The network for 'positive t cell selection' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive t cell selection

The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death.

NameDescriptionProbabilityFunc Analog Organism
CD247CD247 molecule0.946
LCKlymphocyte-specific protein tyrosine kinase0.537
IL4Rinterleukin 4 receptor0.375
BCL2L1BCL2-like 10.271
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.215
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.176
HLA-DMBmajor histocompatibility complex, class II, DM beta0.095
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.078
PTPN6protein tyrosine phosphatase, non-receptor type 60.071
STRADASTE20-related kinase adaptor alpha0.063
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.063
MKL1megakaryoblastic leukemia (translocation) 10.055
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.050
GHRgrowth hormone receptor0.044
IL2RGinterleukin 2 receptor, gamma0.039
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.034
IL6Rinterleukin 6 receptor0.032
SH3BP2SH3-domain binding protein 20.032
VAV1vav 1 guanine nucleotide exchange factor0.031
PTPRCprotein tyrosine phosphatase, receptor type, C0.031
IL8interleukin 80.027
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.026
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.025
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.025
CXCR4chemokine (C-X-C motif) receptor 40.024
CD8ACD8a molecule0.022
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.022
HLA-DRB5major histocompatibility complex, class II, DR beta 50.022
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.021
HLA-DPB1major histocompatibility complex, class II, DP beta 10.021
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.019
LATlinker for activation of T cells0.019
MYOCDmyocardin0.017
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.017
ITGALintegrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)0.017
ITGA1integrin, alpha 10.017
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.015
SHC1SHC (Src homology 2 domain containing) transforming protein 10.015
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D0.014
STRADBSTE20-related kinase adaptor beta0.014
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.014
MAP2K1mitogen-activated protein kinase kinase 10.014
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.013
KSR1kinase suppressor of ras 10.013
INSRinsulin receptor0.013
BAXBCL2-associated X protein0.013
UBASH3Bubiquitin associated and SH3 domain containing B0.013
CD2CD2 molecule0.012
SH2D2ASH2 domain containing 2A0.012
PRKCEprotein kinase C, epsilon0.012
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.012
PRKCQprotein kinase C, theta0.012
IL4interleukin 40.012
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.011
DDIT3DNA-damage-inducible transcript 30.011
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.011
MKL2MKL/myocardin-like 20.011
TMEM173transmembrane protein 1730.011
MYOGmyogenin (myogenic factor 4)0.011
YAP1Yes-associated protein 10.011
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Foxp3forkhead box P30.993
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.990
Ikzf1IKAROS family zinc finger 10.989
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.988
Lcklymphocyte protein tyrosine kinase0.974
Trp53transformation related protein 530.957
FynFyn proto-oncogene0.929
Kitkit oncogene0.924
Cd28CD28 antigen0.908
Stat2signal transducer and activator of transcription 20.900
H2-Eb1histocompatibility 2, class II antigen E beta0.891
H2-Aahistocompatibility 2, class II antigen A, alpha0.869
H2-Ab1histocompatibility 2, class II antigen A, beta 10.857
Cd19CD19 antigen0.853
H2-DMahistocompatibility 2, class II, locus DMa0.853
Latlinker for activation of T cells0.853
Stat5asignal transducer and activator of transcription 5A0.843
Fgfr2fibroblast growth factor receptor 20.819
Ighimmunoglobulin heavy chain complex0.812
FasFas (TNF receptor superfamily member 6)0.783
Ptenphosphatase and tensin homolog0.739
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.716
Il6stinterleukin 6 signal transducer0.705
Il2interleukin 20.694
Irf9interferon regulatory factor 90.692
Stat6signal transducer and activator of transcription 60.680
Cd247CD247 antigen0.664
Cd22CD22 antigen0.651
Stat5bsignal transducer and activator of transcription 5B0.631
Smad3MAD homolog 3 (Drosophila)0.621
Ptgs2prostaglandin-endoperoxide synthase 20.611
Rag1recombination activating gene 10.611
Lyz2lysozyme 20.527
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.468
TcrbT-cell receptor beta chain0.458
Il1r1interleukin 1 receptor, type I0.438
Il27rainterleukin 27 receptor, alpha0.437
Cd3gCD3 antigen, gamma polypeptide0.417
H2-DMb2histocompatibility 2, class II, locus Mb20.391
Itgb1integrin beta 1 (fibronectin receptor beta)0.382
Il21rinterleukin 21 receptor0.382
Ncoa3nuclear receptor coactivator 30.358
Apcadenomatosis polyposis coli0.343
Il4rainterleukin 4 receptor, alpha0.335
Socs1suppressor of cytokine signaling 10.331
Ptpn6protein tyrosine phosphatase, non-receptor type 60.328
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.327
Arandrogen receptor0.304
ItkIL2-inducible T-cell kinase0.303
Stat1signal transducer and activator of transcription 10.302
Stat3signal transducer and activator of transcription 30.296
Ifnginterferon gamma0.294
Il2rbinterleukin 2 receptor, beta chain0.291
TcraT-cell receptor alpha chain0.286
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.275
Irf5interferon regulatory factor 50.258
Vhlvon Hippel-Lindau tumor suppressor0.255
Ciitaclass II transactivator0.225
Traf1TNF receptor-associated factor 10.212
Dock2dedicator of cyto-kinesis 20.210
Vav1vav 1 oncogene0.206
Smad4MAD homolog 4 (Drosophila)0.200
Cd2CD2 antigen0.191
Cd4CD4 antigen0.187
Irf4interferon regulatory factor 40.186
Prf1perforin 1 (pore forming protein)0.179
Tgfb1transforming growth factor, beta 10.178
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.174
Itgalintegrin alpha L0.173
Inpp5dinositol polyphosphate-5-phosphatase D0.171
WasWiskott-Aldrich syndrome homolog (human)0.170
Lef1lymphoid enhancer binding factor 10.162
Isg15ISG15 ubiquitin-like modifier0.160
Uba7ubiquitin-like modifier activating enzyme 70.151
Esr1estrogen receptor 1 (alpha)0.148
Cd8aCD8 antigen, alpha chain0.138
Irf8interferon regulatory factor 80.132
Wt1Wilms tumor 1 homolog0.130
Ptprcprotein tyrosine phosphatase, receptor type, C0.129
Cxcr3chemokine (C-X-C motif) receptor 30.121
Sh2d2aSH2 domain protein 2A0.120
Notch2Notch gene homolog 2 (Drosophila)0.120
Tnfaip3tumor necrosis factor, alpha-induced protein 30.120
Lystlysosomal trafficking regulator0.119
Ikzf3IKAROS family zinc finger 30.119
Gli3GLI-Kruppel family member GLI30.119
Cd3dCD3 antigen, delta polypeptide0.116
Cd3eCD3 antigen, epsilon polypeptide0.113
BlnkB-cell linker0.110
Trim21tripartite motif-containing 210.108
Zap70zeta-chain (TCR) associated protein kinase0.104
Ptprcapprotein tyrosine phosphatase, receptor type, C polypeptide-associated protein0.103
Nckap1lNCK associated protein 1 like0.103
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.099
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.097
Rhohras homolog gene family, member H0.096
Il10interleukin 100.095
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.093
Ifnar1interferon (alpha and beta) receptor 10.092
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.091
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism