The network for 'oxidative demethylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

oxidative demethylation

The process of removing one or more methyl groups from a molecule, involving the oxidation (i.e. electron loss) of one or more atoms in the substrate.

NameDescriptionProbabilityFunc Analog Organism
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 91.000
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 61.000
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.987
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.984
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.979
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.952
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.906
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.741
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.602
C8Acomplement component 8, alpha polypeptide0.544
C8Bcomplement component 8, beta polypeptide0.516
C6complement component 60.452
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.436
GLYATglycine-N-acyltransferase0.425
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.389
HRGhistidine-rich glycoprotein0.379
F9coagulation factor IX0.367
MASP2mannan-binding lectin serine peptidase 20.355
ADH6alcohol dehydrogenase 6 (class V)0.347
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.291
ALDOBaldolase B, fructose-bisphosphate0.243
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.191
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.187
FMO4flavin containing monooxygenase 40.185
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.169
DAOD-amino-acid oxidase0.164
OTCornithine carbamoyltransferase0.159
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.158
MAT1Amethionine adenosyltransferase I, alpha0.154
CFHR4complement factor H-related 40.147
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.146
CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 70.138
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.119
KNG1kininogen 10.110
HABP2hyaluronan binding protein 20.107
APCSamyloid P component, serum0.087
ACRV1acrosomal vesicle protein 10.086
CCL16chemokine (C-C motif) ligand 160.086
AADACarylacetamide deacetylase (esterase)0.084
GBA3glucosidase, beta, acid 3 (cytosolic)0.074
PON1paraoxonase 10.070
BHMTbetaine--homocysteine S-methyltransferase0.069
NR1I2nuclear receptor subfamily 1, group I, member 20.066
PLGplasminogen0.064
LECT2leukocyte cell-derived chemotaxin 20.062
GPLD1glycosylphosphatidylinositol specific phospholipase D10.059
F11coagulation factor XI0.057
UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B150.056
ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)0.055
C4BPAcomplement component 4 binding protein, alpha0.055
AGXT2alanine--glyoxylate aminotransferase 20.054
C4BPBcomplement component 4 binding protein, beta0.051
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.048
GSTA3glutathione S-transferase alpha 30.047
FETUBfetuin B0.047
G6PCglucose-6-phosphatase, catalytic subunit0.045
AFMafamin0.043
APOC4apolipoprotein C-IV0.042
XDHxanthine dehydrogenase0.041
ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 110.041
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.040
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.040
CRPC-reactive protein, pentraxin-related0.040
DPYSdihydropyrimidinase0.037
CYP2D6cytochrome P450, family 2, subfamily D, polypeptide 60.037
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.037
APOC3apolipoprotein C-III0.036
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.036
HAO1hydroxyacid oxidase (glycolate oxidase) 10.036
F13Bcoagulation factor XIII, B polypeptide0.035
TMPRSS6transmembrane protease, serine 60.033
ITIH2inter-alpha (globulin) inhibitor H20.032
LAMC3laminin, gamma 30.030
HALhistidine ammonia-lyase0.030
ANXA10annexin A100.030
MEP1Bmeprin A, beta0.029
PIK3C2Gphosphoinositide-3-kinase, class 2, gamma polypeptide0.029
A1CFAPOBEC1 complementation factor0.029
MTTPmicrosomal triglyceride transfer protein0.029
TATtyrosine aminotransferase0.028
TTPAtocopherol (alpha) transfer protein0.028
MASP1mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)0.027
MAST1microtubule associated serine/threonine kinase 10.026
C9complement component 90.026
GYS2glycogen synthase 2 (liver)0.025
NR1H4nuclear receptor subfamily 1, group H, member 40.025
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.025
SLC22A1solute carrier family 22 (organic cation transporter), member 10.025
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.023
APOBapolipoprotein B (including Ag(x) antigen)0.023
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.023
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.022
CYP7A1cytochrome P450, family 7, subfamily A, polypeptide 10.022
LGALS4lectin, galactoside-binding, soluble, 40.021
NR1I3nuclear receptor subfamily 1, group I, member 30.021
LPAlipoprotein, Lp(a)0.021
HNF4Ahepatocyte nuclear factor 4, alpha0.021
CYP1A1cytochrome P450, family 1, subfamily A, polypeptide 10.020
DNASE1L3deoxyribonuclease I-like 30.020
TM4SF4transmembrane 4 L six family member 40.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cx45.6connexin 45.60.109
hapln3hyaluronan and proteoglycan link protein 30.085
mep1a.1meprin A, alpha.10.051
aqp8a.1aquaporin 8a, tandem duplicate 10.051
cx43connexin 430.050
itpk1inositol 1,3,4-triphosphate 5/6 kinase0.048
prom1aprominin 1a0.041
dusp5dual specificity phosphatase 50.040
maomonoamine oxidase0.039
cldn15laclaudin 15-like a0.038
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.036
cyp1acytochrome P450, family 1, subfamily A0.036
ftr82finTRIM family, member 820.036
gstp1glutathione S-transferase pi0.035
epas1bendothelial PAS domain protein 1b0.034
mt2metallothionein 20.031
epoerythropoietin0.030
zgc:113200zgc:1132000.028
cyp1b1cytochrome P450, family 1, subfamily B, polypeptide 10.026
si:ch211-93f2.1si:ch211-93f2.10.026
vil1lvillin 1 like0.023
socs1suppressor of cytokine signaling 10.023
rnf128aring finger protein 128a0.023
igfbp1ainsulin-like growth factor binding protein 1a0.022
fabp6fatty acid binding protein 6, ileal (gastrotropin)0.022
lpar1lysophosphatidic acid receptor 10.021
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.020
fabp11afatty acid binding protein 11a0.020
cacnb2acalcium channel, voltage-dependent, beta 2a0.019
adipor2adiponectin receptor 20.019
cyp1c1cytochrome P450, family 1, subfamily C, polypeptide 10.019
rhcgbRhesus blood group, C glycoprotein b0.018
nr5a5nuclear receptor subfamily 5, group A, member 50.017
ca2carbonic anhydrase II0.017
selenbp1selenium binding protein 10.016
hsp70heat shock cognate 70-kd protein0.016
nosipnitric oxide synthase interacting protein0.016
cpa4carboxypeptidase A40.016
cyp1d1cytochrome P450, family 1, subfamily D, polypeptide 10.015
sgk1serum/glucocorticoid regulated kinase 10.014
cyp1c2cytochrome P450, family 1, subfamily C, polypeptide 20.014
sat1bspermidine/spermine N1-acetyl transferase 1b0.014
hgdhomogentisate 1,2-dioxygenase0.014
crhcorticotropin releasing hormone0.014
cx32.3connexin 32.30.013
zgc:92066zgc:920660.013
tspotranslocator protein0.013
hsh2dhematopoietic SH2 domain containing0.013
LOC569642hypothetical protein LOC5696420.013
acox1acyl-Coenzyme A oxidase 1, palmitoyl0.013
zgc:66484zgc:664840.013
keap1akelch-like ECH-associated protein 1a0.012
recql5RecQ protein-like 50.012
nfe2l2nuclear factor (erythroid-derived 2)-like 20.012
park7parkinson disease (autosomal recessive, early onset) 70.012
hspb11heat shock protein, alpha-crystallin-related, b110.012
desmbdesmin b0.012
cldnkclaudin k0.012
srd5a2asteroid-5-alpha-reductase, alpha polypeptide 2a0.011
catcatalase0.011
msxamuscle segment homeobox A0.011
si:ch211-284e13.2si:ch211-284e13.20.011
sult6b1sulfotransferase family, cytosolic, 6b, member 10.011
zgc:110343zgc:1103430.011
cbr1lcarbonyl reductase 1-like0.011
zgc:175131zgc:1751310.011
zgc:112986zgc:1129860.010
esamaendothelial cell adhesion molecule a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otcornithine transcarbamylase0.995
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.993
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.977
Cps1carbamoyl-phosphate synthetase 10.952
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.921
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.908
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.883
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.819
Cyp3a44cytochrome P450, family 3, subfamily a, polypeptide 440.776
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.753
Nr1i2nuclear receptor subfamily 1, group I, member 20.751
F9coagulation factor IX0.747
Sult1d1sulfotransferase family 1D, member 10.739
Ces2acarboxylesterase 2A0.692
Sult1b1sulfotransferase family 1B, member 10.651
Ugt2b34UDP glucuronosyltransferase 2 family, polypeptide B340.650
Akr1c6aldo-keto reductase family 1, member C60.629
Aldobaldolase B, fructose-bisphosphate0.620
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.612
Cyp2c37cytochrome P450, family 2. subfamily c, polypeptide 370.558
Rdh7retinol dehydrogenase 70.550
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.481
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.476
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.449
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.440
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.432
Cyp2c68cytochrome P450, family 2, subfamily c, polypeptide 680.427
Aadacarylacetamide deacetylase (esterase)0.419
CrpC-reactive protein, pentraxin-related0.398
Hrghistidine-rich glycoprotein0.398
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.382
Cyp2d10cytochrome P450, family 2, subfamily d, polypeptide 100.380
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.354
Mbl2mannose-binding lectin (protein C) 20.351
Cyp2c55cytochrome P450, family 2, subfamily c, polypeptide 550.332
Slco1b2solute carrier organic anion transporter family, member 1b20.326
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.314
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.303
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.295
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.281
G6pcglucose-6-phosphatase, catalytic0.266
Ces1gcarboxylesterase 1G0.263
Cfhr1complement factor H-related 10.256
Timd2T-cell immunoglobulin and mucin domain containing 20.249
Tdo2tryptophan 2,3-dioxygenase0.247
F13bcoagulation factor XIII, beta subunit0.230
Slco1a1solute carrier organic anion transporter family, member 1a10.227
Ugt3a1UDP glycosyltransferases 3 family, polypeptide A10.227
Cyp3a16cytochrome P450, family 3, subfamily a, polypeptide 160.224
Ugt2b36UDP glucuronosyltransferase 2 family, polypeptide B360.212
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.204
Cyp3a41bcytochrome P450, family 3, subfamily a, polypeptide 41B0.199
Adh4alcohol dehydrogenase 4 (class II), pi polypeptide0.196
Ces1ccarboxylesterase 1C0.194
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.183
Fabp2fatty acid binding protein 2, intestinal0.177
Cyp2d26cytochrome P450, family 2, subfamily d, polypeptide 260.164
Uoxurate oxidase0.158
Mug2murinoglobulin 20.157
Ces3acarboxylesterase 3A0.152
Albalbumin0.150
Ugt2b35UDP glucuronosyltransferase 2 family, polypeptide B350.145
Cml2camello-like 20.140
Sval1seminal vesicle antigen-like 10.139
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.139
Mug1murinoglobulin 10.136
Fabp1fatty acid binding protein 1, liver0.132
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.132
Cyp2c65cytochrome P450, family 2, subfamily c, polypeptide 650.131
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.125
Gcgroup specific component0.124
Bhmtbetaine-homocysteine methyltransferase0.124
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.122
Tex12testis expressed gene 120.117
Azgp1alpha-2-glycoprotein 1, zinc0.113
Akr1d1aldo-keto reductase family 1, member D10.113
Slc22a1solute carrier family 22 (organic cation transporter), member 10.112
Apohapolipoprotein H0.109
Acot12acyl-CoA thioesterase 120.105
Fbp1fructose bisphosphatase 10.104
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.103
BC089597cDNA sequence BC0895970.102
Clec2hC-type lectin domain family 2, member h0.099
Mup3major urinary protein 30.098
Hgdhomogentisate 1, 2-dioxygenase0.098
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.096
Apobapolipoprotein B0.094
Glyatglycine-N-acyltransferase0.092
Vmn1r45vomeronasal 1 receptor 450.092
Cyp2j5cytochrome P450, family 2, subfamily j, polypeptide 50.091
Fmo5flavin containing monooxygenase 50.089
Cyp4a31cytochrome P450, family 4, subfamily a, polypeptide 310.086
Hsd17b13hydroxysteroid (17-beta) dehydrogenase 130.086
D630002G06RikRIKEN cDNA D630002G06 gene0.085
Vmn1r56vomeronasal 1 receptor 560.084
Gm4788predicted gene 47880.080
Apoc3apolipoprotein C-III0.079
AB056442cDNA sequence AB0564420.079
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.075
Pahphenylalanine hydroxylase0.074
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.437
Mettl7bmethyltransferase like 7B0.328
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.276
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.262
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.232
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.116
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.109
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.102
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.076
Obp1fodorant binding protein I f0.070
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.066
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.053
Otcornithine carbamoyltransferase0.042
Slco1a1solute carrier organic anion transporter family, member 1a10.039
Slco1a4solute carrier organic anion transporter family, member 1a40.038
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.036
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.035
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.035
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.034
Cyp2a2cytochrome P450, family 2, subfamily a, polypeptide 20.033
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.032
Dhfrdihydrofolate reductase0.030
Olr59olfactory receptor 590.025
LOC293989cytochrome P450-like0.023
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.023
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.023
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.022
Asgr1asialoglycoprotein receptor 10.022
A1i3alpha-1-inhibitor III0.020
Ndufs8NADH dehydrogenase (ubiquinone) Fe-S protein 80.019
Olr1701olfactory receptor 17010.019
Pigrpolymeric immunoglobulin receptor0.017
Olr1413olfactory receptor 14130.017
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.016
Aqp9aquaporin 90.015
LOC494499LOC494499 protein0.013
Fgfr4fibroblast growth factor receptor 40.013
Ndufs7NADH dehydrogenase (ubiquinone) Fe-S protein 70.013
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.012
Pfkfb16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.012
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.012
Zfp37zinc finger protein 370.011
Fabp1fatty acid binding protein 1, liver0.011
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.011
Akr1c12aldo-keto reductase family 1, member C120.011
Akr1c18aldo-keto reductase family 1, member C180.011
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.010
Slco1b3solute carrier organic anion transporter family, member 1b30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism