The network for 'sequestering of metal ion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

sequestering of metal ion

The process of binding or confining metal ions such that they are separated from other components of a biological system.

NameDescriptionProbabilityFunc Analog Organism
CCR5chemokine (C-C motif) receptor 50.998
GSTM1glutathione S-transferase mu 10.991
GSTM2glutathione S-transferase mu 2 (muscle)0.980
CCL5chemokine (C-C motif) ligand 50.978
FGFR2fibroblast growth factor receptor 20.968
IL8interleukin 80.960
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.952
CXCL9chemokine (C-X-C motif) ligand 90.910
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.905
CD22CD22 molecule0.881
CXCL3chemokine (C-X-C motif) ligand 30.837
FGF1fibroblast growth factor 1 (acidic)0.801
DPP4dipeptidyl-peptidase 40.786
TRPC4transient receptor potential cation channel, subfamily C, member 40.780
NCF1neutrophil cytosolic factor 10.754
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.749
CCL22chemokine (C-C motif) ligand 220.721
BCL2L1BCL2-like 10.721
IFNGinterferon, gamma0.704
CCL8chemokine (C-C motif) ligand 80.674
CXCL2chemokine (C-X-C motif) ligand 20.667
ADORA2Aadenosine A2a receptor0.646
CXCL5chemokine (C-X-C motif) ligand 50.628
CCL4chemokine (C-C motif) ligand 40.625
CCL20chemokine (C-C motif) ligand 200.618
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.612
TGFBR1transforming growth factor, beta receptor 10.606
CCR7chemokine (C-C motif) receptor 70.599
GSTM4glutathione S-transferase mu 40.594
DTNAdystrobrevin, alpha0.594
CCR2chemokine (C-C motif) receptor 20.588
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.513
PKD1polycystic kidney disease 1 (autosomal dominant)0.506
CCL7chemokine (C-C motif) ligand 70.505
IL1Binterleukin 1, beta0.484
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.481
BCL2B-cell CLL/lymphoma 20.442
CCR1chemokine (C-C motif) receptor 10.406
CXCL13chemokine (C-X-C motif) ligand 130.402
CCL19chemokine (C-C motif) ligand 190.392
IL2RBinterleukin 2 receptor, beta0.391
IL6interleukin 6 (interferon, beta 2)0.373
TRPC1transient receptor potential cation channel, subfamily C, member 10.369
CCL2chemokine (C-C motif) ligand 20.364
IL10interleukin 100.360
NCF2neutrophil cytosolic factor 20.360
PDZD11PDZ domain containing 110.352
PKD2polycystic kidney disease 2 (autosomal dominant)0.341
NCF4neutrophil cytosolic factor 4, 40kDa0.337
CCL3chemokine (C-C motif) ligand 30.329
TRPC3transient receptor potential cation channel, subfamily C, member 30.317
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.307
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.300
PDIA4protein disulfide isomerase family A, member 40.280
PTPN1protein tyrosine phosphatase, non-receptor type 10.268
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.266
PSEN2presenilin 2 (Alzheimer disease 4)0.264
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.254
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.248
PRKCAprotein kinase C, alpha0.246
FYNFYN oncogene related to SRC, FGR, YES0.242
FTLferritin, light polypeptide0.232
BTKBruton agammaglobulinemia tyrosine kinase0.231
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.230
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.223
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.222
CCR4chemokine (C-C motif) receptor 40.220
CXCR5chemokine (C-X-C motif) receptor 50.212
SYNMsynemin, intermediate filament protein0.211
RGS1regulator of G-protein signaling 10.211
FGF7fibroblast growth factor 70.209
CXCR3chemokine (C-X-C motif) receptor 30.207
BADBCL2-associated agonist of cell death0.207
ACVR1Bactivin A receptor, type IB0.205
BCL2L11BCL2-like 11 (apoptosis facilitator)0.200
CCL13chemokine (C-C motif) ligand 130.199
PF4platelet factor 40.197
CLEC7AC-type lectin domain family 7, member A0.196
MAPTmicrotubule-associated protein tau0.195
MMP12matrix metallopeptidase 12 (macrophage elastase)0.194
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.188
FSTL1follistatin-like 10.187
SHC1SHC (Src homology 2 domain containing) transforming protein 10.182
CCL11chemokine (C-C motif) ligand 110.180
FTH1ferritin, heavy polypeptide 10.178
RHOAras homolog gene family, member A0.174
SNCAIPsynuclein, alpha interacting protein0.172
AKAP6A kinase (PRKA) anchor protein 60.171
CCR3chemokine (C-C motif) receptor 30.167
CXCL10chemokine (C-X-C motif) ligand 100.164
CD40LGCD40 ligand0.162
CXCL11chemokine (C-X-C motif) ligand 110.160
BAK1BCL2-antagonist/killer 10.160
ACTBactin, beta0.158
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.157
NTRK1neurotrophic tyrosine kinase, receptor, type 10.155
FGFR1fibroblast growth factor receptor 10.154
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
opn4lopsin 4, like0.754
dbhdopamine beta hydroxylase0.735
opn4x1opsin 4x10.689
chatcholine acetyltransferase0.653
opn4aopsin 4a (melanopsin)0.569
wnt1wingless-type MMTV integration site family, member 10.522
pitx3paired-like homeodomain transcription factor 30.457
tnnt2atroponin T2a, cardiac0.415
wnt10awingless-type MMTV integration site family, member 10a0.376
ryr3ryanodine receptor 30.362
col11a2collagen type XI alpha-20.350
glra1glycine receptor, alpha 10.310
wnt3wingless-type MMTV integration site family, member 30.292
paqr8progestin and adipoQ receptor family member VIII0.291
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.287
nbl1neuroblastoma, suppression of tumorigenicity 10.286
pink1PTEN induced putative kinase 10.283
stac3SH3 and cysteine rich domain 30.264
th2tyrosine hydroxylase 20.253
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.240
avplarginine vasopressin-like0.231
fbln1fibulin 10.226
rtn4rreticulon 4 receptor0.211
wnt2wingless-type MMTV integration site family member 20.209
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.199
gngt2bguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b0.199
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.197
per3period homolog 3 (Drosophila)0.197
rspo3R-spondin 3 homolog (Xenopus laevis)0.193
a1cfapobec1 complementation factor0.191
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.190
lin7alin-7 homolog A (C. elegans)0.186
rbm24aRNA binding motif protein 24a0.185
tfpi2tissue factor pathway inhibitor 20.180
opn1mw1opsin 1 (cone pigments), medium-wave-sensitive, 10.177
ckmacreatine kinase, muscle a0.175
tgfb3transforming growth factor, beta 30.173
pomcaproopiomelanocortin a0.171
wnt4awingless-type MMTV integration site family, member 4a0.171
spry4sprouty (Drosophila) homolog 40.171
drd2ldopamine receptor D2 like0.170
zfyve26zinc finger, FYVE domain containing 260.169
ldb3bLIM domain binding 3b0.168
coblcordon-bleu homolog (mouse)0.168
lmx1b.1LIM homeobox transcription factor 1, beta 10.166
flhfloating head0.159
spry2sprouty homolog 20.155
trpc5transient receptor potential cation channel, subfamily C, member 50.154
fgf17fibroblast growth factor 170.154
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.154
valopbvertebrate ancient long opsin b0.149
wnt9bwingless-type MMTV integration site family, member 9B0.148
zbtb4zinc finger and BTB domain containing 40.143
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.141
pth2parathyroid hormone 20.140
men1multiple endocrine neoplasia type 1 and multiple endocrine neoplasia I0.140
ighzimmunoglobulin heavy constant zeta0.138
grk7aG-protein-coupled receptor kinase 7a0.138
arf1ADP-ribosylation factor 10.133
LOC557062hypothetical protein LOC5570620.131
ntrk1neurotrophic tyrosine kinase, receptor, type 10.126
wnt16wingless-type MMTV integration site family, member 160.124
trim55btripartite motif-containing 55b0.122
foxb1.2forkhead box B1.20.120
mapk8bmitogen-activated protein kinase 8b0.120
hmx1H6 homeo box 10.119
lhx6LIM homeobox 60.116
ippkinositol 1,3,4,5,6-pentakisphosphate 2-kinase0.112
foxj1aforkhead box J1a0.112
ism1isthmin 10.112
ryr1aryanodine receptor 1a (skeletal)0.112
vmhcventricular myosin heavy chain0.112
baxbbcl2-associated X protein, b0.110
scn1labsodium channel, voltage-gated, type I like, alpha b0.109
actn4actinin, alpha 40.109
lhx2bLIM homeobox 2b0.107
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.105
wnt2bbwingless-type MMTV integration site family, member 2Bb0.104
cald1caldesmon 10.103
LOC566708FL cytokine receptor-like0.102
parapinopsinbparapinopsin b0.100
tnikaTRAF2 and NCK interacting kinase a0.099
cnga5cyclic nucleotide gated channel alpha 50.099
cd8aCD8 antigen, alpha polypeptide0.098
gngt1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 10.097
fbxl14bF-box and leucine-rich repeat protein 14b0.097
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.982
FynFyn proto-oncogene0.965
Cd40CD40 antigen0.910
Ikzf1IKAROS family zinc finger 10.898
Ccl2chemokine (C-C motif) ligand 20.857
Ldb3LIM domain binding 30.840
Ccr2chemokine (C-C motif) receptor 20.811
Drd2dopamine receptor D20.787
Cd22CD22 antigen0.757
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.732
Ptk2PTK2 protein tyrosine kinase 20.710
Ccl3chemokine (C-C motif) ligand 30.705
Inpp5dinositol polyphosphate-5-phosphatase D0.670
Prkcbprotein kinase C, beta0.670
Ccl8chemokine (C-C motif) ligand 80.665
Ccr1chemokine (C-C motif) receptor 10.653
Fcgr1Fc receptor, IgG, high affinity I0.645
Prkccprotein kinase C, gamma0.588
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.575
Ptenphosphatase and tensin homolog0.575
SrcRous sarcoma oncogene0.557
Grb2growth factor receptor bound protein 20.556
Nrg1neuregulin 10.546
Ccr6chemokine (C-C motif) receptor 60.541
C3ar1complement component 3a receptor 10.524
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.498
Itgaxintegrin alpha X0.488
Ryr2ryanodine receptor 2, cardiac0.484
Cacna1scalcium channel, voltage-dependent, L type, alpha 1S subunit0.482
Folr2folate receptor 2 (fetal)0.451
Ccr5chemokine (C-C motif) receptor 50.447
Cd209dCD209d antigen0.433
Itgb1integrin beta 1 (fibronectin receptor beta)0.431
Ptprcprotein tyrosine phosphatase, receptor type, C0.428
Cd209bCD209b antigen0.421
Retret proto-oncogene0.411
Ccl7chemokine (C-C motif) ligand 70.409
Selpselectin, platelet0.403
CblCasitas B-lineage lymphoma0.392
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.388
FcrlaFc receptor-like A0.383
Msr1macrophage scavenger receptor 10.383
Necap2NECAP endocytosis associated 20.375
Itpr2inositol 1,4,5-triphosphate receptor 20.355
Ckmcreatine kinase, muscle0.354
Dok1docking protein 10.350
Cys1cystin 10.346
Aif1allograft inflammatory factor 10.345
Hrchistidine rich calcium binding protein0.341
Ccl12chemokine (C-C motif) ligand 120.337
Hbb-b1hemoglobin, beta adult major chain0.333
Slamf1signaling lymphocytic activation molecule family member 10.320
Hcls1hematopoietic cell specific Lyn substrate 10.307
Ftl1ferritin light chain 10.302
Srpk3serine/arginine-rich protein specific kinase 30.296
Atg12autophagy-related 12 (yeast)0.293
Ccl17chemokine (C-C motif) ligand 170.293
Klrg1killer cell lectin-like receptor subfamily G, member 10.292
Tlr8toll-like receptor 80.289
Meox2mesenchyme homeobox 20.288
Ptk2bPTK2 protein tyrosine kinase 2 beta0.283
Casq1calsequestrin 10.281
Pkd2polycystic kidney disease 20.279
Cd7CD7 antigen0.276
Foxc1forkhead box C10.275
Spna1spectrin alpha 10.272
Il4interleukin 40.269
Vti1avesicle transport through interaction with t-SNAREs homolog 1A (yeast)0.267
Rasgrp1RAS guanyl releasing protein 10.263
Klrk1killer cell lectin-like receptor subfamily K, member 10.262
WasWiskott-Aldrich syndrome homolog (human)0.261
Itpr3inositol 1,4,5-triphosphate receptor 30.261
Npy2rneuropeptide Y receptor Y20.261
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.258
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.255
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.252
Cd209gCD209g antigen0.250
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.240
Ncr1natural cytotoxicity triggering receptor 10.239
Fcgr2bFc receptor, IgG, low affinity IIb0.237
Foxg1forkhead box G10.234
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.231
Ptgfrprostaglandin F receptor0.231
Mmp12matrix metallopeptidase 120.230
Ftl2ferritin light chain 20.229
Coro1bcoronin, actin binding protein 1B0.227
Cd86CD86 antigen0.225
Itgamintegrin alpha M0.223
Il1rninterleukin 1 receptor antagonist0.222
BlkB lymphoid kinase0.221
Ch25hcholesterol 25-hydroxylase0.220
Scn4asodium channel, voltage-gated, type IV, alpha0.219
Myo1fmyosin IF0.218
Fgf7fibroblast growth factor 70.217
Bcl2B-cell leukemia/lymphoma 20.217
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.217
Sfpi1SFFV proviral integration 10.215
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il2rginterleukin 2 receptor, gamma0.213
Chrm2cholinergic receptor, muscarinic 20.174
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.164
Ly86lymphocyte antigen 860.160
Csf1colony stimulating factor 1 (macrophage)0.114
Ccl4chemokine (C-C motif) ligand 40.113
Lst1leukocyte specific transcript 10.112
Slc18a2solute carrier family 18 (vesicular monoamine), member 20.110
Sirpasignal-regulatory protein alpha0.103
Cxcr3chemokine (C-X-C motif) receptor 30.100
Vav1vav 1 guanine nucleotide exchange factor0.100
Flt1FMS-related tyrosine kinase 10.095
Arrb2arrestin, beta 20.095
Grpel1GrpE-like 1, mitochondrial0.090
Xcl1chemokine (C motif) ligand 10.088
Il1ainterleukin 1 alpha0.087
Cd53Cd53 molecule0.086
Fgf16fibroblast growth factor 160.081
Tbxas1thromboxane A synthase 1, platelet0.080
Ccr5chemokine (C-C motif) receptor 50.079
Mpeg1macrophage expressed 10.078
Inpp5dinositol polyphosphate-5-phosphatase D0.077
Ednraendothelin receptor type A0.076
Arhgap25Rho GTPase activating protein 250.075
P2ry14purinergic receptor P2Y, G-protein coupled, 140.073
Igh-6immunoglobulin heavy chain 60.073
Pygmphosphorylase, glycogen, muscle0.071
Cxcl13chemokine (C-X-C motif) ligand 130.069
Syt8synaptotagmin VIII0.068
Cd247Cd247 molecule0.068
Slco2b1solute carrier organic anion transporter family, member 2b10.068
Il1binterleukin 1 beta0.068
Calcrlcalcitonin receptor-like0.066
Dock8dedicator of cytokinesis 80.065
Ccl2chemokine (C-C motif) ligand 20.063
Ppyr1pancreatic polypeptide receptor 10.063
Olr1278olfactory receptor 12780.063
Lcp1lymphocyte cytosolic protein 10.062
Slasrc-like adaptor0.062
Actc1actin, alpha, cardiac muscle 10.061
Chrna7cholinergic receptor, nicotinic, alpha 70.061
Slc14a2solute carrier family 14 (urea transporter), member 20.060
Lcp2lymphocyte cytosolic protein 20.059
Cd38CD38 molecule0.058
RT1-Db1RT1 class II, locus Db10.058
Cd8aCD8a molecule0.056
Rac2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.056
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.055
Pstpip1proline-serine-threonine phosphatase-interacting protein 10.055
Gja6gap junction protein, alpha 60.055
Hcrtr2hypocretin (orexin) receptor 20.054
Prl6a1prolactin family 6, subfamily a, member 10.053
Lim2lens intrinsic membrane protein 20.053
Pnlippancreatic lipase0.053
Prf1perforin 1 (pore forming protein)0.052
MosMoloney sarcoma oncogene0.052
Cd86CD86 molecule0.051
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.051
Ptpn7protein tyrosine phosphatase, non-receptor type 70.050
Cacng1calcium channel, voltage-dependent, gamma subunit 10.050
Emr1EGF-like module containing, mucin-like, hormone receptor-like 10.050
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.049
Mybpc1myosin binding protein C, slow type0.049
Ampd1adenosine monophosphate deaminase 1 (isoform M)0.048
Tcf4transcription factor 40.048
Cntnap1contactin associated protein 10.048
Olr287olfactory receptor 2870.048
CdonCdon homolog (mouse)0.048
Phkg1phosphorylase kinase, gamma 10.048
P2ry1purinergic receptor P2Y, G-protein coupled, 10.047
Esr2estrogen receptor 2 (ER beta)0.047
Ndufa5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 50.047
Il9rinterleukin 9 receptor0.047
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.046
Lcklymphocyte-specific protein tyrosine kinase0.046
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.046
Lrrc39leucine rich repeat containing 390.046
Ptprcprotein tyrosine phosphatase, receptor type, C0.046
Prkcbprotein kinase C, beta0.045
Nrasneuroblastoma ras oncogene0.045
Pzppregnancy-zone protein0.045
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.045
Clec4a3C-type lectin domain family 4, member a30.045
Adam10ADAM metallopeptidase domain 100.044
Myl7myosin, light chain 7, regulatory0.044
Itpr2inositol 1,4,5-triphosphate receptor, type 20.044
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.044
Syt7synaptotagmin VII0.043
Ncf4neutrophil cytosolic factor 40.043
Lrrc14bleucine rich repeat containing 14B0.043
Rassf5Ras association (RalGDS/AF-6) domain family member 50.042
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.042
Pgam2phosphoglycerate mutase 2 (muscle)0.042
Arhgap23Rho GTPase activating protein 230.042
Ccbp2chemokine binding protein 20.041
Ptprqprotein tyrosine phosphatase, receptor type, Q0.041
Cd3dCD3 molecule, delta0.041
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YMR086Whypothetical protein0.010