The network for 'drug metabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

drug metabolic process

The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice.

NameDescriptionProbabilityFunc Analog Organism
SULT1A1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 11.000
SULT1A2sulfotransferase family, cytosolic, 1A, phenol-preferring, member 21.000
SULT1A4sulfotransferase family, cytosolic, 1A, phenol-preferring, member 41.000
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 90.998
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.994
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.905
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.856
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 60.797
HNF4Ahepatocyte nuclear factor 4, alpha0.759
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.752
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.724
NCOR2nuclear receptor corepressor 20.693
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.649
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.641
C8Bcomplement component 8, beta polypeptide0.568
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.523
VAC14Vac14 homolog (S. cerevisiae)0.465
GLYATglycine-N-acyltransferase0.454
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.435
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.416
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.410
C6complement component 60.358
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.312
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.289
MASP2mannan-binding lectin serine peptidase 20.250
UGT1A1UDP glucuronosyltransferase 1 family, polypeptide A10.247
ADH6alcohol dehydrogenase 6 (class V)0.213
C8Acomplement component 8, alpha polypeptide0.199
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.179
KNG1kininogen 10.142
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.139
HRGhistidine-rich glycoprotein0.137
F9coagulation factor IX0.133
DAOD-amino-acid oxidase0.127
HRhairless homolog (mouse)0.122
CYP2D6cytochrome P450, family 2, subfamily D, polypeptide 60.105
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.094
MAT1Amethionine adenosyltransferase I, alpha0.093
APOC4apolipoprotein C-IV0.090
CHD9chromodomain helicase DNA binding protein 90.086
TTPAtocopherol (alpha) transfer protein0.078
HABP2hyaluronan binding protein 20.070
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.064
FMO4flavin containing monooxygenase 40.060
ALDOBaldolase B, fructose-bisphosphate0.058
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.058
APCSamyloid P component, serum0.057
CCL16chemokine (C-C motif) ligand 160.051
CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 70.050
HAO1hydroxyacid oxidase (glycolate oxidase) 10.049
NR1I3nuclear receptor subfamily 1, group I, member 30.048
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.048
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.047
UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B150.046
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.046
AADACarylacetamide deacetylase (esterase)0.045
BHMTbetaine--homocysteine S-methyltransferase0.044
C4BPAcomplement component 4 binding protein, alpha0.042
A1CFAPOBEC1 complementation factor0.038
FETUBfetuin B0.038
RAB35RAB35, member RAS oncogene family0.038
CFHR4complement factor H-related 40.037
PIK3C2Gphosphoinositide-3-kinase, class 2, gamma polypeptide0.037
OTCornithine carbamoyltransferase0.036
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.035
MTTPmicrosomal triglyceride transfer protein0.035
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.033
F11coagulation factor XI0.032
ACRV1acrosomal vesicle protein 10.032
NR1I2nuclear receptor subfamily 1, group I, member 20.031
UGT1A9UDP glucuronosyltransferase 1 family, polypeptide A90.031
ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)0.030
GPLD1glycosylphosphatidylinositol specific phospholipase D10.030
GBA3glucosidase, beta, acid 3 (cytosolic)0.029
ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 110.028
ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide0.027
G6PCglucose-6-phosphatase, catalytic subunit0.027
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.027
AFMafamin0.026
PON1paraoxonase 10.025
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.025
XDHxanthine dehydrogenase0.024
TATtyrosine aminotransferase0.024
FABP1fatty acid binding protein 1, liver0.023
HALhistidine ammonia-lyase0.023
HIPK2homeodomain interacting protein kinase 20.022
GSTA3glutathione S-transferase alpha 30.022
ABCG5ATP-binding cassette, sub-family G (WHITE), member 50.021
PLGplasminogen0.020
F13Bcoagulation factor XIII, B polypeptide0.020
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.020
ALDH1L1aldehyde dehydrogenase 1 family, member L10.020
MEP1Bmeprin A, beta0.018
SLC2A9solute carrier family 2 (facilitated glucose transporter), member 90.018
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.018
AGXT2alanine--glyoxylate aminotransferase 20.017
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.017
HGDhomogentisate 1,2-dioxygenase0.017
LECT2leukocyte cell-derived chemotaxin 20.017
CNGA1cyclic nucleotide gated channel alpha 10.016
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lepleptin0.994
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.982
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.980
Leprleptin receptor0.975
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.973
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.970
Otcornithine transcarbamylase0.967
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.960
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.958
Cps1carbamoyl-phosphate synthetase 10.954
Cyp2f2cytochrome P450, family 2, subfamily f, polypeptide 20.922
Inmtindolethylamine N-methyltransferase0.889
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.880
Fmo1flavin containing monooxygenase 10.840
Sult2a2sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 20.813
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.811
Slc10a6solute carrier family 10 (sodium/bile acid cotransporter family), member 60.807
Fmo2flavin containing monooxygenase 20.804
Nr1i2nuclear receptor subfamily 1, group I, member 20.794
Sult1d1sulfotransferase family 1D, member 10.783
Fmo3flavin containing monooxygenase 30.765
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.761
Sult1a1sulfotransferase family 1A, phenol-preferring, member 10.756
G6pcglucose-6-phosphatase, catalytic0.732
Vdrvitamin D receptor0.717
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.705
Ces1dcarboxylesterase 1D0.691
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.686
Cyp2b13cytochrome P450, family 2, subfamily b, polypeptide 130.625
Gsta3glutathione S-transferase, alpha 30.620
Adipoqadiponectin, C1Q and collagen domain containing0.603
Tattyrosine aminotransferase0.585
Fmo5flavin containing monooxygenase 50.558
Apoeapolipoprotein E0.540
Nr1i3nuclear receptor subfamily 1, group I, member 30.531
Dpep1dipeptidase 1 (renal)0.512
Gstm3glutathione S-transferase, mu 30.506
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.489
Ptgs2prostaglandin-endoperoxide synthase 20.475
Ces1gcarboxylesterase 1G0.467
Adh1alcohol dehydrogenase 1 (class I)0.452
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.390
Cdhr5cadherin-related family member 50.377
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.372
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.361
Ren1renin 1 structural0.336
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.330
Defb1defensin beta 10.320
Sult1b1sulfotransferase family 1B, member 10.314
Agtr1aangiotensin II receptor, type 1a0.312
Il10interleukin 100.302
Ppargperoxisome proliferator activated receptor gamma0.301
Ces2acarboxylesterase 2A0.293
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 20.284
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.283
Hnf4ghepatocyte nuclear factor 4, gamma0.282
Vnn3vanin 30.269
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.261
Ugt2b34UDP glucuronosyltransferase 2 family, polypeptide B340.254
Slc22a18solute carrier family 22 (organic cation transporter), member 180.251
Pplperiplakin0.241
Sec14l4SEC14-like 4 (S. cerevisiae)0.239
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.235
Azgp1alpha-2-glycoprotein 1, zinc0.230
Esr1estrogen receptor 1 (alpha)0.217
Ldlrlow density lipoprotein receptor0.207
Hsd11b1hydroxysteroid 11-beta dehydrogenase 10.204
Ces2ecarboxylesterase 2E0.202
Pon1paraoxonase 10.199
Acox2acyl-Coenzyme A oxidase 2, branched chain0.191
Acot12acyl-CoA thioesterase 120.190
Cyp3a44cytochrome P450, family 3, subfamily a, polypeptide 440.185
Rdh7retinol dehydrogenase 70.185
Slc22a1solute carrier family 22 (organic cation transporter), member 10.178
Akr1c6aldo-keto reductase family 1, member C60.169
Il6interleukin 60.153
Mat1amethionine adenosyltransferase I, alpha0.151
Gpr182G protein-coupled receptor 1820.140
Akr1d1aldo-keto reductase family 1, member D10.137
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.137
Stat3signal transducer and activator of transcription 30.137
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.130
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.125
Insrinsulin receptor0.125
Klk1b4kallikrein 1-related pepidase b40.124
Hamphepcidin antimicrobial peptide0.123
Adamdec1ADAM-like, decysin 10.122
Rdh16retinol dehydrogenase 160.119
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.115
Pigrpolymeric immunoglobulin receptor0.113
Trehtrehalase (brush-border membrane glycoprotein)0.109
Tdo2tryptophan 2,3-dioxygenase0.107
Tgfb1transforming growth factor, beta 10.106
Apohapolipoprotein H0.105
Mmp9matrix metallopeptidase 90.103
Iydiodotyrosine deiodinase0.103
Ephx1epoxide hydrolase 1, microsomal0.102
Prlrprolactin receptor0.098
Ces1fcarboxylesterase 1F0.097
Mmp7matrix metallopeptidase 70.095
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.996
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.989
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.982
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.934
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.930
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.929
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.821
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.769
Apobapolipoprotein B0.735
Fmo3flavin containing monooxygenase 30.719
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.671
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.660
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.653
Sult1a1sulfotransferase family, cytosolic, 1A, phenol-preferring, member 10.613
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.571
LOC293989cytochrome P450-like0.568
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.528
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.461
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.436
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.422
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.369
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.328
Slc22a7solute carrier family 22 (organic anion transporter), member 70.296
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.295
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.292
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.291
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.281
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.271
Mosc1MOCO sulphurase C-terminal domain containing 10.262
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.235
Fmo1flavin containing monooxygenase 10.233
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.220
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.189
Ces1ecarboxylesterase 1E0.180
Ces1ccarboxylesterase 1C0.154
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.153
Slco1b3solute carrier organic anion transporter family, member 1b30.136
Acot12acyl-CoA thioesterase 120.136
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.135
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.126
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.120
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.108
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.099
Gsta2glutathione S-transferase A20.098
Omdosteomodulin0.091
Cps1carbamoyl-phosphate synthetase 10.087
Dhfrdihydrofolate reductase0.086
Slco1a4solute carrier organic anion transporter family, member 1a40.083
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.081
Crygfcrystallin, gamma F0.076
Otcornithine carbamoyltransferase0.076
Aqp9aquaporin 90.073
G6pcglucose-6-phosphatase, catalytic subunit0.072
Fmo2flavin containing monooxygenase 20.070
Mettl7bmethyltransferase like 7B0.070
LOC100365112carboxylesterase-like0.069
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.062
Dpysdihydropyrimidinase0.062
A1i3alpha-1-inhibitor III0.061
Cyp4a3cytochrome P450, family 4, subfamily a, polypeptide 30.060
Krtcap2keratinocyte associated protein 20.059
Acsm5acyl-CoA synthetase medium-chain family member 50.056
Nr0b2nuclear receptor subfamily 0, group B, member 20.053
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.052
Gnmtglycine N-methyltransferase0.049
Adh1alcohol dehydrogenase 1 (class I)0.048
Zfp37zinc finger protein 370.047
LOC494499LOC494499 protein0.047
Slco1a1solute carrier organic anion transporter family, member 1a10.044
Cyp2d1cytochrome P450, family 2, subfamily d, polypeptide 10.044
Hnf4ahepatocyte nuclear factor 4, alpha0.043
Akr1c12aldo-keto reductase family 1, member C120.043
Fabp1fatty acid binding protein 1, liver0.041
Ugt2b7UDP glucuronosyltransferase 2 family, polypeptide B70.041
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.040
Ces2ccarboxylesterase 2C0.037
Ces1fcarboxylesterase 1F0.034
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.034
Akr1c18aldo-keto reductase family 1, member C180.033
Hmgcs23-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)0.032
Cyp3a9cytochrome P450, family 3, subfamily a, polypeptide 90.031
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.030
Efcab4aEF-hand calcium binding domain 4A0.029
Abcc2ATP-binding cassette, subfamily C (CFTR/MRP), member 20.028
Cml3camello-like 30.026
Fdxrferredoxin reductase0.024
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.024
Sult2a1sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.024
Akr1c14aldo-keto reductase family 1, member C140.024
Ugt2a1UDP glucuronosyltransferase 2 family, polypeptide A10.022
Cyp2j3cytochrome P450, family 2, subfamily j, polypeptide 30.021
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.020
LOC100361864UDP-glucuronosyltransferase 2B3-like0.019
Pon1paraoxonase 10.019
Adhfe1alcohol dehydrogenase, iron containing, 10.018
Akr1c1aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)0.018
Srd5a2steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)0.018
Cyp4f6cytochrome P450, family 4, subfamily f, polypeptide 60.018
Afmafamin0.017
Mgst2microsomal glutathione S-transferase 20.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism