The network for 'positive regulation of peptide secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of peptide secretion

Any process that activates or increases the frequency, rate, or extent of peptide secretion.

NameDescriptionProbabilityFunc Analog Organism
PTPN1protein tyrosine phosphatase, non-receptor type 10.749
TEKTEK tyrosine kinase, endothelial0.599
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.545
HCKhemopoietic cell kinase0.468
S100A8S100 calcium binding protein A80.454
EGFRepidermal growth factor receptor0.451
GRB2growth factor receptor-bound protein 20.417
INSRinsulin receptor0.414
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.337
FGAfibrinogen alpha chain0.315
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.296
CAPNS1calpain, small subunit 10.283
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.280
S100A9S100 calcium binding protein A90.266
FYNFYN oncogene related to SRC, FGR, YES0.248
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.243
HLA-DQA1major histocompatibility complex, class II, DQ alpha 10.228
HLA-DMBmajor histocompatibility complex, class II, DM beta0.208
SNAP23synaptosomal-associated protein, 23kDa0.190
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.158
ADORA2Aadenosine A2a receptor0.144
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.144
HLA-DRB5major histocompatibility complex, class II, DR beta 50.131
IGF1Rinsulin-like growth factor 1 receptor0.106
SYKspleen tyrosine kinase0.103
FGBfibrinogen beta chain0.093
VAMP3vesicle-associated membrane protein 3 (cellubrevin)0.091
PSEN1presenilin 10.069
GRB7growth factor receptor-bound protein 70.051
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.049
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.046
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.042
PSEN2presenilin 2 (Alzheimer disease 4)0.038
FGGfibrinogen gamma chain0.038
SNAP25synaptosomal-associated protein, 25kDa0.037
HLA-DPA1major histocompatibility complex, class II, DP alpha 10.036
HLA-DPB1major histocompatibility complex, class II, DP beta 10.035
CREBBPCREB binding protein0.032
SH3KBP1SH3-domain kinase binding protein 10.031
IFNGR1interferon gamma receptor 10.030
BLNKB-cell linker0.028
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.028
CLASP1cytoplasmic linker associated protein 10.028
ARRB2arrestin, beta 20.028
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.025
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.022
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.021
HLA-DRB4major histocompatibility complex, class II, DR beta 40.021
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.020
SH2B1SH2B adaptor protein 10.019
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.019
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.018
GLIS2GLIS family zinc finger 20.018
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.018
TTRtransthyretin0.017
GRB10growth factor receptor-bound protein 100.016
ESRRGestrogen-related receptor gamma0.016
CRHR1corticotropin releasing hormone receptor 10.016
KAT2BK(lysine) acetyltransferase 2B0.016
STX5syntaxin 50.016
ARF4ADP-ribosylation factor 40.015
EPORerythropoietin receptor0.014
TOM1L1target of myb1 (chicken)-like 10.014
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.013
GNA13guanine nucleotide binding protein (G protein), alpha 130.013
ITKIL2-inducible T-cell kinase0.013
NAMPTnicotinamide phosphoribosyltransferase0.012
CTTNcortactin0.012
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.012
HIC1hypermethylated in cancer 10.012
GNAQguanine nucleotide binding protein (G protein), q polypeptide0.012
ANGPT2angiopoietin 20.012
GAS7growth arrest-specific 70.011
SOCS1suppressor of cytokine signaling 10.011
PIK3R3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.011
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
S100a6S100 calcium binding protein A6 (calcyclin)0.881
Bglapbone gamma carboxyglutamate protein0.826
S100a13S100 calcium binding protein A130.763
Lepleptin0.697
Itgb1integrin beta 1 (fibronectin receptor beta)0.689
Nr3c1nuclear receptor subfamily 3, group C, member 10.672
Map3k14mitogen-activated protein kinase kinase kinase 140.587
Ltblymphotoxin B0.572
Fgfr2fibroblast growth factor receptor 20.556
S100a9S100 calcium binding protein A9 (calgranulin B)0.551
Arrb1arrestin, beta 10.550
Ltalymphotoxin A0.541
S100a8S100 calcium binding protein A8 (calgranulin A)0.539
Anxa2annexin A20.500
Bglap2bone gamma-carboxyglutamate protein 20.474
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.465
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.449
Nf1neurofibromatosis 10.437
Nos3nitric oxide synthase 3, endothelial cell0.435
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.417
Retret proto-oncogene0.346
S100a10S100 calcium binding protein A10 (calpactin)0.331
S100a11S100 calcium binding protein A11 (calgizzarin)0.328
Ptpn11protein tyrosine phosphatase, non-receptor type 110.327
Aldoaaldolase A, fructose-bisphosphate0.315
Leprleptin receptor0.284
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.282
Bsgbasigin0.241
Prop1paired like homeodomain factor 10.234
Klklotho0.223
Ghrgrowth hormone receptor0.212
Socs1suppressor of cytokine signaling 10.206
Pkm2pyruvate kinase, muscle0.199
Insm1insulinoma-associated 10.197
Insrinsulin receptor0.191
Emx1empty spiracles homolog 1 (Drosophila)0.183
Lef1lymphoid enhancer binding factor 10.183
Il7interleukin 70.183
Lgals1lectin, galactose binding, soluble 10.178
Sox11SRY-box containing gene 110.170
Gckglucokinase0.164
Ldb3LIM domain binding 30.164
Isl1ISL1 transcription factor, LIM/homeodomain0.162
Amhanti-Mullerian hormone0.159
Tcf7transcription factor 7, T-cell specific0.158
Cxcr5chemokine (C-X-C motif) receptor 50.157
Pthlhparathyroid hormone-like peptide0.155
Otporthopedia homolog (Drosophila)0.152
S100a4S100 calcium binding protein A40.148
Toxthymocyte selection-associated high mobility group box0.142
Prlrprolactin receptor0.138
Lhcgrluteinizing hormone/choriogonadotropin receptor0.136
Tnftumor necrosis factor0.133
Map3k5mitogen-activated protein kinase kinase kinase 50.132
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.131
Vdrvitamin D receptor0.131
Traf6TNF receptor-associated factor 60.127
Cd160CD160 antigen0.127
Adra2aadrenergic receptor, alpha 2a0.127
Fgf8fibroblast growth factor 80.126
Meox2mesenchyme homeobox 20.126
Clockcircadian locomotor output cycles kaput0.122
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.121
Arrb2arrestin, beta 20.121
Sox1SRY-box containing gene 10.116
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.113
Gpi1glucose phosphate isomerase 10.113
Ikzf1IKAROS family zinc finger 10.109
Egfrepidermal growth factor receptor0.108
Cd247CD247 antigen0.108
Cav1caveolin 1, caveolae protein0.104
Pax6paired box gene 60.104
Gprc6aG protein-coupled receptor, family C, group 6, member A0.103
Ntf3neurotrophin 30.102
F2coagulation factor II0.100
Sim1single-minded homolog 1 (Drosophila)0.098
Smpd3sphingomyelin phosphodiesterase 3, neutral0.097
Hprthypoxanthine guanine phosphoribosyl transferase0.096
Ppypancreatic polypeptide0.096
Esr1estrogen receptor 1 (alpha)0.095
Cdkn1bcyclin-dependent kinase inhibitor 1B0.093
RrasHarvey rat sarcoma oncogene, subgroup R0.089
Irs1insulin receptor substrate 10.086
Fggfibrinogen gamma chain0.085
Rpgrip1lRpgrip1-like0.085
Ins2insulin II0.081
Irs2insulin receptor substrate 20.079
Sox4SRY-box containing gene 40.078
Slc34a1solute carrier family 34 (sodium phosphate), member 10.076
Lmx1bLIM homeobox transcription factor 1 beta0.076
WwoxWW domain-containing oxidoreductase0.075
Tmem116transmembrane protein 1160.074
Coro1bcoronin, actin binding protein 1B0.073
Lhx3LIM homeobox protein 30.072
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.071
Cxcl13chemokine (C-X-C motif) ligand 130.071
Shc3src homology 2 domain-containing transforming protein C30.070
TyrobpTYRO protein tyrosine kinase binding protein0.070
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.068
Sox2SRY-box containing gene 20.068
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
G6pcglucose-6-phosphatase, catalytic subunit0.300
Pparaperoxisome proliferator activated receptor alpha0.278
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.197
Nfascneurofascin0.189
Dnase1deoxyribonuclease I0.180
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.167
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.167
Uoxurate oxidase0.137
Hrh3histamine receptor H30.118
P2rx2purinergic receptor P2X, ligand-gated ion channel, 20.114
Csf1colony stimulating factor 1 (macrophage)0.104
Csn2casein beta0.103
Lhx5LIM homeobox 50.101
Prss3protease, serine, 30.097
Neurod2neurogenic differentiation 20.096
Necab2N-terminal EF-hand calcium binding protein 20.093
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.087
Unc13cunc-13 homolog C (C. elegans)0.086
Ush1cUsher syndrome 1C homolog (human)0.082
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.082
Aqp2aquaporin 2 (collecting duct)0.080
Ednraendothelin receptor type A0.079
Cgaglycoprotein hormones, alpha polypeptide0.076
Synj1synaptojanin 10.074
Thtyrosine hydroxylase0.068
Gckglucokinase0.067
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.066
Scn10asodium channel, voltage-gated, type X, alpha subunit0.066
Slc8a3solute carrier family 8 (sodium/calcium exchanger), member 30.065
RGD1310262hypothetical LOC3046500.064
Csn1s2acasein alpha s2-like A0.064
MlxiplMLX interacting protein-like0.062
Tff3trefoil factor 3, intestinal0.062
Mamdc4MAM domain containing 40.061
Pik3r1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.061
Trib1tribbles homolog 1 (Drosophila)0.059
Ugt2b7UDP glucuronosyltransferase 2 family, polypeptide B70.059
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.059
Glra1glycine receptor, alpha 10.059
Slc5a2solute carrier family 5 (sodium/glucose cotransporter), member 20.058
Chrna7cholinergic receptor, nicotinic, alpha 70.057
Crhr1corticotropin releasing hormone receptor 10.057
Gabbr1gamma-aminobutyric acid (GABA) B receptor 10.055
Slc2a4solute carrier family 2 (facilitated glucose transporter), member 40.055
Grm6glutamate receptor, metabotropic 60.054
Dmrta1DMRT-like family A10.054
Smcpsperm mitochondria-associated cysteine-rich protein0.053
Tubb3tubulin, beta 30.052
Ahsgalpha-2-HS-glycoprotein0.052
Ptprhprotein tyrosine phosphatase, receptor type, H0.052
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.051
Crygecrystallin, gamma E0.051
Col10a1collagen, type X, alpha 10.050
Hnrpmheterogeneous nuclear ribonucleoprotein M0.050
Grm4glutamate receptor, metabotropic 40.049
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.049
Tbxa2rthromboxane A2 receptor0.048
Mmp10matrix metallopeptidase 100.048
DaoD-amino-acid oxidase0.047
Adam5a disintegrin and metallopeptidase domain 50.047
Slco2a1solute carrier organic anion transporter family, member 2a10.045
Kcnq2potassium voltage-gated channel, KQT-like subfamily, member 20.045
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.044
Pklrpyruvate kinase, liver and RBC0.043
Grm7glutamate receptor, metabotropic 70.043
Prlhrprolactin releasing hormone receptor0.043
Gdi2GDP dissociation inhibitor 20.043
Esr2estrogen receptor 2 (ER beta)0.043
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.042
Phox2apaired-like homeobox 2a0.042
Hrhairless0.042
Casp3caspase 30.041
Nmuneuromedin U0.041
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.041
Olr1654olfactory receptor 16540.041
Zic1Zic family member 1 (odd-paired homolog, Drosophila)0.040
Gpr135G protein-coupled receptor 1350.040
Gcnt3glucosaminyl (N-acetyl) transferase 3, mucin type0.040
Slc48a1solute carrier family 48 (heme transporter), member 10.040
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.040
Slc27a2solute carrier family 27 (fatty acid transporter), member 20.040
Ins2insulin 20.039
Il1r1interleukin 1 receptor, type I0.039
Dnase1l3deoxyribonuclease 1-like 30.039
Insrrinsulin receptor-related receptor0.038
Cryaacrystallin, alpha A0.038
Prlrprolactin receptor0.038
Npffr2neuropeptide FF receptor 20.038
Kcna5potassium voltage-gated channel, shaker-related subfamily, member 50.038
St8sia3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 30.038
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.038
Hlfhepatic leukemia factor0.038
Ghrlghrelin/obestatin prepropeptide0.038
Picalmphosphatidylinositol binding clathrin assembly protein0.038
Foxi2forkhead box I20.038
Tshbthyroid stimulating hormone, beta0.038
Grifingalectin-related inter-fiber protein0.038
Iappislet amyloid polypeptide0.037
Jak1Janus kinase 10.037
Sgp158proline-rich glycoprotein (sgp158)0.037
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism