The network for 'regulation of reactive oxygen species biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of reactive oxygen species biosynthetic process

Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.

NameDescriptionProbabilityFunc Analog Organism
IL1R1interleukin 1 receptor, type I0.994
EGFRepidermal growth factor receptor0.994
ESR1estrogen receptor 10.990
TNFAIP3tumor necrosis factor, alpha-induced protein 30.968
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.961
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.916
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.814
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.758
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.725
KLF6Kruppel-like factor 60.713
BCL3B-cell CLL/lymphoma 30.689
PTPN1protein tyrosine phosphatase, non-receptor type 10.670
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.650
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.585
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.571
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.571
IGF1Rinsulin-like growth factor 1 receptor0.542
BCAR1breast cancer anti-estrogen resistance 10.531
TRAF6TNF receptor-associated factor 60.524
STAT5Asignal transducer and activator of transcription 5A0.520
FYNFYN oncogene related to SRC, FGR, YES0.498
TNIP2TNFAIP3 interacting protein 20.474
IRAK2interleukin-1 receptor-associated kinase 20.442
FOSFBJ murine osteosarcoma viral oncogene homolog0.438
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.398
LATlinker for activation of T cells0.390
DLG1discs, large homolog 1 (Drosophila)0.385
TICAM2toll-like receptor adaptor molecule 20.366
PRKCZprotein kinase C, zeta0.364
IL8interleukin 80.351
NOXA1NADPH oxidase activator 10.323
IL10RAinterleukin 10 receptor, alpha0.315
IRS1insulin receptor substrate 10.302
MYD88myeloid differentiation primary response gene (88)0.281
MPDZmultiple PDZ domain protein0.247
GOPCgolgi-associated PDZ and coiled-coil motif containing0.240
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.238
NTRK1neurotrophic tyrosine kinase, receptor, type 10.216
MEF2Amyocyte enhancer factor 2A0.212
MAP3K8mitogen-activated protein kinase kinase kinase 80.211
DLG2discs, large homolog 2 (Drosophila)0.209
JAK2Janus kinase 20.199
TNIP1TNFAIP3 interacting protein 10.190
CAV1caveolin 1, caveolae protein, 22kDa0.188
PICK1protein interacting with PRKCA 10.183
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.179
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.169
IFNGR1interferon gamma receptor 10.164
GHRgrowth hormone receptor0.164
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.163
PKD1polycystic kidney disease 1 (autosomal dominant)0.162
MYLK2myosin light chain kinase 20.161
FOSL2FOS-like antigen 20.159
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.157
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.156
MGEA5meningioma expressed antigen 5 (hyaluronidase)0.153
EPORerythropoietin receptor0.152
PPP5Cprotein phosphatase 5, catalytic subunit0.148
SOCS3suppressor of cytokine signaling 30.148
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.140
NCOA3nuclear receptor coactivator 30.140
INSRinsulin receptor0.138
JUNjun proto-oncogene0.138
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.135
ARandrogen receptor0.135
BIRC3baculoviral IAP repeat containing 30.127
TRPC1transient receptor potential cation channel, subfamily C, member 10.126
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.123
KLF4Kruppel-like factor 4 (gut)0.121
SMAD3SMAD family member 30.120
IL1R2interleukin 1 receptor, type II0.120
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.118
NRIP1nuclear receptor interacting protein 10.115
SQSTM1sequestosome 10.115
NCOA1nuclear receptor coactivator 10.114
NCOA2nuclear receptor coactivator 20.114
CAPN1calpain 1, (mu/I) large subunit0.113
CDCP1CUB domain containing protein 10.113
METmet proto-oncogene (hepatocyte growth factor receptor)0.112
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.109
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.108
CTBP1C-terminal binding protein 10.108
SH3RF1SH3 domain containing ring finger 10.108
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.107
ALDOBaldolase B, fructose-bisphosphate0.103
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.102
DDR2discoidin domain receptor tyrosine kinase 20.099
MATKmegakaryocyte-associated tyrosine kinase0.098
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.098
MAPTmicrotubule-associated protein tau0.095
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.094
DUSP1dual specificity phosphatase 10.094
SOD1superoxide dismutase 1, soluble0.093
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.091
CALCAcalcitonin-related polypeptide alpha0.090
TRAF1TNF receptor-associated factor 10.090
SSTR3somatostatin receptor 30.089
RIPK2receptor-interacting serine-threonine kinase 20.088
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.087
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
alpha-Catalpha Catenin0.018
e(r)enhancer of rudimentary0.017
RpL19Ribosomal protein L190.016
RpL13ARibosomal protein L13A0.015
Aos1CG12276 gene product from transcript CG12276-RA0.014
RnpS1RNA-binding protein S10.013
Su(var)205Suppressor of variegation 2050.013
DrefDNA replication-related element factor0.013
Rm62CG10279 gene product from transcript CG10279-RD0.012
BEAF-32Boundary element-associated factor of 32kD0.012
His2AvHistone H2A variant0.011
Rpd3CG7471 gene product from transcript CG7471-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tlr4toll-like receptor 41.000
Lyz2lysozyme 20.993
Nos3nitric oxide synthase 3, endothelial cell0.987
Il6interleukin 60.979
Leprleptin receptor0.971
Ccr2chemokine (C-C motif) receptor 20.966
Nos1nitric oxide synthase 1, neuronal0.955
Cd44CD44 antigen0.952
H2-D1histocompatibility 2, D region locus 10.951
Nos2nitric oxide synthase 2, inducible0.946
B2mbeta-2 microglobulin0.945
H2-K1histocompatibility 2, K1, K region0.926
Tnftumor necrosis factor0.923
Klrk1killer cell lectin-like receptor subfamily K, member 10.918
Klra9killer cell lectin-like receptor subfamily A, member 90.914
Ppargperoxisome proliferator activated receptor gamma0.912
Tgfb1transforming growth factor, beta 10.912
Myd88myeloid differentiation primary response gene 880.882
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.876
Ptenphosphatase and tensin homolog0.825
Il10interleukin 100.769
Vdrvitamin D receptor0.736
Ccl2chemokine (C-C motif) ligand 20.724
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.720
Slc12a1solute carrier family 12, member 10.704
Apoeapolipoprotein E0.703
Col1a1collagen, type I, alpha 10.664
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.623
Unc93b1unc-93 homolog B1 (C. elegans)0.612
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.562
Lystlysosomal trafficking regulator0.550
Casp4caspase 4, apoptosis-related cysteine peptidase0.534
Lifleukemia inhibitory factor0.517
FaslFas ligand (TNF superfamily, member 6)0.504
Klrd1killer cell lectin-like receptor, subfamily D, member 10.503
Smad3MAD homolog 3 (Drosophila)0.476
Stat1signal transducer and activator of transcription 10.469
Ncr1natural cytotoxicity triggering receptor 10.457
Socs1suppressor of cytokine signaling 10.449
Ptgs2prostaglandin-endoperoxide synthase 20.442
Tlr2toll-like receptor 20.426
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.420
Mef2dmyocyte enhancer factor 2D0.417
Stat3signal transducer and activator of transcription 30.406
Arandrogen receptor0.405
Itgalintegrin alpha L0.405
C3complement component 30.399
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.397
Ren1renin 1 structural0.375
Insrinsulin receptor0.374
Il1ainterleukin 1 alpha0.366
H2-Q7histocompatibility 2, Q region locus 70.365
Ptrfpolymerase I and transcript release factor0.365
Csf1colony stimulating factor 1 (macrophage)0.356
Esr1estrogen receptor 1 (alpha)0.353
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.346
Klrc1killer cell lectin-like receptor subfamily C, member 10.342
Ccr5chemokine (C-C motif) receptor 50.338
Ctnnb1catenin (cadherin associated protein), beta 10.336
Mmp9matrix metallopeptidase 90.335
Sytl5synaptotagmin-like 50.324
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.301
Plauplasminogen activator, urokinase0.300
Hspa8heat shock protein 80.299
Casp1caspase 10.291
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.282
Spp1secreted phosphoprotein 10.276
H2-Q6histocompatibility 2, Q region locus 60.276
Agtr1aangiotensin II receptor, type 1a0.272
H2-Eb1histocompatibility 2, class II antigen E beta0.271
Cav1caveolin 1, caveolae protein0.269
Adora3adenosine A3 receptor0.268
Cd14CD14 antigen0.266
Ms4a4cmembrane-spanning 4-domains, subfamily A, member 4C0.266
Ostm1osteopetrosis associated transmembrane protein 10.265
Klra2killer cell lectin-like receptor, subfamily A, member 20.258
Dusp1dual specificity phosphatase 10.245
Nr3c1nuclear receptor subfamily 3, group C, member 10.241
Ghrgrowth hormone receptor0.241
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.238
Klra3killer cell lectin-like receptor, subfamily A, member 30.237
Pyhin1pyrin and HIN domain family, member 10.236
Gzmkgranzyme K0.225
Cd74CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)0.219
Lair1leukocyte-associated Ig-like receptor 10.218
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.210
TapbpTAP binding protein0.208
H2-Ab1histocompatibility 2, class II antigen A, beta 10.200
Il7rinterleukin 7 receptor0.197
Stat6signal transducer and activator of transcription 60.195
Akt1thymoma viral proto-oncogene 10.195
SrcRous sarcoma oncogene0.194
FasFas (TNF receptor superfamily member 6)0.189
Runx2runt related transcription factor 20.188
H2-Aahistocompatibility 2, class II antigen A, alpha0.183
Ccl5chemokine (C-C motif) ligand 50.182
AF251705cDNA sequence AF2517050.180
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Hspd1heat shock protein 1 (chaperonin)0.079
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.075
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.075
Dccdeleted in colorectal carcinoma0.072
Hspe1heat shock protein 1 (chaperonin 10)0.070
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.063
Rab1bRAB1B, member RAS oncogene family0.062
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.058
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.057
Hsph1heat shock 105/110 protein 10.056
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.056
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.054
Agtr1aangiotensin II receptor, type 1a0.052
Sirpasignal-regulatory protein alpha0.052
Aqp9aquaporin 90.051
Mbl1mannose-binding lectin (protein A) 10.050
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.048
Dmgdhdimethylglycine dehydrogenase0.048
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.047
Stat3signal transducer and activator of transcription 30.047
Hspb1heat shock protein 10.046
Cxcl10chemokine (C-X-C motif) ligand 100.046
Cxcl2chemokine (C-X-C motif) ligand 20.045
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.045
Procprotein C0.044
Foxa2forkhead box A20.044
Apohapolipoprotein H (beta-2-glycoprotein I)0.044
Irf1interferon regulatory factor 10.042
Slco2a1solute carrier organic anion transporter family, member 2a10.042
Orm1orosomucoid 10.042
Zfc3h1zinc finger, C3H1-type containing0.042
Litaflipopolysaccharide-induced TNF factor0.041
Runx1runt-related transcription factor 10.041
Cpb2carboxypeptidase B2 (plasma)0.041
Tgfbr3transforming growth factor, beta receptor III0.041
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.039
C8bcomplement component 8, beta polypeptide0.039
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.039
Fgafibrinogen alpha chain0.039
Sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.039
Eef2eukaryotic translation elongation factor 20.039
Myh9myosin, heavy chain 9, non-muscle0.039
Akap1A kinase (PRKA) anchor protein 10.039
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.038
LOC299282Serine protease inhibitor0.038
Tff3trefoil factor 3, intestinal0.038
Klf6Kruppel-like factor 60.038
Ptpn1protein tyrosine phosphatase, non-receptor type 10.038
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.037
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.037
Agxt2alanine-glyoxylate aminotransferase 20.037
Cx3cl1chemokine (C-X3-C motif) ligand 10.037
Kng1kininogen 10.037
Il18interleukin 180.037
Spp2secreted phosphoprotein 20.037
Fggfibrinogen gamma chain0.036
Rgs14regulator of G-protein signaling 140.036
Rararetinoic acid receptor, alpha0.036
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.035
Mvpmajor vault protein0.034
Ptger3prostaglandin E receptor 3 (subtype EP3)0.034
Ncf4neutrophil cytosolic factor 40.034
C4bpacomplement component 4 binding protein, alpha0.034
Tfebtranscription factor EB0.033
AhnakAHNAK nucleoprotein0.033
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.033
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.032
Mst1Macrophage stimulating 1 (hepatocyte growth factor-like)0.032
Acsm2acyl-CoA synthetase medium-chain family member 20.032
Fmnl1formin-like 10.031
A1i3alpha-1-inhibitor III0.031
Cyfip2cytoplasmic FMR1 interacting protein 20.031
Jak1Janus kinase 10.031
Odf3bouter dense fiber of sperm tails 3B0.031
Il1ainterleukin 1 alpha0.030
Atp2b1ATPase, Ca++ transporting, plasma membrane 10.030
Serpina11serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 110.030
Mmp12matrix metallopeptidase 120.030
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.030
Ccl20chemokine (C-C motif) ligand 200.030
Rap1bRAP1B, member of RAS oncogene family0.030
Nek9NIMA (never in mitosis gene a)- related kinase 90.030
Hist1h1ahistone cluster 1, H1a0.030
Lipclipase, hepatic0.030
Gria2glutamate receptor, ionotropic, AMPA 20.029
Ccl3chemokine (C-C motif) ligand 30.029
Ptgs2prostaglandin-endoperoxide synthase 20.029
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.029
Atp1b3ATPase, Na+/K+ transporting, beta 3 polypeptide0.029
Gprc5aG protein-coupled receptor, family C, group 5, member A0.029
Il1rl1interleukin 1 receptor-like 10.028
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism