like 30.025
NTN1netrin 10.025
WNT4wingless-type MMTV integration site family, member 40.025
DLX2distal-less homeobox 20.024
SFRP1secreted frizzled-related protein 10.023
TCF21transcription factor 210.023
RAXretina and anterior neural fold homeobox0.023
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.023
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 20.995
Hand1heart and neural crest derivatives expressed transcript 10.990
Gli3GLI-Kruppel family member GLI30.985
Pax2paired box gene 20.982
Msx1homeobox, msh-like 10.967
Nr5a1nuclear receptor subfamily 5, group A, member 10.963
Sall4sal-like 4 (Drosophila)0.952
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.886
Bmp7bone morphogenetic protein 70.868
Ror2receptor tyrosine kinase-like orphan receptor 20.862
Fgf8fibroblast growth factor 80.817
Bmp4bone morphogenetic protein 40.798
Lhx1LIM homeobox protein 10.787
Eya1eyes absent 1 homolog (Drosophila)0.762
Tbx1T-box 10.761
C1qccomplement component 1, q subcomponent, C chain0.740
Sall1sal-like 1 (Drosophila)0.699
Dlx5distal-less homeobox 50.677
Nr0b1nuclear receptor subfamily 0, group B, member 10.666
Emx2empty spiracles homolog 2 (Drosophila)0.630
Hand2heart and neural crest derivatives expressed transcript 20.630
Fgfr3fibroblast growth factor receptor 30.586
Hoxd11homeobox D110.556
Hoxa1homeobox A10.538
Msx2homeobox, msh-like 20.492
Foxc2forkhead box C20.491
Hoxa11homeobox A110.468
Foxc1forkhead box C10.458
Gata4GATA binding protein 40.363
Foxf1aforkhead box F1a0.356
Gli2GLI-Kruppel family member GLI20.356
Sox9SRY-box containing gene 90.352
Prrx2paired related homeobox 20.337
Pbx1pre B-cell leukemia transcription factor 10.324
Fgfr1fibroblast growth factor receptor 10.319
Pitx2paired-like homeodomain transcription factor 20.315
Arandrogen receptor0.293
Prrx1paired related homeobox 10.282
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.281
Nab2Ngfi-A binding protein 20.271
Tbx3T-box 30.265
Gata6GATA binding protein 60.259
Zeb1zinc finger E-box binding homeobox 10.245
Fgf3fibroblast growth factor 30.239
Rspo2R-spondin 2 homolog (Xenopus laevis)0.236
Tgfb2transforming growth factor, beta 20.231
Sox2SRY-box containing gene 20.218
Pax3paired box gene 30.215
Otx2orthodenticle homolog 2 (Drosophila)0.213
Smosmoothened homolog (Drosophila)0.209
Lhx9LIM homeobox protein 90.204
Gdf5growth differentiation factor 50.203
Hoxd13homeobox D130.194
Dkk1dickkopf homolog 1 (Xenopus laevis)0.192
Tcfap2atranscription factor AP-2, alpha0.188
Hoxa13homeobox A130.187
NanogNanog homeobox0.186
Gas1growth arrest specific 10.183
Tcf21transcription factor 210.173
Pax8paired box gene 80.170
Fgf10fibroblast growth factor 100.170
Foxh1forkhead box H10.160
Hoxb3homeobox B30.157
Tbx2T-box 20.153
Pou5f1POU domain, class 5, transcription factor 10.148
Lef1lymphoid enhancer binding factor 10.145
TyrobpTYRO protein tyrosine kinase binding protein0.134
Runx2runt related transcription factor 20.129
Col2a1collagen, type II, alpha 10.127
Wt1Wilms tumor 1 homolog0.124
Smad6MAD homolog 6 (Drosophila)0.117
Meox2mesenchyme homeobox 20.109
C1qacomplement component 1, q subcomponent, alpha polypeptide0.106
Lmx1aLIM homeobox transcription factor 1 alpha0.102
Twist2twist homolog 2 (Drosophila)0.101
Bnc1basonuclin 10.097
Npr2natriuretic peptide receptor 20.094
Gdnfglial cell line derived neurotrophic factor0.084
Kiss1KiSS-1 metastasis-suppressor0.084
Ctsscathepsin S0.083
Tbx15T-box 150.083
Pitx1paired-like homeodomain transcription factor 10.081
Sox7SRY-box containing gene 70.079
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.079
Isl1ISL1 transcription factor, LIM/homeodomain0.078
Lhx3LIM homeobox protein 30.076
Hoxa2homeobox A20.073
Lrp2low density lipoprotein receptor-related protein 20.069
Gata5GATA binding protein 50.068
Hoxd9homeobox D90.068
Fgf9fibroblast growth factor 90.067
Gscgoosecoid homeobox0.063
Rargretinoic acid receptor, gamma0.063
Hoxb6homeobox B60.062
Esrrbestrogen related receptor, beta0.061
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Irf7interferon regulatory factor 70.568
Sp110SP110 nuclear body protein0.402
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.378
Rnf213ring finger protein 2130.200
Parp14poly (ADP-ribose) polymerase family, member 140.195
Ddr1discoidin domain receptor tyrosine kinase 10.157
Parp9poly (ADP-ribose) polymerase family, member 90.119
Rararetinoic acid receptor, alpha0.098
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.091
Usp18ubiquitin specific peptidase 180.089
Dtx3ldeltex 3-like (Drosophila)0.085
Gata3GATA binding protein 30.075
Stat2signal transducer and activator of transcription 20.066
Igf2insulin-like growth factor 20.061
Mx1myxovirus (influenza virus) resistance 10.060
RT1-S3RT1 class Ib, locus S30.059
Krt5keratin 50.059
Il6stinterleukin 6 signal transducer0.058
Ifi35interferon-induced protein 350.054
Fat2FAT tumor suppressor homolog 2 (Drosophila)0.049
Olr1469olfactory receptor Olr14690.047
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.045
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.045
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.043
Fut4fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)0.042
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.040
Bmp7bone morphogenetic protein 70.039
Rps6ka1ribosomal protein S6 kinase polypeptide 10.037
Irs3insulin receptor substrate 30.037
Hdac7histone deacetylase 70.036
Efnb1ephrin B10.036
Lhx1LIM homeobox 10.035
Igtpinterferon gamma induced GTPase0.035
Rxraretinoid X receptor alpha0.035
Ptpn1protein tyrosine phosphatase, non-receptor type 10.034
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.034
LOC363060similar to RIKEN cDNA 1600029D210.034
Tgfbr2transforming growth factor, beta receptor II0.034
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.033
LOC100362108poly (ADP-ribose) polymerase family, member 100.032
JunJun oncogene0.032
Olr1701olfactory receptor 17010.032
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.031
Smad1SMAD family member 10.030
Hyal2hyaluronoglucosaminidase 20.030
Pnpla7patatin-like phospholipase domain containing 70.029
Cmklr1chemokine-like receptor 10.029
Stat1signal transducer and activator of transcription 10.028
Tgfbr3transforming growth factor, beta receptor III0.028
RGD735175hypothetical protein MGC:726160.028
Klf13Kruppel-like factor 130.028
Zfp36zinc finger protein 360.027
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.026
NrarpNotch-regulated ankyrin repeat protein0.026
Bcl2l1Bcl2-like 10.025
Tgm1transglutaminase 1, K polypeptide0.025
Scnn1bsodium channel, nonvoltage-gated 1, beta0.025
Tfebtranscription factor EB0.024
Krt14keratin 140.024
Tpsb2tryptase beta 20.023
Trim5tripartite motif-containing 50.023
Irgmimmunity-related GTPase family, M0.023
Ube2l6ubiquitin-conjugating enzyme E2L 60.022
Lgals7lectin, galactoside-binding, soluble, 70.022
Prdm2PR domain containing 2, with ZNF domain0.021
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.021
Flt1FMS-related tyrosine kinase 10.021
Mx2myxovirus (influenza virus) resistance 20.021
Crygecrystallin, gamma E0.021
Gja5gap junction protein, alpha 50.021
Flnbfilamin, beta0.021
Eif2c2eukaryotic translation initiation factor 2C, 20.020
RGD1305793similar to hypothetical protein FLJ201540.020
Ptpruprotein tyrosine phosphatase, receptor type, U0.020
Add2adducin 2 (beta)0.019
Cishcytokine inducible SH2-containing protein0.019
Pim3pim-3 oncogene0.019
Clcnkbchloride channel Kb0.019
Il1r1interleukin 1 receptor, type I0.018
Atxn1ataxin 10.018
Mef2dmyocyte enhancer factor 2D0.018
Irf9interferon regulatory factor 90.018
Coq10acoenzyme Q10 homolog A (S. cerevisiae)0.018
Rab34RAB34, member RAS oncogene family0.018
Psen1presenilin 10.018
Gsk3bglycogen synthase kinase 3 beta0.017
Map3k3mitogen activated protein kinase kinase kinase 30.017
Timp3TIMP metallopeptidase inhibitor 30.017
Pdzk1ip1PDZK1 interacting protein 10.016
Nr2f2nuclear receptor subfamily 2, group F, member 20.016
Ctbschitobiase, di-N-acetyl-0.016
Slc39a14solute carrier family 39 (zinc transporter), member 140.016
Prl3d1Prolactin family 3, subfamily d, member 10.016
Irs1insulin receptor substrate 10.016
Gna11guanine nucleotide binding protein, alpha 110.015
C1rcomplement component 1, r subcomponent0.015
Nr5a1nuclear receptor subfamily 5, group A, member 10.015
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism