The network for 'regulation of phospholipase c activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of phospholipase c activity

Any process that modulates the frequency, rate or extent of phospholipase C activity.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
FGF1fibroblast growth factor 1 (acidic)1.000
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.986
PLCG1phospholipase C, gamma 10.861
MPDZmultiple PDZ domain protein0.860
SPRR2Asmall proline-rich protein 2A0.843
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.808
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.806
ANGangiogenin, ribonuclease, RNase A family, 50.726
RNASE4ribonuclease, RNase A family, 40.654
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.620
FGF10fibroblast growth factor 100.583
SOS1son of sevenless homolog 1 (Drosophila)0.550
FGFR1fibroblast growth factor receptor 10.497
VEGFAvascular endothelial growth factor A0.448
FRS2fibroblast growth factor receptor substrate 20.411
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.370
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.349
BCAR1breast cancer anti-estrogen resistance 10.340
FYBFYN binding protein0.259
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.229
LATlinker for activation of T cells0.197
FGF7fibroblast growth factor 70.189
ARRB1arrestin, beta 10.189
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.186
SHC2SHC (Src homology 2 domain containing) transforming protein 20.185
EGFRepidermal growth factor receptor0.173
PLEKHA1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.134
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.123
ARRDC3arrestin domain containing 30.104
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.103
MAPTmicrotubule-associated protein tau0.090
KITLGKIT ligand0.087
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.087
CDH5cadherin 5, type 2 (vascular endothelium)0.064
SOS2son of sevenless homolog 2 (Drosophila)0.061
PTPRJprotein tyrosine phosphatase, receptor type, J0.057
SELPselectin P (granule membrane protein 140kDa, antigen CD62)0.056
PGFplacental growth factor0.055
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.051
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.050
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.050
KRT8keratin 80.046
FYNFYN oncogene related to SRC, FGR, YES0.046
NINninein (GSK3B interacting protein)0.044
GSK3Bglycogen synthase kinase 3 beta0.042
FGFR3fibroblast growth factor receptor 30.041
GAB1GRB2-associated binding protein 10.040
FLT4fms-related tyrosine kinase 40.040
HPGDShematopoietic prostaglandin D synthase0.039
HSPG2heparan sulfate proteoglycan 20.037
CPA3carboxypeptidase A3 (mast cell)0.035
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.033
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.031
CTGFconnective tissue growth factor0.031
AGTR1angiotensin II receptor, type 10.031
SHANK3SH3 and multiple ankyrin repeat domains 30.030
HDChistidine decarboxylase0.030
RNH1ribonuclease/angiogenin inhibitor 10.030
SHBSrc homology 2 domain containing adaptor protein B0.028
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.028
SELEselectin E0.028
GRAP2GRB2-related adaptor protein 20.027
PTENphosphatase and tensin homolog0.026
LDLRlow density lipoprotein receptor0.025
CCR2chemokine (C-C motif) receptor 20.021
OR2AG1olfactory receptor, family 2, subfamily AG, member 10.021
MAP2microtubule-associated protein 20.019
PDGFAplatelet-derived growth factor alpha polypeptide0.019
RIN1Ras and Rab interactor 10.019
RETret proto-oncogene0.019
RNASE3ribonuclease, RNase A family, 30.019
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.019
PRKCQprotein kinase C, theta0.019
FGF8fibroblast growth factor 8 (androgen-induced)0.018
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.018
GPR171G protein-coupled receptor 1710.017
CTSGcathepsin G0.017
VAV1vav 1 guanine nucleotide exchange factor0.017
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.016
PTK2BPTK2B protein tyrosine kinase 2 beta0.015
MAPK8mitogen-activated protein kinase 80.014
ADRB3adrenergic, beta-3-, receptor0.014
FASLGFas ligand (TNF superfamily, member 6)0.013
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.013
MAPK10mitogen-activated protein kinase 100.013
NOSTRINnitric oxide synthase trafficker0.013
HTR1B5-hydroxytryptamine (serotonin) receptor 1B0.012
CCR3chemokine (C-C motif) receptor 30.012
GHRHRgrowth hormone releasing hormone receptor0.012
NEDD4neural precursor cell expressed, developmentally down-regulated 40.012
DARCDuffy blood group, chemokine receptor0.011
PDGFCplatelet derived growth factor C0.011
GPR6G protein-coupled receptor 60.011
EFSembryonal Fyn-associated substrate0.011
ADORA3adenosine A3 receptor0.011
TNFSF8tumor necrosis factor (ligand) superfamily, member 80.011
PGRprogesterone receptor0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.707
esr2bestrogen receptor 2b0.263
fgf4fibroblast growth factor 40.210
sulf1sulfatase 10.165
rhoubras homolog gene family, member Ub0.134
tie2endothelium-specific receptor tyrosine kinase 20.125
meis2.2myeloid ecotropic viral integration site 2.20.118
fstl1bfollistatin-like 1b0.081
esamaendothelial cell adhesion molecule a0.080
tbpl2TATA box binding protein like 20.055
bmpr1babone morphogenetic protein receptor, type 1ba0.055
fgf8bfibroblast growth factor 8 b0.048
plxnd1plexin D10.048
bmp15bone morphogenetic protein 150.047
tjp1tight junction protein 1 (zona occludens 1)0.043
st14asuppression of tumorigenicity 14 (colon carcinoma) a0.040
dnmt4DNA (cytosine-5-)-methyltransferase 40.039
notch3notch homolog 30.037
prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.036
efnb2aephrin B2a0.034
phf21aPHD finger protein 21A0.032
fmnl2aformin-like 2a0.032
phexphosphate regulating gene with homologues to endopeptidases on the X chromosome0.031
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.029
lmx1b.1LIM homeobox transcription factor 1, beta 10.028
lrrtm1leucine rich repeat transmembrane neuronal 10.025
pea3ETS-domain transcription factor pea30.025
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.024
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.024
sinupsiaz-interacting nuclear protein0.023
arap3ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 30.023
cnga5cyclic nucleotide gated channel alpha 50.023
stab2stabilin 20.023
cald1caldesmon 10.022
msi1musashi homolog 1 (Drosophila)0.022
bsk146brain specific kinase 1460.022
abcc5ATP-binding cassette, sub-family C (CFTR/MRP), member 50.021
nppanatriuretic peptide precursor A0.021
rykreceptor-like tyrosine kinase0.021
fgf22fibroblast growth factor 220.020
csrnp1bcysteine-serine-rich nuclear protein 1b0.020
igf1rbinsulin-like growth factor 1b receptor0.020
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.019
cnn2calponin 20.019
ptpraprotein tyrosine phosphatase, receptor type, A0.019
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.019
mtmr8myotubularin related protein 80.019
arhgef11Rho guanine nucleotide exchange factor (GEF) 110.019
pdlim3bPDZ and LIM domain 3b0.018
vtg4vitellogenin 40.018
alpalkaline phosphatase0.018
akt2v-akt murine thymoma viral oncogene homolog 20.018
ddcdopa decarboxylase0.017
six4.3sine oculis homeobox homolog 4.30.017
lhx2bLIM homeobox 2b0.017
usp49ubiquitin specific peptidase 490.017
pdgfbplatelet derived growth factor, B polypeptide0.017
spry1sprouty homolog 1 (Drosophila)0.017
chrm2acholinergic receptor, muscarinic 2a0.017
mmp17amatrix metallopeptidase 17a0.017
ifnphi1interferon phi 10.017
edaectodysplasin A0.017
fynaFYN oncogene related to SRC, FGR, YES a0.016
fzd7bfrizzled homolog 7b0.016
pth2rparathyroid hormone 2 receptor0.016
lmx1b.2LIM homeobox transcription factor 1, beta 20.016
adrbk2adrenergic, beta, receptor kinase 20.015
vegfaavascular endothelial growth factor Aa0.015
rhbdl2rhomboid, veinlet-like 2 (Drosophila)0.015
prickle2prickle-like 2 (Drosophila)0.015
nr1h3nuclear receptor subfamily 1, group H, member 30.015
sema3aasemaphorin 3aa0.015
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.014
oc90otoconin 900.014
sfrp5secreted frizzled-related protein 50.014
dazldaz-like gene0.014
acp5bacid phosphatase 5b, tartrate resistant0.014
kirrelakin of IRRE like a0.014
wnt3awingless-type MMTV integration site family, member 3A0.014
lgi1bleucine-rich, glioma inactivated 1b0.013
siah2lseven in absentia homolog 2 (Drosophila)-like0.013
gro1groucho 10.013
tas2r202taste receptor, type 2, member 2020.012
jazf1bJAZF zinc finger 1b0.012
ppap2cphosphatidic acid phosphatase type 2C0.012
trpv4transient receptor potential cation channel, subfamily V, member 40.012
hcrthypocretin (orexin) neuropeptide precursor0.012
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.012
tjp2atight junction protein 2a (zona occludens 2)0.012
rbm24bRNA binding motif protein 24b0.011
six1bsine oculis homeobox homolog 1b0.011
vtg2vitellogenin 20.011
per3period homolog 3 (Drosophila)0.011
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
CblCasitas B-lineage lymphoma0.993
Ptk2PTK2 protein tyrosine kinase 20.973
Leprleptin receptor0.824
Dok1docking protein 10.820
WasWiskott-Aldrich syndrome homolog (human)0.819
Inpp5dinositol polyphosphate-5-phosphatase D0.798
Rab6RAB6, member RAS oncogene family0.755
Trp53transformation related protein 530.630
Dok2docking protein 20.622
TcraT-cell receptor alpha chain0.619
Thrathyroid hormone receptor alpha0.593
Ptenphosphatase and tensin homolog0.523
Plcg1phospholipase C, gamma 10.509
Itgb1integrin beta 1 (fibronectin receptor beta)0.493
Cd247CD247 antigen0.486
FynFyn proto-oncogene0.477
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.466
Nos2nitric oxide synthase 2, inducible0.461
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.450
Csf1colony stimulating factor 1 (macrophage)0.438
Acvr1activin A receptor, type 10.432
Sellselectin, lymphocyte0.430
Notch2Notch gene homolog 2 (Drosophila)0.425
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.416
Fgfr2fibroblast growth factor receptor 20.382
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.373
Cd19CD19 antigen0.369
Selpselectin, platelet0.342
Plcg2phospholipase C, gamma 20.330
Agtr1aangiotensin II receptor, type 1a0.319
Prrx1paired related homeobox 10.307
Il2rbinterleukin 2 receptor, beta chain0.293
Ptpreprotein tyrosine phosphatase, receptor type, E0.291
Fgfr1fibroblast growth factor receptor 10.287
Prkceprotein kinase C, epsilon0.286
Hcls1hematopoietic cell specific Lyn substrate 10.264
Bcar1breast cancer anti-estrogen resistance 10.258
Ptprcprotein tyrosine phosphatase, receptor type, C0.251
Bmp2bone morphogenetic protein 20.249
Tgfbr2transforming growth factor, beta receptor II0.243
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.235
Runx2runt related transcription factor 20.224
Cd22CD22 antigen0.219
Apoeapolipoprotein E0.213
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.209
Vegfavascular endothelial growth factor A0.200
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.195
Duox2dual oxidase 20.194
Itgb3integrin beta 30.191
Tnfrsf11btumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)0.191
Ldlrlow density lipoprotein receptor0.191
Sykbspleen tyrosine kinase0.188
Cd40CD40 antigen0.185
Fshrfollicle stimulating hormone receptor0.180
Hckhemopoietic cell kinase0.178
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.176
Lyl1lymphoblastomic leukemia 10.174
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.174
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.172
Ednraendothelin receptor type A0.170
Itgb2integrin beta 20.167
FybFYN binding protein0.166
Nos3nitric oxide synthase 3, endothelial cell0.165
Fcgr1Fc receptor, IgG, high affinity I0.155
BlnkB-cell linker0.155
F2rl2coagulation factor II (thrombin) receptor-like 20.149
Wt1Wilms tumor 1 homolog0.143
Igf1rinsulin-like growth factor I receptor0.142
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.141
Cybbcytochrome b-245, beta polypeptide0.136
Lcklymphocyte protein tyrosine kinase0.134
Cd28CD28 antigen0.132
Pgrprogesterone receptor0.131
Ms4a2membrane-spanning 4-domains, subfamily A, member 20.131
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.128
Ncr1natural cytotoxicity triggering receptor 10.128
C5ar1complement component 5a receptor 10.123
Gna15guanine nucleotide binding protein, alpha 150.120
Ren1renin 1 structural0.119
Kitkit oncogene0.115
Slc9a3r2solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 20.114
Gpr97G protein-coupled receptor 970.114
Cnr2cannabinoid receptor 2 (macrophage)0.114
Psen1presenilin 10.112
Ghrgrowth hormone receptor0.109
Latlinker for activation of T cells0.109
Zap70zeta-chain (TCR) associated protein kinase0.108
Itgaxintegrin alpha X0.107
Ccr6chemokine (C-C motif) receptor 60.104
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.104
Fgfr4fibroblast growth factor receptor 40.100
Aoahacyloxyacyl hydrolase0.099
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.097
S1pr4sphingosine-1-phosphate receptor 40.097
Clnkcytokine-dependent hematopoietic cell linker0.097
Fgf7fibroblast growth factor 70.095
Pdgfbplatelet derived growth factor, B polypeptide0.094
SrcRous sarcoma oncogene0.092
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Akt2v-akt murine thymoma viral oncogene homolog 20.045
Rup2urinary protein 20.039
Lims1LIM and senescent cell antigen-like domains 10.025
Ccr5chemokine (C-C motif) receptor 50.022
Epas1endothelial PAS domain protein 10.017
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.016
Spp2secreted phosphoprotein 20.016
Igf2insulin-like growth factor 20.015
Csf1colony stimulating factor 1 (macrophage)0.015
Map3k3mitogen activated protein kinase kinase kinase 30.014
Foxa1forkhead box A10.014
Mpeg1macrophage expressed 10.014
Folh1folate hydrolase 10.012
Cfpcomplement factor properdin0.012
Ntsr2neurotensin receptor 20.012
Slc22a7solute carrier family 22 (organic anion transporter), member 70.011
Apohapolipoprotein H (beta-2-glycoprotein I)0.011
Sh2b3SH2B adaptor protein 30.011
Gcgroup specific component0.011
Lim2lens intrinsic membrane protein 20.011
Sdc3syndecan 30.010
Il1rl1interleukin 1 receptor-like 10.010
Gucy1b3guanylate cyclase 1, soluble, beta 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism