The network for 'regulation of amyloid precursor protein biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of amyloid precursor protein biosynthetic process

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid.

NameDescriptionProbabilityFunc Analog Organism
LAMP2lysosomal-associated membrane protein 20.106
POLR2Jpolymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa0.099
LAPTM4Alysosomal protein transmembrane 4 alpha0.077
ATP6AP2ATPase, H+ transporting, lysosomal accessory protein 20.063
ASAH1N-acylsphingosine amidohydrolase (acid ceramidase) 10.037
APPamyloid beta (A4) precursor protein0.034
CTBSchitobiase, di-N-acetyl-0.033
SP1Sp1 transcription factor0.029
RB1retinoblastoma 10.026
B2Mbeta-2-microglobulin0.026
GNSglucosamine (N-acetyl)-6-sulfatase0.023
SH3BGRLSH3 domain binding glutamic acid-rich protein like0.023
SERINC1serine incorporator 10.021
WDR74WD repeat domain 740.019
CCPG1cell cycle progression 10.017
CHEK2CHK2 checkpoint homolog (S. pombe)0.014
LEPROTleptin receptor overlapping transcript0.013
RBBP8retinoblastoma binding protein 80.012
CREG1cellular repressor of E1A-stimulated genes 10.012
ADORA2Aadenosine A2a receptor0.012
TMEM59transmembrane protein 590.011
RRAS2related RAS viral (r-ras) oncogene homolog 20.011
SDCBPsyndecan binding protein (syntenin)0.010
TM9SF2transmembrane 9 superfamily member 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.432
Npc1Niemann Pick type C10.298
Apoeapolipoprotein E0.255
Lrp1low density lipoprotein receptor-related protein 10.142
Sepp1selenoprotein P, plasma, 10.125
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.118
Prnpprion protein0.085
Rdh8retinol dehydrogenase 80.084
Appamyloid beta (A4) precursor protein0.081
Serinc3serine incorporator 30.048
Ndfip1Nedd4 family interacting protein 10.046
Lamp2lysosomal-associated membrane protein 20.045
Ptenphosphatase and tensin homolog0.041
Rnase4ribonuclease, RNase A family 40.034
B2mbeta-2 microglobulin0.031
Ctslcathepsin L0.028
Cyp4v3cytochrome P450, family 4, subfamily v, polypeptide 30.026
Hsd17b11hydroxysteroid (17-beta) dehydrogenase 110.026
Klf5Kruppel-like factor 50.024
Rbl2retinoblastoma-like 20.021
Cfhcomplement component factor h0.021
Pttg1ippituitary tumor-transforming 1 interacting protein0.021
Clstn1calsyntenin 10.020
Tpp1tripeptidyl peptidase I0.019
Nfibnuclear factor I/B0.019
Ldlrlow density lipoprotein receptor0.017
Abcg5ATP-binding cassette, sub-family G (WHITE), member 50.015
Pros1protein S (alpha)0.014
Cd47CD47 antigen (Rh-related antigen, integrin-associated signal transducer)0.013
0610007C21RikRIKEN cDNA 0610007C21 gene0.013
Psapprosaposin0.012
Foxo1forkhead box O10.012
Laptm4alysosomal-associated protein transmembrane 4A0.012
Fth1ferritin heavy chain 10.012
Pcyt1aphosphate cytidylyltransferase 1, choline, alpha isoform0.012
Mylipmyosin regulatory light chain interacting protein0.012
Dazap2DAZ associated protein 20.011
Atp13a2ATPase type 13A20.011
Pgrmc1progesterone receptor membrane component 10.011
Nop14NOP14 nucleolar protein homolog (yeast)0.011
Ruvbl1RuvB-like protein 10.011
Aplp2amyloid beta (A4) precursor-like protein 20.011
Larsleucyl-tRNA synthetase0.010
Nfe2l2nuclear factor, erythroid derived 2, like 20.010
Gpatch4G patch domain containing 40.010
Cst3cystatin C0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism