The network for 'sphingolipid metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sphingolipid metabolic process

The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).

NameDescriptionProbabilityFunc Analog Organism
LAMP1lysosomal-associated membrane protein 10.587
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.544
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.367
COTL1coactosin-like 1 (Dictyostelium)0.302
CTSAcathepsin A0.288
TMBIM6transmembrane BAX inhibitor motif containing 60.275
SQLEsqualene epoxidase0.258
CYP51A1cytochrome P450, family 51, subfamily A, polypeptide 10.236
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.220
RPTORregulatory associated protein of MTOR, complex 10.185
NOXA1NADPH oxidase activator 10.165
PDPK13-phosphoinositide dependent protein kinase-10.153
RTN4reticulon 40.148
INSRinsulin receptor0.128
CTGFconnective tissue growth factor0.125
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.124
BCL2L1BCL2-like 10.119
SURF4surfeit 40.118
HMGCR3-hydroxy-3-methylglutaryl-CoA reductase0.106
SIGMAR1sigma non-opioid intracellular receptor 10.103
USP22ubiquitin specific peptidase 220.094
CASP7caspase 7, apoptosis-related cysteine peptidase0.093
DUSP23dual specificity phosphatase 230.087
ANXA4annexin A40.081
CCDC115coiled-coil domain containing 1150.079
BAK1BCL2-antagonist/killer 10.078
LATlinker for activation of T cells0.075
MFSD5major facilitator superfamily domain containing 50.067
PRKCBprotein kinase C, beta0.066
RNF144Bring finger protein 144B0.064
HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)0.062
SLC39A1solute carrier family 39 (zinc transporter), member 10.060
SC5DLsterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like0.055
SH3RF1SH3 domain containing ring finger 10.055
GNSglucosamine (N-acetyl)-6-sulfatase0.053
IDI1isopentenyl-diphosphate delta isomerase 10.053
RNR2l-rRNA0.052
KITLGKIT ligand0.051
PREX1phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 10.051
MAPTmicrotubule-associated protein tau0.049
LAMP2lysosomal-associated membrane protein 20.048
ELOVL1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.047
CCL14chemokine (C-C motif) ligand 140.046
PICK1protein interacting with PRKCA 10.045
NR1H2nuclear receptor subfamily 1, group H, member 20.043
RICTORRPTOR independent companion of MTOR, complex 20.041
TM9SF1transmembrane 9 superfamily member 10.041
ARF3ADP-ribosylation factor 30.040
NUMBnumb homolog (Drosophila)0.038
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.038
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.037
TMEM173transmembrane protein 1730.037
AKT1S1AKT1 substrate 1 (proline-rich)0.036
INSIG1insulin induced gene 10.036
HEXAhexosaminidase A (alpha polypeptide)0.035
DEPTORDEP domain containing MTOR-interacting protein0.034
MTORmechanistic target of rapamycin (serine/threonine kinase)0.033
LASS2LAG1 homolog, ceramide synthase 20.032
ZHX1zinc fingers and homeoboxes 10.032
SHC1SHC (Src homology 2 domain containing) transforming protein 10.031
SNX9sorting nexin 90.030
JAK2Janus kinase 20.030
NMT2N-myristoyltransferase 20.030
ALOX12Barachidonate 12-lipoxygenase, 12R type0.030
PRKCZprotein kinase C, zeta0.030
CDCP1CUB domain containing protein 10.030
NCF1neutrophil cytosolic factor 10.030
ATXN1ataxin 10.029
CD58CD58 molecule0.029
CDC37cell division cycle 37 homolog (S. cerevisiae)0.029
CTSL1cathepsin L10.029
RNF13ring finger protein 130.029
PDK1pyruvate dehydrogenase kinase, isozyme 10.028
ZNF71zinc finger protein 710.027
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.027
FDFT1farnesyl-diphosphate farnesyltransferase 10.027
SOAT1sterol O-acyltransferase 10.026
ACSL3acyl-CoA synthetase long-chain family member 30.026
BCL2L11BCL2-like 11 (apoptosis facilitator)0.025
GLB1galactosidase, beta 10.025
CARD11caspase recruitment domain family, member 110.025
MAPKAP1mitogen-activated protein kinase associated protein 10.025
ENPP5ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)0.024
CYB561D2cytochrome b-561 domain containing 20.024
RHOXF2Rhox homeobox family, member 20.023
KRT5keratin 50.023
RARAretinoic acid receptor, alpha0.023
BRF2BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like0.023
TMEM165transmembrane protein 1650.023
CPDcarboxypeptidase D0.022
ASXL1additional sex combs like 1 (Drosophila)0.022
ATP6V0E1ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e10.022
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.022
NSDHLNAD(P) dependent steroid dehydrogenase-like0.022
NPTNneuroplastin0.022
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.022
C14orf1chromosome 14 open reading frame 10.021
BADBCL2-associated agonist of cell death0.021
MFSD1major facilitator superfamily domain containing 10.021
GM2AGM2 ganglioside activator0.021
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
cat-1Protein CAT-10.037
W01C8.5Protein W01C8.50.028
ZC328.3Protein ZC328.30.028
spon-1Protein SPON-10.027
nhr-68Protein NHR-680.026
gspd-1Protein GSPD-10.026
egl-44Protein EGL-440.025
sur-5Protein SUR-50.021
vha-15Protein VHA-150.020
pcyt-1Protein PCYT-10.020
nhr-97Protein NHR-970.019
C44B7.11Protein C44B7.110.019
daf-36Protein DAF-360.019
mboa-3Protein MBOA-30.019
ncr-1Protein NCR-10.018
CELE_Y57G11C.31Protein Y57G11C.310.018
C48B4.1Protein C48B4.10.018
nhr-143Protein NHR-1430.017
pmp-1Protein PMP-10.017
elo-2Protein ELO-20.017
tre-1Protein TRE-10.016
C06G3.5Protein C06G3.50.016
prx-5Protein PRX-50.016
M03B6.2Protein M03B6.20.016
CELE_Y57G11C.3Protein Y57G11C.30.016
nmur-4Protein NMUR-40.016
best-13Protein BEST-130.016
F53E4.1Protein F53E4.10.015
ZK742.3Protein ZK742.30.015
erm-1Protein ERM-10.015
pmp-2Protein PMP-20.014
elt-2Protein ELT-20.014
lact-4Protein LACT-40.014
maoc-1Protein MAOC-10.014
fat-4Protein FAT-40.013
CELE_C27A7.1Protein C27A7.10.013
tre-3Protein TRE-30.013
snf-11Protein SNF-110.013
ZK185.3Protein ZK185.30.013
T13C2.3Protein T13C2.30.013
rop-1Protein ROP-10.013
vha-5Protein VHA-50.012
F36A2.3Protein F36A2.30.012
ZK686.2Protein ZK686.20.012
T22D1.3Protein T22D1.30.012
CELE_Y48A6C.4Protein Y48A6C.40.012
hot-6Protein HOT-60.011
elo-5Protein ELO-50.011
ugt-61Protein UGT-610.011
ccch-1Protein CCCH-10.011
sptl-2Protein SPTL-20.011
aqp-10Protein AQP-100.011
tbc-3Protein TBC-30.011
prx-3Protein PRX-30.010
CELE_F54F3.4Protein F54F3.40.010
prx-12Protein PRX-120.010
unc-112Protein UNC-1120.010
sars-1Protein SARS-10.010
F55A4.8Protein F55A4.80.010
daf-1Protein DAF-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cyp19a1bcytochrome P450, family 19, subfamily A, polypeptide 1b0.292
trpm7transient receptor potential cation channel, subfamily M, member 70.082
plce1phospholipase C, epsilon 10.042
neu3.5Neu3.50.036
oc90otoconin 900.027
hspb15heat shock protein, alpha-crystallin-related, b150.023
otompotolith matrix protein0.022
neu3.3sialidase 3.30.020
bcl2l1bcl2-like 10.020
renrenin0.019
mitfamicrophthalmia-associated transcription factor a0.015
per2period homolog 2 (Drosophila)0.014
ltkleukocyte tyrosine kinase0.014
pcdh15bprotocadherin 15b0.014
pmelapremelanosome protein a0.013
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.013
esr2bestrogen receptor 2b0.013
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.013
eml2echinoderm microtubule associated protein like 20.013
sox9aSRY-box containing gene 9a0.012
ppm1fprotein phosphatase 1F (PP2C domain containing)0.012
c1galt1bcore 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b0.012
itga2bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)0.012
si:dkey-49m19.7si:dkey-49m19.70.011
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.011
sh3gl1aSH3-domain GRB2-like 1a0.010
hsd17b12ahydroxysteroid (17-beta) dehydrogenase 12a0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CG16904CG16904 gene product from transcript CG16904-RA0.131
CG30008CG30008 gene product from transcript CG30008-RA0.106
Pi4KIIalphaCG2929 gene product from transcript CG2929-RC0.106
CG18609CG18609 gene product from transcript CG18609-RA0.102
Fad2CG7923 gene product from transcript CG7923-RA0.088
CG9458CG9458 gene product from transcript CG9458-RA0.066
CG9459CG9459 gene product from transcript CG9459-RA0.064
easeasily shocked0.058
CG7910CG7910 gene product from transcript CG7910-RA0.054
brubrunelleschi0.047
CG13091CG13091 gene product from transcript CG13091-RA0.042
CSN4COP9 complex homolog subunit 40.037
cibciboulot0.031
CG1443CG1443 gene product from transcript CG1443-RA0.028
CG4729CG4729 gene product from transcript CG4729-RA0.025
twftwinfilin0.023
Vha100-1CG1709 gene product from transcript CG1709-RF0.023
lazalazaro0.023
Rab11Rab-protein 110.023
CG10590CG10590 gene product from transcript CG10590-RA0.021
CG33129CG33129 gene product from transcript CG33129-RE0.020
CG17560CG17560 gene product from transcript CG17560-RA0.019
AIFApoptosis inducing factor0.019
ric8aCG15797 gene product from transcript CG15797-RA0.019
CG11350CG11350 gene product from transcript CG11350-RB0.016
desat1CG5887 gene product from transcript CG5887-RA0.015
CG9053CG9053 gene product from transcript CG9053-RA0.015
bifbifocal0.015
par-1CG8201 gene product from transcript CG8201-RA0.015
CG15531CG15531 gene product from transcript CG15531-RB0.015
exo84CG6095 gene product from transcript CG6095-RA0.014
CG1441CG1441 gene product from transcript CG1441-RB0.014
CG32528CG32528 gene product from transcript CG32528-RA0.014
CG33523CG33523 gene product from transcript CG33523-RD0.013
ifcinfertile crescent0.013
vibvibrator0.013
RhoLrho-like0.013
CG12268CG12268 gene product from transcript CG12268-RB0.013
CheB93aChemosensory protein B 93a0.012
Sc2CG10849 gene product from transcript CG10849-RA0.012
l(2)37Bblethal (2) 37Bb0.012
CG34120CG34120 gene product from transcript CG34120-RC0.012
Ost48Oligosaccharyltransferase 48kD subunit0.012
spictspichthyin0.012
Cpr51ACuticular protein 51A0.012
Kr-h2Kruppel homolog 20.012
Cyp4g1Cytochrome P450-4g10.011
CG3638CG3638 gene product from transcript CG3638-RE0.011
CG9426CG9426 gene product from transcript CG9426-RA0.011
cnccap-n-collar0.011
CctgammaCG8977 gene product from transcript CG8977-RC0.011
Kap3Kinesin associated protein 30.011
CG3016CG3016 gene product from transcript CG3016-RA0.011
CG9855CG9855 gene product from transcript CG9855-RA0.010
Mpk2CG5475 gene product from transcript CG5475-RB0.010
CG4666CG4666 gene product from transcript CG4666-RA0.010
CG10175CG10175 gene product from transcript CG10175-RA0.010
trpmltransient receptor potential mucolipin0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.999
Trp53transformation related protein 530.976
Bcl2B-cell leukemia/lymphoma 20.972
Csf1colony stimulating factor 1 (macrophage)0.950
BaxBCL2-associated X protein0.948
0610031J06RikRIKEN cDNA 0610031J06 gene0.943
Nos3nitric oxide synthase 3, endothelial cell0.909
Dpp7dipeptidylpeptidase 70.861
Tgfb1transforming growth factor, beta 10.854
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.802
Tgfbr2transforming growth factor, beta receptor II0.718
Ctsdcathepsin D0.638
Elovl1elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 10.598
TiparpTCDD-inducible poly(ADP-ribose) polymerase0.589
Ikzf1IKAROS family zinc finger 10.560
Gusbglucuronidase, beta0.557
WwoxWW domain-containing oxidoreductase0.552
Flt4FMS-like tyrosine kinase 40.518
Lgmnlegumain0.513
Selpselectin, platelet0.513
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.510
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.469
Lystlysosomal trafficking regulator0.462
Ldlrlow density lipoprotein receptor0.421
Nfe2l2nuclear factor, erythroid derived 2, like 20.414
Pld3phospholipase D family, member 30.395
Ctgfconnective tissue growth factor0.376
Ctsacathepsin A0.349
Sptlc2serine palmitoyltransferase, long chain base subunit 20.347
Sgpl1sphingosine phosphate lyase 10.346
Thbs1thrombospondin 10.343
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.339
Lmf1lipase maturation factor 10.335
Apoeapolipoprotein E0.335
Prf1perforin 1 (pore forming protein)0.306
Inpp5dinositol polyphosphate-5-phosphatase D0.305
Sqlesqualene epoxidase0.302
Soat1sterol O-acyltransferase 10.299
Plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.297
Rptorregulatory associated protein of MTOR, complex 10.292
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.291
Gaaglucosidase, alpha, acid0.289
Gbaglucosidase, beta, acid0.287
Pdgfbplatelet derived growth factor, B polypeptide0.281
Cdh5cadherin 50.273
Atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.269
Cyr61cysteine rich protein 610.265
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.263
Itm2cintegral membrane protein 2C0.248
Itga5integrin alpha 5 (fibronectin receptor alpha)0.246
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.242
NagaN-acetyl galactosaminidase, alpha0.240
Pthlhparathyroid hormone-like peptide0.239
Ebpphenylalkylamine Ca2+ antagonist (emopamil) binding protein0.234
Pold4polymerase (DNA-directed), delta 40.231
Engendoglin0.229
Lamp1lysosomal-associated membrane protein 10.228
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.222
Retret proto-oncogene0.222
Notch2Notch gene homolog 2 (Drosophila)0.211
Ncoa3nuclear receptor coactivator 30.204
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.203
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.200
LitafLPS-induced TN factor0.198
Il6stinterleukin 6 signal transducer0.198
Mfsd1major facilitator superfamily domain containing 10.197
Kdrkinase insert domain protein receptor0.193
Sirpasignal-regulatory protein alpha0.186
F2coagulation factor II0.178
Vhlvon Hippel-Lindau tumor suppressor0.176
Hiatl1hippocampus abundant transcript-like 10.172
Sox10SRY-box containing gene 100.172
Arid5bAT rich interactive domain 5B (MRF1-like)0.170
Tcn2transcobalamin 20.167
Scpep1serine carboxypeptidase 10.165
Ighimmunoglobulin heavy chain complex0.163
Ptprbprotein tyrosine phosphatase, receptor type, B0.155
Clcn5chloride channel 50.154
Grngranulin0.151
Commd6COMM domain containing 60.150
Vegfavascular endothelial growth factor A0.147
Mybphmyosin binding protein H0.146
Esr1estrogen receptor 1 (alpha)0.144
Ctszcathepsin Z0.142
Ednrbendothelin receptor type B0.138
Myo1cmyosin IC0.136
FosFBJ osteosarcoma oncogene0.132
Ctsbcathepsin B0.131
Npc2Niemann Pick type C20.130
Edem1ER degradation enhancer, mannosidase alpha-like 10.127
Platplasminogen activator, tissue0.126
Asah1N-acylsphingosine amidohydrolase 10.126
Ikzf3IKAROS family zinc finger 30.125
Ecm1extracellular matrix protein 10.125
CblCasitas B-lineage lymphoma0.124
S1pr3sphingosine-1-phosphate receptor 30.123
Mlst8MTOR associated protein, LST8 homolog (S. cerevisiae)0.122
Slc33a1solute carrier family 33 (acetyl-CoA transporter), member 10.117
Gucy1b3guanylate cyclase 1, soluble, beta 30.117
Man2b1mannosidase 2, alpha B10.116
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
LCB2Lcb2p0.994
LAG1Lag1p0.885
TOR1Tor1p0.858
LCB3Lcb3p0.822
LAC1Lac1p0.806
IFA38Ifa38p0.651
MDS3Mds3p0.612
SCS7Scs7p0.588
SLM1Slm1p0.544
SAC1Sac1p0.462
SUR2Sur2p0.424
KSP1Ksp1p0.418
SUR1Sur1p0.400
ORM2Orm2p0.359
SHR3Shr3p0.301
CRZ1Crz1p0.298
CSG2Csg2p0.285
GSF2Gsf2p0.269
AVO1Avo1p0.245
SVP26Svp26p0.230
PTK2Ptk2p0.192
TOR2Tor2p0.191
ERG11Erg11p0.190
SRO7Sro7p0.188
TSC3Tsc3p0.183
SLG1Slg1p0.175
YPK1Ypk1p0.167
RTS1Rts1p0.156
FPK1Fpk1p0.144
GAB1Gab1p0.144
SEF1Sef1p0.131
FEN1Fen1p0.124
GPI8Gpi8p0.114
IPT1Ipt1p0.111
TCO89Tco89p0.105
FMP48Fmp48p0.104
AGP1Agp1p0.103
BRE5Bre5p0.100
LSM2Lsm2p0.093
GPR1Gpr1p0.093
VHS3Vhs3p0.092
AZF1Azf1p0.084
LCB1Lcb1p0.082
FAT1Fat1p0.082
HRK1Hrk1p0.081
AKL1Akl1p0.081
GIC1Gic1p0.081
AUR1Aur1p0.078
AVT1Avt1p0.076
SKI8Ski8p0.076
ISC1Isc1p0.076
RAX1Rax1p0.075
CTR2Ctr2p0.075
KIN82Kin82p0.074
PRR2Prr2p0.074
YPL260Whypothetical protein0.074
UBP9Ubp9p0.071
MKS1Mks1p0.070
LDB16Ldb16p0.068
AKR2Akr2p0.067
YNL190Whypothetical protein0.067
HAL5Hal5p0.066
NTH2Nth2p0.066
SKS1Sks1p0.064
VHS1Vhs1p0.063
PHO86Pho86p0.063
PRS2Prs2p0.062
IMD2Imd2p0.061
RIM101Rim101p0.061
OST6Ost6p0.060
PIS1Pis1p0.058
IZH3Izh3p0.057
CTT1Ctt1p0.056
CRR1Crr1p0.055
PRO3Pro3p0.054
YGR016Whypothetical protein0.053
YNR014Whypothetical protein0.053
SIA1Sia1p0.052
UTR1Utr1p0.050
OSH3Osh3p0.050
PSD1Psd1p0.049
MEP2Mep2p0.048
PAR32Par32p0.048
ATG4Atg4p0.048
SFT1Sft1p0.047
YBR235Whypothetical protein0.047
PBN1Pbn1p0.046
VPS16Vps16p0.045
AVT7Avt7p0.044
ATO3Ato3p0.044
PSR1Psr1p0.043
FAA2Faa2p0.043
CTF13Ctf13p0.043
OPI10Opi10p0.043
CMK2Cmk2p0.043
ESP1Esp1p0.042
CSH1Csh1p0.041
YLR257Whypothetical protein0.040
VPS17Vps17p0.040
RHO5Rho5p0.040