The network for 'determination of adult lifespan' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

determination of adult lifespan

The control of viability and duration in the adult phase of the life-cycle.

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.999
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.998
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.998
PABPC1poly(A) binding protein, cytoplasmic 10.998
HSPA9heat shock 70kDa protein 9 (mortalin)0.997
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.996
HSPB1heat shock 27kDa protein 10.996
ATP5BATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide0.996
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.995
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.991
CSNK2A1casein kinase 2, alpha 1 polypeptide0.988
UBCubiquitin C0.988
ATP5C1ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 10.988
SQSTM1sequestosome 10.983
ATG3ATG3 autophagy related 3 homolog (S. cerevisiae)0.979
PSMB4proteasome (prosome, macropain) subunit, beta type, 40.978
GABARAPL2GABA(A) receptor-associated protein-like 20.978
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.978
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.977
NCLnucleolin0.974
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.973
HSPB8heat shock 22kDa protein 80.972
ATP5G3ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)0.966
CREBBPCREB binding protein0.962
SMAD3SMAD family member 30.962
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.961
BAG3BCL2-associated athanogene 30.961
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.960
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.958
NDUFA2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa0.956
SRSF2serine/arginine-rich splicing factor 20.956
HSPD1heat shock 60kDa protein 1 (chaperonin)0.951
UQCRC1ubiquinol-cytochrome c reductase core protein I0.948
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.948
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.944
SLC25A3solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 30.944
EIF4G1eukaryotic translation initiation factor 4 gamma, 10.942
MDM2Mdm2 p53 binding protein homolog (mouse)0.941
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.941
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.940
YBX1Y box binding protein 10.940
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.935
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.932
CRYABcrystallin, alpha B0.932
TSC2tuberous sclerosis 20.930
PSMA4proteasome (prosome, macropain) subunit, alpha type, 40.930
EP300E1A binding protein p3000.929
PSMB7proteasome (prosome, macropain) subunit, beta type, 70.929
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.928
INSRinsulin receptor0.928
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.928
PARP1poly (ADP-ribose) polymerase 10.927
AKT1v-akt murine thymoma viral oncogene homolog 10.924
CDK2cyclin-dependent kinase 20.923
HNRNPH2heterogeneous nuclear ribonucleoprotein H2 (H')0.923
PSMD10proteasome (prosome, macropain) 26S subunit, non-ATPase, 100.918
TKTtransketolase0.916
COX7Bcytochrome c oxidase subunit VIIb0.914
PSMA2proteasome (prosome, macropain) subunit, alpha type, 20.914
ATP5A1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle0.913
ARRB1arrestin, beta 10.912
COX6Ccytochrome c oxidase subunit VIc0.910
VCPvalosin containing protein0.904
ESR1estrogen receptor 10.904
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.904
MAPK1mitogen-activated protein kinase 10.901
PSMA1proteasome (prosome, macropain) subunit, alpha type, 10.901
COX5Acytochrome c oxidase subunit Va0.897
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.891
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.889
C1QBPcomplement component 1, q subcomponent binding protein0.888
HNRNPH1heterogeneous nuclear ribonucleoprotein H1 (H)0.885
PBX1pre-B-cell leukemia homeobox 10.881
HNRNPDheterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)0.880
UQCRHubiquinol-cytochrome c reductase hinge protein0.880
NDUFS3NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)0.875
HDAC1histone deacetylase 10.872
PSMA7proteasome (prosome, macropain) subunit, alpha type, 70.870
SIRT1sirtuin 10.869
HNRNPA2B1heterogeneous nuclear ribonucleoprotein A2/B10.869
PKM2pyruvate kinase, muscle0.865
PSMB6proteasome (prosome, macropain) subunit, beta type, 60.864
SLC25A6solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 60.857
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.855
UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.853
HSPA8heat shock 70kDa protein 80.848
AIFM1apoptosis-inducing factor, mitochondrion-associated, 10.843
ARRB2arrestin, beta 20.842
NFE2L2nuclear factor (erythroid-derived 2)-like 20.841
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.836
HNRNPUheterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)0.835
HNRNPH3heterogeneous nuclear ribonucleoprotein H3 (2H9)0.832
TBK1TANK-binding kinase 10.831
ILF3interleukin enhancer binding factor 3, 90kDa0.830
CALM1calmodulin 1 (phosphorylase kinase, delta)0.822
FLNAfilamin A, alpha0.820
ALDOAaldolase A, fructose-bisphosphate0.819
HSPA4heat shock 70kDa protein 40.818
PGK1phosphoglycerate kinase 10.817
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cts-1Protein CTS-10.644
abu-15Protein ABU-150.624
ant-1.1Protein ANT-1.10.617
ucr-1Protein UCR-10.610
CELE_F59C6.5Protein F59C6.50.607
pat-12Protein PAT-120.606
dlc-1Protein DLC-10.600
F37C12.3Protein F37C12.30.571
R53.4Protein R53.40.562
vha-8Protein VHA-80.552
par-5Protein PAR-50.546
vit-6Protein VIT-60.541
inx-8Protein INX-80.534
acbp-3Protein ACBP-30.533
inx-15Protein INX-150.523
egal-1Protein EGAL-10.521
CELE_Y57A10A.23Protein Y57A10A.230.520
npl-4.1Protein NPL-4.10.512
npl-4.2Protein NPL-4.20.495
daf-11Protein DAF-110.493
cel-1Protein CEL-10.486
atp-5Protein ATP-50.483
C26B9.5Protein C26B9.50.482
gst-13Protein GST-130.476
ptr-4Protein PTR-40.465
daf-22Protein DAF-220.465
rpn-1Protein RPN-10.463
mig-5Protein MIG-50.457
apy-1Protein APY-10.454
glp-1Protein GLP-10.444
his-59Protein HIS-590.441
ttr-48Protein TTR-480.433
rpt-3Protein RPT-30.433
gst-5Protein GST-50.429
tbc-2Protein TBC-20.429
ahcy-1Protein AHCY-10.426
pbs-6Protein PBS-60.424
mel-26Protein MEL-260.424
eef-1A.1Protein EEF-1A.10.421
F01G4.6Protein F01G4.60.419
rps-8Protein RPS-80.419
rpn-2Protein RPN-20.416
che-14Protein CHE-140.414
R05G6.7Protein R05G6.70.414
CELE_C08H9.2Protein C08H9.20.413
C30C11.4Protein C30C11.40.412
tba-2Protein TBA-20.405
rol-8Protein ROL-80.402
lys-1Protein LYS-10.401
pqn-44Protein PQN-440.401
rpl-3Protein RPL-30.401
pmt-1Protein PMT-10.401
acs-4Protein ACS-40.398
nspb-3Protein NSPB-30.394
CELE_Y57E12AL.1Protein Y57E12AL.10.394
unc-51Protein UNC-510.394
W03C9.5Protein W03C9.50.394
pas-1Protein PAS-10.393
pfd-6Protein PFD-60.392
T20H4.5Protein T20H4.50.391
F29B9.11Protein F29B9.110.389
hsp-70Protein HSP-700.388
CELE_R102.4Protein R102.40.384
K07C11.4Protein K07C11.40.382
pmk-1Protein PMK-10.379
R09H10.5Protein R09H10.50.378
CELE_ZK550.3Protein ZK550.30.376
icd-1Protein ICD-10.374
CELE_B0334.3Protein B0334.30.373
rpl-18Protein RPL-180.371
CELE_F53F4.10Protein F53F4.100.370
hsp-1Protein HSP-10.370
atg-16.1Protein ATG-16.10.369
F56C9.10Protein F56C9.100.369
atn-1Protein ATN-10.366
fzo-1Protein FZO-10.365
daf-21Protein DAF-210.365
CELE_Y40D12A.2Protein Y40D12A.20.365
rps-2Protein RPS-20.364
mpk-1Protein MPK-10.362
aip-1Protein AIP-10.362
daf-10Protein DAF-100.361
H28O16.1Protein H28O16.10.360
gdh-1Protein GDH-10.358
R07E4.3Protein R07E4.30.358
tag-322Protein TAG-3220.357
hpo-8Protein HPO-80.354
acdh-3Protein ACDH-30.353
alp-1Protein ALP-10.353
hsp-16.41Protein HSP-16.410.353
rpt-2Protein RPT-20.353
dpf-3Protein DPF-30.353
chd-3Protein CHD-30.352
C18B2.5Protein C18B2.50.351
wdr-23Protein WDR-230.350
rpl-5Protein RPL-50.350
lrp-2Protein LRP-20.348
daf-25Protein DAF-250.348
lsy-22Protein LSY-220.348
F35G12.12Protein F35G12.120.347
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rprreaper0.997
Pi3K92ECG4141 gene product from transcript CG4141-RB0.989
p38bCG7393 gene product from transcript CG7393-RA0.982
MoeMoesin0.970
Atg1Autophagy-specific gene 10.952
Atg8aAutophagy-specific gene 8a0.943
cazcabeza0.941
chicoCG5686 gene product from transcript CG5686-RB0.931
TorTarget of rapamycin0.900
MadMothers against dpp0.890
SmoxSmad on X0.887
Hsp68Heat shock protein 680.878
IndyI'm not dead yet0.876
S6kRPS6-p70-protein kinase0.875
Hsp70AbHeat-shock-protein-70Ab0.871
bskbasket0.866
Ilp5Insulin-like peptide 50.833
spinspinster0.807
bratbrain tumor0.805
EcREcdysone receptor0.798
Prx5Peroxiredoxin 50.796
foxoforkhead box, sub-group O0.788
Top2Topoisomerase 20.771
lokloki0.768
dmdiminutive0.767
Sod2Superoxide dismutase 2 (Mn)0.751
staistathmin0.749
Mov34CG3416 gene product from transcript CG3416-RA0.742
GLazGlial Lazarillo0.742
Lis-1Lissencephaly-10.738
GugGrunge0.730
CaMKIICalcium/calmodulin-dependent protein kinase II0.722
SpargelCG9809 gene product from transcript CG9809-RB0.719
Eps-15Epidermal growth factor receptor pathway substrate clone 150.710
Hsp26Heat shock protein 260.709
Hsp22Heat shock protein 220.676
CG11347CG11347 gene product from transcript CG11347-RE0.665
porinCG6647 gene product from transcript CG6647-RA0.663
pumpumilio0.662
ThorCG8846 gene product from transcript CG8846-RA0.655
POSHPlenty of SH3s0.655
dawdawdle0.655
RhebCG1081 gene product from transcript CG1081-RA0.642
RpS3Ribosomal protein S30.632
shishibire0.622
CG10664CG10664 gene product from transcript CG10664-RB0.620
alpha-Man-Ialpha Mannosidase I0.609
CG9140CG9140 gene product from transcript CG9140-RA0.596
Rpt1CG1341 gene product from transcript CG1341-RA0.596
Dlc90FDynein light chain 90F0.594
tefutelomere fusion0.593
SodSuperoxide dismutase0.589
bmmbrummer0.588
CG6783CG6783 gene product from transcript CG6783-RC0.588
FatpFatty acid (long chain) transport protein0.583
liclicorne0.582
Rpn2CG11888 gene product from transcript CG11888-RA0.580
Rack1Receptor of activated protein kinase C 10.574
M6CG7540 gene product from transcript CG7540-RA0.573
RagACG11968 gene product from transcript CG11968-RA0.572
pucpuckered0.566
kiskismet0.560
Sir2CG5216 gene product from transcript CG5216-RA0.550
LnkCG17367 gene product from transcript CG17367-RC0.546
cnkconnector enhancer of ksr0.544
LamLamin0.542
tsrtwinstar0.537
ND42NADH:ubiquinone reductase 42kD subunit precursor0.531
Tsc1CG6147 gene product from transcript CG6147-RA0.527
Rho1CG8416 gene product from transcript CG8416-RB0.518
AmphAmphiphysin0.514
mtsmicrotubule star0.507
CG42863CG42863 gene product from transcript CG42863-RB0.503
RpL31Ribosomal protein L310.501
giggigas0.501
CG8155CG8155 gene product from transcript CG8155-RA0.500
InRInsulin-like receptor0.492
ltlight0.489
CG18624CG18624 gene product from transcript CG18624-RC0.486
Hsp70AaHeat-shock-protein-70Aa0.482
G-salpha60AG protein salpha 60A0.480
MerMerlin0.478
armarmadillo0.476
CG13349CG13349 gene product from transcript CG13349-RA0.475
Pglym78Phosphoglyceromutase0.473
CG8801CG8801 gene product from transcript CG8801-RA0.462
mubmushroom-body expressed0.451
RpL7ARibosomal protein L7A0.449
Hsp70BcHeat-shock-protein-70Bc0.444
Rpn9CG10230 gene product from transcript CG10230-RB0.443
ImpL2Ecdysone-inducible gene L20.438
dcodiscs overgrown0.428
Ptp69DProtein tyrosine phosphatase 69D0.422
RelRelish0.418
dysdysfusion0.417
Trxr-1Thioredoxin reductase-10.414
CG5794CG5794 gene product from transcript CG5794-RB0.403
Hsp27Heat shock protein 270.402
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.395
CG12079CG12079 gene product from transcript CG12079-RA0.388
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.951
Trp53transformation related protein 530.573
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.561
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.480
Rpgrip1lRpgrip1-like0.447
Mapk14mitogen-activated protein kinase 140.371
Hif1ahypoxia inducible factor 1, alpha subunit0.313
Ezh2enhancer of zeste homolog 2 (Drosophila)0.235
Mtormechanistic target of rapamycin (serine/threonine kinase)0.207
Atf2activating transcription factor 20.193
Insrinsulin receptor0.168
Akt1thymoma viral proto-oncogene 10.153
Psma1proteasome (prosome, macropain) subunit, alpha type 10.152
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.151
Tsc1tuberous sclerosis 10.137
Ppargperoxisome proliferator activated receptor gamma0.123
Nr3c1nuclear receptor subfamily 3, group C, member 10.121
Vegfavascular endothelial growth factor A0.114
Hdac2histone deacetylase 20.098
Shc1src homology 2 domain-containing transforming protein C10.092
Tgfb1transforming growth factor, beta 10.090
Nf2neurofibromatosis 20.087
Aldoaaldolase A, fructose-bisphosphate0.085
Eif4g1eukaryotic translation initiation factor 4, gamma 10.083
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.080
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.078
Epas1endothelial PAS domain protein 10.076
Hbb-b1hemoglobin, beta adult major chain0.073
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.072
Ptpn11protein tyrosine phosphatase, non-receptor type 110.066
Pou5f1POU domain, class 5, transcription factor 10.064
Tgfbr1transforming growth factor, beta receptor I0.064
BrafBraf transforming gene0.063
Mta2metastasis-associated gene family, member 20.060
Iqcb1IQ calmodulin-binding motif containing 10.059
Pabpn1poly(A) binding protein, nuclear 10.059
Cyldcylindromatosis (turban tumor syndrome)0.054
Foxa2forkhead box A20.053
Psmb7proteasome (prosome, macropain) subunit, beta type 70.053
Mknk2MAP kinase-interacting serine/threonine kinase 20.053
Msh2mutS homolog 2 (E. coli)0.051
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.051
Cox5bcytochrome c oxidase, subunit Vb0.050
Rxraretinoid X receptor alpha0.049
Cftrcystic fibrosis transmembrane conductance regulator homolog0.049
Ndufs3NADH dehydrogenase (ubiquinone) Fe-S protein 30.049
Skp1aS-phase kinase-associated protein 1A0.049
Esrrbestrogen related receptor, beta0.049
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.049
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.048
Lmnalamin A0.047
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.047
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.046
Wdr5WD repeat domain 50.046
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.045
Inpp5dinositol polyphosphate-5-phosphatase D0.045
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.044
Leprleptin receptor0.043
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.043
Bcl2B-cell leukemia/lymphoma 20.042
Smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.041
Lystlysosomal trafficking regulator0.040
Nos3nitric oxide synthase 3, endothelial cell0.040
Gab2growth factor receptor bound protein 2-associated protein 20.040
Psmd14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.039
Foxo1forkhead box O10.039
Uqcrc1ubiquinol-cytochrome c reductase core protein 10.039
Rbbp4retinoblastoma binding protein 40.038
Pgls6-phosphogluconolactonase0.038
Nos1nitric oxide synthase 1, neuronal0.038
RictorRPTOR independent companion of MTOR, complex 20.038
Hrhairless0.037
Tlr4toll-like receptor 40.037
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.036
NanogNanog homeobox0.035
Nfibnuclear factor I/B0.035
Becn1beclin 1, autophagy related0.033
Rb1retinoblastoma 10.033
Suz12suppressor of zeste 12 homolog (Drosophila)0.032
Atp5oATP synthase, H+ transporting, mitochondrial F1 complex, O subunit0.032
Dnm1ldynamin 1-like0.031
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.030
BlnkB-cell linker0.030
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.030
Cacybpcalcyclin binding protein0.030
Grpel1GrpE-like 1, mitochondrial0.029
Smad3MAD homolog 3 (Drosophila)0.029
Rararetinoic acid receptor, alpha0.029
Eedembryonic ectoderm development0.029
Psma7proteasome (prosome, macropain) subunit, alpha type 70.028
Vdac3voltage-dependent anion channel 30.028
Atp5dATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit0.028
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.028
Lims1LIM and senescent cell antigen-like domains 10.028
Prkceprotein kinase C, epsilon0.027
Nr2f2nuclear receptor subfamily 2, group F, member 20.027
Ctnnb1catenin (cadherin associated protein), beta 10.027
Notch2Notch gene homolog 2 (Drosophila)0.027
Tpi1triosephosphate isomerase 10.027
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism