The network for 'regulation of ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of ossification

Any process that modulates the frequency, rate or extent of bone formation.

NameDescriptionProbabilityFunc Analog Organism
EP300E1A binding protein p3001.000
SMAD2SMAD family member 20.997
CCR5chemokine (C-C motif) receptor 50.993
SKILSKI-like oncogene0.987
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.985
SMAD4SMAD family member 40.975
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.971
CCL5chemokine (C-C motif) ligand 50.969
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.965
FBLN1fibulin 10.963
JUNjun proto-oncogene0.952
SMAD3SMAD family member 30.951
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.937
BMPR1Abone morphogenetic protein receptor, type IA0.918
BMP2bone morphogenetic protein 20.917
HDAC4histone deacetylase 40.894
IFITM2interferon induced transmembrane protein 2 (1-8D)0.888
POU3F2POU class 3 homeobox 20.866
CXCL9chemokine (C-X-C motif) ligand 90.826
NOTCH1notch 10.805
ESR1estrogen receptor 10.792
SP1Sp1 transcription factor0.792
JAG1jagged 10.779
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.763
TGFB1transforming growth factor, beta 10.736
NCOR2nuclear receptor corepressor 20.722
IFITM3interferon induced transmembrane protein 3 (1-8U)0.717
TP53tumor protein p530.641
NOTCH3notch 30.624
SOCS3suppressor of cytokine signaling 30.622
FKBP1AFK506 binding protein 1A, 12kDa0.600
NCOR1nuclear receptor corepressor 10.589
MEIS2Meis homeobox 20.563
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.555
MDM2Mdm2 p53 binding protein homolog (mouse)0.502
ENGendoglin0.497
ATF3activating transcription factor 30.491
SMAD7SMAD family member 70.489
BCL6B-cell CLL/lymphoma 60.483
HIPK2homeodomain interacting protein kinase 20.482
FN1fibronectin 10.478
FSTL1follistatin-like 10.477
EGR1early growth response 10.463
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.458
CTGFconnective tissue growth factor0.451
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.425
CCL22chemokine (C-C motif) ligand 220.421
GABARAPGABA(A) receptor-associated protein0.415
MMP14matrix metallopeptidase 14 (membrane-inserted)0.409
CCL3chemokine (C-C motif) ligand 30.396
COL1A2collagen, type I, alpha 20.386
IFITM1interferon induced transmembrane protein 1 (9-27)0.381
FZD1frizzled homolog 1 (Drosophila)0.372
MEF2Amyocyte enhancer factor 2A0.368
SKIv-ski sarcoma viral oncogene homolog (avian)0.363
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.362
STAT4signal transducer and activator of transcription 40.361
SIN3ASIN3 homolog A, transcription regulator (yeast)0.361
JUPjunction plakoglobin0.351
CCL4chemokine (C-C motif) ligand 40.347
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.346
BMP1bone morphogenetic protein 10.322
SMURF2SMAD specific E3 ubiquitin protein ligase 20.314
BMP7bone morphogenetic protein 70.307
CXXC5CXXC finger protein 50.303
COL6A1collagen, type VI, alpha 10.301
FBN1fibrillin 10.301
KDM2Blysine (K)-specific demethylase 2B0.300
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.300
ACVR1activin A receptor, type I0.296
TGFB3transforming growth factor, beta 30.294
CAV1caveolin 1, caveolae protein, 22kDa0.292
FOSFBJ murine osteosarcoma viral oncogene homolog0.280
MYOD1myogenic differentiation 10.278
VCANversican0.275
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.271
PTPN12protein tyrosine phosphatase, non-receptor type 120.267
YAP1Yes-associated protein 10.256
TCF4transcription factor 40.250
NRP1neuropilin 10.248
CCL2chemokine (C-C motif) ligand 20.242
GATA2GATA binding protein 20.241
LAMC1laminin, gamma 1 (formerly LAMB2)0.231
IGFBP3insulin-like growth factor binding protein 30.230
MEF2Cmyocyte enhancer factor 2C0.229
PTPRCprotein tyrosine phosphatase, receptor type, C0.228
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.217
SMAD6SMAD family member 60.217
IFNGinterferon, gamma0.208
HDAC9histone deacetylase 90.207
CREBBPCREB binding protein0.202
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.196
TGFBR1transforming growth factor, beta receptor 10.192
EPAS1endothelial PAS domain protein 10.192
FGF1fibroblast growth factor 1 (acidic)0.189
CCR1chemokine (C-C motif) receptor 10.188
CCR4chemokine (C-C motif) receptor 40.186
IL2RBinterleukin 2 receptor, beta0.186
NOGnoggin0.186
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.182
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.871
col1a1acollagen, type I, alpha 1a0.655
col1a2collagen, type I, alpha 20.563
sox9aSRY-box containing gene 9a0.471
pitx3paired-like homeodomain transcription factor 30.370
runx2brunt-related transcription factor 2b0.329
col5a1procollagen, type V, alpha 10.292
tcf7transcription factor 7 (T-cell specific, HMG-box)0.271
kdrlkinase insert domain receptor like0.189
wnt5bwingless-type MMTV integration site family, member 5b0.186
col10a1collagen, type X, alpha 10.120
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.086
runx2arunt-related transcription factor 2a0.077
epha4aeph receptor A4a0.073
notch3notch homolog 30.056
wnt9awingless-type MMTV integration site family, member 9A0.054
dusp6dual specificity phosphatase 60.051
rargbretinoic acid receptor, gamma b0.049
jag1bjagged 1b0.046
sox9bSRY-box containing gene 9b0.040
tbx1T-box 10.033
dkk1bdickkopf 1b0.032
xylt1xylosyltransferase 10.031
chdchordin0.029
apoebapolipoprotein Eb0.027
twist1atwist1a0.026
bmperBMP binding endothelial regulator0.026
pkd2polycystic kidney disease 20.024
wnt3wingless-type MMTV integration site family, member 30.023
sox3SRY-box containing gene 30.021
gyltl1bglycosyltransferase-like 1b0.020
mef2camyocyte enhancer factor 2ca0.019
dlx4adistal-less homeobox gene 4a0.019
tcf12transcription factor 120.018
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.018
cmybtranscription factor cmyb0.016
fstl1bfollistatin-like 1b0.016
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.016
zgc:158603zgc:1586030.016
zgc:85866zgc:858660.015
col5a2lcollagen, type V, alpha 2-like0.015
notch2notch homolog 20.015
sparcsecreted acidic cysteine rich glycoprotein0.015
foxn4forkhead box N40.015
bmp1abone morphogenetic protein 1a0.014
arl4abADP-ribosylation factor-like 4ab0.014
dlx2adistal-less homeobox gene 2a0.014
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.014
wnt11rwingless-type MMTV integration site family, member 11, related0.013
igf1rbinsulin-like growth factor 1b receptor0.013
ptgs2aprostaglandin-endoperoxide synthase 2a0.013
gli2aGLI-Kruppel family member GLI2a0.012
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.012
mxi1max interacting protein0.012
fli1afriend leukemia integration 1a0.011
dcndecorin0.011
rasl11bRAS-like, family 11, member B0.011
dlx3bdistal-less homeobox gene 3b0.011
shhasonic hedgehog a0.011
gpc4glypican 40.010
foxi1forkhead box I10.010
itga3bintegrin, alpha 3b0.010
twist2twist20.010
col2a1acollagen type II, alpha-1a0.010
wnt9bwingless-type MMTV integration site family, member 9B0.010
klf4Kruppel-like factor 40.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.983
Notch1Notch gene homolog 1 (Drosophila)0.980
Pthlhparathyroid hormone-like peptide0.952
Smad6MAD homolog 6 (Drosophila)0.949
Fgf8fibroblast growth factor 80.940
Gli2GLI-Kruppel family member GLI20.932
Tgfb2transforming growth factor, beta 20.922
Prrx2paired related homeobox 20.897
Nodalnodal0.845
Fgfr3fibroblast growth factor receptor 30.830
Runx2runt related transcription factor 20.818
Eya1eyes absent 1 homolog (Drosophila)0.777
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.777
Smad3MAD homolog 3 (Drosophila)0.774
Fgfr1fibroblast growth factor receptor 10.764
Gli1GLI-Kruppel family member GLI10.758
Lef1lymphoid enhancer binding factor 10.745
Klklotho0.743
Twist1twist homolog 1 (Drosophila)0.732
Ptenphosphatase and tensin homolog0.728
Ntf3neurotrophin 30.718
Fzd1frizzled homolog 1 (Drosophila)0.718
Sfrp2secreted frizzled-related protein 20.715
Hoxa2homeobox A20.701
Ctnnb1catenin (cadherin associated protein), beta 10.685
Gli3GLI-Kruppel family member GLI30.685
Gata4GATA binding protein 40.684
Dll1delta-like 1 (Drosophila)0.683
Pax2paired box gene 20.665
Axin1axin 10.655
Smad7MAD homolog 7 (Drosophila)0.646
Csf1colony stimulating factor 1 (macrophage)0.644
Fgf15fibroblast growth factor 150.633
Pax3paired box gene 30.625
Prrx1paired related homeobox 10.616
Hand1heart and neural crest derivatives expressed transcript 10.614
Smad4MAD homolog 4 (Drosophila)0.598
Ror2receptor tyrosine kinase-like orphan receptor 20.597
Retret proto-oncogene0.595
Bmpr1abone morphogenetic protein receptor, type 1A0.590
Nos3nitric oxide synthase 3, endothelial cell0.588
Zic3zinc finger protein of the cerebellum 30.586
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.577
Acvr1activin A receptor, type 10.572
Trp53transformation related protein 530.541
Pkd1polycystic kidney disease 1 homolog0.534
Ascl1achaete-scute complex homolog 1 (Drosophila)0.515
Ptgs2prostaglandin-endoperoxide synthase 20.512
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.508
Edn3endothelin 30.503
Zfpm2zinc finger protein, multitype 20.495
Ncoa3nuclear receptor coactivator 30.469
Epas1endothelial PAS domain protein 10.463
Gdnfglial cell line derived neurotrophic factor0.462
Mndalmyeloid nuclear differentiation antigen like0.450
Pou3f3POU domain, class 3, transcription factor 30.449
Fgf18fibroblast growth factor 180.442
Vdrvitamin D receptor0.440
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.437
Smosmoothened homolog (Drosophila)0.437
Alx4aristaless-like homeobox 40.431
Msx1homeobox, msh-like 10.429
Edaectodysplasin-A0.424
Hes1hairy and enhancer of split 1 (Drosophila)0.424
Cd80CD80 antigen0.424
Notch3Notch gene homolog 3 (Drosophila)0.416
Dkk1dickkopf homolog 1 (Xenopus laevis)0.411
Smad2MAD homolog 2 (Drosophila)0.404
Acanaggrecan0.403
Robo3roundabout homolog 3 (Drosophila)0.403
Foxd3forkhead box D30.397
Ptch2patched homolog 20.394
Bmp5bone morphogenetic protein 50.392
Efsembryonal Fyn-associated substrate0.392
Col13a1collagen, type XIII, alpha 10.392
Thbs1thrombospondin 10.389
Tcf4transcription factor 40.388
Gja1gap junction protein, alpha 10.385
Neurog3neurogenin 30.383
Gpr50G-protein-coupled receptor 500.382
Zic1zinc finger protein of the cerebellum 10.380
Ptgirprostaglandin I receptor (IP)0.377
Gpc3glypican 30.374
Adra2aadrenergic receptor, alpha 2a0.373
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.373
Tbx2T-box 20.371
Foxf1aforkhead box F1a0.364
Fzd2frizzled homolog 2 (Drosophila)0.362
Pax9paired box gene 90.362
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.348
Twist2twist homolog 2 (Drosophila)0.347
Tgfb1i1transforming growth factor beta 1 induced transcript 10.344
Foxd2forkhead box D20.340
Smad1MAD homolog 1 (Drosophila)0.335
Fgf10fibroblast growth factor 100.331
Bdkrb2bradykinin receptor, beta 20.326
Rararetinoic acid receptor, alpha0.325
Bcl2B-cell leukemia/lymphoma 20.325
Ednrbendothelin receptor type B0.321
Neurod1neurogenic differentiation 10.319
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.612
Cd40lgCD40 ligand0.258
Jak1Janus kinase 10.244
Olr1500olfactory receptor 15000.242
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.196
Plauplasminogen activator, urokinase0.174
Adam7ADAM metallopeptidase domain 70.172
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.163
Prlprolactin0.160
Foxe3forkhead box E30.148
Cxcl2chemokine (C-X-C motif) ligand 20.143
Fgf10fibroblast growth factor 100.136
Ptgs2prostaglandin-endoperoxide synthase 20.136
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.127
Fgf22fibroblast growth factor 220.126
Mmp23matrix metallopeptidase 230.123
Nr2f2nuclear receptor subfamily 2, group F, member 20.123
Npy5rneuropeptide Y receptor Y50.119
Defb22defensin beta 220.111
Id1inhibitor of DNA binding 10.110
Pmchpro-melanin-concentrating hormone0.109
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.101
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.099
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.098
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.098
Has2hyaluronan synthase 20.094
Mc5rmelanocortin 5 receptor0.092
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.091
Cpxm2carboxypeptidase X (M14 family), member 20.088
Prrx1paired related homeobox 10.088
Zic1Zic family member 1 (odd-paired homolog, Drosophila)0.087
Edn1endothelin 10.085
Ptpn14protein tyrosine phosphatase, non-receptor type 140.080
Nr1d2nuclear receptor subfamily 1, group D, member 20.080
Prss1protease, serine, 1 (trypsin 1)0.078
Il4interleukin 40.078
Selpselectin P0.077
Hdgfl1hepatoma derived growth factor-like 10.076
Mas1MAS1 oncogene0.076
Insrrinsulin receptor-related receptor0.076
Syt8synaptotagmin VIII0.073
Pipprolactin induced protein0.073
Tcf3transcription factor 30.072
Fam65afamily with sequence similarity 65, member A0.071
Prl7a3prolactin family 7, subfamily a, member 30.071
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.070
Id3inhibitor of DNA binding 30.070
Pthparathyroid hormone0.068
Ascl1achaete-scute complex homolog 1 (Drosophila)0.068
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.068
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.067
Phlda1pleckstrin homology-like domain, family A, member 10.067
Bcl2B-cell CLL/lymphoma 20.066
Ctsjcathepsin J0.066
Pth2rparathyroid hormone 2 receptor0.065
Leprleptin receptor0.064
Slc8a2solute carrier family 8 (sodium/calcium exchanger), member 20.064
Trhthyrotropin releasing hormone0.064
Clphcasein-like phosphoprotein0.063
Nedd4neural precursor cell expressed, developmentally down-regulated 40.063
Il6interleukin 60.062
Grm5glutamate receptor, metabotropic 50.061
Tgfb2transforming growth factor, beta 20.060
Usp25ubiquitin specific peptidase 250.060
Folh1folate hydrolase 10.059
Oprm1opioid receptor, mu 10.058
Col5a1collagen, type V, alpha 10.058
Pax8paired box 80.057
Atf3activating transcription factor 30.057
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.056
Jak2Janus kinase 20.056
Hbe2hemoglobin, epsilon 20.055
KlKlotho0.055
Cd52CD52 antigen0.054
Elnelastin0.054
Itpr2inositol 1,4,5-triphosphate receptor, type 20.054
Cgaglycoprotein hormones, alpha polypeptide0.052
Slit3slit homolog 3 (Drosophila)0.052
Htr1b5-hydroxytryptamine (serotonin) receptor 1B0.052
Fosl1fos-like antigen 10.052
Ccl4chemokine (C-C motif) ligand 40.052
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.051
Notch2Notch homolog 2 (Drosophila)0.051
Jubjub, ajuba homolog (Xenopus laevis)0.051
Bocbiregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein0.050
Prol1proline rich, lacrimal 10.050
Vcanversican0.049
Igfbp3insulin-like growth factor binding protein 30.049
Znf503zinc finger protein 5030.049
Mcpt1mast cell protease 10.049
Asphaspartate-beta-hydroxylase0.048
Sycp1synaptonemal complex protein 10.048
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.048
Fgfr1Fibroblast growth factor receptor 10.047
Fgf18fibroblast growth factor 180.047
DbpD site of albumin promoter (albumin D-box) binding protein0.047
Myh9myosin, heavy chain 9, non-muscle0.046
Col12a1collagen, type XII, alpha 10.046
Tas2r105taste receptor, type 2, member 1050.046
Gabra2gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 20.045
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism