The network for 'regulation of i kappab kinase nf kappab signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of i kappab kinase nf kappab signaling

Any process that modulates I-kappaB kinase/NF-kappaB signaling.

NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma1.000
TRAF6TNF receptor-associated factor 61.000
BIRC3baculoviral IAP repeat containing 31.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 11.000
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)1.000
RIPK2receptor-interacting serine-threonine kinase 21.000
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha1.000
XIAPX-linked inhibitor of apoptosis1.000
SQSTM1sequestosome 11.000
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta1.000
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
TRAF1TNF receptor-associated factor 11.000
UBE2V1ubiquitin-conjugating enzyme E2 variant 11.000
MAP3K7mitogen-activated protein kinase kinase kinase 71.000
UBCubiquitin C1.000
MYD88myeloid differentiation primary response gene (88)1.000
TRAF2TNF receptor-associated factor 21.000
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.999
BIRC2baculoviral IAP repeat containing 20.999
UBE2D3ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)0.998
MDM2Mdm2 p53 binding protein homolog (mouse)0.997
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.997
TNFAIP3tumor necrosis factor, alpha-induced protein 30.997
TRAF3TNF receptor-associated factor 30.996
CFLARCASP8 and FADD-like apoptosis regulator0.991
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.988
FASFas (TNF receptor superfamily, member 6)0.988
CHUKconserved helix-loop-helix ubiquitous kinase0.987
CDC37cell division cycle 37 homolog (S. cerevisiae)0.984
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.982
TRIM63tripartite motif containing 630.980
IRAK1interleukin-1 receptor-associated kinase 10.973
TNIP2TNFAIP3 interacting protein 20.969
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.967
SMAD3SMAD family member 30.965
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.964
TRADDTNFRSF1A-associated via death domain0.959
ESR1estrogen receptor 10.958
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.953
FADDFas (TNFRSF6)-associated via death domain0.945
C1QAcomplement component 1, q subcomponent, A chain0.945
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.938
CASP3caspase 3, apoptosis-related cysteine peptidase0.936
CD40CD40 molecule, TNF receptor superfamily member 50.935
TNFtumor necrosis factor0.921
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.903
CARD11caspase recruitment domain family, member 110.902
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.893
CASP10caspase 10, apoptosis-related cysteine peptidase0.888
MAP3K14mitogen-activated protein kinase kinase kinase 140.887
S100A6S100 calcium binding protein A60.874
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.868
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.868
BCL10B-cell CLL/lymphoma 100.866
PMLpromyelocytic leukemia0.864
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.862
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.852
ICAM1intercellular adhesion molecule 10.825
IRAK2interleukin-1 receptor-associated kinase 20.817
S100A9S100 calcium binding protein A90.803
TANKTRAF family member-associated NFKB activator0.798
TLR4toll-like receptor 40.797
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.796
TRAF5TNF receptor-associated factor 50.760
CAV1caveolin 1, caveolae protein, 22kDa0.757
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.749
ANXA2annexin A20.729
CCL4chemokine (C-C motif) ligand 40.695
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.694
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.680
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.673
IL1R1interleukin 1 receptor, type I0.665
S100A8S100 calcium binding protein A80.662
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.654
MAP3K8mitogen-activated protein kinase kinase kinase 80.645
MAP3K5mitogen-activated protein kinase kinase kinase 50.626
CXCL9chemokine (C-X-C motif) ligand 90.624
IL8interleukin 80.610
MAP3K3mitogen-activated protein kinase kinase kinase 30.608
S100A16S100 calcium binding protein A160.599
S100A11S100 calcium binding protein A110.568
ANXA1annexin A10.559
BCL3B-cell CLL/lymphoma 30.549
SMAD7SMAD family member 70.544
CXCL10chemokine (C-X-C motif) ligand 100.535
S100A14S100 calcium binding protein A140.533
MYH9myosin, heavy chain 9, non-muscle0.531
PTPN1protein tyrosine phosphatase, non-receptor type 10.518
IL2RBinterleukin 2 receptor, beta0.514
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.506
LTAlymphotoxin alpha (TNF superfamily, member 1)0.490
TBK1TANK-binding kinase 10.488
INSRinsulin receptor0.486
CCR5chemokine (C-C motif) receptor 50.485
CCL2chemokine (C-C motif) ligand 20.479
UBQLN1ubiquilin 10.479
EEF1Geukaryotic translation elongation factor 1 gamma0.474
TLR2toll-like receptor 20.466
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.461
IRF1interferon regulatory factor 10.460
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.749
cav1caveolin 10.442
itm2bbintegral membrane protein 2Bb0.434
adipor2adiponectin receptor 20.404
nod1nucleotide-binding oligomerization domain containing 10.378
grifingalectin related inter-fiber protein0.317
cd63Cd63 antigen0.281
tnfatumor necrosis factor a (TNF superfamily, member 2)0.262
caspacaspase a0.261
tlr3toll-like receptor 30.248
pycardPYD and CARD domain containing0.242
lats1LATS, large tumor suppressor, homolog 1 (Drosophila)0.227
relv-rel reticuloendotheliosis viral oncogene homolog0.227
card9caspase recruitment domain family, member 90.219
cbr1lcarbonyl reductase 1-like0.208
tlr9toll-like receptor 90.192
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.177
tgm2btransglutaminase 2b0.172
slc15a2solute carrier family 15 (H+/peptide transporter), member 20.161
LOC557072caspase recruitment domain-containing protein 11-like0.157
hcrthypocretin (orexin) neuropeptide precursor0.149
LOC100003514protein kinase C alpha type-like0.142
ip6k2inositol hexaphosphate kinase 20.141
mmp15bmatrix metallopeptidase 15b0.135
s100v2S100 calcium binding protein V20.132
brd2bbromodomain containing 2b0.131
slc4a1asolute carrier family 4, anion exchanger, member 1a0.130
unc5cunc-5 homolog C (C. elegans)0.129
lgals3llectin, galactoside-binding, soluble, 3 (galectin 3)-like0.127
stat1asignal transduction and activation of transcription 1a0.122
nt5c2l15'-nucleotidase, cytosolic II, like 10.117
comtacatechol-O-methyltransferase a0.116
per2period homolog 2 (Drosophila)0.116
il8interleukin 80.113
nccrp1nonspecific cytotoxic cell receptor protein 10.111
s100a10bS100 calcium binding protein A10b0.108
bhlhe40basic helix-loop-helix family, member e400.108
card14caspase recruitment domain family, member 140.107
ube2nbubiquitin-conjugating enzyme E2Nb0.106
klfdKruppel-like factor d0.106
bhlhe41basic helix-loop-helix family, member e410.105
sema3fbsemaphorin 3fb0.104
foxo3bforkhead box O3b0.104
acp5bacid phosphatase 5b, tartrate resistant0.102
th2tyrosine hydroxylase 20.100
elovl4aelongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4a0.099
zgc:110340zgc:1103400.098
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.098
adipor1badiponectin receptor 1b0.097
anxa5bannexin A5b0.097
tsen54tRNA splicing endonuclease 54 homolog (S. cerevisiae)0.096
vcanbversican b0.095
si:ch211-9d9.3si:ch211-9d9.30.093
ighzimmunoglobulin heavy constant zeta0.093
LOC100004946transient receptor potential cation channel subfamily M member 4-like0.089
slc39a1solute carrier family 39 (zinc transporter), member 10.087
zfand5azinc finger, AN1-type domain 5a0.087
rad21RAD21 homolog (S. pombe)0.086
blvrbbiliverdin reductase B (flavin reductase (NADPH))0.085
adrb2aadrenergic receptor, beta 2a0.085
angptl1angiopoietin-like 10.084
nfkbiabnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b0.083
stxbp2syntaxin binding protein 20.083
slc7a6solute carrier family 7 (cationic amino acid transporter, y+ system), member 60.082
sirt1sirtuin (silent mating type information regulation 2 homolog) 10.080
LOC100000934hypothetical protein LOC1000009340.080
tlr18toll-like receptor 180.079
arhgdigRho GDP dissociation inhibitor (GDI) gamma0.079
epb41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)0.077
icnictacalcin0.074
litaflipopolysaccharide-induced TNF factor0.073
rnf180ring finger protein 1800.073
ela2lelastase 2 like0.073
tnfbtumor necrosis factor b (TNF superfamily, member 2)0.073
tlr2toll-like receptor 20.072
timm17atranslocase of inner mitochondrial membrane 17 homolog A (yeast)0.069
sdcbpsyndecan binding protein (syntenin)0.069
hoxa13ahomeo box A13a0.069
mcl1bmyeloid cell leukemia sequence 1b0.069
ecscrendothelial cell-specific chemotaxis regulator0.068
zgc:92027zgc:920270.068
mobkl3MOB1, Mps One Binder kinase activator-like 3 (yeast)0.067
crygm2d1crystallin, gamma M2d10.067
keap1akelch-like ECH-associated protein 1a0.066
pdcd6programmed cell death 60.066
hbaa1hemoglobin alpha adult-10.066
stc1lstanniocalcin 1, like0.065
trpv6transient receptor potential cation channel, subfamily V, member 60.065
prkczprotein kinase C, zeta0.065
tph2tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)0.065
chukconserved helix-loop-helix ubiquitous kinase0.064
pdgfaaplatelet-derived growth factor alpha a0.064
ctsbacathepsin B, a0.064
carm1coactivator-associated arginine methyltransferase 10.063
ptger4bprostaglandin E receptor 4 (subtype EP4) b0.063
atf3activating transcription factor 30.062
cldniclaudin i0.062
msi1musashi homolog 1 (Drosophila)0.062
cotl1coactosin-like 1 (Dictyostelium)0.062
mipamajor intrinsic protein of lens fiber a0.062
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
TlToll0.399
baibaiser0.390
Toll-6CG7250 gene product from transcript CG7250-RA0.281
ird5immune response deficient 50.266
Myd88CG2078 gene product from transcript CG2078-RA0.265
BG4CG12297 gene product from transcript CG12297-RA0.250
Toll-7CG8595 gene product from transcript CG8595-RA0.248
imdimmune deficiency0.219
Hsp27Heat shock protein 270.181
Tak1TGF-beta activated kinase 10.171
18w18 wheeler0.169
CamCalmodulin0.154
spzspatzle0.126
PliPellino0.125
RelRelish0.114
panpangolin0.109
p24-1p24-related-10.106
Df31Decondensation factor 310.096
pumpumilio0.094
Akt1CG4006 gene product from transcript CG4006-RA0.084
Dcr-2Dicer-20.082
Cf2Chorion factor 20.082
CG10650CG10650 gene product from transcript CG10650-RA0.077
qkr58E-3quaking related 58E-30.076
keykenny0.074
DuoxDual oxidase0.071
Nrx-IVNeurexin IV0.069
Hsp23Heat shock protein 230.069
CTCFCG8591 gene product from transcript CG8591-RA0.068
HcfHost cell factor0.066
Hsp68Heat shock protein 680.065
egreiger0.065
aPKCatypical protein kinase C0.065
latlatheo0.064
grngrain0.063
CG16718CG16718 gene product from transcript CG16718-RA0.061
hthhomothorax0.060
e(y)3enhancer of yellow 30.060
unc-13CG2999 gene product from transcript CG2999-RA0.059
jarjaguar0.058
DreddDeath related ced-3/Nedd2-like protein0.058
Atf-2Activating transcription factor-20.057
TER94CG2331 gene product from transcript CG2331-RA0.057
Spn27ASerpin 27A0.056
pr-set7CG3307 gene product from transcript CG3307-RC0.056
Cyt-c-dCytochrome c distal0.056
Dlc90FDynein light chain 90F0.056
SdcSyndecan0.055
mus309mutagen-sensitive 3090.055
necnecrotic0.055
PRL-1CG4993 gene product from transcript CG4993-RB0.055
Vap-33-1CG5014 gene product from transcript CG5014-RB0.054
ari-2ariadne 20.051
rokRho-kinase0.051
CG5384CG5384 gene product from transcript CG5384-RA0.051
SuURSuppressor of Under-Replication0.051
Mpk2CG5475 gene product from transcript CG5475-RB0.051
weeCG4488 gene product from transcript CG4488-RA0.050
mnbminibrain0.049
nopono poles0.049
liglingerer0.049
CG12918CG12918 gene product from transcript CG12918-RA0.049
ash1absent, small, or homeotic discs 10.048
SoxNSoxNeuro0.046
AGO2Argonaute 20.046
AdarAdenosine deaminase acting on RNA0.046
TBPHCG10327 gene product from transcript CG10327-RC0.046
MED31Mediator complex subunit 310.046
CatCatalase0.045
Rac2CG8556 gene product from transcript CG8556-RA0.044
maguCG2264 gene product from transcript CG2264-RD0.044
ecechinus0.043
hephemipterous0.042
trptransient receptor potential0.042
Pi3K68DPhosphotidylinositol 3 kinase 68D0.042
MedMedea0.041
ttan0.041
Gycalpha99BGuanylyl cyclase alpha-subunit at 99B0.041
CG32711CG32711 gene product from transcript CG32711-RA0.041
slowslowdown0.040
Akap200A kinase anchor protein 2000.040
Hsp26Heat shock protein 260.039
cactcactus0.039
cln3CG5582 gene product from transcript CG5582-RA0.038
Cdk5alphaCdk5 activator-like protein0.038
ThorCG8846 gene product from transcript CG8846-RA0.038
TM9SF4CG7364 gene product from transcript CG7364-RA0.037
sinusinuous0.037
CG5741CG5741 gene product from transcript CG5741-RC0.036
Paip2polyA-binding protein interacting protein 20.036
inaDinactivation no afterpotential D0.036
PGRP-LEPeptidoglycan recognition protein LE0.036
CG11299CG11299 gene product from transcript CG11299-RA0.036
Smg5CG8954 gene product from transcript CG8954-RA0.036
janAjanus A0.035
l(2)k16918lethal (2) k169180.035
RASSF8CG5053 gene product from transcript CG5053-RA0.035
rtrotated abdomen0.035
Nhe3Na[+]/H[+] hydrogen exchanger 30.035
CG17107CG17107 gene product from transcript CG17107-RA0.035
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Vdac1voltage-dependent anion channel 10.061
Il1ainterleukin 1 alpha0.044
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.031
Myd88myeloid differentiation primary response gene 880.030
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.029
Tnftumor necrosis factor (TNF superfamily, member 2)0.029
Il6interleukin 60.029
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.028
Ccl2chemokine (C-C motif) ligand 20.026
Cdk4cyclin-dependent kinase 40.026
Stat3signal transducer and activator of transcription 30.025
Cxcl10chemokine (C-X-C motif) ligand 100.025
Eif4heukaryotic translation initiation factor 4H0.024
Rab7aRAB7A, member RAS oncogene family0.023
Lgals5lectin, galactose binding, soluble 50.020
Dtx3ldeltex 3-like (Drosophila)0.019
Cxcl2chemokine (C-X-C motif) ligand 20.018
Syngr2synaptogyrin 20.018
Vcam1vascular cell adhesion molecule 10.017
Tpm3tropomyosin 3, gamma0.017
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.017
Zfp36zinc finger protein 360.017
Pfn1profilin 10.015
Selpselectin P0.015
Adrb2adrenergic, beta-2-, receptor, surface0.014
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.014
Ednrbendothelin receptor type B0.014
Mca32mast cell antigen 320.014
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.014
Ube2e3ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog (yeast)0.013
Apol3apolipoprotein L, 30.013
Casp1caspase 10.013
Ccl4chemokine (C-C motif) ligand 40.013
Gnb2guanine nucleotide binding protein (G protein), beta polypeptide 20.012
Marcksmyristoylated alanine rich protein kinase C substrate0.012
Hn1hematological and neurological expressed 10.012
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.011
Prkar1aprotein kinase, cAMP-dependent, regulatory, type I, alpha0.011
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.011
Socs3suppressor of cytokine signaling 30.011
Fgfr1Fibroblast growth factor receptor 10.011
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.010
Nr1d2nuclear receptor subfamily 1, group D, member 20.010
Nrg2neuregulin 20.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism