The network for 'lymphatic endothelial cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

lymphatic endothelial cell fate commitment

The commitment of a venous blood vessel endothelial cell to a lymphatic endothelial cell fate and its capacity to differentiate into a lymphatic endothelial cell.

NameDescriptionProbabilityFunc Analog Organism
RARAretinoic acid receptor, alpha1.000
NCOA1nuclear receptor coactivator 10.999
MED25mediator complex subunit 250.998
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.857
HNF4Ahepatocyte nuclear factor 4, alpha0.671
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.571
PROX1prospero homeobox 10.303
RXRAretinoid X receptor, alpha0.300
NR0B2nuclear receptor subfamily 0, group B, member 20.236
SREBF2sterol regulatory element binding transcription factor 20.169
SPOPspeckle-type POZ protein0.125
FAM46Afamily with sequence similarity 46, member A0.120
NCOA3nuclear receptor coactivator 30.115
RXRBretinoid X receptor, beta0.052
NCOR2nuclear receptor corepressor 20.047
ESRRGestrogen-related receptor gamma0.036
NCOA6nuclear receptor coactivator 60.030
NR5A2nuclear receptor subfamily 5, group A, member 20.027
PRKD2protein kinase D20.026
PPARGperoxisome proliferator-activated receptor gamma0.024
HNF1AHNF1 homeobox A0.021
NR1I3nuclear receptor subfamily 1, group I, member 30.020
NR1H3nuclear receptor subfamily 1, group H, member 30.016
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.016
HRhairless homolog (mouse)0.015
NR1H2nuclear receptor subfamily 1, group H, member 20.014
ESR1estrogen receptor 10.013
ACVR1Bactivin A receptor, type IB0.013
TADA3transcriptional adaptor 30.012
KANK2KN motif and ankyrin repeat domains 20.011
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nr2f1anuclear receptor subfamily 2, group F, member 1a0.984
rxrabretinoid x receptor, alpha b0.925
nr2f2nuclear receptor subfamily 2, group F, member 20.758
raraaretinoic acid receptor, alpha a0.670
tead3aTEA domain family member 3 a0.587
plekhg4pleckstrin homology domain containing, family G (with RhoGef domain) member 40.540
nr2f5nuclear receptor subfamily 2, group F, member 50.418
rxraaretinoid X receptor, alpha a0.391
foxb1.1forkhead box B1.10.336
meis2.1myeloid ecotropic viral integration site 2.10.292
pax3apaired box gene 3a0.269
lrrtm1leucine rich repeat transmembrane neuronal 10.212
rargbretinoic acid receptor, gamma b0.169
zgc:66326zgc:663260.169
robo4roundabout homolog 40.163
pou3f3bPOU class 3 homeobox 3b0.149
sox19aSRY-box containing gene 19a0.138
aldobaldolase b, fructose-bisphosphate0.117
lfnglunatic fringe homolog0.113
irx3biroquois homeobox protein 3b0.109
rxrgaretinoid x receptor, gamma a0.103
jam3bjunctional adhesion molecule 3b0.103
mxi1max interacting protein0.099
meis1myeloid ecotropic viral integration 10.077
gngt2aguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a0.073
mtpmicrosomal triglyceride transfer protein0.069
hhexhematopoietically expressed homeobox0.068
nrp2bneuropilin 2b0.066
nkx1.2laNK1 transcription factor related 2-like,a0.066
emilin1aelastin microfibril interfacer 1a0.064
rxrbaretinoid x receptor, beta a0.058
zgc:56326zgc:563260.058
neo1neogenin 10.058
coe2coe20.057
slc25a37solute carrier family 25, member 370.057
sp8bsp8 transcription factor b0.053
cldn5aclaudin 5a0.051
ntn1anetrin 1a0.050
gng2guanine nucleotide binding protein (G protein), gamma 20.049
pcdh18aprotocadherin 18a0.048
wu:fb17g07wu:fb17g070.048
pou3f2POU class 3 homeobox 20.047
her4.2hairy-related 4.20.046
rhot2ras homolog gene family, member T20.045
irx3airoquois homeobox protein 3a0.044
rxrgbretinoid X receptor, gamma b0.044
nr2f6bnuclear receptor subfamily 2, group F, member 6b0.043
irx5airoquois homeobox protein 5a0.042
rxrbbretinoid x receptor, beta b0.042
tbx24T-box 240.041
shbgsex hormone binding globulin0.041
prickle1aprickle-like 1 (Drosophila) a0.040
pou2f1aPOU class 2 homeobox 1a0.039
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.037
otx2orthodenticle homolog 20.037
rx2retinal homeobox gene 20.033
gng13bguanine nucleotide binding protein (G protein), gamma 13b0.032
cyp3a65cytochrome P450, family 3, subfamily A, polypeptide 650.032
tshz1teashirt family zinc finger 10.031
lmo3LIM domain only 30.031
fabp10afatty acid binding protein 10a, liver basic0.031
sox11aSRY-box containing gene 11a0.030
sesn1sestrin 10.029
her9hairy-related 90.028
mcm6MCM6 minichromosome maintenance deficient 6, mitotin (S. cerevisiae)0.028
irx1biroquois homeobox protein 1, b0.025
tie1endothelium-specific receptor tyrosine kinase 10.025
cpoxcoproporphyrinogen oxidase0.025
rorcbRAR-related orphan receptor C b0.025
otx5orthodenticle homolog 50.025
hbae3hemoglobin alpha embryonic-30.024
thbs1thrombospondin 10.023
sox4aSRY-box containing gene 4a0.023
sox7SRY-box containing gene 70.023
ikzf1IKAROS family zinc finger 1 (Ikaros)0.023
clockclock0.022
wu:fb76c12wu:fb76c120.022
pou3f1POU class 3 homeobox 10.021
scdstearoyl-CoA desaturase (delta-9-desaturase)0.019
akt2v-akt murine thymoma viral oncogene homolog 20.019
wnt7bbwingless-type MMTV integration site family, member 7Bb0.019
dladeltaA0.019
pdgfaaplatelet-derived growth factor alpha a0.019
tfr1btransferrin receptor 1b0.019
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.018
sall1asal-like 1a (Drosophila)0.018
flt4fms-related tyrosine kinase 40.018
tbx6T-box gene 60.018
vat1vesicle amine transport protein 1 homolog (T californica)0.018
her12hairy-related 120.018
her2hairy-related 20.017
pcdh10bprotocadherin 10b0.017
slc9a3r1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.016
rx1retinal homeobox gene 10.016
tcf12transcription factor 120.016
mpped2metallophosphoesterase domain containing 20.015
nr2f1bnuclear receptor subfamily 2, group F, member 1b0.014
gng13aguanine nucleotide binding protein (G protein), gamma 13a0.014
hbae1hemoglobin alpha embryonic-10.014
rhbdl3rhomboid, veinlet-like 3 (Drosophila)0.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism