The network for 'zymogen activation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

zymogen activation

The proteolytic processing of an inactive enzyme to an active form.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
BCL2B-cell CLL/lymphoma 21.000
BCL2L1BCL2-like 10.999
MDM2Mdm2 p53 binding protein homolog (mouse)0.999
BCL2L11BCL2-like 11 (apoptosis facilitator)0.994
CASP3caspase 3, apoptosis-related cysteine peptidase0.991
CASP10caspase 10, apoptosis-related cysteine peptidase0.982
SMN1survival of motor neuron 1, telomeric0.980
FASFas (TNF receptor superfamily, member 6)0.979
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.967
CASP9caspase 9, apoptosis-related cysteine peptidase0.954
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.941
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.940
BIDBH3 interacting domain death agonist0.935
S100BS100 calcium binding protein B0.935
HIPK2homeodomain interacting protein kinase 20.934
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.919
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.917
TP53tumor protein p530.913
XIAPX-linked inhibitor of apoptosis0.888
NPM1nucleophosmin (nucleolar phosphoprotein B23, numatrin)0.887
S100A6S100 calcium binding protein A60.877
CFLARCASP8 and FADD-like apoptosis regulator0.860
RB1retinoblastoma 10.857
CASP2caspase 2, apoptosis-related cysteine peptidase0.856
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.845
NLRC4NLR family, CARD domain containing 40.802
S100A8S100 calcium binding protein A80.797
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.708
S100A9S100 calcium binding protein A90.696
BAXBCL2-associated X protein0.685
SMAD3SMAD family member 30.658
S100A1S100 calcium binding protein A10.651
COL4A1collagen, type IV, alpha 10.640
ANXA2annexin A20.637
PLAUplasminogen activator, urokinase0.627
GGT1gamma-glutamyltransferase 10.624
S100A4S100 calcium binding protein A40.608
DAXXdeath-domain associated protein0.575
COL4A2collagen, type IV, alpha 20.544
FADDFas (TNFRSF6)-associated via death domain0.520
SMAD1SMAD family member 10.513
METmet proto-oncogene (hepatocyte growth factor receptor)0.495
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.485
NCLnucleolin0.481
BIRC2baculoviral IAP repeat containing 20.470
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.465
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.458
S100A14S100 calcium binding protein A140.448
GGTLC1gamma-glutamyltransferase light chain 10.445
RXRAretinoid X receptor, alpha0.429
APAF1apoptotic peptidase activating factor 10.422
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.419
FASLGFas ligand (TNF superfamily, member 6)0.402
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.400
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.382
PYCARDPYD and CARD domain containing0.381
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.376
HDAC2histone deacetylase 20.373
FYNFYN oncogene related to SRC, FGR, YES0.369
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.368
CHEK2CHK2 checkpoint homolog (S. pombe)0.361
SOCS1suppressor of cytokine signaling 10.361
BAK1BCL2-antagonist/killer 10.332
SP1Sp1 transcription factor0.332
SMURF2SMAD specific E3 ubiquitin protein ligase 20.325
C4orf14chromosome 4 open reading frame 140.305
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.302
GAS7growth arrest-specific 70.291
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.291
GASTgastrin0.289
SMAD2SMAD family member 20.285
PTPN1protein tyrosine phosphatase, non-receptor type 10.285
CREBBPCREB binding protein0.277
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.272
PLATplasminogen activator, tissue0.269
VDAC2voltage-dependent anion channel 20.268
KLK10kallikrein-related peptidase 100.262
NR4A1nuclear receptor subfamily 4, group A, member 10.254
PMLpromyelocytic leukemia0.251
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.251
SETSET nuclear oncogene0.242
CDK2cyclin-dependent kinase 20.239
KLK7kallikrein-related peptidase 70.234
HCKhemopoietic cell kinase0.234
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.224
SP100SP100 nuclear antigen0.213
SQSTM1sequestosome 10.209
COL4A4collagen, type IV, alpha 40.206
S100A11S100 calcium binding protein A110.201
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.193
ESR1estrogen receptor 10.191
VDAC1voltage-dependent anion channel 10.186
PRSS2protease, serine, 2 (trypsin 2)0.185
BIKBCL2-interacting killer (apoptosis-inducing)0.184
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.180
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.177
PIAS1protein inhibitor of activated STAT, 10.176
PELP1proline, glutamate and leucine rich protein 10.175
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.171
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
caspacaspase a0.393
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.309
mmp2matrix metalloproteinase 20.228
ccng1cyclin G10.192
mychmyelocytomatosis oncogene homolog0.187
mycamyelocytomatosis oncogene a0.187
stc1lstanniocalcin 1, like0.174
lap3leucine aminopeptidase 30.173
ahcyS-adenosylhomocysteine hydrolase0.170
hspa9heat shock protein 90.169
lamc3laminin, gamma 30.160
ela2lelastase 2 like0.143
ef1aelongation factor 1-alpha0.141
si:rp71-39b20.7si:rp71-39b20.70.114
sulf1sulfatase 10.110
prdm5PR domain containing 50.104
bmperBMP binding endothelial regulator0.102
grhl1grainyhead-like 1 (Drosophila)0.102
LOC569128hypothetical protein LOC5691280.100
tfe3btranscription factor binding to IGHM enhancer 3b0.100
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.095
col12a1collagen, type XII, alpha 10.089
gata3GATA-binding protein 30.089
eporerythropoietin receptor0.085
dhfrdihydrofolate reductase0.085
zgc:171553zgc:1715530.084
il8interleukin 80.084
ncapg2non-SMC condensin II complex, subunit G20.083
zgc:172161zgc:1721610.083
prmt1protein arginine methyltransferase 10.083
bbc3BCL2 binding component 30.082
matn4matrilin 40.082
msh6mutS homolog 6 (E. coli)0.081
myh11amyosin, heavy polypeptide 11, smooth muscle a0.079
eif3s2eukaryotic translation initiation factor 3, subunit 2 beta0.079
ahr2aryl hydrocarbon receptor 20.074
slc15a1bsolute carrier family 15 (oligopeptide transporter), member 1b0.074
s100a10bS100 calcium binding protein A10b0.073
mycbp2MYC binding protein 20.073
cdkn1acyclin-dependent kinase inhibitor 1A0.071
tmprss4atransmembrane protease, serine 4a0.070
fabp2fatty acid binding protein 2, intestinal0.070
tecrbtrans-2,3-enoyl-CoA reductase b0.069
timp2btissue inhibitor of metalloproteinase 2b0.068
gpiaglucose phosphate isomerase a0.067
xirp2axin actin-binding repeat containing 2a0.064
lamc1laminin, gamma 10.062
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.062
adipor1badiponectin receptor 1b0.061
zgc:113054zgc:1130540.060
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.060
rps15aribosomal protein S15a0.060
ctrb1chymotrypsinogen B10.060
si:ch211-212m21.5si:ch211-212m21.50.059
pold1polymerase (DNA directed), delta 1, catalytic subunit0.058
cntfrciliary neurotrophic factor receptor0.058
prdx4peroxiredoxin 40.058
scxascleraxis homolog A (mouse)0.058
zgc:92237zgc:922370.058
limk2LIM domain kinase 20.057
tm4sf4transmembrane 4 L six family member 40.056
pkzprotein kinase containing Z-DNA binding domains0.056
igf1rbinsulin-like growth factor 1b receptor0.056
gata5GATA-binding protein 50.054
bcl2B-cell leukemia/lymphoma 20.054
immtinner membrane protein, mitochondrial (mitofilin)0.053
myl9myosin, light polypeptide 9, regulatory0.052
aldh7a1aldehyde dehydrogenase 7 family, member A10.052
loxl2blysyl oxidase-like 2b0.052
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.052
phospho1phosphatase, orphan 10.052
cops4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.052
duoxdual oxidase0.051
zgc:66382zgc:663820.051
fanciFanconi anemia, complementation group I0.051
ercc2excision repair cross-complementing rodent repair deficiency, complementation group 20.049
cd247lCD247 antigen like0.049
anxa1aannexin A1a0.049
atp1a3bATPase, Na+/K+ transporting, alpha 3b polypeptide0.048
scarb1scavenger receptor class B, member 10.048
acat1acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)0.048
mmp14bmatrix metalloproteinase 14b (membrane-inserted)0.047
atf3activating transcription factor 30.047
faddFas (tnfrsf6)-associated via death domain0.046
loxlysyl oxidase0.046
timp2atissue inhibitor of metalloproteinase 2a0.045
tp53inp1tumor protein p53 inducible nuclear protein 10.045
prim1primase polypeptide 10.045
lgals2alectin, galactoside-binding, soluble, 2a0.045
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.045
mbtps1membrane-bound transcription factor protease, site 10.045
zff9zinc finger protein 90.044
stat1bsignal transducer and activator of transcription 1b0.044
sult3st1sulfotransferase family 3, cytosolic sulfotransferase 10.044
rpsaribosomal protein SA0.043
adrb2aadrenergic receptor, beta 2a0.043
il1binterleukin 1, beta and interleukin 1, beta0.043
mical3flavoprotein oxidoreductase MICAL30.043
ranras-related nuclear protein0.043
cldn15lbclaudin 15-like b0.042
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
imdimmune deficiency0.567
ththread0.508
DreddDeath related ced-3/Nedd2-like protein0.341
CG9772CG9772 gene product from transcript CG9772-RB0.294
egreiger0.291
PliPellino0.273
PGRP-LCPeptidoglycan recognition protein LC0.252
CG4030CG4030 gene product from transcript CG4030-RA0.248
Mcm3Minichromosome maintenance 30.242
RfabgRetinoid- and fatty acid-binding glycoprotein0.201
Spn28DSerpin 28D0.186
Spn27ASerpin 27A0.165
PGRP-SAPeptidoglycan recognition protein SA0.152
Cyt-c-dCytochrome c distal0.147
NcNedd2-like caspase0.137
grimCG4345 gene product from transcript CG4345-RA0.125
CG5731CG5731 gene product from transcript CG5731-RA0.122
Df31Decondensation factor 310.116
ArkApaf-1-related-killer0.112
Sra-1specifically Rac1-associated protein 10.112
CG6361CG6361 gene product from transcript CG6361-RA0.107
Sox14Sox box protein 140.103
Dcp-1Death caspase-10.102
Trip1CG8882 gene product from transcript CG8882-RA0.090
CG13597CG13597 gene product from transcript CG13597-RA0.087
CG6426CG6426 gene product from transcript CG6426-RA0.083
Mst77FMale-specific transcript 77F0.082
necnecrotic0.079
CG12766CG12766 gene product from transcript CG12766-RA0.078
FhosCG42610 gene product from transcript CG42610-RC0.076
slowslowdown0.076
Sp7Serine protease 70.072
Mcm7Minichromosome maintenance 70.071
XNPCG4548 gene product from transcript CG4548-RA0.066
CG9691CG9691 gene product from transcript CG9691-RB0.065
Spn1Serine protease inhibitor 10.064
Pkd2Polycystic kidney disease gene-20.063
ird5immune response deficient 50.061
jarjaguar0.058
Idgf2Imaginal disc growth factor 20.058
CG5146CG5146 gene product from transcript CG5146-RA0.057
RnrLRibonucleoside diphosphate reductase large subunit0.055
cathDCG1548 gene product from transcript CG1548-RA0.053
wtswarts0.052
gsbgooseberry0.049
msl-1male-specific lethal 10.049
lealeak0.048
eIF3-S8CG4954 gene product from transcript CG4954-RA0.048
dre4CG1828 gene product from transcript CG1828-RB0.048
HtrA2CG8464 gene product from transcript CG8464-RA0.047
Acp62FAccessory gland peptide 62F0.045
alphaTub84Dalpha-Tubulin at 84D0.044
spzspatzle0.044
PGRP-SDCG7496 gene product from transcript CG7496-RA0.043
CG8600CG8600 gene product from transcript CG8600-RB0.043
Pvf2PDGF- and VEGF-related factor 20.041
CG34110CG34110 gene product from transcript CG34110-RC0.041
CG9372CG9372 gene product from transcript CG9372-RA0.040
Obp56dOdorant-binding protein 56d0.040
CG14213CG14213 gene product from transcript CG14213-RB0.036
Uba2Smt3 activating enzyme 20.034
yuriyuri gagarin0.034
eastenhanced adult sensory threshold0.033
Art4Arginine methyltransferase 40.033
lmglemming0.033
CG15917CG15917 gene product from transcript CG15917-RA0.032
Acp53C14aCG8626 gene product from transcript CG8626-RA0.032
trioCG18214 gene product from transcript CG18214-RA0.031
sharkSrc homology 2, ankyrin repeat, tyrosine kinase0.031
omeomega0.031
Lsp2Larval serum protein 20.030
Traf4TNF-receptor-associated factor 40.030
CG5902CG5902 gene product from transcript CG5902-RB0.030
5-HT7Serotonin receptor 70.030
nulloCG14426 gene product from transcript CG14426-RB0.030
CG18258CG18258 gene product from transcript CG18258-RA0.030
Aats-glyGlycyl-tRNA synthetase0.029
Fer2LCHFerritin 2 light chain homologue0.029
DuoxDual oxidase0.029
alphaTub85Ealpha-Tubulin at 85E0.028
vigvasa intronic gene0.028
EndoGEndonuclease G0.028
Bub1Bub1 homologue0.028
swshort wing0.028
Fmr1CG6203 gene product from transcript CG6203-RC0.028
Atg8aAutophagy-specific gene 8a0.028
RpL39Ribosomal protein L390.028
Acp53C14bCG15616 gene product from transcript CG15616-RA0.027
MntCG13316 gene product from transcript CG13316-RD0.027
Nup75Nucleoporin 750.026
l(2)05510lethal (2) 055100.026
msopamale-specific opa containing gene0.026
nocteno circadian temperature entrainment0.026
Rbp1RNA-binding protein 10.025
BG642163CG34102 gene product from transcript CG34102-RA0.025
enokenoki mushroom0.025
vvlventral veins lacking0.025
iHoginterference Hedgehog0.025
yellow-cCG4182 gene product from transcript CG4182-RA0.025
Mekk1CG7717 gene product from transcript CG7717-RB0.023
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.973
Tnftumor necrosis factor0.932
Cd44CD44 antigen0.918
Casp4caspase 4, apoptosis-related cysteine peptidase0.917
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.849
Klk1b11kallikrein 1-related peptidase b110.792
Klk1b5kallikrein 1-related peptidase b50.783
Klk1b8kallikrein 1-related peptidase b80.778
Bcl2B-cell leukemia/lymphoma 20.721
Casp1caspase 10.714
Lyz2lysozyme 20.652
FasFas (TNF receptor superfamily member 6)0.628
Ltalymphotoxin A0.597
SkilSKI-like0.562
Klk1b21kallikrein 1-related peptidase b210.553
S100a8S100 calcium binding protein A8 (calgranulin A)0.520
Kitkit oncogene0.519
Klk1b4kallikrein 1-related pepidase b40.497
Klk1b1kallikrein 1-related peptidase b10.486
Ikzf1IKAROS family zinc finger 10.439
Irf9interferon regulatory factor 90.433
Klk1kallikrein 10.430
Ptgs2prostaglandin-endoperoxide synthase 20.417
PycardPYD and CARD domain containing0.406
Vhlvon Hippel-Lindau tumor suppressor0.400
S100a9S100 calcium binding protein A9 (calgranulin B)0.372
Map3k14mitogen-activated protein kinase kinase kinase 140.340
Il1r1interleukin 1 receptor, type I0.316
2210010C04RikRIKEN cDNA 2210010C04 gene0.305
Klk1b26kallikrein 1-related petidase b260.290
Try5trypsin 50.289
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.287
Rb1retinoblastoma 10.276
Prss2protease, serine, 20.270
Mcl1myeloid cell leukemia sequence 10.269
BaxBCL2-associated X protein0.261
Stat5asignal transducer and activator of transcription 5A0.257
Ptprcprotein tyrosine phosphatase, receptor type, C0.255
Cela2achymotrypsin-like elastase family, member 2A0.242
Rps3ribosomal protein S30.232
Hist1h1chistone cluster 1, H1c0.230
Il10interleukin 100.224
Stat5bsignal transducer and activator of transcription 5B0.212
Fndc7fibronectin type III domain containing 70.209
Tff2trefoil factor 2 (spasmolytic protein 1)0.209
Ptpn2protein tyrosine phosphatase, non-receptor type 20.206
Itih1inter-alpha trypsin inhibitor, heavy chain 10.205
Klk1b9kallikrein 1-related peptidase b90.204
Casp8caspase 80.200
Klk1b24kallikrein 1-related peptidase b240.195
5430421N21RikRIKEN cDNA 5430421N21 gene0.194
Tlr4toll-like receptor 40.183
Ctrb1chymotrypsinogen B10.182
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.181
Itgb1integrin beta 1 (fibronectin receptor beta)0.181
Rbl1retinoblastoma-like 1 (p107)0.181
Stat3signal transducer and activator of transcription 30.178
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.172
Il2rginterleukin 2 receptor, gamma chain0.170
Gbp5guanylate binding protein 50.166
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.164
Cd247CD247 antigen0.155
Klk1b3kallikrein 1-related peptidase b30.153
FaddFas (TNFRSF6)-associated via death domain0.153
Spna1spectrin alpha 10.151
Sycnsyncollin0.145
Il22interleukin 220.143
Slit3slit homolog 3 (Drosophila)0.138
Wt1Wilms tumor 1 homolog0.135
Apcadenomatosis polyposis coli0.134
F2coagulation factor II0.133
Ilkintegrin linked kinase0.130
Klk1b27kallikrein 1-related peptidase b270.122
Hif1ahypoxia inducible factor 1, alpha subunit0.121
Egfrepidermal growth factor receptor0.120
Il1binterleukin 1 beta0.120
Zg16zymogen granule protein 160.120
Afmafamin0.118
Klk1b16kallikrein 1-related peptidase b160.116
Procprotein C0.115
Jak2Janus kinase 20.114
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.113
Socs1suppressor of cytokine signaling 10.113
Ltblymphotoxin B0.112
Ncoa3nuclear receptor coactivator 30.108
Aim2absent in melanoma 20.103
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.102
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.101
Ighimmunoglobulin heavy chain complex0.096
Hbb-b1hemoglobin, beta adult major chain0.095
Pcsk1proprotein convertase subtilisin/kexin type 10.094
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.094
Emx1empty spiracles homolog 1 (Drosophila)0.094
Cuzd1CUB and zona pellucida-like domains 10.093
Cxcr5chemokine (C-X-C motif) receptor 50.093
Clpscolipase, pancreatic0.089
Hoxa13homeobox A130.088
Dmbt1deleted in malignant brain tumors 10.088
Leprleptin receptor0.086
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.081
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism