The network for 'negative regulation of interleukin 2 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of interleukin 2 production

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.

NameDescriptionProbabilityFunc Analog Organism
CCR5chemokine (C-C motif) receptor 50.815
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.444
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.322
CXCL2chemokine (C-X-C motif) ligand 20.266
WDR5WD repeat domain 50.230
CXCL9chemokine (C-X-C motif) ligand 90.192
ARandrogen receptor0.100
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.090
KAT5K(lysine) acetyltransferase 50.076
TRIM21tripartite motif containing 210.074
CCL2chemokine (C-C motif) ligand 20.070
CCL8chemokine (C-C motif) ligand 80.063
PMLpromyelocytic leukemia0.061
MED15mediator complex subunit 150.058
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.055
CCR7chemokine (C-C motif) receptor 70.053
CXCL10chemokine (C-X-C motif) ligand 100.052
RGS1regulator of G-protein signaling 10.049
SLMAPsarcolemma associated protein0.048
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.047
TRIM5tripartite motif containing 50.045
CCL13chemokine (C-C motif) ligand 130.041
DPP4dipeptidyl-peptidase 40.039
CCL5chemokine (C-C motif) ligand 50.035
EIF3Feukaryotic translation initiation factor 3, subunit F0.033
ZNF263zinc finger protein 2630.033
TNFtumor necrosis factor0.031
PRKD2protein kinase D20.029
CDK11Bcyclin-dependent kinase 11B0.028
HDAC4histone deacetylase 40.026
MDM4Mdm4 p53 binding protein homolog (mouse)0.026
CXCL11chemokine (C-X-C motif) ligand 110.026
TRIM39tripartite motif containing 390.025
IL8interleukin 80.023
PLK3polo-like kinase 30.022
PPARAperoxisome proliferator-activated receptor alpha0.022
IFI16interferon, gamma-inducible protein 160.022
IFNGinterferon, gamma0.021
IL6interleukin 6 (interferon, beta 2)0.018
MAGEA2melanoma antigen family A, 20.018
CCR4chemokine (C-C motif) receptor 40.018
RNF11ring finger protein 110.017
EEF1Geukaryotic translation elongation factor 1 gamma0.017
IL1Binterleukin 1, beta0.017
ARIH2ariadne homolog 2 (Drosophila)0.016
FPR3formyl peptide receptor 30.016
MMP12matrix metallopeptidase 12 (macrophage elastase)0.016
IKZF3IKAROS family zinc finger 3 (Aiolos)0.016
CCL19chemokine (C-C motif) ligand 190.014
IDEinsulin-degrading enzyme0.014
ZNF473zinc finger protein 4730.013
CXCL13chemokine (C-X-C motif) ligand 130.013
HDAC7histone deacetylase 70.013
CCL4chemokine (C-C motif) ligand 40.013
ATMataxia telangiectasia mutated0.013
TRIM17tripartite motif containing 170.012
UBDubiquitin D0.012
CCL22chemokine (C-C motif) ligand 220.011
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.011
IL7Rinterleukin 7 receptor0.011
NCOR1nuclear receptor corepressor 10.011
IL2RBinterleukin 2 receptor, beta0.011
TRIM26tripartite motif containing 260.010
FHL1four and a half LIM domains 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gata6GATA binding protein 60.975
Cd80CD80 antigen0.905
Irf1interferon regulatory factor 10.841
Gata4GATA binding protein 40.427
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.404
Sox4SRY-box containing gene 40.367
PycardPYD and CARD domain containing0.340
Pdcd1programmed cell death 10.311
Ikzf1IKAROS family zinc finger 10.238
Socs1suppressor of cytokine signaling 10.225
Appamyloid beta (A4) precursor protein0.199
Il27rainterleukin 27 receptor, alpha0.172
Dmap1DNA methyltransferase 1-associated protein 10.170
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.167
Il2interleukin 20.161
Foxp2forkhead box P20.150
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.125
Tbx5T-box 50.116
Foxp1forkhead box P10.111
Zfpm2zinc finger protein, multitype 20.104
Foxp3forkhead box P30.085
Dll1delta-like 1 (Drosophila)0.085
TcraT-cell receptor alpha chain0.081
Card11caspase recruitment domain family, member 110.081
Cd28CD28 antigen0.080
Ctla4cytotoxic T-lymphocyte-associated protein 40.073
Map3k8mitogen-activated protein kinase kinase kinase 80.073
Gata5GATA binding protein 50.068
Foxn1forkhead box N10.065
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.064
Ifngr1interferon gamma receptor 10.052
Prf1perforin 1 (pore forming protein)0.049
Ep400E1A binding protein p4000.048
Il4interleukin 40.047
Stat6signal transducer and activator of transcription 60.046
Il2rbinterleukin 2 receptor, beta chain0.045
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.044
Cd44CD44 antigen0.044
Map3k14mitogen-activated protein kinase kinase kinase 140.043
Mybmyeloblastosis oncogene0.041
Aplp2amyloid beta (A4) precursor-like protein 20.039
Ptpn14protein tyrosine phosphatase, non-receptor type 140.038
Casp4caspase 4, apoptosis-related cysteine peptidase0.038
MefvMediterranean fever0.036
Batf2basic leucine zipper transcription factor, ATF-like 20.035
Ttc7tetratricopeptide repeat domain 70.033
Tbx21T-box 210.033
Tnip1TNFAIP3 interacting protein 10.033
Atxn1ataxin 10.032
Cd5CD5 antigen0.031
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.031
Ifnginterferon gamma0.031
MaxMax protein0.029
Cyp26c1cytochrome P450, family 26, subfamily c, polypeptide 10.027
Gli2GLI-Kruppel family member GLI20.026
Arid1bAT rich interactive domain 1B (SWI-like)0.025
Latlinker for activation of T cells0.024
Plp1proteolipid protein (myelin) 10.022
Notch3Notch gene homolog 3 (Drosophila)0.022
P4hbprolyl 4-hydroxylase, beta polypeptide0.022
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.021
Jak1Janus kinase 10.020
Cd4CD4 antigen0.020
Zfp362zinc finger protein 3620.020
Epha1Eph receptor A10.020
Rgs1regulator of G-protein signaling 10.020
Relreticuloendotheliosis oncogene0.019
Dsg4desmoglein 40.019
Il22interleukin 220.019
Sp110Sp110 nuclear body protein0.017
Casp1caspase 10.017
Ctslcathepsin L0.017
Cxcl9chemokine (C-X-C motif) ligand 90.017
Ooepoocyte expressed protein homolog (dog)0.017
Ciccapicua homolog (Drosophila)0.017
Hoxa1homeobox A10.017
Traf6TNF receptor-associated factor 60.016
Opcmlopioid binding protein/cell adhesion molecule-like0.016
TcrdT-cell receptor delta chain0.016
Batfbasic leucine zipper transcription factor, ATF-like0.016
Icosinducible T-cell co-stimulator0.015
Tbx3T-box 30.015
Mst1rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)0.015
Tle6transducin-like enhancer of split 6, homolog of Drosophila E(spl)0.015
Naip6NLR family, apoptosis inhibitory protein 60.015
Cd274CD274 antigen0.014
Cd160CD160 antigen0.014
Rc3h1RING CCCH (C3H) domains 10.014
Rxraretinoid X receptor alpha0.014
Inhbainhibin beta-A0.014
Ubdubiquitin D0.014
Dusp2dual specificity phosphatase 20.013
Runx1runt related transcription factor 10.013
Wizwidely-interspaced zinc finger motifs0.013
Ccl24chemokine (C-C motif) ligand 240.013
Tbx20T-box 200.013
Cxcr2chemokine (C-X-C motif) receptor 20.013
Ticam1toll-like receptor adaptor molecule 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ctsjcathepsin J0.013
Olr1078olfactory receptor 10780.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism