The network for 'negative regulation of transmission of nerve impulse' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transmission of nerve impulse

Any process that stops, prevents, or reduces the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.

NameDescriptionProbabilityFunc Analog Organism
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.748
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 30.674
OPRK1opioid receptor, kappa 10.668
GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 40.657
MTNR1Amelatonin receptor 1A0.578
GRIA1glutamate receptor, ionotropic, AMPA 10.575
CACNG3calcium channel, voltage-dependent, gamma subunit 30.549
UGT2B7UDP glucuronosyltransferase 2 family, polypeptide B70.501
GRIK1glutamate receptor, ionotropic, kainate 10.483
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.482
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.481
RIT2Ras-like without CAAX 20.452
CDH8cadherin 8, type 20.449
GPC5glypican 50.440
GRM1glutamate receptor, metabotropic 10.412
GABRA5gamma-aminobutyric acid (GABA) A receptor, alpha 50.408
SV2Csynaptic vesicle glycoprotein 2C0.403
SNTG1syntrophin, gamma 10.386
SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 20.384
GLRA1glycine receptor, alpha 10.365
SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 60.364
GLRA3glycine receptor, alpha 30.361
GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 10.355
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.331
CACNB4calcium channel, voltage-dependent, beta 4 subunit0.319
RALYLRALY RNA binding protein-like0.303
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.301
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.300
SYT13synaptotagmin XIII0.278
SLC1A6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.269
GRIA2glutamate receptor, ionotropic, AMPA 20.260
GRM5glutamate receptor, metabotropic 50.259
NRXN1neurexin 10.258
DCCdeleted in colorectal carcinoma0.257
NPYneuropeptide Y0.255
RGS7regulator of G-protein signaling 70.248
ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.248
DAB1disabled homolog 1 (Drosophila)0.243
WSCD2WSC domain containing 20.232
DRD5dopamine receptor D50.228
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.226
PEX5Lperoxisomal biogenesis factor 5-like0.224
RIMS2regulating synaptic membrane exocytosis 20.220
TAC1tachykinin, precursor 10.200
NTRK3neurotrophic tyrosine kinase, receptor, type 30.188
NEUROD2neurogenic differentiation 20.181
GABRR1gamma-aminobutyric acid (GABA) receptor, rho 10.175
VSTM2AV-set and transmembrane domain containing 2A0.166
DDX25DEAD (Asp-Glu-Ala-Asp) box polypeptide 250.166
GABRB2gamma-aminobutyric acid (GABA) A receptor, beta 20.165
DLGAP1discs, large (Drosophila) homolog-associated protein 10.156
SNAP91synaptosomal-associated protein, 91kDa homolog (mouse)0.154
GABRQgamma-aminobutyric acid (GABA) receptor, theta0.150
RGS6regulator of G-protein signaling 60.149
SCN2Asodium channel, voltage-gated, type II, alpha subunit0.146
FABP7fatty acid binding protein 7, brain0.144
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)0.142
NHLH2nescient helix loop helix 20.139
SULT4A1sulfotransferase family 4A, member 10.138
NELL1NEL-like 1 (chicken)0.137
GRM3glutamate receptor, metabotropic 30.131
KCNA6potassium voltage-gated channel, shaker-related subfamily, member 60.130
SLC12A5solute carrier family 12 (potassium/chloride transporter), member 50.129
RIMS1regulating synaptic membrane exocytosis 10.126
PRKCGprotein kinase C, gamma0.125
SLITRK3SLIT and NTRK-like family, member 30.120
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 10.120
DSCAMDown syndrome cell adhesion molecule0.119
STXBP5Lsyntaxin binding protein 5-like0.117
SYN2synapsin II0.116
SERPINI2serpin peptidase inhibitor, clade I (pancpin), member 20.114
MUSKmuscle, skeletal, receptor tyrosine kinase0.110
GRIA3glutamate receptor, ionotrophic, AMPA 30.109
DGKIdiacylglycerol kinase, iota0.107
GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 20.107
CDH10cadherin 10, type 2 (T2-cadherin)0.106
GNG4guanine nucleotide binding protein (G protein), gamma 40.106
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.105
CCKBRcholecystokinin B receptor0.104
LRRTM4leucine rich repeat transmembrane neuronal 40.101
ACTL6Bactin-like 6B0.099
FGF12fibroblast growth factor 120.098
OPRM1opioid receptor, mu 10.096
PRMT8protein arginine methyltransferase 80.095
DLG2discs, large homolog 2 (Drosophila)0.094
KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 30.094
SEZ6Lseizure related 6 homolog (mouse)-like0.093
PURGpurine-rich element binding protein G0.093
MCF2MCF.2 cell line derived transforming sequence0.092
AKAP5A kinase (PRKA) anchor protein 50.092
ADAM18ADAM metallopeptidase domain 180.090
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.090
MGAT4Cmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)0.090
SSTR2somatostatin receptor 20.089
FAM5Bfamily with sequence similarity 5, member B0.089
GRIA4glutamate receptor, ionotrophic, AMPA 40.089
GPR22G protein-coupled receptor 220.087
KHDRBS2KH domain containing, RNA binding, signal transduction associated 20.086
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism