The network for 'negative regulation of toll signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of toll signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of the Tl signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
ZNF496zinc finger protein 4960.374
PELP1proline, glutamate and leucine rich protein 10.272
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.181
IRAK1interleukin-1 receptor-associated kinase 10.142
LAS1LLAS1-like (S. cerevisiae)0.138
RANGAP1Ran GTPase activating protein 10.093
USPL1ubiquitin specific peptidase like 10.076
HIPK2homeodomain interacting protein kinase 20.073
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.065
IRAK2interleukin-1 receptor-associated kinase 20.056
TDGthymine-DNA glycosylase0.051
TRAF6TNF receptor-associated factor 60.050
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.047
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.047
PIAS2protein inhibitor of activated STAT, 20.045
MUL1mitochondrial E3 ubiquitin protein ligase 10.044
PIAS4protein inhibitor of activated STAT, 40.042
ATF7IPactivating transcription factor 7 interacting protein0.032
ELK1ELK1, member of ETS oncogene family0.030
MYBv-myb myeloblastosis viral oncogene homolog (avian)0.026
DAXXdeath-domain associated protein0.024
SUMO4SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)0.023
MDN1MDN1, midasin homolog (yeast)0.021
MEF2Amyocyte enhancer factor 2A0.020
MBD1methyl-CpG binding domain protein 10.019
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.018
MDM2Mdm2 p53 binding protein homolog (mouse)0.015
SP100SP100 nuclear antigen0.015
PMLpromyelocytic leukemia0.014
TEX10testis expressed 100.014
SAE1SUMO1 activating enzyme subunit 10.013
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.013
PYDC2pyrin domain containing 20.013
MYST1MYST histone acetyltransferase 10.013
TP53BP1tumor protein p53 binding protein 10.012
N4BP2L2NEDD4 binding protein 2-like 20.012
ATMataxia telangiectasia mutated0.012
GBP5guanylate binding protein 50.011
PRDM1PR domain containing 1, with ZNF domain0.011
MDM4Mdm4 p53 binding protein homolog (mouse)0.011
DCAF7DDB1 and CUL4 associated factor 70.011
AAMPangio-associated, migratory cell protein0.010
UBXN7UBX domain protein 70.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.033
KhcKinesin heavy chain0.020
EgfrEpidermal growth factor receptor0.014
TorTarget of rapamycin0.013
SfmbtScm-related gene containing four mbt domains0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Arrb1arrestin, beta 10.874
Arrb2arrestin, beta 20.818
Foxm1forkhead box M10.283
Prozprotein Z, vitamin K-dependent plasma glycoprotein0.224
Sparcsecreted acidic cysteine rich glycoprotein0.183
F10coagulation factor X0.082
Mdm2transformed mouse 3T3 cell double minute 20.071
Coro1acoronin, actin binding protein 1A0.070
P4ha1procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide0.054
Fstl1follistatin-like 10.043
Akt1thymoma viral proto-oncogene 10.040
Ambpalpha 1 microglobulin/bikunin0.036
Tcf3transcription factor 30.029
Zfp740zinc finger protein 7400.028
Cmtm3CKLF-like MARVEL transmembrane domain containing 30.026
Sipa1signal-induced proliferation associated gene 10.023
Irak1interleukin-1 receptor-associated kinase 10.023
Egr2early growth response 20.022
Pafah1b2platelet-activating factor acetylhydrolase, isoform 1b, subunit 20.021
Rbp1retinol binding protein 1, cellular0.020
Cacna1fcalcium channel, voltage-dependent, alpha 1F subunit0.020
Lipclipase, hepatic0.020
Grk6G protein-coupled receptor kinase 60.020
EvlEna-vasodilator stimulated phosphoprotein0.019
Sdccag3serologically defined colon cancer antigen 30.018
Kif2akinesin family member 2A0.018
Cerkceramide kinase0.018
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.017
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.017
Fgbfibrinogen beta chain0.017
Gcgroup specific component0.016
Col4a1collagen, type IV, alpha 10.016
Pea15aphosphoprotein enriched in astrocytes 15A0.016
Cficomplement component factor i0.016
Kpna1karyopherin (importin) alpha 10.016
Mdm4transformed mouse 3T3 cell double minute 40.016
Prodh2proline dehydrogenase (oxidase) 20.016
Fggfibrinogen gamma chain0.016
Plxnd1plexin D10.015
Serpinf2serine (or cysteine) peptidase inhibitor, clade F, member 20.015
Plekho1pleckstrin homology domain containing, family O member 10.014
F2coagulation factor II0.014
Slc25a2solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 20.014
Pbx2pre B-cell leukemia transcription factor 20.013
Apoa1apolipoprotein A-I0.013
Apohapolipoprotein H0.012
Mkl1MKL (megakaryoblastic leukemia)/myocardin-like 10.012
Fkbp10FK506 binding protein 100.012
Agap3ArfGAP with GTPase domain, ankyrin repeat and PH domain 30.012
Apcsserum amyloid P-component0.012
Serpinc1serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 10.011
Saa4serum amyloid A 40.011
Adrbk1adrenergic receptor kinase, beta 10.011
Pcolceprocollagen C-endopeptidase enhancer protein0.011
Pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.011
Itih4inter alpha-trypsin inhibitor, heavy chain 40.011
Rassf5Ras association (RalGDS/AF-6) domain family member 50.011
Mast3microtubule associated serine/threonine kinase 30.010
Prkcdbpprotein kinase C, delta binding protein0.010
Otcornithine transcarbamylase0.010
Acin1apoptotic chromatin condensation inducer 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism