The network for 'mesenchymal cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesenchymal cell differentiation

The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.

NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.999
SMAD3SMAD family member 30.996
COL1A1collagen, type I, alpha 10.995
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.994
BBS10Bardet-Biedl syndrome 100.993
JAG1jagged 10.990
NOTCH1notch 10.989
COL6A1collagen, type VI, alpha 10.987
SMAD4SMAD family member 40.982
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.978
TGFB1transforming growth factor, beta 10.972
SMAD1SMAD family member 10.950
SMAD2SMAD family member 20.937
EGFRepidermal growth factor receptor0.935
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.930
BMP2bone morphogenetic protein 20.918
SMAD7SMAD family member 70.906
SIRT1sirtuin 10.898
COL1A2collagen, type I, alpha 20.888
SMURF2SMAD specific E3 ubiquitin protein ligase 20.876
SKILSKI-like oncogene0.874
EP300E1A binding protein p3000.832
COL2A1collagen, type II, alpha 10.827
NOTCH3notch 30.823
COL6A2collagen, type VI, alpha 20.814
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.801
FHL2four and a half LIM domains 20.762
COL4A1collagen, type IV, alpha 10.738
POU3F2POU class 3 homeobox 20.722
POU5F1POU class 5 homeobox 10.706
COL4A2collagen, type IV, alpha 20.689
BMPR1Abone morphogenetic protein receptor, type IA0.686
ARandrogen receptor0.683
SOX10SRY (sex determining region Y)-box 100.675
PAX3paired box 30.648
DDR2discoidin domain receptor tyrosine kinase 20.622
COL3A1collagen, type III, alpha 10.592
RUNX1runt-related transcription factor 10.567
SMAD6SMAD family member 60.554
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.549
SMAD9SMAD family member 90.546
SOX1SRY (sex determining region Y)-box 10.535
NR4A1nuclear receptor subfamily 4, group A, member 10.534
FSTL1follistatin-like 10.531
FKBP1AFK506 binding protein 1A, 12kDa0.530
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.511
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.491
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.483
PTK2PTK2 protein tyrosine kinase 20.481
TBX5T-box 50.473
PTBP1polypyrimidine tract binding protein 10.446
COL5A1collagen, type V, alpha 10.431
WWP2WW domain containing E3 ubiquitin protein ligase 20.428
NRP1neuropilin 10.416
BMP4bone morphogenetic protein 40.411
CREBBPCREB binding protein0.396
FOXF2forkhead box F20.392
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.388
COL5A2collagen, type V, alpha 20.374
TGFB3transforming growth factor, beta 30.370
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.359
FZD1frizzled homolog 1 (Drosophila)0.354
EIF2C2eukaryotic translation initiation factor 2C, 20.349
PAPPApregnancy-associated plasma protein A, pappalysin 10.348
YAP1Yes-associated protein 10.342
GSK3Bglycogen synthase kinase 3 beta0.336
TP53tumor protein p530.336
HIC1hypermethylated in cancer 10.333
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.333
GATA4GATA binding protein 40.328
APCadenomatous polyposis coli0.322
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.315
FGF1fibroblast growth factor 1 (acidic)0.304
LRP6low density lipoprotein receptor-related protein 60.300
SFRP1secreted frizzled-related protein 10.292
FZD8frizzled homolog 8 (Drosophila)0.292
COL18A1collagen, type XVIII, alpha 10.292
FOXF1forkhead box F10.292
TCF4transcription factor 40.286
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.278
WNT3Awingless-type MMTV integration site family, member 3A0.265
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.259
GATA2GATA binding protein 20.257
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.250
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.237
ZFYVE9zinc finger, FYVE domain containing 90.234
FN1fibronectin 10.232
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.230
GRB7growth factor receptor-bound protein 70.227
AXIN1axin 10.212
PDX1pancreatic and duodenal homeobox 10.210
PTCH1patched 10.206
THBS1thrombospondin 10.202
SOX11SRY (sex determining region Y)-box 110.196
MSX1msh homeobox 10.191
FBLN2fibulin 20.187
PIAS1protein inhibitor of activated STAT, 10.183
CAV1caveolin 1, caveolae protein, 22kDa0.182
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
foxd3forkhead box D30.996
aldh1a2aldehyde dehydrogenase 1 family, member A20.976
foxi1forkhead box I10.971
sox10SRY-box containing gene 100.951
foxa3forkhead box A30.949
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.938
tbx1T-box 10.935
shhasonic hedgehog a0.917
lef1lymphocyte enhancer binding factor 10.868
mibmind bomb0.854
rargaretinoic acid receptor gamma a0.843
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.829
pax6apaired box gene 6a0.814
pax2apaired box gene 2a0.799
cdh2cadherin 2, neuronal0.776
restRE1-silencing transcription factor0.771
bmp4bone morphogenetic protein 40.767
gata3GATA-binding protein 30.767
tcf7transcription factor 7 (T-cell specific, HMG-box)0.756
sox2SRY-box containing gene 20.743
tp53tumor protein p530.741
snai1bsnail homolog 1b (Drosophila)0.729
emx3empty spiracles homeobox 30.726
eya1eyes absent homolog 10.704
bmp2bbone morphogenetic protein 2b0.699
kitakit receptor a0.673
mitfamicrophthalmia-associated transcription factor a0.666
dlx2adistal-less homeobox gene 2a0.663
notch1anotch homolog 1a0.661
cdx4caudal type homeo box transcription factor 40.634
ndr2nodal-related 20.630
wnt5bwingless-type MMTV integration site family, member 5b0.620
mecomMDS1 and EVI1 complex locus0.619
pax7apaired box gene 7a0.613
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.610
pea3ETS-domain transcription factor pea30.600
otx2orthodenticle homolog 20.593
col15a1bcollagen, type XV, alpha 1b0.590
osr1odd-skipped related 1 (Drosophila)0.555
tfap2atranscription factor AP-2 alpha0.551
her6hairy-related 60.550
prdm5PR domain containing 50.545
gpr126G protein-coupled receptor 1260.544
jag1bjagged 1b0.542
ascl1aachaete-scute complex-like 1a (Drosophila)0.527
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.524
spns2spinster homolog 2 (Drosophila)0.521
gria4aglutamate receptor, ionotropic, AMPA 4a0.516
pax6bpaired box gene 6b0.512
tgfbitransforming growth factor, beta-induced0.511
cdh6cadherin 60.491
tll1tolloid-like 10.487
supt6hsuppressor of Ty 6 homolog0.478
fzd7bfrizzled homolog 7b0.472
tfectranscription factor EC0.469
her1hairy-related 10.466
hoxb1bhomeo box B1b0.435
rx2retinal homeobox gene 20.434
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.434
hey1hairy/enhancer-of-split related with YRPW motif 10.433
raraaretinoic acid receptor, alpha a0.421
dctdopachrome tautomerase0.407
tgfb3transforming growth factor, beta 30.399
tmem2transmembrane protein 20.376
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.363
fli1afriend leukemia integration 1a0.362
traf4atnf receptor-associated factor 4a0.352
alcamaactivated leukocyte cell adhesion molecule a0.349
bmp2abone morphogenetic protein 2a0.339
spry4sprouty (Drosophila) homolog 40.338
znf503zinc finger protein 5030.336
notch3notch homolog 30.326
sox1aSRY-box containing gene 1a0.318
dhrs3adehydrogenase/reductase (SDR family) member 3a0.314
gria1aglutamate receptor, ionotropic, AMPA 1a0.313
lamc1laminin, gamma 10.308
tp63tumor protein p630.306
gria4bglutamate receptor, ionotropic, AMPA 4b0.305
fstafollistatin a0.303
zic5zic family member 5 (odd-paired homolog, Drosophila)0.299
pax9paired box gene 90.299
has2hyaluronan synthase 20.293
lmx1b.1LIM homeobox transcription factor 1, beta 10.289
wnt11wingless-type MMTV integration site family, member 110.287
nrp1bneuropilin 1b0.287
crabp2acellular retinoic acid binding protein 2, a0.285
msxcmuscle segment homeobox C0.282
barhl1.2BarH-like 1.20.271
id3inhibitor of DNA binding 30.270
dnmt7DNA (cytosine-5-)-methyltransferase 70.269
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.935
EgfrEpidermal growth factor receptor0.810
MadMothers against dpp0.675
slp1sloppy paired 10.520
Ras85DRas oncogene at 85D0.431
bowlbrother of odd with entrails limited0.429
SmoxSmad on X0.387
fasfaint sausage0.361
LanB2Laminin B20.309
Su(H)Suppressor of Hairless0.297
ik2IkappaB kinase-like 20.292
nkdnaked cuticle0.283
Pi3K92ECG4141 gene product from transcript CG4141-RB0.281
eyaeyes absent0.258
emcextra macrochaetae0.257
numbCG3779 gene product from transcript CG3779-RB0.233
gcmglial cells missing0.233
Mef2Myocyte enhancer factor 20.232
osaCG7467 gene product from transcript CG7467-RD0.228
slmbsupernumerary limbs0.212
rapretina aberrant in pattern0.191
Nrx-IVNeurexin IV0.189
TolloCG6890 gene product from transcript CG6890-RA0.187
cwoclockwork orange0.185
oddodd skipped0.175
Eip74EFEcdysone-induced protein 74EF0.175
CG32354CG32354 gene product from transcript CG32354-RA0.173
E(spl)Enhancer of split0.158
rictorrapamycin-insensitive companion of Tor0.152
Stat92ESignal-transducer and activator of transcription protein at 92E0.151
PhmPeptidylglycine-alpha-hydroxylating monooxygenase0.151
stumpsCG31317 gene product from transcript CG31317-RC0.148
Akt1CG4006 gene product from transcript CG4006-RA0.141
eveeven skipped0.136
sogshort gastrulation0.132
CG11347CG11347 gene product from transcript CG11347-RE0.128
l(2)gd1lethal (2) giant discs 10.125
ftz-f1ftz transcription factor 10.124
Wnt2Wnt oncogene analog 20.113
Cp190Centrosomal protein 190kD0.109
kibrakibra ortholog0.109
OptixCG18455 gene product from transcript CG18455-RA0.098
ash2absent, small, or homeotic discs 20.092
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Gli3GLI-Kruppel family member GLI31.000
Bmp4bone morphogenetic protein 41.000
Shhsonic hedgehog1.000
Pitx2paired-like homeodomain transcription factor 21.000
Foxc1forkhead box C11.000
Pax3paired box gene 31.000
Fgfr2fibroblast growth factor receptor 21.000
Tgfb2transforming growth factor, beta 21.000
Ctnnb1catenin (cadherin associated protein), beta 10.999
Fgf8fibroblast growth factor 80.998
Msx1homeobox, msh-like 10.998
Pax6paired box gene 60.998
Sox9SRY-box containing gene 90.997
Acvr1activin A receptor, type 10.997
Fgfr1fibroblast growth factor receptor 10.997
Otx2orthodenticle homolog 2 (Drosophila)0.997
Hand2heart and neural crest derivatives expressed transcript 20.997
Bcl2B-cell leukemia/lymphoma 20.996
Hand1heart and neural crest derivatives expressed transcript 10.995
Vegfavascular endothelial growth factor A0.993
Hoxa1homeobox A10.993
Gata4GATA binding protein 40.993
Isl1ISL1 transcription factor, LIM/homeodomain0.992
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.990
Lhx1LIM homeobox protein 10.989
Gdnfglial cell line derived neurotrophic factor0.989
Tbx1T-box 10.988
Prrx1paired related homeobox 10.985
Efnb2ephrin B20.984
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.977
Prrx2paired related homeobox 20.976
Gli2GLI-Kruppel family member GLI20.974
Zic3zinc finger protein of the cerebellum 30.973
Notch1Notch gene homolog 1 (Drosophila)0.973
Runx2runt related transcription factor 20.971
Rargretinoic acid receptor, gamma0.968
Dlx5distal-less homeobox 50.968
Tcfap2atranscription factor AP-2, alpha0.965
Ednraendothelin receptor type A0.962
Gbx2gastrulation brain homeobox 20.956
Bmpr1abone morphogenetic protein receptor, type 1A0.952
Retret proto-oncogene0.952
Foxc2forkhead box C20.951
Sox2SRY-box containing gene 20.951
Msx2homeobox, msh-like 20.950
Ptpn11protein tyrosine phosphatase, non-receptor type 110.947
Sox10SRY-box containing gene 100.947
Fgfr3fibroblast growth factor receptor 30.945
Crb2crumbs homolog 2 (Drosophila)0.944
Rarbretinoic acid receptor, beta0.942
Pou3f3POU domain, class 3, transcription factor 30.938
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.938
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.938
Twist2twist homolog 2 (Drosophila)0.931
Gata6GATA binding protein 60.929
Snai1snail homolog 1 (Drosophila)0.927
Foxg1forkhead box G10.926
Fgf10fibroblast growth factor 100.918
Eya1eyes absent 1 homolog (Drosophila)0.918
Gpc3glypican 30.917
Tcf21transcription factor 210.913
Ptenphosphatase and tensin homolog0.906
Gscgoosecoid homeobox0.903
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.903
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.898
Lef1lymphoid enhancer binding factor 10.892
Ascl1achaete-scute complex homolog 1 (Drosophila)0.891
Atoh7atonal homolog 7 (Drosophila)0.890
Notch2Notch gene homolog 2 (Drosophila)0.876
Vangl2vang-like 2 (van gogh, Drosophila)0.871
Ror2receptor tyrosine kinase-like orphan receptor 20.869
Wt1Wilms tumor 1 homolog0.869
Tlx3T-cell leukemia, homeobox 30.868
Smad4MAD homolog 4 (Drosophila)0.860
Pbx1pre B-cell leukemia transcription factor 10.856
Emx1empty spiracles homolog 1 (Drosophila)0.849
Hspg2perlecan (heparan sulfate proteoglycan 2)0.847
Meox2mesenchyme homeobox 20.840
Pax2paired box gene 20.839
Col2a1collagen, type II, alpha 10.833
Hes1hairy and enhancer of split 1 (Drosophila)0.830
Hic1hypermethylated in cancer 10.812
Wnt3awingless-related MMTV integration site 3A0.788
Smad3MAD homolog 3 (Drosophila)0.782
Dkk1dickkopf homolog 1 (Xenopus laevis)0.781
Nr5a1nuclear receptor subfamily 5, group A, member 10.779
Hoxb1homeobox B10.777
Smad6MAD homolog 6 (Drosophila)0.770
Tbx3T-box 30.768
Lhx3LIM homeobox protein 30.763
Neurog2neurogenin 20.752
Efnb1ephrin B10.751
Tbx15T-box 150.740
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.729
Ror1receptor tyrosine kinase-like orphan receptor 10.727
Efna2ephrin A20.723
Pitx1paired-like homeodomain transcription factor 10.716
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.036
Col12a1collagen, type XII, alpha 10.023
Igfbp5insulin-like growth factor binding protein 50.020
Pfn1profilin 10.016
Unc5bunc-5 homolog B (C. elegans)0.015
Nek9NIMA (never in mitosis gene a)- related kinase 90.015
Smad7SMAD family member 70.014
Dchs1dachsous 1 (Drosophila)0.014
Prrx1paired related homeobox 10.013
Fzd2frizzled homolog 2 (Drosophila)0.013
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.012
Lamc1laminin, gamma 10.011
Metmet proto-oncogene0.011
Gata6GATA binding protein 60.011
Slco2a1solute carrier organic anion transporter family, member 2a10.011
Pxdnperoxidasin homolog (Drosophila)0.011
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.011
Irf2interferon regulatory factor 20.010
Nab1Ngfi-A binding protein 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism