The network for 'notch receptor processing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

notch receptor processing

The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor.

NameDescriptionProbabilityFunc Analog Organism
NCSTNnicastrin0.997
APH1Aanterior pharynx defective 1 homolog A (C. elegans)0.981
ABI2abl-interactor 20.784
PSEN2presenilin 2 (Alzheimer disease 4)0.744
PSEN1presenilin 10.656
PKP4plakophilin 40.281
UBQLN1ubiquilin 10.267
PARP9poly (ADP-ribose) polymerase family, member 90.259
PSENENpresenilin enhancer 2 homolog (C. elegans)0.224
FLNBfilamin B, beta0.208
EEA1early endosome antigen 10.205
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.169
PARP14poly (ADP-ribose) polymerase family, member 140.162
SNX33sorting nexin 330.135
SNX9sorting nexin 90.132
DLG1discs, large homolog 1 (Drosophila)0.105
DNM1dynamin 10.077
PACSIN3protein kinase C and casein kinase substrate in neurons 30.071
APPamyloid beta (A4) precursor protein0.065
SH3D19SH3 domain containing 190.061
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.059
FLNAfilamin A, alpha0.059
BCL2L1BCL2-like 10.058
CTNND1catenin (cadherin-associated protein), delta 10.046
SH3PXD2ASH3 and PX domains 2A0.046
ARRB2arrestin, beta 20.045
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.040
IFNGR1interferon gamma receptor 10.035
CLPTM1cleft lip and palate associated transmembrane protein 10.034
DNM2dynamin 20.033
LRRK2leucine-rich repeat kinase 20.033
PICALMphosphatidylinositol binding clathrin assembly protein0.030
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.030
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.029
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.028
SDCBPsyndecan binding protein (syntenin)0.027
TRIM39tripartite motif containing 390.022
RAB6ARAB6A, member RAS oncogene family0.022
APBA1amyloid beta (A4) precursor protein-binding, family A, member 10.020
EIF4G1eukaryotic translation initiation factor 4 gamma, 10.019
PDIA3protein disulfide isomerase family A, member 30.018
IGFBP3insulin-like growth factor binding protein 30.018
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.017
NPHP1nephronophthisis 1 (juvenile)0.017
STC2stanniocalcin 20.016
UBE2Hubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)0.015
RHOAras homolog gene family, member A0.015
HK2hexokinase 20.015
SAMD9sterile alpha motif domain containing 90.015
DDX4DEAD (Asp-Glu-Ala-Asp) box polypeptide 40.014
ZFYVE1zinc finger, FYVE domain containing 10.014
KIAA0100KIAA01000.014
AP1S1adaptor-related protein complex 1, sigma 1 subunit0.014
DEDDdeath effector domain containing0.014
RNF17ring finger protein 170.014
TGOLN2trans-golgi network protein 20.014
ZNRF1zinc and ring finger 10.013
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.013
RAB1ARAB1A, member RAS oncogene family0.013
ADAM18ADAM metallopeptidase domain 180.013
VIPARVPS33B interacting protein, apical-basolateral polarity regulator0.012
JUPjunction plakoglobin0.012
OCRLoculocerebrorenal syndrome of Lowe0.012
ADIPOR1adiponectin receptor 10.012
BAXBCL2-associated X protein0.012
GLIS2GLIS family zinc finger 20.012
C19orf6chromosome 19 open reading frame 60.012
LAMP1lysosomal-associated membrane protein 10.012
FSTL3follistatin-like 3 (secreted glycoprotein)0.011
TMCO6transmembrane and coiled-coil domains 60.011
ZFYVE20zinc finger, FYVE domain containing 200.011
RNF5ring finger protein 50.011
RIT1Ras-like without CAAX 10.011
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.010
SUN2Sad1 and UNC84 domain containing 20.010
MAD2L1BPMAD2L1 binding protein0.010
GTF2F1general transcription factor IIF, polypeptide 1, 74kDa0.010
BIKBCL2-interacting killer (apoptosis-inducing)0.010
CLIC4chloride intracellular channel 40.010
CALCOCO1calcium binding and coiled-coil domain 10.010
ANKRD13Dankyrin repeat domain 13 family, member D0.010
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
carcarnation0.615
rstroughest0.320
kirrekin of irre0.265
hbshibris0.230
snssticks and stones0.165
bibbig brain0.119
nctnicastrin0.118
neurneuralized0.102
Dsor1Downstream of raf10.083
S6kIIRPS6-protein kinase-II0.082
rlrolled0.078
RalaRas-related protein0.071
lmdlame duck0.071
wlswntless0.066
hkhook0.064
X11LCG5675 gene product from transcript CG5675-RB0.062
rokRho-kinase0.057
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.057
bonbonus0.053
CG10277CG10277 gene product from transcript CG10277-RB0.048
cicubitus interruptus0.048
EloAElongin A0.047
O-fut1O-fucosyltransferase 10.047
Su(H)Suppressor of Hairless0.047
mtsmicrotubule star0.042
kuzkuzbanian0.041
swshort wing0.040
CG6359CG6359 gene product from transcript CG6359-RA0.040
DlicDynein light intermediate chain0.038
E(spl)Enhancer of split0.038
rolsrolling pebbles0.034
fzfrizzled0.030
bynbrachyenteron0.030
mopmyopic0.030
Akt1CG4006 gene product from transcript CG4006-RA0.029
bwbrown0.029
aopanterior open0.027
mbtmushroom bodies tiny0.027
slouslouch0.027
unkunkempt0.026
par-6CG5884 gene product from transcript CG5884-RA0.025
CG6116CG6116 gene product from transcript CG6116-RA0.025
NotumCG13076 gene product from transcript CG13076-RB0.025
rbruby0.025
fwfurrowed0.025
RASSF8CG5053 gene product from transcript CG5053-RA0.024
Vps25Vacuolar protein sorting 250.024
flrflare0.024
ltlight0.023
ospoutspread0.023
scascabrous0.022
naunautilus0.022
arrarrow0.021
GugGrunge0.021
CkIalphaCasein kinase Ialpha0.021
Tre1trapped in endoderm-10.020
msl-1male-specific lethal 10.019
sqhspaghetti squash0.018
Prosbeta2Proteasome beta2 subunit0.018
lqfliquid facets0.018
Cdc42CG12530 gene product from transcript CG12530-RA0.018
porporcupine0.017
StimStromal interaction molecule0.016
cnocanoe0.016
caclaret0.015
mib1mind bomb 10.015
stanstarry night0.015
CG10777CG10777 gene product from transcript CG10777-RB0.015
dgodiego0.015
trctricornered0.015
Vrp1Verprolin 10.014
aph-1anterior pharynx defective 10.014
Arp66BActin-related protein 66B0.014
captcapulet0.013
flflfalafel0.013
CG17218CG17218 gene product from transcript CG17218-RA0.013
CG6954CG6954 gene product from transcript CG6954-RB0.013
Cpr72EaCuticular protein 72Ea0.013
giggigas0.013
tinctincar0.013
Gpi1CG32578 gene product from transcript CG32578-RA0.013
sanoserrano0.013
CG11592CG11592 gene product from transcript CG11592-RA0.013
SmrSmrter0.012
Tsc1CG6147 gene product from transcript CG6147-RA0.012
kibrakibra ortholog0.012
drddrop dead0.012
aseasense0.012
crbcrumbs0.012
rumiCG31152 gene product from transcript CG31152-RA0.012
nejnejire0.012
ltdlightoid0.012
sinaseven in absentia0.011
CG1599CG1599 gene product from transcript CG1599-RA0.011
matsmob as tumor suppressor0.011
SrpRbetaSignal recognition particle receptor beta0.011
HLH54FCG5005 gene product from transcript CG5005-RA0.011
dshdishevelled0.011
Hr39Hormone receptor-like in 390.011
WASpCG1520 gene product from transcript CG1520-RA0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Psen1presenilin 11.000
Ncstnnicastrin0.930
Aph1aanterior pharynx defective 1a homolog (C. elegans)0.865
Psen2presenilin 20.414
Syvn1synovial apoptosis inhibitor 1, synoviolin0.282
Notch2Notch gene homolog 2 (Drosophila)0.280
Notch1Notch gene homolog 1 (Drosophila)0.230
Appamyloid beta (A4) precursor protein0.186
Hif1ahypoxia inducible factor 1, alpha subunit0.157
Erlin2ER lipid raft associated 20.105
Ctnnb1catenin (cadherin associated protein), beta 10.062
Psenenpresenilin enhancer 2 homolog (C. elegans)0.044
Chukconserved helix-loop-helix ubiquitous kinase0.027
Hps4Hermansky-Pudlak syndrome 4 homolog (human)0.018
Calrcalreticulin0.018
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.017
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.017
Chd7chromodomain helicase DNA binding protein 70.017
Dll3delta-like 3 (Drosophila)0.016
Pi4kbphosphatidylinositol 4-kinase, catalytic, beta polypeptide0.014
Trp73transformation related protein 730.012
Nphs2nephrosis 2 homolog, podocin (human)0.012
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.011
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism