The network for 'activation of janus kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of janus kinase activity

The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it.

NameDescriptionProbabilityFunc Analog Organism
BCAR1breast cancer anti-estrogen resistance 11.000
PTPN1protein tyrosine phosphatase, non-receptor type 11.000
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.998
GH1growth hormone 10.983
CSH1chorionic somatomammotropin hormone 1 (placental lactogen)0.802
LATlinker for activation of T cells0.733
IL23Ainterleukin 23, alpha subunit p190.631
SOCS3suppressor of cytokine signaling 30.548
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.501
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.478
EGFRepidermal growth factor receptor0.415
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.412
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.393
FYNFYN oncogene related to SRC, FGR, YES0.350
CSH2chorionic somatomammotropin hormone 20.340
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.302
GH2growth hormone 20.300
GRB2growth factor receptor-bound protein 20.276
CSHL1chorionic somatomammotropin hormone-like 10.244
MAP3K5mitogen-activated protein kinase kinase kinase 50.207
PTK2PTK2 protein tyrosine kinase 20.195
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.173
PTPN23protein tyrosine phosphatase, non-receptor type 230.154
IFNGR1interferon gamma receptor 10.147
EPORerythropoietin receptor0.143
JAK2Janus kinase 20.135
PTPRBprotein tyrosine phosphatase, receptor type, B0.128
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.122
COMMD1copper metabolism (Murr1) domain containing 10.121
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.115
SREBF2sterol regulatory element binding transcription factor 20.109
DNM1dynamin 10.096
IGF1Rinsulin-like growth factor 1 receptor0.095
INSRinsulin receptor0.091
PTPN12protein tyrosine phosphatase, non-receptor type 120.087
SH2B1SH2B adaptor protein 10.064
PROX1prospero homeobox 10.057
GHRgrowth hormone receptor0.057
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.056
ESRRGestrogen-related receptor gamma0.043
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.043
SOCS2suppressor of cytokine signaling 20.041
IL6interleukin 6 (interferon, beta 2)0.040
SRCIN1SRC kinase signaling inhibitor 10.039
IRS1insulin receptor substrate 10.035
IL12Ainterleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)0.031
GAB1GRB2-associated binding protein 10.031
BCRbreakpoint cluster region0.030
ARRB1arrestin, beta 10.028
STAT5Asignal transducer and activator of transcription 5A0.026
METmet proto-oncogene (hepatocyte growth factor receptor)0.025
PTPRAprotein tyrosine phosphatase, receptor type, A0.024
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.021
PTK2BPTK2B protein tyrosine kinase 2 beta0.021
PTPN2protein tyrosine phosphatase, non-receptor type 20.021
MATKmegakaryocyte-associated tyrosine kinase0.021
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.020
SOS1son of sevenless homolog 1 (Drosophila)0.020
PTPN9protein tyrosine phosphatase, non-receptor type 90.019
JAK1Janus kinase 10.017
SFNstratifin0.017
WASLWiskott-Aldrich syndrome-like0.016
PXNpaxillin0.016
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.015
HNF1AHNF1 homeobox A0.014
NR0B2nuclear receptor subfamily 0, group B, member 20.013
ADAM15ADAM metallopeptidase domain 150.012
CSF1Rcolony stimulating factor 1 receptor0.012
HK3hexokinase 3 (white cell)0.011
TGFB1I1transforming growth factor beta 1 induced transcript 10.011
VAV1vav 1 guanine nucleotide exchange factor0.011
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Leprleptin receptor1.000
Ren1renin 1 structural1.000
Tgfb1transforming growth factor, beta 10.996
Stat3signal transducer and activator of transcription 30.995
Jak2Janus kinase 20.995
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.980
Agtr1aangiotensin II receptor, type 1a0.966
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.966
Il6stinterleukin 6 signal transducer0.910
Stat5asignal transducer and activator of transcription 5A0.878
Ptpn11protein tyrosine phosphatase, non-receptor type 110.837
Slc12a1solute carrier family 12, member 10.822
Socs3suppressor of cytokine signaling 30.813
Cdkn1bcyclin-dependent kinase inhibitor 1B0.781
Nos3nitric oxide synthase 3, endothelial cell0.751
Cishcytokine inducible SH2-containing protein0.694
Tnftumor necrosis factor0.689
Umoduromodulin0.669
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.651
Stat5bsignal transducer and activator of transcription 5B0.610
Cav1caveolin 1, caveolae protein0.580
Socs1suppressor of cytokine signaling 10.559
Foxp3forkhead box P30.538
Vdrvitamin D receptor0.487
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.435
Nr3c2nuclear receptor subfamily 3, group C, member 20.407
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.390
Vav2vav 2 oncogene0.370
Esr1estrogen receptor 1 (alpha)0.360
FasFas (TNF receptor superfamily member 6)0.344
Ptprcprotein tyrosine phosphatase, receptor type, C0.341
Ptgs2prostaglandin-endoperoxide synthase 20.339
Nr2f2nuclear receptor subfamily 2, group F, member 20.299
Egfrepidermal growth factor receptor0.295
Cul5cullin 50.242
Pim1proviral integration site 10.233
Socs2suppressor of cytokine signaling 20.229
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.206
Agtrapangiotensin II, type I receptor-associated protein0.198
Vegfavascular endothelial growth factor A0.189
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.189
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.185
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.168
FynFyn proto-oncogene0.152
Arandrogen receptor0.147
Bcl3B-cell leukemia/lymphoma 30.140
Insrinsulin receptor0.140
Vav3vav 3 oncogene0.134
Rag1recombination activating gene 10.129
Ikzf1IKAROS family zinc finger 10.120
Il2rginterleukin 2 receptor, gamma chain0.118
Thrathyroid hormone receptor alpha0.117
Sh2b1SH2B adaptor protein 10.116
Kitkit oncogene0.105
Irs1insulin receptor substrate 10.102
Nr3c1nuclear receptor subfamily 3, group C, member 10.099
Col1a1collagen, type I, alpha 10.099
Nos2nitric oxide synthase 2, inducible0.095
Jak1Janus kinase 10.095
Lcklymphocyte protein tyrosine kinase0.088
Apoeapolipoprotein E0.077
Csf1colony stimulating factor 1 (macrophage)0.075
WwoxWW domain-containing oxidoreductase0.069
Slc14a2solute carrier family 14 (urea transporter), member 20.061
Bdkrb2bradykinin receptor, beta 20.060
Ptpn2protein tyrosine phosphatase, non-receptor type 20.058
Pnpla2patatin-like phospholipase domain containing 20.057
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.056
Vav1vav 1 oncogene0.055
Nos1nitric oxide synthase 1, neuronal0.052
Wt1Wilms tumor 1 homolog0.051
Efemp2epidermal growth factor-containing fibulin-like extracellular matrix protein 20.048
Lhcgrluteinizing hormone/choriogonadotropin receptor0.048
Il6interleukin 60.047
Itga1integrin alpha 10.046
S1pr1sphingosine-1-phosphate receptor 10.045
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.044
Rap2cRAP2C, member of RAS oncogene family0.044
Plcg1phospholipase C, gamma 10.043
Foxn1forkhead box N10.040
Gcgrglucagon receptor0.038
Hivep2human immunodeficiency virus type I enhancer binding protein 20.036
TcraT-cell receptor alpha chain0.036
Cyp11b2cytochrome P450, family 11, subfamily b, polypeptide 20.033
VgfVGF nerve growth factor inducible0.032
Il1r1interleukin 1 receptor, type I0.031
Ptpn1protein tyrosine phosphatase, non-receptor type 10.031
Igf1insulin-like growth factor 10.031
Irf1interferon regulatory factor 10.030
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.030
Dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)0.030
UgcgUDP-glucose ceramide glucosyltransferase0.030
JunbJun-B oncogene0.028
Rps6ka3ribosomal protein S6 kinase polypeptide 30.027
Rapgef3Rap guanine nucleotide exchange factor (GEF) 30.027
Spred1sprouty protein with EVH-1 domain 1, related sequence0.026
Il10interleukin 100.023
Pim2proviral integration site 20.023
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.023
Ptpn12protein tyrosine phosphatase, non-receptor type 120.022
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Prl3d4prolactin family 3, subfamily d, member 40.143
P22k15cystatin related protein 20.090
Hoxb8homeo box B80.061
Clphcasein-like phosphoprotein0.055
Vcsa2variable coding sequence A20.053
Agtr1aangiotensin II receptor, type 1a0.053
Calcrcalcitonin receptor0.048
Prl5a1prolactin family 5, subfamily a, member 10.039
Pou1f1POU class 1 homeobox 10.036
Klrh1killer cell lectin-like receptor subfamily H, member 10.032
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.029
Fam38bfamily with sequence similarity 38, member B0.025
Pipprolactin induced protein0.024
Trhrthyrotropin releasing hormone receptor0.023
Obp2bodorant binding protein 2B0.023
Folh1folate hydrolase 10.022
Psbpc1prostatic steroid binding protein C10.021
Shox2short stature homeobox 20.021
Tas2r105taste receptor, type 2, member 1050.020
Efnb1ephrin B10.020
Epoerythropoietin0.018
Gjd2gap junction protein, delta 20.017
Prl7a4prolactin family 7, subfamily a, member 40.017
Rnf207ring finger protein 2070.016
Tgfbr2transforming growth factor, beta receptor II0.016
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.015
Acmsdaminocarboxymuconate semialdehyde decarboxylase0.015
Vom1r102vomeronasal 1 receptor 1020.015
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.015
Sh2b3SH2B adaptor protein 30.013
Tas2r13taste receptor, type 2, member 130.013
Slc21a4kidney specific organic anion transporter0.013
Odf1outer dense fiber of sperm tails 10.013
Prl7a3prolactin family 7, subfamily a, member 30.013
Ptprqprotein tyrosine phosphatase, receptor type, Q0.013
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.012
Serpini2serine (or cysteine) peptidase inhibitor, clade I, member 20.012
Tspy1testis specific protein, Y-linked 10.012
Acot12acyl-CoA thioesterase 120.011
Prl3a1Prolactin family 3, subfamily a, member 10.011
Kcnv2potassium channel, subfamily V, member 20.011
RGD1565166similar to MGC45438 protein0.011
Rxraretinoid X receptor alpha0.011
Hcrtr2hypocretin (orexin) receptor 20.011
Vom2r53vomeronasal 2 receptor, 530.011
Mr1major histocompatibility complex, class I-related0.010
Krt24keratin 240.010
Npy5rneuropeptide Y receptor Y50.010
Tas2r121taste receptor, type 2, member 1210.010
Prl6a1prolactin family 6, subfamily a, member 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism