The network for 'blood vessel development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

blood vessel development

The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

NameDescriptionProbabilityFunc Analog Organism
CREBBPCREB binding protein1.000
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.999
JUNjun proto-oncogene0.998
EP300E1A binding protein p3000.997
PTPN1protein tyrosine phosphatase, non-receptor type 10.995
JAG1jagged 10.995
CAV1caveolin 1, caveolae protein, 22kDa0.994
ARandrogen receptor0.993
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.992
RUNX1runt-related transcription factor 10.991
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.989
NOTCH1notch 10.988
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.986
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.983
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.983
FHL2four and a half LIM domains 20.981
FN1fibronectin 10.974
TAL1T-cell acute lymphocytic leukemia 10.972
ACTBactin, beta0.968
FGFR1fibroblast growth factor receptor 10.965
ENGendoglin0.963
TEKTEK tyrosine kinase, endothelial0.963
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.961
CYR61cysteine-rich, angiogenic inducer, 610.956
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.956
VEGFAvascular endothelial growth factor A0.943
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.936
FOSFBJ murine osteosarcoma viral oncogene homolog0.933
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.927
NOTCH3notch 30.908
NRP1neuropilin 10.903
PAX3paired box 30.888
CDH5cadherin 5, type 2 (vascular endothelium)0.884
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.884
ANGPTL2angiopoietin-like 20.884
SMAD3SMAD family member 30.875
SMURF2SMAD specific E3 ubiquitin protein ligase 20.874
IL8interleukin 80.864
YAP1Yes-associated protein 10.855
CTGFconnective tissue growth factor0.854
DUSP1dual specificity phosphatase 10.849
CFLARCASP8 and FADD-like apoptosis regulator0.844
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.842
TP53tumor protein p530.842
EGFRepidermal growth factor receptor0.841
SMAD2SMAD family member 20.840
BRCA1breast cancer 1, early onset0.833
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.830
CD34CD34 molecule0.825
THBS1thrombospondin 10.818
HOXB5homeobox B50.810
COL6A1collagen, type VI, alpha 10.795
EGR1early growth response 10.793
COL3A1collagen, type III, alpha 10.787
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.777
COL1A2collagen, type I, alpha 20.769
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.760
SMAD4SMAD family member 40.754
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.753
FASFas (TNF receptor superfamily, member 6)0.746
FGF1fibroblast growth factor 1 (acidic)0.739
VEGFCvascular endothelial growth factor C0.735
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.734
PLCG1phospholipase C, gamma 10.731
ATF3activating transcription factor 30.730
METmet proto-oncogene (hepatocyte growth factor receptor)0.729
TIMP2TIMP metallopeptidase inhibitor 20.725
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.720
RAMP3receptor (G protein-coupled) activity modifying protein 30.718
FLNAfilamin A, alpha0.716
COL2A1collagen, type II, alpha 10.714
TIMP3TIMP metallopeptidase inhibitor 30.713
CAV2caveolin 20.712
TBX5T-box 50.705
SRFserum response factor (c-fos serum response element-binding transcription factor)0.696
IQGAP1IQ motif containing GTPase activating protein 10.688
COL1A1collagen, type I, alpha 10.686
FKBP1AFK506 binding protein 1A, 12kDa0.680
TCF4transcription factor 40.675
FGFR2fibroblast growth factor receptor 20.673
NID1nidogen 10.670
BCL6B-cell CLL/lymphoma 60.670
JUNBjun B proto-oncogene0.660
FOXO1forkhead box O10.657
MSNmoesin0.651
BMP4bone morphogenetic protein 40.644
E2F7E2F transcription factor 70.644
TGFB1transforming growth factor, beta 10.641
KAT2BK(lysine) acetyltransferase 2B0.637
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.631
ILKintegrin-linked kinase0.629
PMLpromyelocytic leukemia0.625
CALM1calmodulin 1 (phosphorylase kinase, delta)0.624
COL4A1collagen, type IV, alpha 10.623
NR4A1nuclear receptor subfamily 4, group A, member 10.620
PTGISprostaglandin I2 (prostacyclin) synthase0.615
SMAD1SMAD family member 10.615
COL5A1collagen, type V, alpha 10.614
LTBP2latent transforming growth factor beta binding protein 20.611
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.610
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.999
notch3notch homolog 30.999
fbn2bfibrillin 2b0.998
fgfrl1bfibroblast growth factor receptor-like 1b0.995
gata2aGATA-binding protein 2a0.990
etv2ets variant gene 20.986
cxcr4achemokine (C-X-C motif) receptor 4a0.984
dlcdeltaC0.984
shhasonic hedgehog a0.980
lamb1alaminin, beta 1a0.978
tal1T-cell acute lymphocytic leukemia 10.972
wu:fv91b12wu:fv91b120.970
edn1endothelin 10.969
dll4delta-like 4 (Drosophila)0.967
mibmind bomb0.965
osr1odd-skipped related 1 (Drosophila)0.963
efnb2aephrin B2a0.957
traf4atnf receptor-associated factor 4a0.954
fn1fibronectin 10.948
cdh5cadherin 50.947
vegfcvascular endothelial growth factor c0.939
spry4sprouty (Drosophila) homolog 40.937
foxa2forkhead box A20.937
sox9aSRY-box containing gene 9a0.936
jag2jagged 20.931
nrp1aneuropilin 1a0.927
LOC100000687signal peptide, CUB and EGF-like domain-containing protein 3-like0.924
evx1even-skipped homeobox 10.922
tp53tumor protein p530.920
wnt3awingless-type MMTV integration site family, member 3A0.918
jag1bjagged 1b0.916
col1a1acollagen, type I, alpha 1a0.909
ephb4beph receptor B4b0.908
sulf1sulfatase 10.908
wnt3wingless-type MMTV integration site family, member 30.906
mmp2matrix metalloproteinase 20.904
ccm2cerebral cavernous malformation 20.901
sox7SRY-box containing gene 70.896
birc2baculoviral IAP repeat-containing 20.896
tbx1T-box 10.886
aplnraapelin receptor a0.879
foxn4forkhead box N40.876
wnt5bwingless-type MMTV integration site family, member 5b0.868
twist1atwist1a0.864
unc5bunc-5 homolog B (C. elegans)0.860
plxnd1plexin D10.859
col12a1collagen, type XII, alpha 10.856
pitx3paired-like homeodomain transcription factor 30.852
cdx4caudal type homeo box transcription factor 40.849
alcamaactivated leukocyte cell adhesion molecule a0.847
tie2endothelium-specific receptor tyrosine kinase 20.847
foxi1forkhead box I10.843
col8a1acollagen, type VIII, alpha 1a0.842
arnt2aryl hydrocarbon receptor nuclear translocator 20.841
bmp2bbone morphogenetic protein 2b0.838
fgfr2fibroblast growth factor receptor 20.837
lmx1b.1LIM homeobox transcription factor 1, beta 10.826
fli1afriend leukemia integration 1a0.825
tp63tumor protein p630.821
hand2heart and neural crest derivatives expressed transcript 20.820
myf5myogenic factor 50.800
nrarpanotch-regulated ankyrin repeat protein a0.783
pcdh8protocadherin 80.782
hhexhematopoietically expressed homeobox0.781
myod1myogenic differentiation 10.768
sox2SRY-box containing gene 20.767
elmo1engulfment and cell motility 1 (ced-12 homolog, C. elegans)0.762
cxcr4bchemokine (C-X-C motif), receptor 4b0.754
rargaretinoic acid receptor gamma a0.751
ilkintegrin linked kinase0.750
flt4fms-related tyrosine kinase 40.750
notch1anotch homolog 1a0.740
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.735
dlddeltaD0.728
tbx20T-box 200.725
cdoncell adhesion molecule-related/down-regulated by oncogenes0.723
si:ch211-235f6.2si:ch211-235f6.20.714
si:ch211-212m21.5si:ch211-212m21.50.710
atoh8atonal homolog 80.704
gli2aGLI-Kruppel family member GLI2a0.701
emx3empty spiracles homeobox 30.701
mpxmyeloid-specific peroxidase0.697
her9hairy-related 90.695
hoxd4ahomeo box D4a0.695
lft2lefty20.695
dkk1bdickkopf 1b0.695
apcadenomatosis polyposis coli0.692
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.686
fabp11afatty acid binding protein 11a0.684
bocbrother of CDO0.678
dladeltaA0.678
meis1myeloid ecotropic viral integration 10.670
vcanbversican b0.668
flhfloating head0.667
sema3fasemaphorin 3fa0.667
dlx5adistal-less homeobox gene 5a0.665
wnt11rwingless-type MMTV integration site family, member 11, related0.659
lft1lefty10.657
gng2guanine nucleotide binding protein (G protein), gamma 20.652
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.651
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
FosFBJ osteosarcoma oncogene0.750
Il8rbinterleukin 8 receptor, beta0.698
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.575
Ccl3chemokine (C-C motif) ligand 30.570
Il1r1interleukin 1 receptor, type I0.527
Ccl2chemokine (C-C motif) ligand 20.476
Edn1endothelin 10.444
Igfbp5insulin-like growth factor binding protein 50.416
Albalbumin0.387
Npr3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)0.384
Col12a1collagen, type XII, alpha 10.381
Fgfr1Fibroblast growth factor receptor 10.375
Mmp2matrix metallopeptidase 20.369
Timp1TIMP metallopeptidase inhibitor 10.367
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.351
Tgfbr2transforming growth factor, beta receptor II0.343
Nos3nitric oxide synthase 3, endothelial cell0.339
Trim47tripartite motif-containing 470.305
Dab2disabled homolog 2 (Drosophila)0.302
Il9rinterleukin 9 receptor0.299
Ednrbendothelin receptor type B0.294
Ccr5chemokine (C-C motif) receptor 50.285
Mmp3matrix metallopeptidase 30.284
Pecam1platelet/endothelial cell adhesion molecule 10.279
Id3inhibitor of DNA binding 30.273
Il1rl1interleukin 1 receptor-like 10.268
Pou2f3POU class 2 homeobox 30.264
Fgfr2fibroblast growth factor receptor 20.252
Ccr2chemokine (C-C motif) receptor 20.246
Col1a1collagen, type I, alpha 10.245
Acvrl1activin A receptor type II-like 10.239
MdficMyoD family inhibitor domain containing0.233
Fgl2fibrinogen-like 20.231
Kcnj8potassium inwardly-rectifying channel, subfamily J, member 80.227
Cxcl2chemokine (C-X-C motif) ligand 20.226
Junbjun B proto-oncogene0.224
Mrc1mannose receptor, C type 10.224
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.221
Bgnbiglycan0.219
Mmp10matrix metallopeptidase 100.219
GperG protein-coupled estrogen receptor 10.216
Metmet proto-oncogene0.212
Egfl7EGF-like-domain, multiple 70.209
Vcanversican0.207
Col3a1collagen, type III, alpha 10.203
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.203
Il6interleukin 60.200
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.194
Mmp9matrix metallopeptidase 90.190
F13a1coagulation factor XIII, A1 polypeptide0.187
Nek9NIMA (never in mitosis gene a)- related kinase 90.184
Cdh5cadherin 50.179
Tpsab1tryptase alpha/beta 10.172
Pmp22peripheral myelin protein 220.172
Cyp1b1cytochrome P450, family 1, subfamily b, polypeptide 10.172
Atp12aATPase, H+/K+ transporting, nongastric, alpha polypeptide0.166
Kdrkinase insert domain receptor0.163
Gpr20G protein-coupled receptor 200.163
RGD1564327similar to integrin alpha 80.162
Bcl2B-cell CLL/lymphoma 20.162
Sellselectin L0.161
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.158
Cd14CD14 molecule0.156
Socs3suppressor of cytokine signaling 30.156
Emcnendomucin0.153
Stip1stress-induced phosphoprotein 10.152
Adora2aadenosine A2a receptor0.152
Thbdthrombomodulin0.151
Rgs14regulator of G-protein signaling 140.149
Cpxm2carboxypeptidase X (M14 family), member 20.149
Serpina5serine (or cysteine) peptidase inhibitor, clade A, member 50.148
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.148
Crisp1cysteine-rich secretory protein 10.148
Ccl4chemokine (C-C motif) ligand 40.145
Gabrg3gamma-aminobutyric acid (GABA) A receptor, gamma 30.145
Fgf2fibroblast growth factor 20.144
Utrnutrophin0.141
Trib1tribbles homolog 1 (Drosophila)0.140
Il1binterleukin 1 beta0.139
Ptprcprotein tyrosine phosphatase, receptor type, C0.138
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.137
Csf1colony stimulating factor 1 (macrophage)0.137
Ednraendothelin receptor type A0.137
Hspa8heat shock protein 80.136
Il7interleukin 70.133
Arntaryl hydrocarbon receptor nuclear translocator0.133
TekTEK tyrosine kinase, endothelial0.132
Arhgef15Rho guanine nucleotide exchange factor (GEF) 150.132
Twist2twist homolog 2 (Drosophila)0.130
Mpeg1macrophage expressed 10.129
Cmklr1chemokine-like receptor 10.129
Hpxhemopexin0.128
Flt1FMS-related tyrosine kinase 10.126
Gcgroup specific component0.125
Col5a1collagen, type V, alpha 10.124
Fstl1follistatin-like 10.123
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.122
Mapk1mitogen activated protein kinase 10.121
Cd200r1CD200 receptor 10.121
Stc1stanniocalcin 10.119
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism