The network for 'ephrin receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

ephrin receptor signaling pathway

The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.998
BCAR1breast cancer anti-estrogen resistance 10.998
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.994
FYNFYN oncogene related to SRC, FGR, YES0.984
PTK2PTK2 protein tyrosine kinase 20.969
EGFRepidermal growth factor receptor0.959
EPHA2EPH receptor A20.953
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.952
PTPN1protein tyrosine phosphatase, non-receptor type 10.948
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.920
GRB2growth factor receptor-bound protein 20.915
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.869
EPHA7EPH receptor A70.710
SFNstratifin0.664
STAMBPSTAM binding protein0.620
EFNA1ephrin-A10.586
GRB10growth factor receptor-bound protein 100.488
GAB1GRB2-associated binding protein 10.482
MMP14matrix metallopeptidase 14 (membrane-inserted)0.456
ZNF746zinc finger protein 7460.422
PXNpaxillin0.375
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.367
EFNA5ephrin-A50.340
GRB7growth factor receptor-bound protein 70.336
PLCG1phospholipase C, gamma 10.323
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.316
PTPN12protein tyrosine phosphatase, non-receptor type 120.305
NCK2NCK adaptor protein 20.236
VAV1vav 1 guanine nucleotide exchange factor0.173
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.172
PECAM1platelet/endothelial cell adhesion molecule0.171
ATF2activating transcription factor 20.150
MAP4K5mitogen-activated protein kinase kinase kinase kinase 50.135
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.131
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.120
NOTCH1notch 10.119
CD33CD33 molecule0.110
PTPN6protein tyrosine phosphatase, non-receptor type 60.095
FRS2fibroblast growth factor receptor substrate 20.091
EPHB3EPH receptor B30.089
SPENspen homolog, transcriptional regulator (Drosophila)0.088
CAV1caveolin 1, caveolae protein, 22kDa0.083
SRCIN1SRC kinase signaling inhibitor 10.080
EPHA3EPH receptor A30.076
TNK2tyrosine kinase, non-receptor, 20.075
ATXN1Lataxin 1-like0.071
SHC1SHC (Src homology 2 domain containing) transforming protein 10.069
SYKspleen tyrosine kinase0.062
PILRApaired immunoglobin-like type 2 receptor alpha0.062
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.060
MATKmegakaryocyte-associated tyrosine kinase0.049
SH2D3ASH2 domain containing 3A0.047
MAPK14mitogen-activated protein kinase 140.041
LAIR1leukocyte-associated immunoglobulin-like receptor 10.040
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.034
METmet proto-oncogene (hepatocyte growth factor receptor)0.033
LY6G6Flymphocyte antigen 6 complex, locus G6F0.031
FAM118Bfamily with sequence similarity 118, member B0.029
CDK5cyclin-dependent kinase 50.029
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.026
VAV2vav 2 guanine nucleotide exchange factor0.026
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.025
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.024
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.024
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.023
NCK1NCK adaptor protein 10.022
TNS4tensin 40.022
FESfeline sarcoma oncogene0.022
MPZL1myelin protein zero-like 10.021
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.021
IRS1insulin receptor substrate 10.021
PTPN11protein tyrosine phosphatase, non-receptor type 110.020
CAMK2Acalcium/calmodulin-dependent protein kinase II alpha0.019
MAML1mastermind-like 1 (Drosophila)0.019
SH3KBP1SH3-domain kinase binding protein 10.019
PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)0.018
PTPRFprotein tyrosine phosphatase, receptor type, F0.018
DOCK1dedicator of cytokinesis 10.017
TAF1DTATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa0.017
DOK4docking protein 40.016
SPRR2Asmall proline-rich protein 2A0.015
NCOR2nuclear receptor corepressor 20.015
STAM2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.015
MUC1mucin 1, cell surface associated0.014
JAK2Janus kinase 20.014
PRKCAprotein kinase C, alpha0.014
EGFepidermal growth factor0.013
ERRFI1ERBB receptor feedback inhibitor 10.013
BAIAP2BAI1-associated protein 20.013
TNS3tensin 30.013
TGFB1I1transforming growth factor beta 1 induced transcript 10.012
CAV2caveolin 20.012
ABL2v-abl Abelson murine leukemia viral oncogene homolog 20.012
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.012
CLTCclathrin, heavy chain (Hc)0.012
CIR1corepressor interacting with RBPJ, 10.012
IRS4insulin receptor substrate 40.012
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.012
TMSB4Xthymosin beta 4, X-linked0.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
rapretina aberrant in pattern0.030
CaMKIICalcium/calmodulin-dependent protein kinase II0.024
dockdreadlocks0.014
staistathmin0.012
smosmoothened0.010
NcaNeurocalcin0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ephb2Eph receptor B21.000
Efnb2ephrin B21.000
Epha4Eph receptor A41.000
Notch1Notch gene homolog 1 (Drosophila)0.995
Ephb3Eph receptor B30.973
Efnb1ephrin B10.936
Dock1dedicator of cytokinesis 10.813
Grip1glutamate receptor interacting protein 10.738
Itgb1integrin beta 1 (fibronectin receptor beta)0.669
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.626
Nf1neurofibromatosis 10.490
Usp8ubiquitin specific peptidase 80.422
Bcar1breast cancer anti-estrogen resistance 10.404
SrcRous sarcoma oncogene0.404
Zfpm2zinc finger protein, multitype 20.379
Hey2hairy/enhancer-of-split related with YRPW motif 20.360
Rtknrhotekin0.339
Gata4GATA binding protein 40.337
Gpr12G-protein coupled receptor 120.323
Ctnnb1catenin (cadherin associated protein), beta 10.299
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.297
Prox1prospero-related homeobox 10.281
Plxna3plexin A30.265
Cdk5r1cyclin-dependent kinase 5, regulatory subunit 1 (p35)0.254
Apcadenomatosis polyposis coli0.188
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.181
Jag1jagged 10.178
Lrp5low density lipoprotein receptor-related protein 50.169
Cxadrcoxsackie virus and adenovirus receptor0.157
Efna1ephrin A10.155
Epha2Eph receptor A20.155
Sh3rf1SH3 domain containing ring finger 10.148
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.135
Llgl2lethal giant larvae homolog 2 (Drosophila)0.130
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.130
Celsr2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.120
Gata5GATA binding protein 50.120
CblCasitas B-lineage lymphoma0.119
Tnks1bp1tankyrase 1 binding protein 10.118
Gng12guanine nucleotide binding protein (G protein), gamma 120.113
Psen1presenilin 10.110
Irs1insulin receptor substrate 10.105
Hey1hairy/enhancer-of-split related with YRPW motif 10.103
Hif1ahypoxia inducible factor 1, alpha subunit0.103
Plxna4plexin A40.101
Plxna2plexin A20.096
Ikzf4IKAROS family zinc finger 40.094
Mmp15matrix metallopeptidase 150.087
Jupjunction plakoglobin0.087
Fzd3frizzled homolog 3 (Drosophila)0.084
L1camL1 cell adhesion molecule0.082
Smad6MAD homolog 6 (Drosophila)0.079
Cux2cut-like homeobox 20.078
C77080expressed sequence C770800.076
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.076
Spry4sprouty homolog 4 (Drosophila)0.074
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.069
Ttltubulin tyrosine ligase0.066
Efna4ephrin A40.061
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.059
Itga3integrin alpha 30.059
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.058
Cdc42ep1CDC42 effector protein (Rho GTPase binding) 10.058
Grb2growth factor receptor bound protein 20.057
Rasa1RAS p21 protein activator 10.056
Meis2Meis homeobox 20.055
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.055
Ptprkprotein tyrosine phosphatase, receptor type, K0.052
Ptpn13protein tyrosine phosphatase, non-receptor type 130.052
Tead3TEA domain family member 30.051
Wnt7bwingless-related MMTV integration site 7B0.050
Stam2signal transducing adaptor molecule (SH3 domain and ITAM motif) 20.050
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.049
Vhlvon Hippel-Lindau tumor suppressor0.049
Apc2adenomatosis polyposis coli 20.048
Pbx1pre B-cell leukemia transcription factor 10.047
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.047
Cd44CD44 antigen0.047
C77370expressed sequence C773700.046
Pnocprepronociceptin0.046
Tle1transducin-like enhancer of split 1, homolog of Drosophila E(spl)0.045
Fam84afamily with sequence similarity 84, member A0.044
Nrbp2nuclear receptor binding protein 20.044
Dlx1distal-less homeobox 10.043
RgnefRho-guanine nucleotide exchange factor0.042
Chn1chimerin (chimaerin) 10.041
Prkczprotein kinase C, zeta0.041
Ctnnd2catenin (cadherin associated protein), delta 20.041
Adam11a disintegrin and metallopeptidase domain 110.040
Npas2neuronal PAS domain protein 20.040
Zfp40zinc finger protein 400.040
Kcns2K+ voltage-gated channel, subfamily S, 20.039
B3galt1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 10.039
Cdk18cyclin-dependent kinase 180.039
Socs5suppressor of cytokine signaling 50.038
Celf4CUGBP, Elav-like family member 40.038
Pcdh1protocadherin 10.037
Pou3f2POU domain, class 3, transcription factor 20.036
D8Ertd82eDNA segment, Chr 8, ERATO Doi 82, expressed0.036
Myo5bmyosin VB0.036
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dnajc5DnaJ (Hsp40) homolog, subfamily C, member 50.110
Fgfr2fibroblast growth factor receptor 20.043
Robo2roundabout homolog 2 (Drosophila)0.038
Nacc1nucleus accumbens associated 1, BEN and BTB (POZ) domain containing0.037
Gna12guanine nucleotide binding protein (G protein) alpha 120.036
Gabra1gamma-aminobutyric acid (GABA) A receptor, alpha 10.030
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.029
Grip1glutamate receptor interacting protein 10.025
Gabra5gamma-aminobutyric acid (GABA) A receptor, alpha 50.025
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.024
Clic4chloride intracellular channel 40.024
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.023
Gnalguanine nucleotide binding protein, alpha stimulating, olfactory type0.023
Nek9NIMA (never in mitosis gene a)- related kinase 90.023
St8sia2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 20.023
Pick1protein interacting with PRKCA 10.022
Sipa1l1signal-induced proliferation-associated 1 like 10.021
Andproandrogen regulated protein0.020
Ryr2ryanodine receptor 2, cardiac0.019
Pkiaprotein kinase (cAMP-dependent, catalytic) inhibitor alpha0.018
Atf2activating transcription factor 20.018
Lims1LIM and senescent cell antigen-like domains 10.018
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.018
Tgfbr2transforming growth factor, beta receptor II0.017
Npy1rneuropeptide Y receptor Y10.017
Kalrnkalirin, RhoGEF kinase0.017
Drd1adopamine receptor D1A0.017
Gria1glutamate receptor, ionotropic, AMPA 10.017
Uhmk1U2AF homology motif (UHM) kinase 10.017
Dlg2discs, large homolog 2 (Drosophila)0.016
Pvrl2poliovirus receptor-related 20.016
Rxraretinoid X receptor alpha0.016
Gpx5glutathione peroxidase 50.016
Gnazguanine nucleotide binding protein (G protein), alpha z polypeptide0.016
Senp2Sumo1/sentrin/SMT3 specific peptidase 20.015
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.015
Dckdeoxycytidine kinase0.015
Prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.015
Twist2twist homolog 2 (Drosophila)0.014
Rab15RAB15, member RAS oncogene family0.014
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.014
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.014
Rasal1RAS protein activator like 1 (GAP1 like)0.014
Prrx1paired related homeobox 10.014
Bsnbassoon0.014
Tcf12transcription factor 120.014
Grm5glutamate receptor, metabotropic 50.014
Csnk1g1casein kinase 1, gamma 10.014
Cyth3cytohesin 30.013
Arl5aADP-ribosylation factor-like 5A0.013
Zfp382zinc finger protein 3820.013
Sstr2somatostatin receptor 20.013
Pou3f2POU class 3 homeobox 20.013
Myo1bmyosin Ib0.013
Bmp3bone morphogenetic protein 30.013
Gria2glutamate receptor, ionotropic, AMPA 20.013
Ntf4neurotrophin 40.012
Efnb2ephrin B20.012
St3gal3ST3 beta-galactoside alpha-2,3-sialyltransferase 30.012
Zfp94zinc finger protein 940.012
Slc1a1solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 10.012
Exoc5exocyst complex component 50.012
Gabrb1gamma-aminobutyric acid (GABA) A receptor, beta 10.012
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.012
Psen1presenilin 10.012
Sdk2sidekick homolog 2 (chicken)0.011
Cntn1contactin 10.011
Ldlrlow density lipoprotein receptor0.011
Stx2syntaxin 20.011
Akt2v-akt murine thymoma viral oncogene homolog 20.011
Dnahc6dynein, axonemal, heavy chain 60.011
Smad3SMAD family member 30.011
Nrp2neuropilin 20.011
Lppr3lipid phosphate phosphatase-related protein type 30.011
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.011
Mapk9mitogen-activated protein kinase 90.011
Serinc5serine incorporator 50.011
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.011
Ptger3prostaglandin E receptor 3 (subtype EP3)0.011
Tbxa2rthromboxane A2 receptor0.011
Lin7clin-7 homolog C (C. elegans)0.010
Lgi3leucine-rich repeat LGI family, member 30.010
Akap1A kinase (PRKA) anchor protein 10.010
Agtr1aangiotensin II receptor, type 1a0.010
Ntf3neurotrophin 30.010
Foxn1forkhead box N10.010
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism