The network for 'mapk cascade' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mapk cascade

An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)1.000
SMAD2SMAD family member 21.000
SMN1survival of motor neuron 1, telomeric1.000
MAPK1mitogen-activated protein kinase 10.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.999
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.999
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.999
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.998
SH3KBP1SH3-domain kinase binding protein 10.998
BCAR1breast cancer anti-estrogen resistance 10.997
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.996
MAPK14mitogen-activated protein kinase 140.996
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.994
ILKintegrin-linked kinase0.992
IRAK1interleukin-1 receptor-associated kinase 10.990
MAP2K1mitogen-activated protein kinase kinase 10.990
SMAD3SMAD family member 30.988
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.988
GRB2growth factor receptor-bound protein 20.988
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.988
FYNFYN oncogene related to SRC, FGR, YES0.988
FGFR2fibroblast growth factor receptor 20.987
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.987
MAP3K5mitogen-activated protein kinase kinase kinase 50.985
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.985
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.984
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.984
CSNK1Ecasein kinase 1, epsilon0.983
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.981
ESR1estrogen receptor 10.981
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.979
PTPN11protein tyrosine phosphatase, non-receptor type 110.979
IRAK2interleukin-1 receptor-associated kinase 20.974
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.972
SFNstratifin0.972
JUNjun proto-oncogene0.970
DUSP1dual specificity phosphatase 10.963
FLNAfilamin A, alpha0.959
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.959
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.957
NCOA3nuclear receptor coactivator 30.957
SMAD7SMAD family member 70.956
GSK3Bglycogen synthase kinase 3 beta0.954
TRAF6TNF receptor-associated factor 60.949
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.946
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.943
BIRC3baculoviral IAP repeat containing 30.939
FN1fibronectin 10.938
TRAF3TNF receptor-associated factor 30.937
FGFR1fibroblast growth factor receptor 10.937
GAB1GRB2-associated binding protein 10.935
ENGendoglin0.933
MAPK8mitogen-activated protein kinase 80.932
LATlinker for activation of T cells0.931
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.924
C1QAcomplement component 1, q subcomponent, A chain0.920
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.919
MAP3K7mitogen-activated protein kinase kinase kinase 70.918
CCR5chemokine (C-C motif) receptor 50.916
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.908
METmet proto-oncogene (hepatocyte growth factor receptor)0.906
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.904
LRRK2leucine-rich repeat kinase 20.904
TGFB1transforming growth factor, beta 10.901
VEGFAvascular endothelial growth factor A0.898
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.896
XIAPX-linked inhibitor of apoptosis0.893
SRPK2SRSF protein kinase 20.886
MAP2K4mitogen-activated protein kinase kinase 40.884
ZNF43zinc finger protein 430.882
IL6interleukin 6 (interferon, beta 2)0.876
SOCS3suppressor of cytokine signaling 30.870
TEKTEK tyrosine kinase, endothelial0.868
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.868
PTPN1protein tyrosine phosphatase, non-receptor type 10.866
MAP3K3mitogen-activated protein kinase kinase kinase 30.864
GHRgrowth hormone receptor0.861
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.856
IGF1Rinsulin-like growth factor 1 receptor0.851
PTENphosphatase and tensin homolog0.848
FHL2four and a half LIM domains 20.848
PTK2PTK2 protein tyrosine kinase 20.845
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.842
SHC1SHC (Src homology 2 domain containing) transforming protein 10.841
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.840
CALM1calmodulin 1 (phosphorylase kinase, delta)0.833
PRKCAprotein kinase C, alpha0.832
BCRbreakpoint cluster region0.825
IQGAP1IQ motif containing GTPase activating protein 10.819
LCKlymphocyte-specific protein tyrosine kinase0.819
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.816
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.814
SIRT1sirtuin 10.810
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.806
PKM2pyruvate kinase, muscle0.802
BRAFv-raf murine sarcoma viral oncogene homolog B10.792
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
msp-78Protein MSP-780.909
sma-6Protein SMA-60.842
bar-1Protein BAR-10.631
mpk-1Protein MPK-10.556
msp-59Protein MSP-590.544
lin-25Protein LIN-250.539
tps-1Protein TPS-10.492
pdfr-1Protein PDFR-10.474
msp-76Protein MSP-760.472
mec-2Protein MEC-20.437
CELE_Y59E9AR.7Protein Y59E9AR.70.426
cdc-42Protein CDC-420.415
nhr-6Protein NHR-60.381
msp-31Protein MSP-310.370
msp-36Protein MSP-360.349
dpy-22Protein DPY-220.331
egl-18Protein EGL-180.312
msp-77Protein MSP-770.309
msp-45Protein MSP-450.287
msp-40Protein MSP-400.285
inx-4Protein INX-40.276
mig-2Protein MIG-20.267
msp-55Protein MSP-550.262
lat-1Protein LAT-10.262
C06G3.5Protein C06G3.50.244
sek-1Protein SEK-10.229
msp-50Protein MSP-500.206
daf-4Protein DAF-40.206
msp-3Protein MSP-30.205
msp-152Protein MSP-1520.202
pry-1Protein PRY-10.180
eps-8Protein EPS-80.177
msp-33Protein MSP-330.177
glp-1Protein GLP-10.171
msp-49Protein MSP-490.164
npp-7Protein NPP-70.163
ncam-1Protein NCAM-10.154
msp-10Protein MSP-100.152
mig-5Protein MIG-50.145
msp-64Protein MSP-640.138
egal-1Protein EGAL-10.137
vab-3Protein VAB-30.126
daf-19Protein DAF-190.120
unc-9Protein UNC-90.119
zag-1Protein ZAG-10.114
pal-1Protein PAL-10.114
pph-4.1Protein PPH-4.10.113
daf-14Protein DAF-140.111
kal-1Protein KAL-10.108
msp-74Protein MSP-740.107
unc-10Protein UNC-100.107
sma-1Protein SMA-10.106
msp-38Protein MSP-380.105
msp-53Protein MSP-530.103
mab-31Protein MAB-310.102
K08E3.5Protein K08E3.50.096
par-3Protein PAR-30.095
R13A5.9Protein R13A5.90.094
dlk-1Protein DLK-10.094
unc-53Protein UNC-530.093
lin-53Protein LIN-530.092
msp-65Protein MSP-650.091
T13C2.6Protein T13C2.60.090
cki-2Protein CKI-20.089
T01C3.9Protein T01C3.90.087
xpo-1Protein XPO-10.086
ceh-20Protein CEH-200.085
R03H10.2Protein R03H10.20.084
rpm-1Protein RPM-10.083
msp-63Protein MSP-630.081
ham-1Protein HAM-10.079
zyg-9Protein ZYG-90.079
ubc-20Protein UBC-200.078
toca-1Protein TOCA-10.076
CELE_Y41D4B.4Protein Y41D4B.40.076
nipi-3Protein NIPI-30.076
sym-4Protein SYM-40.075
eat-4Protein EAT-40.073
sem-5Protein SEM-50.072
gst-7Protein GST-70.071
cap-2Protein CAP-20.070
sad-1Protein SAD-10.070
hrpf-1Protein HRPF-10.069
swsn-2.1Protein SWSN-2.10.069
cst-1Protein CST-10.069
msp-19Protein MSP-190.069
sur-2Protein SUR-20.068
C04G6.4Protein C04G6.40.066
lin-45Protein LIN-450.065
eor-2Protein EOR-20.064
daf-6Protein DAF-60.063
plc-1Protein PLC-10.063
rgs-6Protein RGS-60.063
psf-1Protein PSF-10.063
tag-260Protein TAG-2600.062
CELE_C50B6.3Protein C50B6.30.062
elt-6Protein ELT-60.060
T10G3.1Protein T10G3.10.059
F14D12.1Protein F14D12.10.059
hmg-1.2Protein HMG-1.20.059
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxd3forkhead box D30.277
spry4sprouty (Drosophila) homolog 40.197
ephb4beph receptor B4b0.161
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.138
dkk1bdickkopf 1b0.125
crip2cysteine-rich protein 20.124
tagln2transgelin 20.123
fn1fibronectin 10.115
gdf6agrowth differentiation factor 6a0.104
efnb2aephrin B2a0.103
hif1abhypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) b0.103
kdrlkinase insert domain receptor like0.078
alcamaactivated leukocyte cell adhesion molecule a0.073
mstnbmyostatin b0.070
fzd7afrizzled homolog 7a0.068
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.065
wu:fv91b12wu:fv91b120.064
smad9MAD homolog 9 (Drosophila)0.063
lmx1b.1LIM homeobox transcription factor 1, beta 10.060
zbtb4zinc finger and BTB domain containing 40.058
sox9bSRY-box containing gene 9b0.056
igf1insulin-like growth factor 10.055
smad1MAD homolog 1 (Drosophila)0.054
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.054
tnfrsfatumor necrosis factor receptor superfamily, member a0.054
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.050
brd4bromodomain containing 40.050
igf1rbinsulin-like growth factor 1b receptor0.049
rag1recombination activating gene 10.048
LOC100537975thyroid receptor-interacting protein 11-like0.047
fgf3fibroblast growth factor 30.047
her9hairy-related 90.047
odc1ornithine decarboxylase 10.045
shhasonic hedgehog a0.045
flhfloating head0.044
ptk2.1protein tyrosine kinase 2a0.043
jag2jagged 20.041
wnt5awingless-type MMTV integration site family, member 5a0.039
nod1nucleotide-binding oligomerization domain containing 10.039
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.039
junbjun B proto-oncogene0.038
esr1estrogen receptor 10.038
furinafurin (paired basic amino acid cleaving enzyme) a0.037
rhoabras homolog gene family, member Ab0.037
vedventrally expressed dharma/bozozok antagonist0.036
vipr2vasoactive intestinal peptide receptor 20.036
nrg2aneuregulin 2a0.036
brd2abromodomain-containing 2a0.036
bmpr1aabone morphogenetic protein receptor, type 1aa0.035
junjun proto-oncogene0.034
ldb1aLIM-domain binding factor 1a0.034
oprd1bopioid receptor, delta 1b0.034
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.032
tbx1T-box 10.031
tpm4tropomyosin 40.031
csrp1acysteine and glycine-rich protein 1a0.031
ptenaphosphatase and tensin homolog A0.031
sulf1sulfatase 10.030
runx3runt-related transcription factor 30.030
mapk6mitogen-activated protein kinase 60.030
nrp2aneuropilin 2a0.029
jag1bjagged 1b0.028
bdnfbrain-derived neurotrophic factor0.028
traf4atnf receptor-associated factor 4a0.028
adra2badrenergic, alpha-2B-, receptor0.028
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.028
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.028
wnt4awingless-type MMTV integration site family, member 4a0.027
crestincrestin0.027
plcb3phospholipase C, beta 3 (phosphatidylinositol-specific)0.027
olfm1aolfactomedin 1a0.027
mapk3mitogen-activated protein kinase 30.026
spry2sprouty homolog 20.026
mbtps1membrane-bound transcription factor protease, site 10.026
csnk1g2acasein kinase 1, gamma 2a0.026
tp53tumor protein p530.026
wnt3wingless-type MMTV integration site family, member 30.026
ahcyl1S-adenosylhomocysteine hydrolase-like 10.026
bnc2basonuclin 20.026
mpped2metallophosphoesterase domain containing 20.025
frzbfrizzled-related protein0.025
tlr21toll-like receptor 210.025
csnk1dacasein kinase 1, delta a0.025
mycamyelocytomatosis oncogene a0.025
her6hairy-related 60.024
mapk1mitogen-activated protein kinase 10.024
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.024
osr1odd-skipped related 1 (Drosophila)0.024
gbx2gastrulation brain homeo box 20.024
ntrk2aneurotrophic tyrosine kinase, receptor, type 2a0.024
fesfeline sarcoma oncogene0.023
sox10SRY-box containing gene 100.023
card9caspase recruitment domain family, member 90.023
thtyrosine hydroxylase0.023
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)0.023
plagl2pleiomorphic adenoma gene-like 20.023
mcoln1mucolipin 10.023
twist1atwist1a0.023
metmet proto-oncogene (hepatocyte growth factor receptor)0.023
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.023
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rlrolled0.985
Akt1CG4006 gene product from transcript CG4006-RA0.969
Ras85DRas oncogene at 85D0.967
tkvthickveins0.963
bskbasket0.911
spispitz0.837
hephemipterous0.776
rokRho-kinase0.742
JraJun-related antigen0.725
kaykayak0.687
Atg1Autophagy-specific gene 10.686
aopanterior open0.673
Cdc42CG12530 gene product from transcript CG12530-RA0.666
p38bCG7393 gene product from transcript CG7393-RA0.622
Pi3K92ECG4141 gene product from transcript CG4141-RB0.591
Src64BSrc oncogene at 64B0.569
eIF-4EEukaryotic initiation factor 4E0.491
EgfrEpidermal growth factor receptor0.459
Src42ASrc oncogene at 42A0.443
VangVan Gogh0.432
Mpk2CG5475 gene product from transcript CG5475-RB0.429
G-oalpha47AG protein oalpha 47A0.412
Rab5Rab-protein 50.378
MybMyb oncogene-like0.378
saxsaxophone0.373
pnutpeanut0.367
Rac2CG8556 gene product from transcript CG8556-RA0.366
wdbwiderborst0.360
mnbminibrain0.357
gekgenghis khan0.351
edechinoid0.351
phlpole hole0.348
Sra-1specifically Rac1-associated protein 10.344
shishibire0.336
mbcmyoblast city0.329
nmonemo0.325
rhorhomboid0.314
DadDaughters against dpp0.302
CkIIalphaCasein kinase II alpha subunit0.302
MadMothers against dpp0.292
Sema-1aCG18405 gene product from transcript CG18405-RD0.288
Smg1CG32743 gene product from transcript CG32743-RA0.273
Pk61CProtein kinase 61C0.265
Nrx-IVNeurexin IV0.265
drkdownstream of receptor kinase0.264
Ced-12CG5336 gene product from transcript CG5336-RA0.263
sevsevenless0.262
chicoCG5686 gene product from transcript CG5686-RB0.261
rheaCG6831 gene product from transcript CG6831-RA0.259
bazbazooka0.255
pucpuckered0.255
wgwingless0.253
roboroundabout0.253
Stat92ESignal-transducer and activator of transcription protein at 92E0.250
ShcSHC-adaptor protein0.243
lqfliquid facets0.243
sdscalloped0.238
ushu-shaped0.238
SdcSyndecan0.235
babobaboon0.230
NetBNetrin-B0.229
giggigas0.225
dcodiscs overgrown0.225
PakPAK-kinase0.223
Pink1PTEN-induced putative kinase 10.217
DptBDiptericin B0.212
kiskismet0.207
Ras64BRas oncogene at 64B0.205
CG4168CG4168 gene product from transcript CG4168-RA0.201
DDichaete0.200
pntpointed0.200
Eb1CG3265 gene product from transcript CG3265-RF0.199
SmoxSmad on X0.197
srpserpent0.195
Pka-C1cAMP-dependent protein kinase 10.195
Socs36ESuppressor of cytokine signaling at 36E0.193
Mef2Myocyte enhancer factor 20.192
p120ctnAdherens junction protein p1200.189
AttAAttacin-A0.188
S6kRPS6-p70-protein kinase0.187
Plc21CPhospholipase C at 21C0.186
Bin1Bicoid interacting protein 10.183
srstripe0.182
PknProtein kinase related to protein kinase N0.181
sbbscribbler0.179
certceramide transfer protein0.178
stcksteamer duck0.175
keykenny0.172
exexpanded0.170
S6kIIRPS6-protein kinase-II0.170
ecdecdysoneless0.168
rapsrapsynoid0.167
mttmangetout0.166
Lis-1Lissencephaly-10.162
Galpha49BG protein alpha49B0.159
RelRelish0.159
stumpsCG31317 gene product from transcript CG31317-RC0.156
alphalphabet0.154
Ssl1CG11115 gene product from transcript CG11115-RA0.153
hipkhomeodomain interacting protein kinase0.152
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ptenphosphatase and tensin homolog0.999
Ctnnb1catenin (cadherin associated protein), beta 10.999
Grb2growth factor receptor bound protein 20.994
Apcadenomatosis polyposis coli0.992
Cav1caveolin 1, caveolae protein0.989
Ptpn11protein tyrosine phosphatase, non-receptor type 110.988
Efnb2ephrin B20.987
Cd40CD40 antigen0.985
Cd44CD44 antigen0.984
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.978
Traf6TNF receptor-associated factor 60.978
Acvr1activin A receptor, type 10.977
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.973
Tbx3T-box 30.971
CblCasitas B-lineage lymphoma0.971
Inpp5dinositol polyphosphate-5-phosphatase D0.967
Smad6MAD homolog 6 (Drosophila)0.965
Prkceprotein kinase C, epsilon0.953
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.948
Ghrgrowth hormone receptor0.944
Mapk14mitogen-activated protein kinase 140.944
Axin1axin 10.943
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.942
Tgfbr2transforming growth factor, beta receptor II0.940
Esr1estrogen receptor 1 (alpha)0.937
Fgf10fibroblast growth factor 100.930
Tnftumor necrosis factor0.925
Mapk8mitogen-activated protein kinase 80.922
Nf1neurofibromatosis 10.921
Vangl2vang-like 2 (van gogh, Drosophila)0.917
Dvl2dishevelled 2, dsh homolog (Drosophila)0.916
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.912
Smad3MAD homolog 3 (Drosophila)0.911
BtkBruton agammaglobulinemia tyrosine kinase0.905
Egfrepidermal growth factor receptor0.904
Tnfaip3tumor necrosis factor, alpha-induced protein 30.901
Plcg1phospholipase C, gamma 10.893
Apoeapolipoprotein E0.890
Bdnfbrain derived neurotrophic factor0.884
Insrinsulin receptor0.883
Shc3src homology 2 domain-containing transforming protein C30.875
FynFyn proto-oncogene0.874
Ptk7PTK7 protein tyrosine kinase 70.873
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.873
Retret proto-oncogene0.870
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.863
Zeb1zinc finger E-box binding homeobox 10.852
Tgfb2transforming growth factor, beta 20.851
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.850
Csf1colony stimulating factor 1 (macrophage)0.850
Nos1nitric oxide synthase 1, neuronal0.850
Epas1endothelial PAS domain protein 10.844
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.843
Usp8ubiquitin specific peptidase 80.834
Ephb2Eph receptor B20.833
Kitlkit ligand0.833
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.831
Grb10growth factor receptor bound protein 100.825
Chrdchordin0.822
Leprleptin receptor0.819
Fgfr1fibroblast growth factor receptor 10.814
Ntf3neurotrophin 30.809
Dok1docking protein 10.807
Nr3c1nuclear receptor subfamily 3, group C, member 10.802
Ccl2chemokine (C-C motif) ligand 20.800
Fgfr2fibroblast growth factor receptor 20.799
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.787
Map3k3mitogen-activated protein kinase kinase kinase 30.786
Arrb2arrestin, beta 20.786
Ednrbendothelin receptor type B0.784
Map3k7mitogen-activated protein kinase kinase kinase 70.782
Gli3GLI-Kruppel family member GLI30.780
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.779
Zic3zinc finger protein of the cerebellum 30.778
Il1r1interleukin 1 receptor, type I0.775
Fjx1four jointed box 1 (Drosophila)0.773
Cd22CD22 antigen0.767
Gab1growth factor receptor bound protein 2-associated protein 10.766
Cx3cr1chemokine (C-X3-C) receptor 10.765
Il6stinterleukin 6 signal transducer0.760
Adam17a disintegrin and metallopeptidase domain 170.760
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.758
Bmpr1abone morphogenetic protein receptor, type 1A0.756
Rassf5Ras association (RalGDS/AF-6) domain family member 50.752
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.752
Plauplasminogen activator, urokinase0.752
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.748
Egr1early growth response 10.747
Gsk3bglycogen synthase kinase 3 beta0.742
SrcRous sarcoma oncogene0.729
Tenc1tensin like C1 domain-containing phosphatase0.729
Fras1Fraser syndrome 1 homolog (human)0.728
Smad7MAD homolog 7 (Drosophila)0.726
Id1inhibitor of DNA binding 10.724
Atf2activating transcription factor 20.717
Hoxd13homeobox D130.714
AxlAXL receptor tyrosine kinase0.713
Pdgfbplatelet derived growth factor, B polypeptide0.704
Stat3signal transducer and activator of transcription 30.702
Tekendothelial-specific receptor tyrosine kinase0.702
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
DbpD site of albumin promoter (albumin D-box) binding protein0.758
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.710
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.687
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.685
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.668
Sirpasignal-regulatory protein alpha0.629
Bcanbrevican0.621
Calcrlcalcitonin receptor-like0.612
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.608
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.584
Ncanneurocan0.583
Ptafrplatelet-activating factor receptor0.570
Egr1early growth response 10.558
Arandrogen receptor0.557
Fgfr2fibroblast growth factor receptor 20.555
Trhrthyrotropin releasing hormone receptor0.555
Fgf2fibroblast growth factor 20.545
Albalbumin0.531
Metmet proto-oncogene0.515
Klf6Kruppel-like factor 60.500
Ccl4chemokine (C-C motif) ligand 40.498
Pparaperoxisome proliferator activated receptor alpha0.493
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.464
Smad3SMAD family member 30.455
Rgs14regulator of G-protein signaling 140.451
Phkg1phosphorylase kinase, gamma 10.443
Nr5a2nuclear receptor subfamily 5, group A, member 20.431
Junbjun B proto-oncogene0.431
Adora2aadenosine A2a receptor0.431
Grm7glutamate receptor, metabotropic 70.416
Slc18a3solute carrier family 18 (vesicular acetylcholine), member 30.411
Ctsjcathepsin J0.410
Ptgfrprostaglandin F receptor0.404
Gzmkgranzyme K0.397
Mapk1mitogen activated protein kinase 10.395
FosFBJ osteosarcoma oncogene0.388
Vom2r27vomeronasal 2 receptor, 270.387
Oprm1opioid receptor, mu 10.385
Pcdhb12protocadherin beta 120.378
Notch3Notch homolog 3 (Drosophila)0.378
Gria1glutamate receptor, ionotropic, AMPA 10.374
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.368
Htr75-hydroxytryptamine (serotonin) receptor 70.348
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.346
Klf4Kruppel-like factor 4 (gut)0.341
Agtr1aangiotensin II receptor, type 1a0.336
Nrg1neuregulin 10.330
Mapk9mitogen-activated protein kinase 90.325
Hpcal4hippocalcin-like 40.317
Efnb1ephrin B10.317
Inpp5dinositol polyphosphate-5-phosphatase D0.317
Cx3cr1chemokine (C-X3-C motif) receptor 10.316
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.310
Ncr1natural cytotoxicity triggering receptor 10.309
Cd38CD38 molecule0.305
Shox2short stature homeobox 20.304
Jtbjumping translocation breakpoint0.303
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.302
Il9rinterleukin 9 receptor0.297
Folh1folate hydrolase 10.297
Dock8dedicator of cytokinesis 80.295
Cxcl2chemokine (C-X-C motif) ligand 20.294
Wdr26WD repeat domain 260.294
Reg1aregenerating islet-derived 1 alpha0.294
RT1-DaRT1 class II, locus Da0.288
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.288
Slco2a1solute carrier organic anion transporter family, member 2a10.287
Jak1Janus kinase 10.278
Psen1presenilin 10.275
Jak2Janus kinase 20.274
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.273
Olr287olfactory receptor 2870.271
S1pr2sphingosine-1-phosphate receptor 20.268
JunJun oncogene0.266
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.266
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.265
Ccl3chemokine (C-C motif) ligand 30.264
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.264
Tgfbr2transforming growth factor, beta receptor II0.262
Prok2prokineticin 20.257
Ccr2chemokine (C-C motif) receptor 20.256
Nrasneuroblastoma ras oncogene0.253
Giprgastric inhibitory polypeptide receptor0.252
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.251
Socs3suppressor of cytokine signaling 30.250
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.248
Muskmuscle, skeletal, receptor tyrosine kinase0.248
Gfra2GDNF family receptor alpha 20.247
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.247
Ptger4prostaglandin E receptor 4 (subtype EP4)0.247
Hckhemopoietic cell kinase0.247
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.245
Il2rainterleukin 2 receptor, alpha0.244
Svs1seminal vesicle secretory protein 10.241
Cxcr3chemokine (C-X-C motif) receptor 30.239
Itgamintegrin, alpha M0.239
Itpr2inositol 1,4,5-triphosphate receptor, type 20.238
Pnlippancreatic lipase0.238
Crip2cysteine-rich protein 20.236
Bdkrb2bradykinin receptor B20.235
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PBS2Pbs2p0.999
NBP2Nbp2p0.993
SSK2Ssk2p0.983
SLT2Slt2p0.982
BCK1Bck1p0.979
STE7Ste7p0.947
CLA4Cla4p0.890
KSS1Kss1p0.826
STE20Ste20p0.822
MSG5Msg5p0.810
SSK1Ssk1p0.774
SNT1Snt1p0.674
SHO1Sho1p0.595
STE11Ste11p0.589
ZDS1Zds1p0.565
FUS3Fus3p0.540
BCK2Bck2p0.511
RLM1Rlm1p0.499
KDX1Kdx1p0.448
SSK22Ssk22p0.442
HOG1Hog1p0.418
STE5Ste5p0.405
SOK1Sok1p0.387
CPR1Cpr1p0.286
HOS4Hos4p0.271
PIL1Pil1p0.236
BMH1Bmh1p0.213
VPS64Vps64p0.197
RGD1Rgd1p0.178
PPH21Pph21p0.169
SIF2Sif2p0.138
VMA13Vma13p0.116
TED1Ted1p0.111
CRZ1Crz1p0.110
CAK1Cak1p0.101
UFO1Ufo1p0.099
GAL7Gal7p0.094
KOG1Kog1p0.093
TAT1Tat1p0.091
AHP1Ahp1p0.088
ALD6Ald6p0.088
YTA6Yta6p0.081
STE4Ste4p0.078
EBS1Ebs1p0.076
SSN8Ssn8p0.076
CRG1Crg1p0.074
MRM1Mrm1p0.073
PCI8Pci8p0.073
ARF2Arf2p0.073
LHS1Lhs1p0.072
BOI2Boi2p0.067
CDC34Cdc34p0.065
KIC1Kic1p0.065
PAM1Pam1p0.065
HST1Hst1p0.064
PTP2Ptp2p0.064
YHB1Yhb1p0.063
HSP60Hsp60p0.062
YPL088Whypothetical protein0.059
IRA1Ira1p0.059
ESF1Esf1p0.053
HKR1Hkr1p0.052
YPL150Whypothetical protein0.052
CDC24Cdc24p0.052
MNN2Mnn2p0.050
TRX2Trx2p0.048
NAB6Nab6p0.048
VPS5Vps5p0.048
SMP1Smp1p0.047
CDC37Cdc37p0.047
HOR7Hor7p0.046
PPH3Pph3p0.045
RHO1Rho1p0.045
FAB1Fab1p0.045
ALO1Alo1p0.044
HSM3Hsm3p0.043
TEC1Tec1p0.043
RAS2Ras2p0.041
YJR084Whypothetical protein0.040
FUS2Fus2p0.040
HOS2Hos2p0.040
OYE2Oye2p0.040
MDS3Mds3p0.039
TPS1Tps1p0.039
NRP1Nrp1p0.039
PTC1Ptc1p0.039
ASK10Ask10p0.038
SET1Set1p0.037
KEL3Kel3p0.036
BCY1Bcy1p0.036
AKL1Akl1p0.036
NUP157Nup157p0.035
GPX2Gpx2p0.034
OPY2Opy2p0.034
SMY2Smy2p0.034
DBF2Dbf2p0.034
YJL193Whypothetical protein0.033
PUS9Pus9p0.031
SKO1Sko1p0.031
MOB2Mob2p0.030