The network for 'negative regulation of transcription initiation from rna polymerase ii promoter' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of transcription initiation from rna polymerase ii promoter

Any process that decreases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.

NameDescriptionProbabilityFunc Analog Organism
RXRAretinoid X receptor, alpha1.000
NCOA1nuclear receptor coactivator 11.000
MED25mediator complex subunit 251.000
CREBBPCREB binding protein1.000
HMGB2high mobility group box 21.000
HMGB1high mobility group box 11.000
NCOR2nuclear receptor corepressor 21.000
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.999
MED1mediator complex subunit 10.998
NCOR1nuclear receptor corepressor 10.998
SKILSKI-like oncogene0.993
PTMAprothymosin, alpha0.989
ESR1estrogen receptor 10.989
HMGN2high mobility group nucleosomal binding domain 20.988
RARAretinoic acid receptor, alpha0.986
CSNK1A1casein kinase 1, alpha 10.986
RXRBretinoid X receptor, beta0.983
NUCKS1nuclear casein kinase and cyclin-dependent kinase substrate 10.983
HMGN1high mobility group nucleosome binding domain 10.977
NCOA3nuclear receptor coactivator 30.977
HMGA1high mobility group AT-hook 10.973
SMAD9SMAD family member 90.965
PPARAperoxisome proliferator-activated receptor alpha0.965
SP1Sp1 transcription factor0.963
SMAD3SMAD family member 30.891
MDM2Mdm2 p53 binding protein homolog (mouse)0.852
ANP32Bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.837
EP300E1A binding protein p3000.835
DUTdeoxyuridine triphosphatase0.788
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.786
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.779
NCOA6nuclear receptor coactivator 60.778
PRKD2protein kinase D20.740
H2AFVH2A histone family, member V0.713
SKIv-ski sarcoma viral oncogene homolog (avian)0.710
SETSET nuclear oncogene0.705
MDM4Mdm4 p53 binding protein homolog (mouse)0.696
ITGB1BP2integrin beta 1 binding protein (melusin) 20.674
CXXC5CXXC finger protein 50.645
KANK2KN motif and ankyrin repeat domains 20.586
DCKdeoxycytidine kinase0.540
PRMT6protein arginine methyltransferase 60.516
LBRlamin B receptor0.431
PPP1R14Aprotein phosphatase 1, regulatory (inhibitor) subunit 14A0.393
ANP32Eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.391
SIN3ASIN3 homolog A, transcription regulator (yeast)0.375
RXRGretinoid X receptor, gamma0.373
SORBS3sorbin and SH3 domain containing 30.317
ARandrogen receptor0.307
CBX5chromobox homolog 50.295
ANP32Aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A0.280
SMAD4SMAD family member 40.262
SPOPspeckle-type POZ protein0.213
KLHL24kelch-like 24 (Drosophila)0.190
BBXbobby sox homolog (Drosophila)0.187
LMNB1lamin B10.185
PRC1protein regulator of cytokinesis 10.172
HEY1hairy/enhancer-of-split related with YRPW motif 10.167
STMN1stathmin 10.166
PMLpromyelocytic leukemia0.157
ARL6IP1ADP-ribosylation factor-like 6 interacting protein 10.155
RAD21RAD21 homolog (S. pombe)0.143
PGRprogesterone receptor0.137
THRAthyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)0.131
AKT1v-akt murine thymoma viral oncogene homolog 10.130
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.123
HNRNPA3heterogeneous nuclear ribonucleoprotein A30.101
HDAC3histone deacetylase 30.101
C5orf41chromosome 5 open reading frame 410.097
KAT2BK(lysine) acetyltransferase 2B0.096
CCNB2cyclin B20.095
PIAS4protein inhibitor of activated STAT, 40.086
SPIN1spindlin 10.080
HIST1H4Chistone cluster 1, H4c0.077
KIAA0101KIAA01010.071
ARNTaryl hydrocarbon receptor nuclear translocator0.066
ZFYVE9zinc finger, FYVE domain containing 90.065
NUSAP1nucleolar and spindle associated protein 10.063
SUMO4SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)0.063
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.061
THRBthyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)0.061
NR4A1nuclear receptor subfamily 4, group A, member 10.061
CSNK1Dcasein kinase 1, delta0.055
DEKDEK oncogene0.055
PPARGperoxisome proliferator-activated receptor gamma0.054
RBPMSRNA binding protein with multiple splicing0.051
RBMXRNA binding motif protein, X-linked0.051
HIPK1homeodomain interacting protein kinase 10.047
SUZ12suppressor of zeste 12 homolog (Drosophila)0.047
SIRT1sirtuin 10.044
NRIP1nuclear receptor interacting protein 10.044
SLC25A36solute carrier family 25, member 360.041
LOC728026hypothetical protein LOC7280260.039
KHDRBS1KH domain containing, RNA binding, signal transduction associated 10.038
CBX1chromobox homolog 10.037
CDK2cyclin-dependent kinase 20.037
NR1H3nuclear receptor subfamily 1, group H, member 30.037
CDK19cyclin-dependent kinase 190.035
GPSM2G-protein signaling modulator 20.035
NR2F6nuclear receptor subfamily 2, group F, member 60.035
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
NNotch0.362
DlDelta0.296
Ras85DRas oncogene at 85D0.186
armarmadillo0.086
phlpole hole0.071
wgwingless0.036
EgfrEpidermal growth factor receptor0.029
EcREcdysone receptor0.022
dppdecapentaplegic0.020
saxsaxophone0.020
glglass0.019
HHairless0.015
sggshaggy0.015
TorTarget of rapamycin0.013
tkvthickveins0.012
pumpumilio0.012
fufused0.012
HopHsp70/Hsp90 organizing protein homolog0.011
Aos1CG12276 gene product from transcript CG12276-RA0.010
E(z)Enhancer of zeste0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism