The network for 'cardiac muscle cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle cell fate commitment

The commitment of cells to specific cardiac muscle cell fates and their capacity to differentiate into cardiac muscle cells. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.

NameDescriptionProbabilityFunc Analog Organism
FKBP1AFK506 binding protein 1A, 12kDa0.999
TGFB1transforming growth factor, beta 10.998
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.995
TGFB3transforming growth factor, beta 30.990
BMP2bone morphogenetic protein 20.988
ENGendoglin0.964
TBX5T-box 50.956
NOTCH1notch 10.946
SPENspen homolog, transcriptional regulator (Drosophila)0.853
FSTL1follistatin-like 10.839
ACVR1activin A receptor, type I0.822
LRP6low density lipoprotein receptor-related protein 60.819
PRKG1protein kinase, cGMP-dependent, type I0.694
NRP1neuropilin 10.691
TGFBR1transforming growth factor, beta receptor 10.682
SMAD7SMAD family member 70.664
ATXN1Lataxin 1-like0.639
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.619
GDF5growth differentiation factor 50.576
SMAD2SMAD family member 20.561
BMPR1Abone morphogenetic protein receptor, type IA0.555
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.516
FZD1frizzled homolog 1 (Drosophila)0.366
JAG1jagged 10.357
ZMYND11zinc finger, MYND-type containing 110.330
MAML1mastermind-like 1 (Drosophila)0.262
MAPK8mitogen-activated protein kinase 80.261
NCOR2nuclear receptor corepressor 20.260
PDGFCplatelet derived growth factor C0.259
GATA4GATA binding protein 40.242
FGF18fibroblast growth factor 180.208
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.200
DVL3dishevelled, dsh homolog 3 (Drosophila)0.200
BMP4bone morphogenetic protein 40.173
IQGAP1IQ motif containing GTPase activating protein 10.086
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.086
SMAD6SMAD family member 60.072
VEGFAvascular endothelial growth factor A0.065
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.060
SNIP1Smad nuclear interacting protein 10.059
WNT1wingless-type MMTV integration site family, member 10.054
SNW1SNW domain containing 10.051
FZD8frizzled homolog 8 (Drosophila)0.049
CIR1corepressor interacting with RBPJ, 10.049
RXRAretinoid X receptor, alpha0.048
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.047
XIAPX-linked inhibitor of apoptosis0.046
IHHIndian hedgehog0.046
NOTCH3notch 30.043
TGFBR3transforming growth factor, beta receptor III0.042
NOTCH2notch 20.041
SFRP1secreted frizzled-related protein 10.041
AQP5aquaporin 50.040
SMURF2SMAD specific E3 ubiquitin protein ligase 20.040
MTORmechanistic target of rapamycin (serine/threonine kinase)0.039
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.039
LBX1ladybird homeobox 10.037
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.035
PGRprogesterone receptor0.033
WNT10Awingless-type MMTV integration site family, member 10A0.033
FNDC3Bfibronectin type III domain containing 3B0.033
WIF1WNT inhibitory factor 10.032
FGF4fibroblast growth factor 40.032
TGFB2transforming growth factor, beta 20.031
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.030
GDNFglial cell derived neurotrophic factor0.030
GATA5GATA binding protein 50.029
ANTXR2anthrax toxin receptor 20.028
HS3ST6heparan sulfate (glucosamine) 3-O-sulfotransferase 60.028
GATA1GATA binding protein 1 (globin transcription factor 1)0.027
FGF8fibroblast growth factor 8 (androgen-induced)0.026
FOXF2forkhead box F20.026
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.026
THBS1thrombospondin 10.025
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.025
HMX1H6 family homeobox 10.024
FGF3fibroblast growth factor 30.024
LRRK2leucine-rich repeat kinase 20.023
FZD7frizzled homolog 7 (Drosophila)0.023
APPamyloid beta (A4) precursor protein0.023
PAX7paired box 70.023
SART1squamous cell carcinoma antigen recognized by T cells0.023
SHHsonic hedgehog0.023
MED25mediator complex subunit 250.022
CTNNBL1catenin, beta like 10.022
TLX3T-cell leukemia homeobox 30.022
SOX21SRY (sex determining region Y)-box 210.021
HOXB13homeobox B130.021
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.021
BHLHE23basic helix-loop-helix family, member e230.021
FOXL1forkhead box L10.021
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.020
CDX1caudal type homeobox 10.020
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.020
HES2hairy and enhancer of split 2 (Drosophila)0.020
DLL1delta-like 1 (Drosophila)0.019
ACVR2Bactivin A receptor, type IIB0.019
SOX1SRY (sex determining region Y)-box 10.019
ACVR2Aactivin A receptor, type IIA0.019
SPRED1sprouty-related, EVH1 domain containing 10.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
osr2odd-skipped related 2 (Drosophila)0.188
hnf1baHNF1 homeobox Ba0.084
etv2ets variant gene 20.067
wnt2bbwingless-type MMTV integration site family, member 2Bb0.052
tbx5aT-box 5a0.051
osr1odd-skipped related 1 (Drosophila)0.044
foxj1aforkhead box J1a0.036
kdrlkinase insert domain receptor like0.035
vegfaavascular endothelial growth factor Aa0.029
tjp1tight junction protein 1 (zona occludens 1)0.029
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.029
gata6GATA-binding protein 60.028
aplnrbapelin receptor b0.027
wt1bwilms tumor 1b0.027
has2hyaluronan synthase 20.026
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.022
hnf1bbHNF1 homeobox Bb0.021
cdh5cadherin 50.021
podxlpodocalyxin-like0.020
vcanaversican a0.019
si:ch211-235f6.2si:ch211-235f6.20.018
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.017
tbx2aT-box gene 2a0.017
myod1myogenic differentiation 10.017
tbx5bT-box 5b0.016
hspb7heat shock protein family, alpha-crystallin-related, b70.014
pdlim7PDZ and LIM domain 70.014
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.014
ttnatitin a0.013
myl7myosin, light polypeptide 7, regulatory0.013
spawsouthpaw0.012
dccdeleted in colorectal carcinoma0.012
ptgs1prostaglandin-endoperoxide synthase 10.012
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.012
hspb12heat shock protein, alpha-crystallin-related, b120.011
foxp1bforkhead box P1b0.011
renrenin0.011
wtipWilms tumor 1 interacting protein0.011
her11hairy-related 110.010
fli1afriend leukemia integration 1a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog0.993
Fgf8fibroblast growth factor 80.961
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.927
Pitx1paired-like homeodomain transcription factor 10.855
Tbx3T-box 30.819
Fgfr2fibroblast growth factor receptor 20.749
Pitx2paired-like homeodomain transcription factor 20.709
Pax2paired box gene 20.583
Otx2orthodenticle homolog 2 (Drosophila)0.520
Gbx2gastrulation brain homeobox 20.516
Sox9SRY-box containing gene 90.494
Wnt3awingless-related MMTV integration site 3A0.432
Hand1heart and neural crest derivatives expressed transcript 10.425
Hoxa1homeobox A10.414
Tbrachyury0.302
Hand2heart and neural crest derivatives expressed transcript 20.301
Lhx1LIM homeobox protein 10.235
Foxc2forkhead box C20.217
Rarbretinoic acid receptor, beta0.208
Nodalnodal0.187
Gli3GLI-Kruppel family member GLI30.179
Pax8paired box gene 80.179
Fgf10fibroblast growth factor 100.171
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.167
Efnb2ephrin B20.146
Gata4GATA binding protein 40.141
Pou5f1POU domain, class 5, transcription factor 10.125
Hoxa2homeobox A20.123
Sox2SRY-box containing gene 20.116
Nr5a1nuclear receptor subfamily 5, group A, member 10.115
Tbx5T-box 50.113
Prrx1paired related homeobox 10.106
Sall4sal-like 4 (Drosophila)0.102
Gli2GLI-Kruppel family member GLI20.100
Gdnfglial cell line derived neurotrophic factor0.098
Nognoggin0.098
Lmx1aLIM homeobox transcription factor 1 alpha0.093
Bmp4bone morphogenetic protein 40.091
Alx3aristaless-like homeobox 30.090
Alx4aristaless-like homeobox 40.090
Fgf15fibroblast growth factor 150.083
Pax3paired box gene 30.081
Ror2receptor tyrosine kinase-like orphan receptor 20.069
Hmx3H6 homeobox 30.067
Tlx3T-cell leukemia, homeobox 30.065
Nkx6-1NK6 homeobox 10.063
Gata6GATA binding protein 60.062
Vax1ventral anterior homeobox containing gene 10.059
Gja5gap junction protein, alpha 50.057
Fgfr3fibroblast growth factor receptor 30.057
Tcfap2atranscription factor AP-2, alpha0.053
Lmx1bLIM homeobox transcription factor 1 beta0.052
Foxc1forkhead box C10.051
Ctnnb1catenin (cadherin associated protein), beta 10.051
Scn5asodium channel, voltage-gated, type V, alpha0.049
Fzd10frizzled homolog 10 (Drosophila)0.048
Tbx1T-box 10.048
Lhx3LIM homeobox protein 30.048
Jag1jagged 10.046
Wnt6wingless-related MMTV integration site 60.046
En1engrailed 10.046
Foxb1forkhead box B10.045
Fgfr1fibroblast growth factor receptor 10.044
Emx2empty spiracles homolog 2 (Drosophila)0.043
Msx1homeobox, msh-like 10.043
Pou3f3POU domain, class 3, transcription factor 30.034
Dlx5distal-less homeobox 50.031
Sox3SRY-box containing gene 30.030
Lhx9LIM homeobox protein 90.030
Col22a1collagen, type XXII, alpha 10.030
Adra2badrenergic receptor, alpha 2b0.030
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.027
Sall3sal-like 3 (Drosophila)0.027
Otx1orthodenticle homolog 1 (Drosophila)0.027
Isl1ISL1 transcription factor, LIM/homeodomain0.027
Twist2twist homolog 2 (Drosophila)0.026
Vangl2vang-like 2 (van gogh, Drosophila)0.026
Pitx3paired-like homeodomain transcription factor 30.025
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.025
Foxe1forkhead box E10.025
Bmpr1abone morphogenetic protein receptor, type 1A0.025
Dkk1dickkopf homolog 1 (Xenopus laevis)0.025
Emx1empty spiracles homolog 1 (Drosophila)0.024
Pax9paired box gene 90.023
Fgf3fibroblast growth factor 30.023
Pdx1pancreatic and duodenal homeobox 10.023
Wt1Wilms tumor 1 homolog0.022
Smad6MAD homolog 6 (Drosophila)0.022
Zic3zinc finger protein of the cerebellum 30.022
Insm1insulinoma-associated 10.021
Foxh1forkhead box H10.021
Pthlhparathyroid hormone-like peptide0.021
Tcf21transcription factor 210.021
Bnc1basonuclin 10.020
Gata3GATA binding protein 30.020
Sox1SRY-box containing gene 10.020
Wnt10bwingless related MMTV integration site 10b0.019
Nab2Ngfi-A binding protein 20.019
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.019
Chd7chromodomain helicase DNA binding protein 70.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism