The network for 'positive regulation of interferon alpha production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of interferon alpha production

Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.

NameDescriptionProbabilityFunc Analog Organism
STAT1signal transducer and activator of transcription 1, 91kDa0.986
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.975
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.921
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.911
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.852
MYD88myeloid differentiation primary response gene (88)0.850
TBK1TANK-binding kinase 10.845
CYLDcylindromatosis (turban tumor syndrome)0.720
TRIM21tripartite motif containing 210.663
SP110SP110 nuclear body protein0.560
STAT2signal transducer and activator of transcription 2, 113kDa0.552
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.445
IRF7interferon regulatory factor 70.431
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.331
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.305
DTX3Ldeltex 3-like (Drosophila)0.264
IRF3interferon regulatory factor 30.254
MAP3K14mitogen-activated protein kinase kinase kinase 140.228
NMIN-myc (and STAT) interactor0.203
IRF9interferon regulatory factor 90.199
IFIH1interferon induced with helicase C domain 10.198
IFI35interferon-induced protein 350.168
MAVSmitochondrial antiviral signaling protein0.168
ADARadenosine deaminase, RNA-specific0.166
PARP12poly (ADP-ribose) polymerase family, member 120.152
PARP9poly (ADP-ribose) polymerase family, member 90.151
TRAF3TNF receptor-associated factor 30.125
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.122
SP100SP100 nuclear antigen0.112
EIF2C2eukaryotic translation initiation factor 2C, 20.100
IFI44interferon-induced protein 440.097
NLRC5NLR family, CARD domain containing 50.094
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.089
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.084
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.083
TANKTRAF family member-associated NFKB activator0.082
TRANK1tetratricopeptide repeat and ankyrin repeat containing 10.062
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.060
MX2myxovirus (influenza virus) resistance 2 (mouse)0.058
IRAK1interleukin-1 receptor-associated kinase 10.053
EIF2C1eukaryotic translation initiation factor 2C, 10.051
SAMD9sterile alpha motif domain containing 90.046
USP18ubiquitin specific peptidase 180.045
C19orf66chromosome 19 open reading frame 660.043
TRAF2TNF receptor-associated factor 20.042
TRIM25tripartite motif containing 250.040
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.036
BIRC3baculoviral IAP repeat containing 30.034
IFI16interferon, gamma-inducible protein 160.033
XAF1XIAP associated factor 10.032
ISG20interferon stimulated exonuclease gene 20kDa0.031
LGALS3BPlectin, galactoside-binding, soluble, 3 binding protein0.030
TNRC6Atrinucleotide repeat containing 6A0.030
HERC5hect domain and RLD 50.029
APOL6apolipoprotein L, 60.029
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.027
PIAS4protein inhibitor of activated STAT, 40.027
AZI25-azacytidine induced 20.025
CASP7caspase 7, apoptosis-related cysteine peptidase0.022
OASL2'-5'-oligoadenylate synthetase-like0.022
LY96lymphocyte antigen 960.022
ZC3HAV1zinc finger CCCH-type, antiviral 10.021
TRIM14tripartite motif containing 140.021
TRIM22tripartite motif containing 220.020
IRF2interferon regulatory factor 20.020
CHUKconserved helix-loop-helix ubiquitous kinase0.019
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.019
DHX58DEXH (Asp-Glu-X-His) box polypeptide 580.019
RTP4receptor (chemosensory) transporter protein 40.019
TLR2toll-like receptor 20.018
CDC37cell division cycle 37 homolog (S. cerevisiae)0.018
TDRD7tudor domain containing 70.018
PARP14poly (ADP-ribose) polymerase family, member 140.017
DNAJA1DnaJ (Hsp40) homolog, subfamily A, member 10.016
TICAM2toll-like receptor adaptor molecule 20.016
TNRC6Ctrinucleotide repeat containing 6C0.016
MYL12Amyosin, light chain 12A, regulatory, non-sarcomeric0.016
IFNAR2interferon (alpha, beta and omega) receptor 20.015
PHF11PHD finger protein 110.015
IRF2BP2interferon regulatory factor 2 binding protein 20.015
UBE2L6ubiquitin-conjugating enzyme E2L 60.015
SAMD9Lsterile alpha motif domain containing 9-like0.014
TLR4toll-like receptor 40.014
ISG15ISG15 ubiquitin-like modifier0.014
HSPH1heat shock 105kDa/110kDa protein 10.014
TRIM5tripartite motif containing 50.013
IFI6interferon, alpha-inducible protein 60.013
APOL3apolipoprotein L, 30.013
EPSTI1epithelial stromal interaction 1 (breast)0.013
CCT8chaperonin containing TCP1, subunit 8 (theta)0.013
CXCL10chemokine (C-X-C motif) ligand 100.013
TMEM173transmembrane protein 1730.012
CLTCclathrin, heavy chain (Hc)0.012
BTKBruton agammaglobulinemia tyrosine kinase0.012
HSPA9heat shock 70kDa protein 9 (mortalin)0.012
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.012
TLR1toll-like receptor 10.012
FOXO3forkhead box O30.011
RSAD2radical S-adenosyl methionine domain containing 20.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.987
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.971
Irgm1immunity-related GTPase family M member 10.941
Stat1signal transducer and activator of transcription 10.923
Irgm2immunity-related GTPase family M member 20.873
Ticam1toll-like receptor adaptor molecule 10.864
Ccr2chemokine (C-C motif) receptor 20.832
Gbp7guanylate binding protein 70.827
Gbp3guanylate binding protein 30.809
Tlr4toll-like receptor 40.808
Ifit1interferon-induced protein with tetratricopeptide repeats 10.801
Igtpinterferon gamma induced GTPase0.781
Ifih1interferon induced with helicase C domain 10.773
Trim25tripartite motif-containing 250.719
Trim30atripartite motif-containing 30A0.716
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.708
Usp18ubiquitin specific peptidase 180.662
Rtp4receptor transporter protein 40.643
Trim21tripartite motif-containing 210.587
Parp14poly (ADP-ribose) polymerase family, member 140.556
Ifit3interferon-induced protein with tetratricopeptide repeats 30.535
Gbp2guanylate binding protein 20.529
Uba7ubiquitin-like modifier activating enzyme 70.509
Cd19CD19 antigen0.509
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.506
Sfpi1SFFV proviral integration 10.498
Unc93b1unc-93 homolog B1 (C. elegans)0.480
FasFas (TNF receptor superfamily member 6)0.461
Rsad2radical S-adenosyl methionine domain containing 20.460
Tnftumor necrosis factor0.456
Samd9lsterile alpha motif domain containing 9-like0.431
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.414
Oasl22'-5' oligoadenylate synthetase-like 20.404
Hspa9heat shock protein 90.402
Map3k8mitogen-activated protein kinase kinase kinase 80.402
Irf9interferon regulatory factor 90.397
Isg15ISG15 ubiquitin-like modifier0.365
Ifi35interferon-induced protein 350.353
Tlr2toll-like receptor 20.344
NmiN-myc (and STAT) interactor0.337
Irf4interferon regulatory factor 40.326
Ifi47interferon gamma inducible protein 470.320
Birc3baculoviral IAP repeat-containing 30.307
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.306
Ifit2interferon-induced protein with tetratricopeptide repeats 20.274
Pyhin1pyrin and HIN domain family, member 10.271
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.260
Mmp9matrix metallopeptidase 90.258
Tor3atorsin family 3, member A0.249
Cd180CD180 antigen0.227
Ccl2chemokine (C-C motif) ligand 20.226
Ikzf1IKAROS family zinc finger 10.207
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.206
Il10interleukin 100.206
Ifnginterferon gamma0.204
Irf7interferon regulatory factor 70.203
Ifi203interferon activated gene 2030.203
Parp9poly (ADP-ribose) polymerase family, member 90.197
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.189
Lyz2lysozyme 20.189
Sp100nuclear antigen Sp1000.188
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.180
BtkBruton agammaglobulinemia tyrosine kinase0.179
BC006779cDNA sequence BC0067790.179
Ifi44interferon-induced protein 440.172
Irf8interferon regulatory factor 80.160
Rnf135ring finger protein 1350.153
Parp12poly (ADP-ribose) polymerase family, member 120.153
Samhd1SAM domain and HD domain, 10.152
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.151
Traf3TNF receptor-associated factor 30.147
Ly86lymphocyte antigen 860.141
Oas1a2'-5' oligoadenylate synthetase 1A0.135
Irf5interferon regulatory factor 50.134
1810019J16RikRIKEN cDNA 1810019J16 gene0.133
Ncoa3nuclear receptor coactivator 30.133
Irak4interleukin-1 receptor-associated kinase 40.128
Cd22CD22 antigen0.126
Tgfb1transforming growth factor, beta 10.122
Cd40CD40 antigen0.121
Zbp1Z-DNA binding protein 10.120
BlnkB-cell linker0.118
Erap1endoplasmic reticulum aminopeptidase 10.118
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.113
Tnfaip3tumor necrosis factor, alpha-induced protein 30.113
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.111
Azi25-azacytidine induced gene 20.110
Cxcl10chemokine (C-X-C motif) ligand 100.109
Ptpn6protein tyrosine phosphatase, non-receptor type 60.105
Chukconserved helix-loop-helix ubiquitous kinase0.103
Ifnar2interferon (alpha and beta) receptor 20.101
Tgtp2T-cell specific GTPase 20.100
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.096
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.095
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.094
TankTRAF family member-associated Nf-kappa B activator0.094
Hspa5heat shock protein 50.093
Cd79bCD79B antigen0.091
Casp1caspase 10.088
Cd44CD44 antigen0.086
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism