The network for 'peptide secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

peptide secretion

The controlled release of a peptide from a cell or a tissue.

NameDescriptionProbabilityFunc Analog Organism
HNF4Ahepatocyte nuclear factor 4, alpha0.988
PDX1pancreatic and duodenal homeobox 10.987
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.972
PTPN1protein tyrosine phosphatase, non-receptor type 10.954
GRB2growth factor receptor-bound protein 20.952
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.945
GABBR2gamma-aminobutyric acid (GABA) B receptor, 20.924
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.901
TEKTEK tyrosine kinase, endothelial0.886
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.854
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.853
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.842
S100A8S100 calcium binding protein A80.842
SNAP23synaptosomal-associated protein, 23kDa0.831
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.817
IL1R1interleukin 1 receptor, type I0.759
HLA-DMBmajor histocompatibility complex, class II, DM beta0.755
MT1Ametallothionein 1A0.755
ZFYVE9zinc finger, FYVE domain containing 90.748
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.743
CRHR1corticotropin releasing hormone receptor 10.718
S100A9S100 calcium binding protein A90.717
KCNE1potassium voltage-gated channel, Isk-related family, member 10.711
CCR5chemokine (C-C motif) receptor 50.708
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.707
HCKhemopoietic cell kinase0.700
CCL4chemokine (C-C motif) ligand 40.685
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.658
FGBfibrinogen beta chain0.630
INSRinsulin receptor0.616
CCNYcyclin Y0.601
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.563
CHD8chromodomain helicase DNA binding protein 80.554
IGF1Rinsulin-like growth factor 1 receptor0.552
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.547
ADORA2Aadenosine A2a receptor0.544
CXCL9chemokine (C-X-C motif) ligand 90.534
NEUROD1neurogenic differentiation 10.484
SOCS1suppressor of cytokine signaling 10.449
FGAfibrinogen alpha chain0.444
EP300E1A binding protein p3000.427
CCL2chemokine (C-C motif) ligand 20.401
LIN7Blin-7 homolog B (C. elegans)0.399
CRHcorticotropin releasing hormone0.395
PPARAperoxisome proliferator-activated receptor alpha0.375
NOSTRINnitric oxide synthase trafficker0.365
HLA-DRB4major histocompatibility complex, class II, DR beta 40.365
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.364
MEOX1mesenchyme homeobox 10.362
CLASP1cytoplasmic linker associated protein 10.347
HLA-DRB5major histocompatibility complex, class II, DR beta 50.343
CREBBPCREB binding protein0.339
PSEN2presenilin 2 (Alzheimer disease 4)0.331
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.326
ONECUT1one cut homeobox 10.314
HLA-DPB1major histocompatibility complex, class II, DP beta 10.314
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.312
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.310
GABBR1gamma-aminobutyric acid (GABA) B receptor, 10.309
TP53tumor protein p530.295
CDX2caudal type homeobox 20.279
SNTB2syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)0.278
IL1Binterleukin 1, beta0.271
ESRRGestrogen-related receptor gamma0.270
DRD2dopamine receptor D20.259
SH2B1SH2B adaptor protein 10.252
CCR1chemokine (C-C motif) receptor 10.251
HOXD12homeobox D120.245
BLNKB-cell linker0.240
CRPC-reactive protein, pentraxin-related0.234
NKX2-1NK2 homeobox 10.233
HNF1BHNF1 homeobox B0.221
CXCL10chemokine (C-X-C motif) ligand 100.221
SNAP25synaptosomal-associated protein, 25kDa0.214
SETD8SET domain containing (lysine methyltransferase) 80.213
SREBF2sterol regulatory element binding transcription factor 20.206
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.205
GJD2gap junction protein, delta 2, 36kDa0.191
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.190
CCL5chemokine (C-C motif) ligand 50.183
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.178
CLOCKclock homolog (mouse)0.173
CHD7chromodomain helicase DNA binding protein 70.172
AHRaryl hydrocarbon receptor0.171
IL1RNinterleukin 1 receptor antagonist0.170
IRS1insulin receptor substrate 10.169
KAT2BK(lysine) acetyltransferase 2B0.166
GRB10growth factor receptor-bound protein 100.162
FGGfibrinogen gamma chain0.161
FGF3fibroblast growth factor 30.161
FOXA2forkhead box A20.158
HNF1AHNF1 homeobox A0.153
SMAD3SMAD family member 30.144
IL6Rinterleukin 6 receptor0.141
PYYpeptide YY0.140
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.140
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.135
IL1R2interleukin 1 receptor, type II0.135
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.134
STX5syntaxin 50.133
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
RicRas which interacts with Calmodulin0.054
ShawShaker cognate w0.038
CaMKIICalcium/calmodulin-dependent protein kinase II0.029
CycJCyclin J0.025
Sema-1aCG18405 gene product from transcript CG18405-RD0.024
trioCG18214 gene product from transcript CG18214-RA0.022
myoglianinCG1838 gene product from transcript CG1838-RD0.019
Eip63F-1Ecdysone-induced protein 63F 10.018
Atg9Autophagy-specific gene 90.016
MTF-1Metal response element-binding Transcription Factor-10.015
Mekk1CG7717 gene product from transcript CG7717-RB0.015
Irk3Inwardly rectifying potassium channel 30.014
kibrakibra ortholog0.014
Mmp2Matrix metalloproteinase 20.014
Pka-C1cAMP-dependent protein kinase 10.012
CG34139CG34139 gene product from transcript CG34139-RD0.012
S6kRPS6-p70-protein kinase0.012
rtGEFrho-type guanine exchange factor0.012
rawCG12437 gene product from transcript CG12437-RB0.011
Plc21CPhospholipase C at 21C0.011
RhoGAP100FCG1976 gene product from transcript CG1976-RB0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 10.987
Drd2dopamine receptor D20.951
Nos3nitric oxide synthase 3, endothelial cell0.927
Leprleptin receptor0.909
Thrbthyroid hormone receptor beta0.907
Gata4GATA binding protein 40.865
Ptenphosphatase and tensin homolog0.859
Esr1estrogen receptor 1 (alpha)0.855
Insm1insulinoma-associated 10.834
Pax8paired box gene 80.834
Smad3MAD homolog 3 (Drosophila)0.812
Fshrfollicle stimulating hormone receptor0.794
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.790
Ephb2Eph receptor B20.789
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.788
Nf1neurofibromatosis 10.778
Lhx3LIM homeobox protein 30.772
Gli3GLI-Kruppel family member GLI30.731
Prlrprolactin receptor0.719
Bmp4bone morphogenetic protein 40.717
Nos2nitric oxide synthase 2, inducible0.708
Per2period homolog 2 (Drosophila)0.700
Nr3c1nuclear receptor subfamily 3, group C, member 10.695
Pdx1pancreatic and duodenal homeobox 10.654
Lef1lymphoid enhancer binding factor 10.648
Pthlhparathyroid hormone-like peptide0.638
Prox1prospero-related homeobox 10.605
Tgfbr3transforming growth factor, beta receptor III0.586
Fgfr3fibroblast growth factor receptor 30.578
Efnb2ephrin B20.546
Adra2badrenergic receptor, alpha 2b0.517
Clockcircadian locomotor output cycles kaput0.505
Gata6GATA binding protein 60.499
Sstr3somatostatin receptor 30.464
Pnpla2patatin-like phospholipase domain containing 20.460
Onecut1one cut domain, family member 10.460
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.427
Kiss1KiSS-1 metastasis-suppressor0.414
Axin1axin 10.408
Hrkharakiri, BCL2 interacting protein (contains only BH3 domain)0.406
Insrinsulin receptor0.402
Sfrp2secreted frizzled-related protein 20.384
S100a9S100 calcium binding protein A9 (calgranulin B)0.383
Cry2cryptochrome 2 (photolyase-like)0.378
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.378
Vdrvitamin D receptor0.377
Arntlaryl hydrocarbon receptor nuclear translocator-like0.373
Chrm1cholinergic receptor, muscarinic 1, CNS0.373
Fgfr2fibroblast growth factor receptor 20.370
Acvr2aactivin receptor IIA0.368
Prop1paired like homeodomain factor 10.366
Pim3proviral integration site 30.354
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.353
Tgfbr2transforming growth factor, beta receptor II0.348
Adra2aadrenergic receptor, alpha 2a0.347
Apoeapolipoprotein E0.346
Fgf8fibroblast growth factor 80.342
S100a8S100 calcium binding protein A8 (calgranulin A)0.342
Otporthopedia homolog (Drosophila)0.336
Eya1eyes absent 1 homolog (Drosophila)0.332
Sstr4somatostatin receptor 40.329
Nrxn3neurexin III0.328
Ppargperoxisome proliferator activated receptor gamma0.326
Bdkrb2bradykinin receptor, beta 20.326
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.320
Tgfbr1transforming growth factor, beta receptor I0.319
Hoxd13homeobox D130.319
Arandrogen receptor0.319
Ghrgrowth hormone receptor0.315
Hand1heart and neural crest derivatives expressed transcript 10.313
Foxh1forkhead box H10.299
Pitx3paired-like homeodomain transcription factor 30.297
Smad4MAD homolog 4 (Drosophila)0.294
IhhIndian hedgehog0.293
Rxraretinoid X receptor alpha0.292
Rapgef4Rap guanine nucleotide exchange factor (GEF) 40.292
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.289
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.287
Il1binterleukin 1 beta0.287
Irs1insulin receptor substrate 10.279
Irs3insulin receptor substrate 30.276
Cry1cryptochrome 1 (photolyase-like)0.275
Wnt7bwingless-related MMTV integration site 7B0.274
Egfrepidermal growth factor receptor0.274
Cckbrcholecystokinin B receptor0.273
Pitx2paired-like homeodomain transcription factor 20.271
Efnb1ephrin B10.268
Oprd1opioid receptor, delta 10.267
Gata5GATA binding protein 50.265
Foxc1forkhead box C10.265
Gabrb2gamma-aminobutyric acid (GABA) A receptor, subunit beta 20.264
Inhbainhibin beta-A0.260
Syt7synaptotagmin VII0.259
Lhcgrluteinizing hormone/choriogonadotropin receptor0.257
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Glp1rglucagon-like peptide 1 receptor0.409
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.363
Arpc1bactin related protein 2/3 complex, subunit 1B0.240
Mef2dmyocyte enhancer factor 2D0.228
Neurod2neurogenic differentiation 20.198
Ptgfrprostaglandin F receptor0.197
Lifrleukemia inhibitory factor receptor alpha0.179
Notch4Notch homolog 4 (Drosophila)0.174
Pparaperoxisome proliferator activated receptor alpha0.164
Cxcr5chemokine (C-X-C motif) receptor 50.162
Accn2amiloride-sensitive cation channel 2, neuronal0.162
Pnliprp2pancreatic lipase-related protein 20.161
G6pcglucose-6-phosphatase, catalytic subunit0.157
Mamdc4MAM domain containing 40.157
Acsl4acyl-CoA synthetase long-chain family member 40.156
Cyp2c11cytochrome P450, subfamily 2, polypeptide 110.151
Scn10asodium channel, voltage-gated, type X, alpha subunit0.150
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.149
Mapk10mitogen activated protein kinase 100.149
Ins2insulin 20.145
Syt4synaptotagmin IV0.145
Scn3asodium channel, voltage-gated, type III, alpha0.143
Necab2N-terminal EF-hand calcium binding protein 20.141
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.139
Lgals3lectin, galactoside-binding, soluble, 30.138
Apoa4apolipoprotein A-IV0.136
Adora2aadenosine A2a receptor0.133
Chrna7cholinergic receptor, nicotinic, alpha 70.130
Thtyrosine hydroxylase0.129
Igf2insulin-like growth factor 20.129
S100a6S100 calcium binding protein A60.129
Grm7glutamate receptor, metabotropic 70.128
Elavl4ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)0.128
Crhbpcorticotropin releasing hormone binding protein0.128
Kcnj16potassium inwardly-rectifying channel, subfamily J, member 160.127
Expiextracellular proteinase inhibitor0.123
Prlhrprolactin releasing hormone receptor0.122
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.122
Mtmr7myotubularin related protein 70.120
Iappislet amyloid polypeptide0.117
Aqp2aquaporin 2 (collecting duct)0.115
Adrb1adrenergic, beta-1-, receptor0.112
Epas1endothelial PAS domain protein 10.112
Pax6paired box 60.111
Casp3caspase 30.108
Unc5aunc-5 homolog A (C. elegans)0.107
Lim2lens intrinsic membrane protein 20.107
Phkg1phosphorylase kinase, gamma 10.107
Kcnq3potassium voltage-gated channel, KQT-like subfamily, member 30.106
Sox17SRY (sex determining region Y)-box 170.105
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.103
Gabra3gamma-aminobutyric acid (GABA) A receptor, alpha 30.102
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.102
Hist1h2aahistone cluster 1, H2aa0.102
Ush1cUsher syndrome 1C homolog (human)0.101
Cntn5contactin 50.099
Gad2glutamate decarboxylase 20.099
Nr1d2nuclear receptor subfamily 1, group D, member 20.099
Nrsn1neurensin 10.099
RT1-BaRT1 class II, locus Ba0.098
Sstr2somatostatin receptor 20.098
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.096
Acaa1bacetyl-Coenzyme A acyltransferase 1B0.095
Kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.094
Fbp1fructose-1,6-bisphosphatase 10.093
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.092
Necab1N-terminal EF-hand calcium binding protein 10.092
Clstn3calsyntenin 30.091
Grm1glutamate receptor, metabotropic 10.088
Adora1adenosine A1 receptor0.088
Rxrgretinoid X receptor gamma0.087
Dio1deiodinase, iodothyronine, type I0.085
Insrrinsulin receptor-related receptor0.085
Avparginine vasopressin0.085
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.085
Sftpdsurfactant protein D0.085
Rims1regulating synaptic membrane exocytosis 10.085
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.084
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.084
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.083
Vipvasoactive intestinal peptide0.083
S100a10S100 calcium binding protein A100.082
Reg3gregenerating islet-derived 3 gamma0.082
DbpD site of albumin promoter (albumin D-box) binding protein0.082
SeboxSEBOX homeobox0.081
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.081
Socs7suppressor of cytokine signaling 70.081
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.080
Cdh22cadherin 220.080
Pcsk1proprotein convertase subtilisin/kexin type 10.079
CartptCART prepropeptide0.079
Ghrgrowth hormone receptor0.078
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.077
Mapk8ip2mitogen-activated protein kinase 8 interacting protein 20.076
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism