The network for 'maintenance of cell polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

maintenance of cell polarity

The maintenance of established anisotropic intracellular organization or cell growth patterns.

NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.996
APCadenomatous polyposis coli0.993
CCT8chaperonin containing TCP1, subunit 8 (theta)0.959
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.833
INADLInaD-like (Drosophila)0.816
ARHGAP1Rho GTPase activating protein 10.721
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.690
LATlinker for activation of T cells0.666
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.540
GAS7growth arrest-specific 70.434
PRKCZprotein kinase C, zeta0.389
CD247CD247 molecule0.334
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.318
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.317
ITGB4integrin, beta 40.291
JUPjunction plakoglobin0.265
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.257
RANBP2RAN binding protein 20.252
ROCK1Rho-associated, coiled-coil containing protein kinase 10.231
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.222
STRADASTE20-related kinase adaptor alpha0.221
VAV1vav 1 guanine nucleotide exchange factor0.186
DLG1discs, large homolog 1 (Drosophila)0.176
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.174
SKA3spindle and kinetochore associated complex subunit 30.174
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.155
LCKlymphocyte-specific protein tyrosine kinase0.142
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.136
SMURF1SMAD specific E3 ubiquitin protein ligase 10.134
STRN3striatin, calmodulin binding protein 30.121
GRB2growth factor receptor-bound protein 20.119
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.119
SMAD1SMAD family member 10.118
YAP1Yes-associated protein 10.114
ATF7IPactivating transcription factor 7 interacting protein0.111
RHOAras homolog gene family, member A0.110
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.107
ERBB2IPerbb2 interacting protein0.103
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)0.097
SH2D3CSH2 domain containing 3C0.095
IQGAP1IQ motif containing GTPase activating protein 10.095
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.094
KIF5Bkinesin family member 5B0.087
RHOCras homolog gene family, member C0.085
ARHGAP5Rho GTPase activating protein 50.078
TJP1tight junction protein 1 (zona occludens 1)0.075
EXOC5exocyst complex component 50.074
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.072
STRADBSTE20-related kinase adaptor beta0.069
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.068
VAPBVAMP (vesicle-associated membrane protein)-associated protein B and C0.067
MAP4K5mitogen-activated protein kinase kinase kinase kinase 50.067
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.067
SOS1son of sevenless homolog 1 (Drosophila)0.063
FBXO30F-box protein 300.062
ABI1abl-interactor 10.061
LLGL2lethal giant larvae homolog 2 (Drosophila)0.061
BCAR1breast cancer anti-estrogen resistance 10.060
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.059
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.058
PTK2PTK2 protein tyrosine kinase 20.058
LGALS1lectin, galactoside-binding, soluble, 10.058
SRCIN1SRC kinase signaling inhibitor 10.057
FLNAfilamin A, alpha0.057
DMAP1DNA methyltransferase 1 associated protein 10.056
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.056
ZC3HAV1zinc finger CCCH-type, antiviral 10.054
EXOC1exocyst complex component 10.053
TNIKTRAF2 and NCK interacting kinase0.051
RHOGras homolog gene family, member G (rho G)0.049
RAB21RAB21, member RAS oncogene family0.048
CD151CD151 molecule (Raph blood group)0.047
CAB39calcium binding protein 390.046
ADAM15ADAM metallopeptidase domain 150.046
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.045
SERTAD4SERTA domain containing 40.045
APIPAPAF1 interacting protein0.044
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.043
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.043
LRRK2leucine-rich repeat kinase 20.042
KCNE3potassium voltage-gated channel, Isk-related family, member 30.042
RDXradixin0.042
ZFP106zinc finger protein 106 homolog (mouse)0.040
REREarginine-glutamic acid dipeptide (RE) repeats0.040
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.040
SPTBN1spectrin, beta, non-erythrocytic 10.039
ELLelongation factor RNA polymerase II0.039
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.038
RANBP9RAN binding protein 90.038
GIGYF2GRB10 interacting GYF protein 20.037
OSBPL11oxysterol binding protein-like 110.037
LLGL1lethal giant larvae homolog 1 (Drosophila)0.036
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme0.036
SCRIBscribbled homolog (Drosophila)0.035
TJP2tight junction protein 2 (zona occludens 2)0.035
PRKCIprotein kinase C, iota0.035
PTPN23protein tyrosine phosphatase, non-receptor type 230.033
CHAC1ChaC, cation transport regulator homolog 1 (E. coli)0.032
PTPN12protein tyrosine phosphatase, non-receptor type 120.032
MACF1microtubule-actin crosslinking factor 10.032
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
CELE_F53C11.4Protein F53C11.40.020
ari-1Protein ARI-10.015
F09E5.7Protein F09E5.70.012
vps-32.1Protein VPS-32.10.011
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
crb2acrumbs homolog 2a0.973
ilkintegrin linked kinase0.646
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.615
epb41l5erythrocyte membrane protein band 4.1 like 50.391
prkciprotein kinase C, iota0.150
pacsin3protein kinase C and casein kinase substrate in neurons 30.128
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.086
si:dkey-97i18.2si:dkey-97i18.20.079
mxi1max interacting protein0.076
tmem2transmembrane protein 20.070
skianuclear oncoprotein skia0.070
map2k4amitogen-activated protein kinase kinase 4a0.059
vsx1visual system homeobox 1 homolog, chx10-like0.057
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.055
rp2retinitis pigmentosa 2 (X-linked recessive)0.055
mibmind bomb0.052
si:ch211-272f3.4si:ch211-272f3.40.052
si:ch211-232m7.1si:ch211-232m7.10.052
ntrk3bneurotrophic tyrosine kinase, receptor, type 3b0.050
prkcqprotein kinase C, theta0.048
prkcbbprotein kinase C, beta b0.046
ift88intraflagellar transport 88 homolog0.045
zgc:110298zgc:1102980.044
b4galt4UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 40.043
zgc:123010zgc:1230100.043
scribscribbled homolog (Drosophila)0.039
suv420h2suppressor of variegation 4-20 homolog 2 (Drosophila)0.038
LOC100003514protein kinase C alpha type-like0.036
rap2cRAP2C, member of RAS oncogene family0.036
gabarapaGABA(A) receptor-associated protein a0.036
rhoabras homolog gene family, member Ab0.035
utrnutrophin0.035
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.034
csadcysteine sulfinic acid decarboxylase0.033
LOC100359374BCL-WAV0.033
ncoa2nuclear receptor coactivator 20.031
lama1laminin, alpha 10.030
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.029
rcn1reticulocalbin 1, EF-hand calcium binding domain0.029
ythdf1YTH domain family, member 10.029
sb:cb472sb:cb4720.027
pobpartial optokinetic response b0.026
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.026
vclvinculin0.026
chmchoroideremia0.025
grk7aG-protein-coupled receptor kinase 7a0.024
hpcahippocalcin0.022
atoh7atonal homolog 70.021
bcl2l10BCL2-like 10 (apoptosis facilitator)0.021
ptk2.1protein tyrosine kinase 2a0.020
far1fatty acyl CoA reductase 10.020
cxadrcoxsackie virus and adenovirus receptor0.019
dynlt3dynein, light chain, Tctex-type 30.019
cdc34acell division cycle 34 homolog (S. cerevisiae) a0.019
grk1bG protein-coupled receptor kinase 1 b0.019
lrrfip2leucine rich repeat (in FLII) interacting protein 20.018
guca1cguanylate cyclase activator 1C0.018
uchl1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.018
crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.018
syt9asynaptotagmin IXa0.017
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.015
krit1KRIT1, ankyrin repeat containing0.015
zgc:114199zgc:1141990.015
dlg4discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)0.015
LOC561662Golgi phosphoprotein 3-like0.014
zgc:85727zgc:857270.014
dpysl2bdihydropyrimidinase-like 2b0.014
crb1crumbs homolog 1 (Drosophila)0.014
dpp7dipeptidyl-peptidase 70.014
tpm1tropomyosin 1 (alpha)0.014
ube2i2ubiquitin-conjugating enzyme E2I20.014
spry2sprouty homolog 20.014
cdc73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.013
vangl2vang-like 2 (van gogh, Drosophila)0.013
ppp3ccaprotein phosphatase 3, catalytic subunit, gamma isozyme, a0.013
si:ch211-207m11.1si:ch211-207m11.10.013
pfn2profilin 20.013
pkp2plakophilin 20.012
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.012
cldn12claudin 120.012
lasp1LIM and SH3 protein 10.012
zgc:92758zgc:927580.012
slc35b2solute carrier family 35, member B20.012
opn4x1opsin 4x10.012
hugHuG0.011
cyt1type I cytokeratin, enveloping layer0.011
mst1macrophage stimulating 1 (hepatocyte growth factor-like)0.011
acp5bacid phosphatase 5b, tartrate resistant0.011
slc14a2solute carrier family 14 (urea transporter), member 20.011
aldh4a1aldehyde dehydrogenase 4 family, member A10.011
bidaBH3 interacting domain death agonist0.011
LOC799274kinesin heavy chain isoform 5A-like0.011
xirp2bxin actin-binding repeat containing 2b0.011
LOC569128hypothetical protein LOC5691280.010
slc24a5solute carrier family 24, member 50.010
dlg1discs, large (Drosophila) homolog 10.010
sp2sp2 transcription factor0.010
zgc:86759zgc:867590.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cdc42CG12530 gene product from transcript CG12530-RA0.896
bazbazooka0.880
Rac1CG2248 gene product from transcript CG2248-RA0.873
sqhspaghetti squash0.716
kstkarst0.546
ghoghost0.397
aPKCatypical protein kinase C0.306
rokRho-kinase0.286
Rab5Rab-protein 50.275
par-1CG8201 gene product from transcript CG8201-RA0.269
crbcrumbs0.200
SNF1ASNF1A/AMP-activated protein kinase0.195
diadiaphanous0.126
PknProtein kinase related to protein kinase N0.109
msnmisshapen0.101
JraJun-related antigen0.095
Syx7Syntaxin 70.094
Ggamma1G protein gamma 10.093
scbscab0.085
vibvibrator0.083
l(2)gllethal (2) giant larvae0.071
chicchickadee0.066
Sop2Suppressor of profilin 20.061
RhoLrho-like0.059
cnocanoe0.059
wunwunen0.058
par-6CG5884 gene product from transcript CG5884-RA0.056
Eb1CG3265 gene product from transcript CG3265-RF0.052
coracoracle0.047
Vhlvon Hippel-Lindau0.046
rheaCG6831 gene product from transcript CG6831-RA0.045
gammaCopgamma-coatomer protein0.044
DlicDynein light intermediate chain0.041
sec23CG1250 gene product from transcript CG1250-RA0.040
toktolkin0.038
frcfringe connection0.038
Rho1CG8416 gene product from transcript CG8416-RB0.037
CDaseCeramidase0.036
Rbsn-5Rabenosyn-50.036
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.033
MoeMoesin0.033
CG4567CG4567 gene product from transcript CG4567-RA0.033
KrnKeren0.030
konkon-tiki0.028
wdbwiderborst0.025
Vps28Vacuolar protein sorting 280.025
Vrp1Verprolin 10.025
lkb1CG9374 gene product from transcript CG9374-RJ0.025
Sgt1CG9617 gene product from transcript CG9617-RA0.024
Chd64CG14996 gene product from transcript CG14996-RB0.024
vps2CG14542 gene product from transcript CG14542-RA0.022
regucalcinCG1803 gene product from transcript CG1803-RA0.022
Rab11Rab-protein 110.021
HspB8CG14207 gene product from transcript CG14207-RB0.020
SdhASuccinate dehydrogenase A0.020
CG1115CG1115 gene product from transcript CG1115-RA0.020
bskbasket0.020
HphHIF prolyl hydroxylase0.019
scfsupercoiling factor0.019
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.019
ifinflated0.018
CG31352CG31352 gene product from transcript CG31352-RA0.018
ttktramtrack0.017
PHGPxCG12013 gene product from transcript CG12013-RC0.017
rawCG12437 gene product from transcript CG12437-RB0.017
RalaRas-related protein0.017
ykiyorkie0.017
IlkIntegrin linked kinase0.016
Myo31DFMyosin 31DF0.016
CG11009CG11009 gene product from transcript CG11009-RB0.016
Mmp1Matrix metalloproteinase 10.016
Nrx-IVNeurexin IV0.016
ensensconsin0.015
Cnx99ACalnexin 99A0.015
PvrPDGF- and VEGF-receptor related0.015
sglsugarless0.014
CG13117CG13117 gene product from transcript CG13117-RA0.014
Tsp42EdTetraspanin 42Ed0.014
GstD1Glutathione S transferase D10.014
HSPC300CG30173 gene product from transcript CG30173-RA0.014
CG17838CG17838 gene product from transcript CG17838-RA0.014
trctricornered0.013
Flo-2flotillin 20.013
Vps25Vacuolar protein sorting 250.013
mmymummy0.013
CragCalmodulin-binding protein related to a Rab3 GDP/GTP exchange protein0.013
nudECG8104 gene product from transcript CG8104-RB0.012
Prosalpha1Proteasome alpha1 subunit0.012
TSG101tumor suppressor protein 1010.012
CG6776CG6776 gene product from transcript CG6776-RA0.012
hpohippo0.012
CG13994CG13994 gene product from transcript CG13994-RA0.012
mfrnmitoferrin0.012
PakPAK-kinase0.012
CrcCalreticulin0.012
CG10373CG10373 gene product from transcript CG10373-RA0.011
locolocomotion defects0.011
Xbp1X box binding protein-10.011
Fps85DFps oncogene analog0.011
SybSynaptobrevin0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC11Cdc11p0.911
RHO1Rho1p0.625
CDC12Cdc12p0.621
CDC3Cdc3p0.336
VPS28Vps28p0.273
CDC10Cdc10p0.267
RDI1Rdi1p0.247
OSH7Osh7p0.167
CDC55Cdc55p0.131
RSR1Rsr1p0.085
VPS36Vps36p0.084
OSH2Osh2p0.051
MDS3Mds3p0.043
PRS2Prs2p0.038
KEL1Kel1p0.036
EXO70Exo70p0.036
BSP1Bsp1p0.031
SGE1Sge1p0.030
UBC9Ubc9p0.028
GIC2Gic2p0.028
NNT1Nnt1p0.026
NDD1Ndd1p0.026
COQ1Coq1p0.025
SCS2Scs2p0.024
URA3Ura3p0.024
SRD1Srd1p0.024
STE4Ste4p0.024
RGD1Rgd1p0.023
YGL242Chypothetical protein0.022
YLR264C-Ahypothetical protein0.021
MNN9Mnn9p0.021
YOL038C-Ahypothetical protein0.021
OSH6Osh6p0.020
LDB17Ldb17p0.020
YLR162Whypothetical protein0.020
BRN1Brn1p0.018
MER1Mer1p0.018
ARP10Arp10p0.018
CUP1-1Cup1-1p0.018
CAB4Cab4p0.018
LEU2Leu2p0.018
AXL2Axl2p0.018
CUE4Cue4p0.017
BEM4Bem4p0.017
ECM25Ecm25p0.017
YIR035Chypothetical protein0.017
SPL2Spl2p0.016
TPM2Tpm2p0.016
YAR068Whypothetical protein0.015
TGL1Tgl1p0.015
FAA1Faa1p0.015
YLR042Chypothetical protein0.015
INN1Inn1p0.015
YLR049Chypothetical protein0.015
ALO1Alo1p0.015
RRP15Rrp15p0.014
TPO4Tpo4p0.014
CHA1Cha1p0.014
ATP6Atp6p0.014
FSH1Fsh1p0.014
WSC4Wsc4p0.014
YBR013Chypothetical protein0.014
YGR035Chypothetical protein0.014
GIC1Gic1p0.014
PHM6Phm6p0.013
CPD1Cpd1p0.013
VAC17Vac17p0.013
YML053Chypothetical protein0.013
HPF1Hpf1p0.013
YPL014Whypothetical protein0.013
TSC3Tsc3p0.013
SWC7Swc7p0.013
CRP1Crp1p0.013
YGR017Whypothetical protein0.013
YIL151Chypothetical protein0.012
YPR157Whypothetical protein0.012
AUA1Aua1p0.012
UPS3Ups3p0.012
DIF1Dif1p0.012
FMT1Fmt1p0.012
PCL9Pcl9p0.012
ZPS1Zps1p0.012
REE1Ree1p0.012
FUI1Fui1p0.012
ARG8Arg8p0.011
OPT2Opt2p0.011
YER186Chypothetical protein0.011
MF(ALPHA)2Mf(alpha)2p0.011
SSO2Sso2p0.011
HXT3Hxt3p0.011
DIC1Dic1p0.011
NRG2Nrg2p0.011
YLR040Chypothetical protein0.010
YJR120Whypothetical protein0.010
GPI11Gpi11p0.010
SCM4Scm4p0.010
YOL013W-Ahypothetical protein0.010
RRN5Rrn5p0.010
CDC1Cdc1p0.010
SWH1Swh1p0.010