The network for 'negative regulation of wnt signaling pathway involved in heart development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of wnt signaling pathway involved in heart development

Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time.

NameDescriptionProbabilityFunc Analog Organism
BMPR1Abone morphogenetic protein receptor, type IA0.877
CTNNBIP1catenin, beta interacting protein 10.697
WDYHV1WDYHV motif containing 10.511
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.395
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.173
FSTL1follistatin-like 10.148
LRRK2leucine-rich repeat kinase 20.083
DKK1dickkopf homolog 1 (Xenopus laevis)0.064
LRP6low density lipoprotein receptor-related protein 60.052
ZFYVE9zinc finger, FYVE domain containing 90.045
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.044
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.042
GSK3Bglycogen synthase kinase 3 beta0.041
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.032
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.030
DSG2desmoglein 20.024
APCadenomatous polyposis coli0.021
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.020
MDFIMyoD family inhibitor0.014
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.013
WNT3Awingless-type MMTV integration site family, member 3A0.013
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.012
CDH3cadherin 3, type 1, P-cadherin (placental)0.011
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mespamesoderm posterior a0.878
tbx16T-box gene 160.751
wnt5bwingless-type MMTV integration site family, member 5b0.704
pcdh8protocadherin 80.612
her7hairy and enhancer of split related-70.475
tbx6T-box gene 60.469
admpanti-dorsalizing morphogenic protein0.432
flhfloating head0.370
bmp4bone morphogenetic protein 40.361
sox17SRY-box containing gene 170.311
tbx24T-box 240.276
msxcmuscle segment homeobox C0.268
has2hyaluronan synthase 20.219
her1hairy-related 10.213
her5hairy-related 50.208
dlx3bdistal-less homeobox gene 3b0.199
foxd5forkhead box D50.184
dkk1bdickkopf 1b0.137
fn1fibronectin 10.124
gata5GATA-binding protein 50.120
vedventrally expressed dharma/bozozok antagonist0.116
cdx4caudal type homeo box transcription factor 40.111
tll1tolloid-like 10.100
foxa3forkhead box A30.097
ventventral expressed homeobox0.090
sox32SRY-box containing gene 320.087
pkd2polycystic kidney disease 20.084
smosmoothened homolog (Drosophila)0.084
ndr2nodal-related 20.079
spint1aserine peptidase inhibitor, Kunitz type 1 a0.075
foxi1forkhead box I10.066
nog1noggin 10.065
osr1odd-skipped related 1 (Drosophila)0.064
klf4Kruppel-like factor 40.062
bmp7abone morphogenetic protein 7a0.061
wnt11wingless-type MMTV integration site family, member 110.053
msgn1mesogenin 10.051
mespbmesoderm posterior b0.050
bmp2bbone morphogenetic protein 2b0.050
prickle1aprickle-like 1 (Drosophila) a0.050
fbn2bfibrillin 2b0.049
tp63tumor protein p630.046
ntlano tail a0.043
hoxb1bhomeo box B1b0.042
LOC100536023hypothetical protein LOC1005360230.041
voxventral homeobox0.039
aplnraapelin receptor a0.036
snai1asnail homolog 1a (Drosophila)0.031
oepone-eyed pinhead0.031
fzd10frizzled homolog 100.029
perpPERP, TP53 apoptosis effector0.029
cdx1acaudal type homeo box transcription factor 1 a0.027
mtpmicrosomal triglyceride transfer protein0.026
cdh1cadherin 1, epithelial0.026
acvr1bactivin A receptor, type IB0.025
hnf1baHNF1 homeobox Ba0.024
ndr1nodal-related 10.023
cdh2cadherin 2, neuronal0.023
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.023
nrarpanotch-regulated ankyrin repeat protein a0.023
tagln2transgelin 20.023
fgf8afibroblast growth factor 8 a0.022
shhbsonic hedgehog b0.022
nkd1naked cuticle homolog 1 (Drosophila)0.021
hsd3b1hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 10.020
gata4GATA-binding protein 40.018
sesn1sestrin 10.018
pnxposterior neuron-specific homeobox0.018
znfl2azinc finger-like gene 2a0.017
her3hairy-related 30.017
nkx2.5NK2 transcription factor related 50.017
dspadesmoplakin a0.017
hoxc8ahomeo box C8a0.017
mesp2mesoderm posterior 2 homolog (mouse)0.017
six4asine oculis homeobox homolog 4a0.017
bonbonnie and clyde0.016
aplnrbapelin receptor b0.015
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.015
sp5lSp5 transcription factor-like0.015
gli1GLI-Kruppel family member 10.015
tbx1T-box 10.014
cxcr4achemokine (C-X-C motif) receptor 4a0.014
sp7Sp7 transcription factor0.014
snai1bsnail homolog 1b (Drosophila)0.014
bmp2abone morphogenetic protein 2a0.014
myf5myogenic factor 50.014
gpc4glypican 40.013
lamb1alaminin, beta 1a0.013
og9xOG9 homeobox gene0.012
krt8keratin 80.012
nkx2.7NK2 transcription factor related 70.012
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 21.000
Bmp4bone morphogenetic protein 41.000
Shhsonic hedgehog1.000
Pax3paired box gene 30.999
Gli3GLI-Kruppel family member GLI30.999
Fgf8fibroblast growth factor 80.998
Pitx2paired-like homeodomain transcription factor 20.997
Meox2mesenchyme homeobox 20.993
Fgfr1fibroblast growth factor receptor 10.988
Ctnnb1catenin (cadherin associated protein), beta 10.985
Tgfb2transforming growth factor, beta 20.984
Isl1ISL1 transcription factor, LIM/homeodomain0.977
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.968
Tcfap2atranscription factor AP-2, alpha0.965
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.957
Smosmoothened homolog (Drosophila)0.956
Ptpn11protein tyrosine phosphatase, non-receptor type 110.949
Vegfavascular endothelial growth factor A0.948
Foxc2forkhead box C20.947
Hand1heart and neural crest derivatives expressed transcript 10.946
Foxc1forkhead box C10.939
Prrx1paired related homeobox 10.919
Hand2heart and neural crest derivatives expressed transcript 20.917
Otx2orthodenticle homolog 2 (Drosophila)0.913
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.910
Gata4GATA binding protein 40.909
Tbx1T-box 10.906
Rargretinoic acid receptor, gamma0.904
Jag1jagged 10.886
Rxraretinoid X receptor alpha0.871
Pkd1polycystic kidney disease 1 homolog0.822
Vangl2vang-like 2 (van gogh, Drosophila)0.805
Msx1homeobox, msh-like 10.777
Acvr1activin A receptor, type 10.759
Tbx3T-box 30.747
Nos3nitric oxide synthase 3, endothelial cell0.710
Pax6paired box gene 60.709
Ror2receptor tyrosine kinase-like orphan receptor 20.699
Chd7chromodomain helicase DNA binding protein 70.694
Fgfr3fibroblast growth factor receptor 30.678
Bmp7bone morphogenetic protein 70.656
Sox11SRY-box containing gene 110.648
Hspg2perlecan (heparan sulfate proteoglycan 2)0.618
Eya1eyes absent 1 homolog (Drosophila)0.617
Sox9SRY-box containing gene 90.615
Itgb1integrin beta 1 (fibronectin receptor beta)0.578
Alx4aristaless-like homeobox 40.573
Rararetinoic acid receptor, alpha0.571
Gbx2gastrulation brain homeobox 20.549
Lrp6low density lipoprotein receptor-related protein 60.523
Pax2paired box gene 20.496
Retret proto-oncogene0.483
Lrp2low density lipoprotein receptor-related protein 20.482
Smad6MAD homolog 6 (Drosophila)0.474
Nf1neurofibromatosis 10.446
Hes1hairy and enhancer of split 1 (Drosophila)0.444
Zeb1zinc finger E-box binding homeobox 10.435
Efnb2ephrin B20.417
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.399
Ece1endothelin converting enzyme 10.396
Ednraendothelin receptor type A0.378
Sox4SRY-box containing gene 40.369
Rarbretinoic acid receptor, beta0.346
Sall4sal-like 4 (Drosophila)0.337
Ntf3neurotrophin 30.335
Foxg1forkhead box G10.332
Pitx1paired-like homeodomain transcription factor 10.314
Fgf10fibroblast growth factor 100.290
Hoxa3homeobox A30.286
Zic3zinc finger protein of the cerebellum 30.283
Hoxa1homeobox A10.257
Ptch1patched homolog 10.252
Gja1gap junction protein, alpha 10.236
Wnt3awingless-related MMTV integration site 3A0.228
Dlx5distal-less homeobox 50.226
Rspo2R-spondin 2 homolog (Xenopus laevis)0.225
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.220
Gata6GATA binding protein 60.218
Runx2runt related transcription factor 20.218
Prrx2paired related homeobox 20.215
Shesrc homology 2 domain-containing transforming protein E0.211
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.207
Psen1presenilin 10.206
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.200
Egfrepidermal growth factor receptor0.192
Tgfbr2transforming growth factor, beta receptor II0.176
Gli2GLI-Kruppel family member GLI20.173
Bmpr1abone morphogenetic protein receptor, type 1A0.166
Lef1lymphoid enhancer binding factor 10.160
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.158
Pbx1pre B-cell leukemia transcription factor 10.157
Bmp2bone morphogenetic protein 20.147
Alx3aristaless-like homeobox 30.146
Rb1retinoblastoma 10.144
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 10.140
Msx2homeobox, msh-like 20.130
Hey2hairy/enhancer-of-split related with YRPW motif 20.129
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism