The network for 'regulation of phosphatidylinositol 3 kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of phosphatidylinositol 3 kinase activity

Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring.

NameDescriptionProbabilityFunc Analog Organism
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.999
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.999
EGFRepidermal growth factor receptor0.996
FGFR2fibroblast growth factor receptor 20.993
FYNFYN oncogene related to SRC, FGR, YES0.974
SHC1SHC (Src homology 2 domain containing) transforming protein 10.962
VEGFAvascular endothelial growth factor A0.915
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.896
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.818
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.802
FGF1fibroblast growth factor 1 (acidic)0.758
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.726
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.626
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.502
FGFR1fibroblast growth factor receptor 10.500
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.361
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.313
NRP1neuropilin 10.291
PLCG1phospholipase C, gamma 10.240
CCR5chemokine (C-C motif) receptor 50.228
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.217
GRB7growth factor receptor-bound protein 70.162
IGF1Rinsulin-like growth factor 1 receptor0.133
NCOA1nuclear receptor coactivator 10.133
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.129
BLNKB-cell linker0.071
ANGPT2angiopoietin 20.069
SH3KBP1SH3-domain kinase binding protein 10.068
MAP3K5mitogen-activated protein kinase kinase kinase 50.067
SPRR2Asmall proline-rich protein 2A0.065
RXRAretinoid X receptor, alpha0.065
MED28mediator complex subunit 280.063
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.062
GRB2growth factor receptor-bound protein 20.050
IBTKinhibitor of Bruton agammaglobulinemia tyrosine kinase0.049
INSRinsulin receptor0.047
CXCL9chemokine (C-X-C motif) ligand 90.046
CDH5cadherin 5, type 2 (vascular endothelium)0.045
PGFplacental growth factor0.045
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.036
CCL13chemokine (C-C motif) ligand 130.036
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.033
CCR7chemokine (C-C motif) receptor 70.032
GAB1GRB2-associated binding protein 10.032
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.024
CCL19chemokine (C-C motif) ligand 190.023
ANGPT1angiopoietin 10.023
CTBP1C-terminal binding protein 10.022
CXCL11chemokine (C-X-C motif) ligand 110.021
HCKhemopoietic cell kinase0.021
MED25mediator complex subunit 250.021
DLG4discs, large homolog 4 (Drosophila)0.021
TGFB3transforming growth factor, beta 30.020
ARRB1arrestin, beta 10.020
CCL22chemokine (C-C motif) ligand 220.020
THBS1thrombospondin 10.019
WIPF1WAS/WASL interacting protein family, member 10.019
IL10interleukin 100.018
FGF10fibroblast growth factor 100.018
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.018
CCL5chemokine (C-C motif) ligand 50.018
CCL4chemokine (C-C motif) ligand 40.017
IL6interleukin 6 (interferon, beta 2)0.017
IDEinsulin-degrading enzyme0.016
PTK6PTK6 protein tyrosine kinase 60.016
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.015
ITKIL2-inducible T-cell kinase0.015
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.015
IL7Rinterleukin 7 receptor0.015
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.014
AXLAXL receptor tyrosine kinase0.014
DPP4dipeptidyl-peptidase 40.013
CXCL13chemokine (C-X-C motif) ligand 130.013
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.013
SH3BP2SH3-domain binding protein 20.013
IFNGinterferon, gamma0.013
KITLGKIT ligand0.013
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.013
GAB2GRB2-associated binding protein 20.013
AKT2v-akt murine thymoma viral oncogene homolog 20.012
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.012
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.012
CCL2chemokine (C-C motif) ligand 20.012
GAS7growth arrest-specific 70.012
PTPRBprotein tyrosine phosphatase, receptor type, B0.012
VAV3vav 3 guanine nucleotide exchange factor0.011
SYKspleen tyrosine kinase0.011
FGF2fibroblast growth factor 2 (basic)0.011
PDCD6IPprogrammed cell death 6 interacting protein0.011
CAV1caveolin 1, caveolae protein, 22kDa0.010
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.010
TNFtumor necrosis factor0.010
FRS2fibroblast growth factor receptor substrate 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Cdc42CG12530 gene product from transcript CG12530-RA0.940
S6kRPS6-p70-protein kinase0.887
Pi3K92ECG4141 gene product from transcript CG4141-RB0.875
mbcmyoblast city0.721
EphrinCG1862 gene product from transcript CG1862-RA0.427
Dhc64CDynein heavy chain 64C0.420
chicoCG5686 gene product from transcript CG5686-RB0.414
Ras85DRas oncogene at 85D0.347
Akt1CG4006 gene product from transcript CG4006-RA0.330
stumpsCG31317 gene product from transcript CG31317-RC0.317
ThorCG8846 gene product from transcript CG8846-RA0.305
DadDaughters against dpp0.303
Rac2CG8556 gene product from transcript CG8556-RA0.299
aopanterior open0.240
Pk61CProtein kinase 61C0.226
Atg1Autophagy-specific gene 10.218
PtenCG5671 gene product from transcript CG5671-RB0.206
Vrp1Verprolin 10.183
drkdownstream of receptor kinase0.167
Rab7Rab-protein 70.110
MntCG13316 gene product from transcript CG13316-RD0.103
MrtfMyocardin-related transcription factor0.091
HcfHost cell factor0.085
Rho1CG8416 gene product from transcript CG8416-RB0.082
zfh1Zn finger homeodomain 10.069
SmoxSmad on X0.065
InRInsulin-like receptor0.062
Src64BSrc oncogene at 64B0.056
par-1CG8201 gene product from transcript CG8201-RA0.051
ImpL2Ecdysone-inducible gene L20.049
RalaRas-related protein0.049
LanB1CG7123 gene product from transcript CG7123-RA0.046
RhoGEF2CG9635 gene product from transcript CG9635-RF0.042
LanALaminin A0.037
reporeversed polarity0.037
Tao-1CG14217 gene product from transcript CG14217-RF0.037
fogfolded gastrulation0.036
Rab11Rab-protein 110.035
myoglianinCG1838 gene product from transcript CG1838-RD0.034
Rac1CG2248 gene product from transcript CG2248-RA0.034
Btk29ABtk family kinase at 29A0.031
CG1021CG1021 gene product from transcript CG1021-RE0.030
PvrPDGF- and VEGF-receptor related0.030
kibrakibra ortholog0.027
Vap-33-1CG5014 gene product from transcript CG5014-RB0.026
MTF-1Metal response element-binding Transcription Factor-10.025
BicDBicaudal D0.025
nrv2nervana 20.024
SpargelCG9809 gene product from transcript CG9809-RB0.023
jebjelly belly0.023
foxoforkhead box, sub-group O0.023
Gef26CG9491 gene product from transcript CG9491-RB0.022
Pvf2PDGF- and VEGF-related factor 20.021
swshort wing0.021
alpha-Man-IIbCG4606 gene product from transcript CG4606-RA0.021
PGRP-LCPeptidoglycan recognition protein LC0.021
CrebB-17ACyclic-AMP response element binding protein B at 17A0.021
HLH106Helix loop helix protein 1060.020
betaInt-nubeta[nu] integrin0.019
DlicDynein light intermediate chain0.019
RhebCG1081 gene product from transcript CG1081-RA0.018
wbwing blister0.018
Gadd45CG11086 gene product from transcript CG11086-RA0.018
CG5794CG5794 gene product from transcript CG5794-RB0.018
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.978
Klk1b8kallikrein 1-related peptidase b80.944
Klk1b26kallikrein 1-related petidase b260.887
CblCasitas B-lineage lymphoma0.874
Grb2growth factor receptor bound protein 20.821
Klk1b5kallikrein 1-related peptidase b50.770
Klk1b1kallikrein 1-related peptidase b10.744
Klk1b11kallikrein 1-related peptidase b110.736
Klk1kallikrein 10.679
Ptenphosphatase and tensin homolog0.669
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.588
Ptprcprotein tyrosine phosphatase, receptor type, C0.574
Grb10growth factor receptor bound protein 100.503
Irs1insulin receptor substrate 10.492
Cd19CD19 antigen0.459
Klk1b21kallikrein 1-related peptidase b210.424
Ephb2Eph receptor B20.406
Efnb2ephrin B20.405
Dab1disabled homolog 1 (Drosophila)0.401
Ctnnb1catenin (cadherin associated protein), beta 10.348
Ctrb1chymotrypsinogen B10.335
Leprleptin receptor0.332
Cela2achymotrypsin-like elastase family, member 2A0.330
Ikzf1IKAROS family zinc finger 10.316
Inpp5dinositol polyphosphate-5-phosphatase D0.314
Csf1colony stimulating factor 1 (macrophage)0.309
Klk1b27kallikrein 1-related peptidase b270.249
SrcRous sarcoma oncogene0.243
Klk1b9kallikrein 1-related peptidase b90.236
Klk1b24kallikrein 1-related peptidase b240.229
Itgb1integrin beta 1 (fibronectin receptor beta)0.219
Ptk2PTK2 protein tyrosine kinase 20.211
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.181
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.181
Vav2vav 2 oncogene0.176
Vav1vav 1 oncogene0.176
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.172
FynFyn proto-oncogene0.166
Ins2insulin II0.155
2210010C04RikRIKEN cDNA 2210010C04 gene0.136
Epha4Eph receptor A40.133
Prkceprotein kinase C, epsilon0.123
Ooepoocyte expressed protein homolog (dog)0.122
Prss2protease, serine, 20.117
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.117
Tgfb1transforming growth factor, beta 10.115
BlnkB-cell linker0.112
Nos3nitric oxide synthase 3, endothelial cell0.111
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.111
Ptpn6protein tyrosine phosphatase, non-receptor type 60.110
Klk1b16kallikrein 1-related peptidase b160.107
Gata5GATA binding protein 50.105
Efnb1ephrin B10.100
Notch2Notch gene homolog 2 (Drosophila)0.097
Cldn5claudin 50.095
Psen1presenilin 10.094
Bcar1breast cancer anti-estrogen resistance 10.087
Prss3protease, serine, 30.084
Ncf1neutrophil cytosolic factor 10.082
Rnase1ribonuclease, RNase A family, 1 (pancreatic)0.079
PycardPYD and CARD domain containing0.079
Cd44CD44 antigen0.079
Rac1RAS-related C3 botulinum substrate 10.078
Dok1docking protein 10.075
Klk1b3kallikrein 1-related peptidase b30.075
Nf1neurofibromatosis 10.072
Ghrgrowth hormone receptor0.069
Lce1hlate cornified envelope 1H0.069
Jag1jagged 10.065
Ephb3Eph receptor B30.065
Cd247CD247 antigen0.064
Ptpn11protein tyrosine phosphatase, non-receptor type 110.064
Lyz2lysozyme 20.064
WasWiskott-Aldrich syndrome homolog (human)0.064
Hcls1hematopoietic cell specific Lyn substrate 10.063
Card11caspase recruitment domain family, member 110.061
Kitkit oncogene0.059
Apoeapolipoprotein E0.059
Plcg2phospholipase C, gamma 20.059
5430421N21RikRIKEN cDNA 5430421N21 gene0.059
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.058
Shank3SH3/ankyrin domain gene 30.057
Nphp3nephronophthisis 3 (adolescent)0.057
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.056
Krt14keratin 140.055
Pdgfbplatelet derived growth factor, B polypeptide0.054
Ptprbprotein tyrosine phosphatase, receptor type, B0.053
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.052
Klk1b4kallikrein 1-related pepidase b40.052
Krt17keratin 170.051
Emx1empty spiracles homolog 1 (Drosophila)0.050
Foxn1forkhead box N10.046
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.046
Plcg1phospholipase C, gamma 10.045
Cuzd1CUB and zona pellucida-like domains 10.043
Itgb2integrin beta 20.043
Sema3fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F0.042
MdfiMyoD family inhibitor0.041
Zg16zymogen granule protein 160.041
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr1Fibroblast growth factor receptor 10.135
Adaradenosine deaminase, RNA-specific0.063
Prkcdprotein kinase C, delta0.057
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.055
Sirpasignal-regulatory protein alpha0.050
Cdc42bpbCDC42 binding protein kinase beta (DMPK-like)0.035
Cd37CD37 molecule0.021
Il2rginterleukin 2 receptor, gamma0.018
Tsc22d3TSC22 domain family, member 30.016
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.016
Klk1c10l2kallikrein 1-related peptidase c10-like 20.016
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.015
Irs3insulin receptor substrate 30.015
Hk1hexokinase 10.015
Capn1calpain 10.014
Ralgdsral guanine nucleotide dissociation stimulator0.012
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.012
Arhgap25Rho GTPase activating protein 250.011
Tgfbr2transforming growth factor, beta receptor II0.011
Marcksmyristoylated alanine rich protein kinase C substrate0.011
Map3k3mitogen activated protein kinase kinase kinase 30.011
Mobkl2aMOB1, Mps One Binder kinase activator-like 2A (yeast)0.011
Zfp706zinc finger protein 7060.011
Stat6signal transducer and activator of transcription 60.010
Plcg2phospholipase C, gamma 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism