The network for 'embryonic axis specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

embryonic axis specification

The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.

NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.998
SMAD3SMAD family member 30.618
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.609
SMAD1SMAD family member 10.551
RBL2retinoblastoma-like 2 (p130)0.521
SMAD2SMAD family member 20.316
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.296
KEAP1kelch-like ECH-associated protein 10.158
OCRLoculocerebrorenal syndrome of Lowe0.146
EIF4A3eukaryotic translation initiation factor 4A30.138
NXF1nuclear RNA export factor 10.113
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.113
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.104
ELAVL1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.096
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.077
BMPR1Abone morphogenetic protein receptor, type IA0.067
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.064
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.063
SMAD7SMAD family member 70.057
CUL1cullin 10.055
PRKCZprotein kinase C, zeta0.055
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.043
SMURF2SMAD specific E3 ubiquitin protein ligase 20.042
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.042
GDAguanine deaminase0.040
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.038
RHOAras homolog gene family, member A0.038
SCHIP1schwannomin interacting protein 10.037
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.037
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.035
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.035
MAGOHmago-nashi homolog, proliferation-associated (Drosophila)0.034
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.033
YAP1Yes-associated protein 10.031
HNRNPCheterogeneous nuclear ribonucleoprotein C (C1/C2)0.027
BBS10Bardet-Biedl syndrome 100.026
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.026
CD44CD44 molecule (Indian blood group)0.025
NCF2neutrophil cytosolic factor 20.025
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.024
CLNS1Achloride channel, nucleotide-sensitive, 1A0.024
PRKCIprotein kinase C, iota0.023
CUL2cullin 20.022
FN1fibronectin 10.021
PTPN11protein tyrosine phosphatase, non-receptor type 110.020
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.019
ANAPC5anaphase promoting complex subunit 50.018
BMP1bone morphogenetic protein 10.018
ANAPC1anaphase promoting complex subunit 10.017
NCF1neutrophil cytosolic factor 10.017
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.017
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.017
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.016
ANAPC7anaphase promoting complex subunit 70.015
RBX1ring-box 1, E3 ubiquitin protein ligase0.014
ADAM17ADAM metallopeptidase domain 170.014
SETSET nuclear oncogene0.014
HSP90AB1heat shock protein 90kDa alpha (cytosolic), class B member 10.014
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.013
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.012
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.012
MAP2K1mitogen-activated protein kinase kinase 10.012
TGFB1transforming growth factor, beta 10.011
PICALMphosphatidylinositol binding clathrin assembly protein0.011
FSTL1follistatin-like 10.011
RAB1ARAB1A, member RAS oncogene family0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
goa-1Protein GOA-10.124
par-5Protein PAR-50.085
mpk-1Protein MPK-10.034
let-60Protein LET-600.028
glh-1Protein GLH-10.027
wrm-1Protein WRM-10.025
lin-45Protein LIN-450.025
pgl-1Protein PGL-10.019
C50B8.1Protein C50B8.10.016
egl-15Protein EGL-150.015
lin-29Protein LIN-290.014
tra-1Protein TRA-10.014
rec-8Protein REC-80.014
chk-1Protein CHK-10.013
snr-3Protein SNR-30.013
mac-1Protein MAC-10.013
gpb-1Protein GPB-10.013
lin-5Protein LIN-50.012
par-2Protein PAR-20.011
cec-9Protein CEC-90.011
nud-1Protein NUD-10.010
W03F8.4Protein W03F8.40.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nanos3nanos homolog 30.928
piwil1piwi-like 1 (Drosophila)0.689
tbx20T-box 200.688
has2hyaluronan synthase 20.580
ca15bcarbonic anhydrase XV b0.371
vasavasa homolog0.265
pou5f1POU domain, class 5, transcription factor 10.264
dazldaz-like gene0.219
tbx16T-box gene 160.203
bmp2bbone morphogenetic protein 2b0.196
runx1runt-related transcription factor 10.190
ntlano tail a0.179
elavl2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.170
orgoogenesis-related gene0.169
pax2apaired box gene 2a0.149
mespbmesoderm posterior b0.126
pak2ap21 (CDKN1A)-activated kinase 2a0.125
dlg2discs, large (Drosophila) homolog 20.120
aplnrbapelin receptor b0.115
etv2ets variant gene 20.109
spsb4asplA/ryanodine receptor domain and SOCS box containing 4a0.104
mespamesoderm posterior a0.102
her1hairy-related 10.098
oepone-eyed pinhead0.089
bmp4bone morphogenetic protein 40.088
fgf3fibroblast growth factor 30.087
pkd2polycystic kidney disease 20.085
ndr2nodal-related 20.084
gngt1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 10.081
her7hairy and enhancer of split related-70.078
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.078
foxi1forkhead box I10.076
cdc42cell division cycle 420.071
pcdh8protocadherin 80.069
brd2abromodomain-containing 2a0.068
sybusyntabulin (syntaxin-interacting)0.059
ryr1bryanodine receptor 1b (skeletal)0.058
acvr1bactivin A receptor, type IB0.055
dnddead end0.054
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.050
evx1even-skipped homeobox 10.048
cdh2cadherin 2, neuronal0.047
gdf6agrowth differentiation factor 6a0.045
wnt4awingless-type MMTV integration site family, member 4a0.043
brca2breast cancer 2, early onset0.042
wnt2bbwingless-type MMTV integration site family, member 2Bb0.042
paqr5aprogestin and adipoQ receptor family member Va0.041
hhiphedgehog interacting protein0.041
copebcore promoter element binding protein0.041
fezf2FEZ family zinc finger 20.039
zfyve26zinc finger, FYVE domain containing 260.039
ef1ETS-related factor10.039
smad5MAD homolog 5 (Drosophila)0.039
rfx2regulatory factor X, 2 (influences HLA class II expression)0.038
pobpartial optokinetic response b0.036
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.035
wnt11wingless-type MMTV integration site family, member 110.035
acvr1lactivin A receptor, type I like0.034
laptm4alysosomal-associated protein transmembrane 4 alpha0.034
gli1GLI-Kruppel family member 10.034
cdx4caudal type homeo box transcription factor 40.033
six4bsine oculis homeobox homolog 4b0.032
flncbfilamin C, gamma b (actin binding protein 280)0.031
epb4.1l4erythrocyte protein band 4.1-like 40.031
arf2ADP-ribosylation factor 20.031
snx6sorting nexin 60.031
lef1lymphocyte enhancer binding factor 10.030
fgf24fibroblast growth factor 240.030
supt6hsuppressor of Ty 6 homolog0.030
sox32SRY-box containing gene 320.029
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.029
ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39b0.028
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.028
tbx6T-box gene 60.028
sesn1sestrin 10.028
spsb1splA/ryanodine receptor domain and SOCS box containing 10.028
gata2aGATA-binding protein 2a0.028
znf711zinc finger protein 7110.027
piwil2piwi-like 2 (Drosophila)0.027
fevFEV (ETS oncogene family)0.026
sept2septin 20.026
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.026
eif1axbeukaryotic translation initiation factor 1A, X-linked, b0.026
tbx5bT-box 5b0.026
neurog1neurogenin 10.025
per3period homolog 3 (Drosophila)0.025
lamc1laminin, gamma 10.025
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
bratbrain tumor0.980
magomago nashi0.943
traltrailer hitch0.920
Hel25EHelicase at 25E0.911
ksrkinase suppressor of ras0.888
par-6CG5884 gene product from transcript CG5884-RA0.855
Dcp1Decapping protein 10.843
Src64BSrc oncogene at 64B0.823
Stat92ESignal-transducer and activator of transcription protein at 92E0.807
phlpole hole0.749
BicDBicaudal D0.725
Fmr1CG6203 gene product from transcript CG6203-RC0.705
orboo18 RNA-binding protein0.697
eyaeyes absent0.688
me31Bmaternal expression at 31B0.647
spn-Espindle E0.598
CG6854CG6854 gene product from transcript CG6854-RC0.574
DadDaughters against dpp0.543
pitaCG3941 gene product from transcript CG3941-RA0.515
sec5CG8843 gene product from transcript CG8843-RA0.502
Hrb27CHeterogeneous nuclear ribonucleoprotein at 27C0.497
par-1CG8201 gene product from transcript CG8201-RA0.487
Myd88CG2078 gene product from transcript CG2078-RA0.467
aPKCatypical protein kinase C0.367
salmspalt major0.362
hydhyperplastic discs0.360
gcmglial cells missing0.338
cpacapping protein alpha0.326
cicubitus interruptus0.320
Fs(2)KetFemale sterile (2) Ketel0.317
KhcKinesin heavy chain0.316
Rac1CG2248 gene product from transcript CG2248-RA0.313
snostrawberry notch0.305
CG4771CG4771 gene product from transcript CG4771-RA0.301
Btk29ABtk family kinase at 29A0.280
fkhfork head0.279
RpL10AbRibosomal protein L10Ab0.269
gbbglass bottom boat0.240
ovoCG6824 gene product from transcript CG6824-RE0.230
DpDP transcription factor0.221
spn-FCG12114 gene product from transcript CG12114-RA0.207
CG10260CG10260 gene product from transcript CG10260-RB0.203
TER94CG2331 gene product from transcript CG2331-RA0.195
Cdc42CG12530 gene product from transcript CG12530-RA0.192
CG34449CG34449 gene product from transcript CG34449-RB0.186
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lhx1LIM homeobox protein 10.960
Pitx2paired-like homeodomain transcription factor 20.957
Ctnnb1catenin (cadherin associated protein), beta 10.945
Shhsonic hedgehog0.902
Pax2paired box gene 20.870
Tbx1T-box 10.856
Emx2empty spiracles homolog 2 (Drosophila)0.849
Msx1homeobox, msh-like 10.846
Fgfr2fibroblast growth factor receptor 20.844
Otx2orthodenticle homolog 2 (Drosophila)0.814
Gata4GATA binding protein 40.759
Foxc1forkhead box C10.686
Smad1MAD homolog 1 (Drosophila)0.660
Fgf8fibroblast growth factor 80.648
Pitx1paired-like homeodomain transcription factor 10.642
Gsk3bglycogen synthase kinase 3 beta0.605
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.576
Smad4MAD homolog 4 (Drosophila)0.554
Gli3GLI-Kruppel family member GLI30.536
Axin1axin 10.479
Foxh1forkhead box H10.470
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.456
Apcadenomatosis polyposis coli0.443
Ptpn11protein tyrosine phosphatase, non-receptor type 110.376
Foxa2forkhead box A20.360
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.330
Wt1Wilms tumor 1 homolog0.326
Bmpr1abone morphogenetic protein receptor, type 1A0.314
Prkar1aprotein kinase, cAMP dependent regulatory, type I, alpha0.313
Dlx5distal-less homeobox 50.304
Dok1docking protein 10.280
Hand1heart and neural crest derivatives expressed transcript 10.264
Gli2GLI-Kruppel family member GLI20.251
Sox9SRY-box containing gene 90.248
Hoxa1homeobox A10.234
UncxUNC homeobox0.218
Snap25synaptosomal-associated protein 250.211
Rxraretinoid X receptor alpha0.203
Alx4aristaless-like homeobox 40.201
Pax3paired box gene 30.201
Inpp5dinositol polyphosphate-5-phosphatase D0.196
Foxa1forkhead box A10.192
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.185
Smad3MAD homolog 3 (Drosophila)0.185
Smad6MAD homolog 6 (Drosophila)0.183
Cdkn1bcyclin-dependent kinase inhibitor 1B0.181
Fgfr1fibroblast growth factor receptor 10.179
Fgf10fibroblast growth factor 100.174
Hoxa2homeobox A20.171
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.169
Stat3signal transducer and activator of transcription 30.169
Gdnfglial cell line derived neurotrophic factor0.159
Ptch1patched homolog 10.158
Amhr2anti-Mullerian hormone type 2 receptor0.154
Pax8paired box gene 80.150
Zic3zinc finger protein of the cerebellum 30.141
Gbx2gastrulation brain homeobox 20.128
Rargretinoic acid receptor, gamma0.127
Nr5a1nuclear receptor subfamily 5, group A, member 10.126
Hoxb6homeobox B60.121
Hmx3H6 homeobox 30.118
Cdkn2acyclin-dependent kinase inhibitor 2A0.118
Wnt3awingless-related MMTV integration site 3A0.116
Meox2mesenchyme homeobox 20.114
Pax9paired box gene 90.112
Nkx2-1NK2 homeobox 10.109
Dlg1discs, large homolog 1 (Drosophila)0.107
Psen1presenilin 10.107
Gdf1growth differentiation factor 10.101
Actn1actinin, alpha 10.100
Ror2receptor tyrosine kinase-like orphan receptor 20.098
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.098
Bmp4bone morphogenetic protein 40.097
Hand2heart and neural crest derivatives expressed transcript 20.095
Cldn3claudin 30.095
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.094
En1engrailed 10.093
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.093
Foxc2forkhead box C20.091
Map3k7mitogen-activated protein kinase kinase kinase 70.091
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.090
Msx2homeobox, msh-like 20.088
Fzd8frizzled homolog 8 (Drosophila)0.088
Gata6GATA binding protein 60.085
Pou4f2POU domain, class 4, transcription factor 20.084
Sox3SRY-box containing gene 30.082
Dlg4discs, large homolog 4 (Drosophila)0.082
Nf1neurofibromatosis 10.082
Arid1aAT rich interactive domain 1A (SWI-like)0.082
Tbx3T-box 30.081
Nab2Ngfi-A binding protein 20.080
Lhx3LIM homeobox protein 30.078
Hoxd11homeobox D110.077
Foxf1aforkhead box F1a0.076
Otx1orthodenticle homolog 1 (Drosophila)0.075
Vax1ventral anterior homeobox containing gene 10.071
Drd2dopamine receptor D20.070
Tcl1T-cell lymphoma breakpoint 10.070
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.460
Mapre1microtubule-associated protein, RP/EB family, member 10.199
Stxbp1syntaxin binding protein 10.095
Rbbp7retinoblastoma binding protein 70.088
Clic4chloride intracellular channel 40.082
Hnrnpfheterogeneous nuclear ribonucleoprotein F0.082
Tcf12transcription factor 120.082
Snap25synaptosomal-associated protein 250.078
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.071
Syn1synapsin I0.063
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.062
Ctxn1cortexin 10.056
Vamp2vesicle-associated membrane protein 20.056
Arf6ADP-ribosylation factor 60.056
Sdk2sidekick homolog 2 (chicken)0.052
Azin1antizyme inhibitor 10.051
Lbrlamin B receptor0.050
Dgkidiacylglycerol kinase, iota0.050
Grin1glutamate receptor, ionotropic, N-methyl D-aspartate 10.048
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.048
Dlg4discs, large homolog 4 (Drosophila)0.047
Baiap2BAI1-associated protein 20.045
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.045
Golph3golgi phosphoprotein 3 (coat-protein)0.045
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.044
Capza2capping protein (actin filament) muscle Z-line, alpha 20.042
Ptprcprotein tyrosine phosphatase, receptor type, C0.041
Actr3ARP3 actin-related protein 3 homolog (yeast)0.041
Kdrkinase insert domain receptor0.041
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.041
Rab3aRAB3A, member RAS oncogene family0.040
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.039
Ddx3xDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.038
Jtbjumping translocation breakpoint0.037
Pcnaproliferating cell nuclear antigen0.037
Pcsk2proprotein convertase subtilisin/kexin type 20.037
Actg2actin, gamma 2, smooth muscle, enteric0.036
Arpc5actin related protein 2/3 complex, subunit 50.035
Ptov1prostate tumor overexpressed 10.035
Cplx1complexin 10.035
Emp1epithelial membrane protein 10.035
Senp2Sumo1/sentrin/SMT3 specific peptidase 20.034
Phaxphosphorylated adaptor for RNA export0.034
Rac1ras-related C3 botulinum toxin substrate 10.034
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.033
Ube2aubiquitin-conjugating enzyme E2A (RAD6 homolog)0.033
Dlgap3discs, large (Drosophila) homolog-associated protein 30.033
Tpm4tropomyosin 40.032
Elk3ELK3, ETS-domain protein0.031
Jak2Janus kinase 20.031
Cltcclathrin, heavy chain (Hc)0.031
Mapk9mitogen-activated protein kinase 90.031
Eef1e1eukaryotic translation elongation factor 1 epsilon 10.031
Stk17bserine/threonine kinase 17b0.030
Nxph4neurexophilin 40.030
Clns1achloride channel, nucleotide-sensitive, 1A0.029
Limd2LIM domain containing 20.029
Dact3dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)0.029
Gpsm3G-protein signaling modulator 3 (AGS3-like, C. elegans)0.029
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.029
Mlf2myeloid leukemia factor 20.028
Hprt1hypoxanthine phosphoribosyltransferase 10.028
Anp32eacidic (leucine-rich) nuclear phosphoprotein 32 family, member E0.028
Tpm3tropomyosin 3, gamma0.028
Sh3gl2SH3-domain GRB2-like 20.028
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.028
Elovl5ELOVL family member 5, elongation of long chain fatty acids (yeast)0.028
Zfand5zinc finger, AN1-type domain 50.028
Akirin2akirin 20.028
Stx1asyntaxin 1A (brain)0.027
Rnf4ring finger protein 40.027
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.027
Actbactin, beta0.027
Sfrs2splicing factor, arginine/serine-rich 20.027
Snap23synaptosomal-associated protein 230.027
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.027
Acta2smooth muscle alpha-actin0.026
Ier5immediate early response 50.026
Mcammelanoma cell adhesion molecule0.026
Atf2activating transcription factor 20.026
Hnrpdlheterogeneous nuclear ribonucleoprotein D-like0.026
FynFYN oncogene related to SRC, FGR, YES0.026
Tmod3tropomodulin 30.025
Arpc2actin related protein 2/3 complex, subunit 20.025
Psma4proteasome (prosome, macropain) subunit, alpha type 40.025
H3f3bH3 histone, family 3B0.025
Cdh5cadherin 50.024
Iqgap1IQ motif containing GTPase activating protein 10.024
Vav1vav 1 guanine nucleotide exchange factor0.024
Vamp3vesicle-associated membrane protein 30.024
Apba2amyloid beta (A4) precursor protein-binding, family A, member 20.024
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.024
Pias2protein inhibitor of activated STAT, 20.024
Gsk3aglycogen synthase kinase 3 alpha0.024
Camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.023
Exoc5exocyst complex component 50.023
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism