The network for 'anion homeostasis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

anion homeostasis

Any process involved in the maintenance of an internal steady state of anions within an organism or cell.

NameDescriptionProbabilityFunc Analog Organism
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.547
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.328
TRPC4transient receptor potential cation channel, subfamily C, member 40.172
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.128
CRPC-reactive protein, pentraxin-related0.121
BBS10Bardet-Biedl syndrome 100.105
LRP1low density lipoprotein receptor-related protein 10.090
ITGB1BP3integrin beta 1 binding protein 30.070
APOC1apolipoprotein C-I0.062
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.051
NR0B2nuclear receptor subfamily 0, group B, member 20.044
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.034
PROX1prospero homeobox 10.033
RPL18Aribosomal protein L18a0.032
LCATlecithin-cholesterol acyltransferase0.031
ELF5E74-like factor 5 (ets domain transcription factor)0.029
SREBF2sterol regulatory element binding transcription factor 20.027
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.026
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.026
IGF2Rinsulin-like growth factor 2 receptor0.026
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.025
APOEapolipoprotein E0.024
TBC1D10ATBC1 domain family, member 10A0.023
INSRinsulin receptor0.023
NR4A1nuclear receptor subfamily 4, group A, member 10.022
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.022
SLC9A3R2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.021
ACACAacetyl-CoA carboxylase alpha0.020
APOC3apolipoprotein C-III0.020
TUBB2Btubulin, beta 2B0.019
FAF1Fas (TNFRSF6) associated factor 10.019
PPARGperoxisome proliferator-activated receptor gamma0.018
WNT3Awingless-type MMTV integration site family, member 3A0.018
ARHGAP22Rho GTPase activating protein 220.017
WNT5Awingless-type MMTV integration site family, member 5A0.017
ASB9ankyrin repeat and SOCS box containing 90.017
APOC2apolipoprotein C-II0.015
EP300E1A binding protein p3000.015
NOVnephroblastoma overexpressed gene0.015
APOA2apolipoprotein A-II0.015
ENPP5ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)0.014
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.014
PTPN1protein tyrosine phosphatase, non-receptor type 10.014
ITGB5integrin, beta 50.014
PDX1pancreatic and duodenal homeobox 10.014
LPHN1latrophilin 10.013
CSNK1Ecasein kinase 1, epsilon0.013
APOBapolipoprotein B (including Ag(x) antigen)0.012
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.012
SETD7SET domain containing (lysine methyltransferase) 70.012
HDAC6histone deacetylase 60.012
RGS2regulator of G-protein signaling 2, 24kDa0.011
MEGF8multiple EGF-like-domains 80.011
BZRAP1benzodiazapine receptor (peripheral) associated protein 10.011
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.011
HES1hairy and enhancer of split 1, (Drosophila)0.010
HAO1hydroxyacid oxidase (glycolate oxidase) 10.010
FGAfibrinogen alpha chain0.010
IGFBP5insulin-like growth factor binding protein 50.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
trpv6transient receptor potential cation channel, subfamily V, member 61.000
rhcgl1Rhesus blood group, C glycoprotein, like 10.996
rhagRhesus blood group-associated glycoprotein0.996
slc12a10.2solute carrier family 12 (sodium/potassium/chloride transporters), member 10.20.974
slc4a4bsolute carrier family 4, sodium bicarbonate cotransporter, member 4b0.950
slc4a1bsolute carrier family 4, anion exchanger, member 1b0.911
ass1argininosuccinate synthetase 10.803
vwfvon Willebrand factor0.782
otcornithine carbamoyltransferase0.776
rhbgRhesus blood group, B glycoprotein0.758
slc26a3solute carrier family 26, member 30.744
grnagranulin a0.658
slc26a4solute carrier family 26, member 40.544
foxi3bforkhead box I3b0.541
cps1carbamoyl-phosphate synthase 1, mitochondrial0.425
aslargininosuccinate lyase0.345
mgpmatrix Gla protein0.324
ca2carbonic anhydrase II0.309
fbp1bfructose-1,6-bisphosphatase 1b0.305
LOC556849ectonucleoside triphosphate diphosphohydrolase 5-like0.265
adipoqladiponectin, C1Q and collagen domain containing, like0.257
bmp1abone morphogenetic protein 1a0.207
adipor2adiponectin receptor 20.183
adipoql2adiponectin, C1Q and collagen domain containing, like 20.150
coro1acoronin, actin binding protein, 1A0.146
slc7a6solute carrier family 7 (cationic amino acid transporter, y+ system), member 60.126
LOC100330224fatty acid binding protein 1b-like0.118
itih2inter-alpha (globulin) inhibitor H20.103
LOC100005108novel protein similar to solute carrier family 26, member 5 (slc26a5)0.103
ctsbacathepsin B, a0.091
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase0.077
hbbe1.1hemoglobin beta embryonic-1.10.077
cdh17cadherin 17, LI cadherin (liver-intestine)0.075
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.075
sepp1bselenoprotein P, plasma, 1b0.059
LOC566708FL cytokine receptor-like0.052
ywhag13-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 10.050
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.047
camsap1l1calmodulin regulated spectrin-associated protein 1-like 10.041
mtpmicrosomal triglyceride transfer protein0.034
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.030
eno2enolase 20.029
foxi3aforkhead box I3a0.027
znf503zinc finger protein 5030.027
slc4a2asolute carrier family 4, anion exchanger, member 2a0.025
camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.024
cx32.3connexin 32.30.021
slc9a3.2solute carrier family 9 (sodium/hydrogen exchanger), member 3.20.021
lama5laminin, alpha 50.019
itpr3inositol 1,4,5-triphosphate receptor, type 30.019
egfepidermal growth factor0.018
cdkl1cyclin-dependent kinase-like 1 (CDC2-related kinase)0.018
pck2phosphoenolpyruvate carboxykinase 2 (mitochondrial)0.018
slc18a3asolute carrier family 18 (vesicular acetylcholine), member 3a0.018
tpbgltrophoblast glycoprotein-like0.017
cyp2y3cytochrome P450, family 2, subfamily Y, polypeptide 30.016
ak3adenylate kinase 30.015
LOC100149353transient receptor potential cation channel subfamily M member 6-like0.015
fmo5flavin containing monooxygenase 50.014
slc6a19bsolute carrier family 6 (neurotransmitter transporter), member 19b0.014
lzicleucine zipper and CTNNBIP1 domain containing0.014
slc13a1solute carrier family 13 (sodium/sulphate symporters), member 10.014
LOC567537chemokine CXCL-C5c0.013
rgs4regulator of G-protein signalling 40.013
rps6ka1ribosomal protein S6 kinase a, polypeptide 10.013
LOC794616chemokine CCL-C10b0.013
hbl3hexose-binding lectin 30.012
mxtx1mix-type homeobox gene 10.012
ca15acarbonic anhydrase XV a0.012
sult2st3sulfotransferase family 2, cytosolic sulfotransferase 30.011
col8a1acollagen, type VIII, alpha 1a0.011
elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.011
nr2e3nuclear receptor subfamily 2, group E, member 30.011
sult1st3sulfotransferase family 1, cytosolic sulfotransferase 30.011
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.011
s1pr2sphingosine-1-phosphate receptor 20.011
slc26a1solute carrier family 26 (sulfate transporter), member 10.011
slc16a1solute carrier family 16 (monocarboxylic acid transporters), member 10.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Yp2Yolk protein 20.930
Yp3Yolk protein 30.767
Cyp6a9Cytochrome P450-6a90.754
Cyp6a21CG10247 gene product from transcript CG10247-RA0.722
Ugt35aUDP-glycosyltransferase 35a0.716
CG3714CG3714 gene product from transcript CG3714-RC0.693
Cyp12a4CG6042 gene product from transcript CG6042-RA0.678
Yp1Yolk protein 10.666
Amy-dAmylase distal0.639
Cyp4ac1CG14032 gene product from transcript CG14032-RA0.409
CG14837CG14837 gene product from transcript CG14837-RC0.401
CG14506CG14506 gene product from transcript CG14506-RA0.379
Cyp12a5CG11821 gene product from transcript CG11821-RA0.369
Cyp28d1CG10833 gene product from transcript CG10833-RA0.333
Cyp6a23CG10242 gene product from transcript CG10242-RA0.278
LvpHLarval visceral protein H0.251
Lk6CG17342 gene product from transcript CG17342-RA0.242
CG5508CG5508 gene product from transcript CG5508-RA0.216
CG14935CG14935 gene product from transcript CG14935-RA0.205
CG10562CG10562 gene product from transcript CG10562-RA0.204
Osi6Osiris 60.199
CG11967CG11967 gene product from transcript CG11967-RA0.197
AdhAlcohol dehydrogenase0.178
CG6834CG6834 gene product from transcript CG6834-RA0.176
Cyp6g1CG8453 gene product from transcript CG8453-RA0.168
Cyp9b2Cytochrome P450-9b20.162
Jheh3Juvenile hormone epoxide hydrolase 30.162
CG10824CG10824 gene product from transcript CG10824-RA0.159
CG10979CG10979 gene product from transcript CG10979-RA0.149
Cyp12e1CG14680 gene product from transcript CG14680-RC0.146
Acox57D-pacyl-Coenzyme A oxidase at 57D proximal0.140
CG11029CG11029 gene product from transcript CG11029-RA0.137
CG9360CG9360 gene product from transcript CG9360-RA0.136
NAAT1Nutrient Amino Acid Transporter 10.133
CG17189CG17189 gene product from transcript CG17189-RA0.130
GlcT-1CG6437 gene product from transcript CG6437-RA0.127
CG8449CG8449 gene product from transcript CG8449-RA0.127
CG18745CG18745 gene product from transcript CG18745-RA0.125
CG8997CG8997 gene product from transcript CG8997-RA0.123
MarfMitochondrial assembly regulatory factor0.123
nAcRalpha-96Aanicotinic Acetylcholine Receptor alpha 96Aa0.123
CG6996CG6996 gene product from transcript CG6996-RB0.122
CG3759CG3759 gene product from transcript CG3759-RB0.120
EpacCG34392 gene product from transcript CG34392-RC0.120
CG10361CG10361 gene product from transcript CG10361-RA0.119
Cyp4d20CG16761 gene product from transcript CG16761-RA0.117
CG6283CG6283 gene product from transcript CG6283-RA0.108
CG6277CG6277 gene product from transcript CG6277-RA0.105
CG14119CG14119 gene product from transcript CG14119-RA0.103
CG5162CG5162 gene product from transcript CG5162-RA0.103
Suv4-20CG13363 gene product from transcript CG13363-RA0.098
Cyp6a13CG2397 gene product from transcript CG2397-RA0.098
Cyp4d21CG6730 gene product from transcript CG6730-RA0.098
CG15408CG15408 gene product from transcript CG15408-RA0.093
CG12374CG12374 gene product from transcript CG12374-RA0.092
CG1887CG1887 gene product from transcript CG1887-RD0.092
lectin-29CaCG17799 gene product from transcript CG17799-RA0.091
Cyp4e1Cytochrome P450-4e10.090
Ugt36BcCG17932 gene product from transcript CG17932-RB0.089
Cyp6a8Cytochrome P450-6a80.087
CG14196CG14196 gene product from transcript CG14196-RA0.087
CG11674CG11674 gene product from transcript CG11674-RA0.085
CG14820CG14820 gene product from transcript CG14820-RA0.084
Tps1Trehalose-6-phosphate synthase 10.084
Est-QEsterase Q0.083
CG10560CG10560 gene product from transcript CG10560-RA0.083
CG6830CG6830 gene product from transcript CG6830-RA0.083
JhI-26Juvenile hormone-inducible protein 260.081
CG9009CG9009 gene product from transcript CG9009-RB0.081
CG9672CG9672 gene product from transcript CG9672-RA0.080
tipEtemperature-induced paralytic E0.078
CG30377CG30377 gene product from transcript CG30377-RA0.076
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.076
CG30494CG30494 gene product from transcript CG30494-RA0.075
Cyp4p1Cytochrome P450-4p10.075
CG14443CG14443 gene product from transcript CG14443-RA0.073
Ugt86DaCG18578 gene product from transcript CG18578-RA0.073
Spn77BbSerpin 77Bb0.073
CG13160CG13160 gene product from transcript CG13160-RA0.072
rostrolling stone0.071
rolsrolling pebbles0.070
CG3841CG3841 gene product from transcript CG3841-RB0.069
CG1774CG1774 gene product from transcript CG1774-RA0.068
CG8562CG8562 gene product from transcript CG8562-RA0.068
Ilp2Insulin-like peptide 20.068
Cyp4ac3CG14031 gene product from transcript CG14031-RA0.067
CG7091CG7091 gene product from transcript CG7091-RB0.067
CG2064CG2064 gene product from transcript CG2064-RA0.066
CG7912CG7912 gene product from transcript CG7912-RA0.065
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Apoeapolipoprotein E0.796
Abca1ATP-binding cassette, sub-family A (ABC1), member 10.511
Shhsonic hedgehog0.384
Slc34a1solute carrier family 34 (sodium phosphate), member 10.355
Pax2paired box gene 20.343
Leprleptin receptor0.272
Ghrgrowth hormone receptor0.188
Casrcalcium-sensing receptor0.118
Lyz2lysozyme 20.113
Pnpla2patatin-like phospholipase domain containing 20.085
Vegfavascular endothelial growth factor A0.083
Ppargperoxisome proliferator activated receptor gamma0.076
Esr1estrogen receptor 1 (alpha)0.069
Irf9interferon regulatory factor 90.067
Sox9SRY-box containing gene 90.067
Npc1Niemann Pick type C10.063
Bcar1breast cancer anti-estrogen resistance 10.061
Fgfr1fibroblast growth factor receptor 10.050
Ptpn11protein tyrosine phosphatase, non-receptor type 110.045
Bmp4bone morphogenetic protein 40.039
Nr3c1nuclear receptor subfamily 3, group C, member 10.039
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.039
Thrbthyroid hormone receptor beta0.039
Fgafibrinogen alpha chain0.038
Pax3paired box gene 30.037
Apobapolipoprotein B0.036
Isl1ISL1 transcription factor, LIM/homeodomain0.035
Fcgr2bFc receptor, IgG, low affinity IIb0.034
Lig1ligase I, DNA, ATP-dependent0.032
Ryr1ryanodine receptor 1, skeletal muscle0.032
Lrp1low density lipoprotein receptor-related protein 10.030
Gfi1growth factor independent 10.030
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.030
Fgf8fibroblast growth factor 80.029
Il6stinterleukin 6 signal transducer0.029
Nr1h3nuclear receptor subfamily 1, group H, member 30.029
Foxp3forkhead box P30.029
Apoa1apolipoprotein A-I0.028
Cftrcystic fibrosis transmembrane conductance regulator homolog0.027
Kitkit oncogene0.027
Arntlaryl hydrocarbon receptor nuclear translocator-like0.026
Itgb1integrin beta 1 (fibronectin receptor beta)0.026
Il10interleukin 100.025
Prlrprolactin receptor0.024
Prox1prospero-related homeobox 10.024
Myo6myosin VI0.024
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.023
Rb1retinoblastoma 10.022
Prf1perforin 1 (pore forming protein)0.022
Pkd1polycystic kidney disease 1 homolog0.022
Ptenphosphatase and tensin homolog0.022
Bmp8bbone morphogenetic protein 8b0.021
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.021
Nos3nitric oxide synthase 3, endothelial cell0.021
Ldlrlow density lipoprotein receptor0.021
Col1a1collagen, type I, alpha 10.020
Cdhr5cadherin-related family member 50.020
Pou4f3POU domain, class 4, transcription factor 30.020
Timelesstimeless homolog (Drosophila)0.020
Thrathyroid hormone receptor alpha0.020
Rxraretinoid X receptor alpha0.019
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.019
Rbl2retinoblastoma-like 20.019
Lpllipoprotein lipase0.019
Barx1BarH-like homeobox 10.019
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.018
Pax8paired box gene 80.018
Itpr2inositol 1,4,5-triphosphate receptor 20.018
Il1r1interleukin 1 receptor, type I0.018
Apomapolipoprotein M0.017
Bcl2B-cell leukemia/lymphoma 20.017
Retret proto-oncogene0.017
Otx2orthodenticle homolog 2 (Drosophila)0.017
Cdkn1bcyclin-dependent kinase inhibitor 1B0.017
Notch2Notch gene homolog 2 (Drosophila)0.017
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.016
Ifnar2interferon (alpha and beta) receptor 20.016
Rargretinoic acid receptor, gamma0.016
Dll1delta-like 1 (Drosophila)0.016
Vav2vav 2 oncogene0.016
Ednrbendothelin receptor type B0.016
BrafBraf transforming gene0.016
Ncoa3nuclear receptor coactivator 30.016
Vdrvitamin D receptor0.016
Rc3h1RING CCCH (C3H) domains 10.015
Serpina12serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 120.015
Fbp2fructose bisphosphatase 20.015
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.015
Fgbfibrinogen beta chain0.015
Nf1neurofibromatosis 10.015
Ltbp1latent transforming growth factor beta binding protein 10.014
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.014
Gli2GLI-Kruppel family member GLI20.014
Tbx1T-box 10.014
Neurod1neurogenic differentiation 10.014
Rab27aRAB27A, member RAS oncogene family0.014
Srebf1sterol regulatory element binding transcription factor 10.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.015
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism