The network for 'type b pancreatic cell development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

type b pancreatic cell development

The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.

NameDescriptionProbabilityFunc Analog Organism
CCND1cyclin D10.994
BMPR1Abone morphogenetic protein receptor, type IA0.975
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.972
CDK6cyclin-dependent kinase 60.928
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.913
CDK4cyclin-dependent kinase 40.845
RB1retinoblastoma 10.824
CCND3cyclin D30.824
BMPR1Bbone morphogenetic protein receptor, type IB0.651
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.578
CLOCKclock homolog (mouse)0.530
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.384
CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.351
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.327
NOGnoggin0.278
UHRF2ubiquitin-like with PHD and ring finger domains 20.251
CCND2cyclin D20.195
CDKN2Ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.148
FSTL1follistatin-like 10.135
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.134
ZFYVE9zinc finger, FYVE domain containing 90.109
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.106
RUNX1runt-related transcription factor 10.083
CCNE1cyclin E10.067
CDK2cyclin-dependent kinase 20.058
AHRaryl hydrocarbon receptor0.058
BMP2bone morphogenetic protein 20.054
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.052
C1orf93chromosome 1 open reading frame 930.040
CDK14cyclin-dependent kinase 140.039
CDK11Bcyclin-dependent kinase 11B0.036
HNF1AHNF1 homeobox A0.035
FZD1frizzled homolog 1 (Drosophila)0.035
CDKN2Dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.035
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.031
HNF4Ahepatocyte nuclear factor 4, alpha0.029
CDK5cyclin-dependent kinase 50.029
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.026
BCL11AB-cell CLL/lymphoma 11A (zinc finger protein)0.026
TRAP1TNF receptor-associated protein 10.025
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.025
MDM2Mdm2 p53 binding protein homolog (mouse)0.024
DTNBP1dystrobrevin binding protein 10.024
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.023
AKT1v-akt murine thymoma viral oncogene homolog 10.023
PITX2paired-like homeodomain 20.021
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.020
ZC3HC1zinc finger, C3HC-type containing 10.020
TAL1T-cell acute lymphocytic leukemia 10.019
NPAS2neuronal PAS domain protein 20.018
EPAS1endothelial PAS domain protein 10.018
FOXA2forkhead box A20.017
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.017
HAND1heart and neural crest derivatives expressed 10.016
KAT2BK(lysine) acetyltransferase 2B0.016
GJD2gap junction protein, delta 2, 36kDa0.016
MTORmechanistic target of rapamycin (serine/threonine kinase)0.016
PDX1pancreatic and duodenal homeobox 10.015
CCNDBP1cyclin D-type binding-protein 10.015
SNIP1Smad nuclear interacting protein 10.015
NEUROD1neurogenic differentiation 10.015
HOXC8homeobox C80.015
COL2A1collagen, type II, alpha 10.015
TDGF1teratocarcinoma-derived growth factor 10.014
SPRED1sprouty-related, EVH1 domain containing 10.014
TNFSF11tumor necrosis factor (ligand) superfamily, member 110.014
PROX1prospero homeobox 10.014
MPP3membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)0.014
SOX2SRY (sex determining region Y)-box 20.014
MYT1myelin transcription factor 10.014
HOXD8homeobox D80.013
SLC22A2solute carrier family 22 (organic cation transporter), member 20.013
FOXF1forkhead box F10.013
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.013
SLC6A4solute carrier family 6 (neurotransmitter transporter, serotonin), member 40.013
TGFB2transforming growth factor, beta 20.013
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.013
FZD10frizzled homolog 10 (Drosophila)0.013
ULK2unc-51-like kinase 2 (C. elegans)0.013
FOXF2forkhead box F20.013
LECT1leukocyte cell derived chemotaxin 10.013
MAXMYC associated factor X0.013
HOXB7homeobox B70.013
CCNA1cyclin A10.013
FOXB1forkhead box B10.013
HES2hairy and enhancer of split 2 (Drosophila)0.013
AIMP2aminoacyl tRNA synthetase complex-interacting multifunctional protein 20.012
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.012
USH1CUsher syndrome 1C (autosomal recessive, severe)0.012
MLLT3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 30.012
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila)0.012
FGF4fibroblast growth factor 40.012
HOXD10homeobox D100.012
REG3Aregenerating islet-derived 3 alpha0.012
AMY2Aamylase, alpha 2A (pancreatic)0.012
KLHL12kelch-like 12 (Drosophila)0.012
XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.012
SLC25A5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.012
MAF1MAF1 homolog (S. cerevisiae)0.012
ZIC3Zic family member 3 (odd-paired homolog, Drosophila)0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dladeltaA0.883
olig2oligodendrocyte lineage transcription factor 20.844
inspreproinsulin0.836
osr2odd-skipped related 2 (Drosophila)0.787
mnx1motor neuron and pancreas homeobox 10.787
nkx2.2aNK2 transcription factor related 2a0.778
hnf1baHNF1 homeobox Ba0.731
lhx1aLIM homeobox 1a0.726
foxa2forkhead box A20.569
sim1asingle-minded homolog 1a (Drosophila)0.568
foxa1forkhead box A10.553
isl1islet10.529
lhx2bLIM homeobox 2b0.499
pdx1pancreatic and duodenal homeobox 10.465
ascl1aachaete-scute complex-like 1a (Drosophila)0.455
jag1bjagged 1b0.442
ascl1bachaete-scute complex-like 1b (Drosophila)0.431
mecomMDS1 and EVI1 complex locus0.411
tbx1T-box 10.409
nkx2.3NK2 transcription factor related 30.407
dlx2adistal-less homeobox gene 2a0.389
evx1even-skipped homeobox 10.368
shhasonic hedgehog a0.353
lmx1b.2LIM homeobox transcription factor 1, beta 20.350
dbx1adeveloping brain homeobox 1a0.336
pax8paired box gene 80.326
dlx2bdistal-less homeobox gene 2b0.257
mibmind bomb0.243
neurog1neurogenin 10.239
gdf6agrowth differentiation factor 6a0.229
hhexhematopoietically expressed homeobox0.225
flot1flotillin 10.217
ihhaIndian hedgehog homolog a0.215
pax2apaired box gene 2a0.206
dlx6adistal-less homeobox gene 6a0.205
hoxa2bhomeo box A2b0.204
hlxb9lahomeo box HB9 like a0.201
nkx6.2NK6 transcription factor related, locus 20.197
hoxb2ahomeo box B2a0.192
dlbdeltaB0.183
osr1odd-skipped related 1 (Drosophila)0.175
otpborthopedia homolog b0.175
jag2jagged 20.171
gcgaglucagon a and glucagon a-like0.167
her5hairy-related 50.165
lmx1b.1LIM homeobox transcription factor 1, beta 10.162
hnf4ahepatocyte nuclear factor 4, alpha0.154
tal2T-cell acute lymphocytic leukemia 20.151
runx2arunt-related transcription factor 2a0.146
dlddeltaD0.142
insm1binsulinoma-associated 1b0.130
lhx5LIM homeobox 50.129
hapln1ahyaluronan and proteoglycan link protein 1a0.125
irx3airoquois homeobox protein 3a0.120
pax9paired box gene 90.118
tgfb2transforming growth factor, beta 20.114
dlx1adistal-less homeobox gene 1a0.112
adcyap1r1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I0.112
hoxa4ahomeo box A4a0.111
rx3retinal homeobox gene 30.110
inka1ainduced in neural crest by AP2, 1a0.109
gata6GATA-binding protein 60.109
fgfr4fibroblast growth factor receptor 40.109
fgf20afibroblast growth factor 20a0.107
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.106
prlprolactin0.103
wt1bwilms tumor 1b0.101
gfra1bgdnf family receptor alpha 1b0.098
bmp2bbone morphogenetic protein 2b0.095
sst2somatostatin 20.092
cry2bcryptochrome 2b0.092
sst1.1somatostatin 1, tandem duplicate 10.092
pthlhparathyroid hormone-like hormone0.092
pitx2paired-like homeodomain transcription factor 20.091
hhiphedgehog interacting protein0.090
pax4paired box 40.090
foxa3forkhead box A30.087
ghrlghrelin/obestatin preprohormone0.087
gli2aGLI-Kruppel family member GLI2a0.084
dccdeleted in colorectal carcinoma0.082
six2asine oculis-related homeobox 2a0.081
lef1lymphocyte enhancer binding factor 10.081
ism1isthmin 10.080
slc8a4bsolute carrier family 8 (sodium/calcium exchanger), member 4b0.079
hoxb8ahomeo box B8a0.076
lhx8aLIM homeobox 8a0.073
gbx1gastrulation brain homeobox 10.073
gata4GATA-binding protein 40.073
lhx6LIM homeobox 60.068
tlx2T-cell leukemia, homeobox 20.067
six4bsine oculis homeobox homolog 4b0.067
dlx3bdistal-less homeobox gene 3b0.064
hoxc4ahomeo box C4a0.063
ap1m2adaptor-related protein complex 1, mu 2 subunit0.062
hgfahepatocyte growth factor a0.060
hoxb1ahomeo box B1a0.055
entpd3ectonucleoside triphosphate diphosphohydrolase 30.055
fggfibrinogen, gamma polypeptide0.054
gsx1GS homeobox 10.053
tbx22T-box 220.053
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sox9SRY-box containing gene 90.916
Cry1cryptochrome 1 (photolyase-like)0.841
Shhsonic hedgehog0.722
Fgfr2fibroblast growth factor receptor 20.640
Fgf8fibroblast growth factor 80.610
Wnt3awingless-related MMTV integration site 3A0.399
Pax8paired box gene 80.253
Arntlaryl hydrocarbon receptor nuclear translocator-like0.245
Rargretinoic acid receptor, gamma0.240
Gli2GLI-Kruppel family member GLI20.231
Hand2heart and neural crest derivatives expressed transcript 20.224
Gli3GLI-Kruppel family member GLI30.208
Bmp7bone morphogenetic protein 70.173
Nognoggin0.164
Pitx2paired-like homeodomain transcription factor 20.150
Nkx6-1NK6 homeobox 10.142
Ror2receptor tyrosine kinase-like orphan receptor 20.125
Foxa2forkhead box A20.123
Otx2orthodenticle homolog 2 (Drosophila)0.118
Pdx1pancreatic and duodenal homeobox 10.116
Per2period homolog 2 (Drosophila)0.111
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.106
Tbx1T-box 10.102
Dkk1dickkopf homolog 1 (Xenopus laevis)0.084
Ctnnb1catenin (cadherin associated protein), beta 10.081
Wnt4wingless-related MMTV integration site 40.073
Fgfr1fibroblast growth factor receptor 10.069
Rararetinoic acid receptor, alpha0.061
Hes1hairy and enhancer of split 1 (Drosophila)0.059
Gata6GATA binding protein 60.058
Fgf15fibroblast growth factor 150.057
Lhx3LIM homeobox protein 30.053
Chrdchordin0.052
Rarbretinoic acid receptor, beta0.050
Foxe1forkhead box E10.050
Insm1insulinoma-associated 10.045
Fgfr3fibroblast growth factor receptor 30.045
Vax1ventral anterior homeobox containing gene 10.045
Clockcircadian locomotor output cycles kaput0.045
Lhx1LIM homeobox protein 10.045
Gata4GATA binding protein 40.043
Pax2paired box gene 20.042
Hand1heart and neural crest derivatives expressed transcript 10.041
Fgf18fibroblast growth factor 180.041
Foxc1forkhead box C10.040
Msx1homeobox, msh-like 10.038
Col2a1collagen, type II, alpha 10.036
Tbx3T-box 30.035
Foxf1aforkhead box F1a0.033
Barx1BarH-like homeobox 10.032
Pou3f3POU domain, class 3, transcription factor 30.031
Tbrachyury0.031
Tcf21transcription factor 210.030
Tbx2T-box 20.030
Isl1ISL1 transcription factor, LIM/homeodomain0.030
Gdnfglial cell line derived neurotrophic factor0.030
Ccnd2cyclin D20.030
Alx3aristaless-like homeobox 30.028
Emx1empty spiracles homolog 1 (Drosophila)0.028
Otporthopedia homolog (Drosophila)0.025
Cry2cryptochrome 2 (photolyase-like)0.025
Efna4ephrin A40.023
Pitx1paired-like homeodomain transcription factor 10.023
Smad6MAD homolog 6 (Drosophila)0.022
Wnt2bwingless related MMTV integration site 2b0.022
Acvr1activin A receptor, type 10.022
Tbx5T-box 50.022
Meox2mesenchyme homeobox 20.021
Sox1SRY-box containing gene 10.021
Gpc3glypican 30.021
Pax6paired box gene 60.020
Fgf10fibroblast growth factor 100.020
Npas1neuronal PAS domain protein 10.020
Ahraryl-hydrocarbon receptor0.020
Wnt5awingless-related MMTV integration site 5A0.019
Sim1single-minded homolog 1 (Drosophila)0.019
Wnt6wingless-related MMTV integration site 60.018
Foxc2forkhead box C20.018
Emx2empty spiracles homolog 2 (Drosophila)0.018
BmperBMP-binding endothelial regulator0.018
Retret proto-oncogene0.018
Onecut1one cut domain, family member 10.018
Wnt7awingless-related MMTV integration site 7A0.017
Col13a1collagen, type XIII, alpha 10.017
Fzd1frizzled homolog 1 (Drosophila)0.017
Fgfr4fibroblast growth factor receptor 40.017
Scn5asodium channel, voltage-gated, type V, alpha0.017
Bmpr1abone morphogenetic protein receptor, type 1A0.017
Gli1GLI-Kruppel family member GLI10.017
Foxi3forkhead box I30.016
Foxf2forkhead box F20.016
Adra2badrenergic receptor, alpha 2b0.016
Pthlhparathyroid hormone-like peptide0.015
Ptenphosphatase and tensin homolog0.015
Epha1Eph receptor A10.015
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.014
Leprleptin receptor0.014
Ascl1achaete-scute complex homolog 1 (Drosophila)0.014
Npas2neuronal PAS domain protein 20.014
Fzd8frizzled homolog 8 (Drosophila)0.014
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism