The network for 'regulation of epithelial to mesenchymal transition' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of epithelial to mesenchymal transition

Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa1.000
SMAD1SMAD family member 10.986
SMURF2SMAD specific E3 ubiquitin protein ligase 20.983
SMAD3SMAD family member 30.981
NOTCH1notch 10.967
SMAD2SMAD family member 20.967
SMAD7SMAD family member 70.961
JAG1jagged 10.961
COL1A1collagen, type I, alpha 10.955
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.945
COL3A1collagen, type III, alpha 10.815
COL4A1collagen, type IV, alpha 10.802
FSTL1follistatin-like 10.751
ARandrogen receptor0.738
SMAD4SMAD family member 40.677
COL1A2collagen, type I, alpha 20.668
POU5F1POU class 5 homeobox 10.638
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.561
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.546
MAP3K5mitogen-activated protein kinase kinase kinase 50.518
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.494
BMPR1Abone morphogenetic protein receptor, type IA0.493
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.491
SMAD5SMAD family member 50.486
TBX5T-box 50.462
FHL2four and a half LIM domains 20.390
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.351
GATA4GATA binding protein 40.319
NOTCH3notch 30.310
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.304
SETD8SET domain containing (lysine methyltransferase) 80.303
TGFBR1transforming growth factor, beta receptor 10.299
TGFB3transforming growth factor, beta 30.298
PARVAparvin, alpha0.291
STRN3striatin, calmodulin binding protein 30.279
COL5A1collagen, type V, alpha 10.271
COL6A1collagen, type VI, alpha 10.263
SMURF1SMAD specific E3 ubiquitin protein ligase 10.256
DDR2discoidin domain receptor tyrosine kinase 20.255
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.247
YAP1Yes-associated protein 10.241
SKILSKI-like oncogene0.236
SMAD6SMAD family member 60.228
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.193
WWP2WW domain containing E3 ubiquitin protein ligase 20.193
CTNNBIP1catenin, beta interacting protein 10.190
APCadenomatous polyposis coli0.189
FBLN1fibulin 10.185
TCF4transcription factor 40.183
PTK2PTK2 protein tyrosine kinase 20.178
ZFYVE9zinc finger, FYVE domain containing 90.173
COL5A2collagen, type V, alpha 20.169
GLIS2GLIS family zinc finger 20.159
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.153
TGFB1transforming growth factor, beta 10.148
RUNX1runt-related transcription factor 10.147
GATA2GATA binding protein 20.143
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.136
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.136
NRP1neuropilin 10.135
NCK2NCK adaptor protein 20.130
PDX1pancreatic and duodenal homeobox 10.123
FN1fibronectin 10.119
CXXC5CXXC finger protein 50.114
FOXF2forkhead box F20.113
AXIN1axin 10.105
POSTNperiostin, osteoblast specific factor0.103
BTRCbeta-transducin repeat containing0.103
HIC1hypermethylated in cancer 10.095
MYOD1myogenic differentiation 10.094
WDYHV1WDYHV motif containing 10.087
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.084
LIMS1LIM and senescent cell antigen-like domains 10.081
FGF3fibroblast growth factor 30.081
PAX8paired box 80.080
ADAM12ADAM metallopeptidase domain 120.079
COL11A1collagen, type XI, alpha 10.075
SKIv-ski sarcoma viral oncogene homolog (avian)0.073
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.073
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.071
TJP2tight junction protein 2 (zona occludens 2)0.069
EP300E1A binding protein p3000.069
MXRA5matrix-remodelling associated 50.066
DNMT1DNA (cytosine-5-)-methyltransferase 10.065
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif, 20.064
COL2A1collagen, type II, alpha 10.064
DLL1delta-like 1 (Drosophila)0.063
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.062
CREBBPCREB binding protein0.055
PHF21APHD finger protein 21A0.055
LOXlysyl oxidase0.055
FOXD3forkhead box D30.054
GSK3Bglycogen synthase kinase 3 beta0.054
SOX1SRY (sex determining region Y)-box 10.053
HOXA1homeobox A10.053
LRRN2leucine rich repeat neuronal 20.053
S100BS100 calcium binding protein B0.052
JUBjub, ajuba homolog (Xenopus laevis)0.052
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.891
col1a2collagen, type I, alpha 20.834
tcf7transcription factor 7 (T-cell specific, HMG-box)0.765
bmp2abone morphogenetic protein 2a0.677
bmp4bone morphogenetic protein 40.646
lhx2bLIM homeobox 2b0.399
gdf6agrowth differentiation factor 6a0.320
col5a1procollagen, type V, alpha 10.242
hapln1ahyaluronan and proteoglycan link protein 1a0.211
shhasonic hedgehog a0.201
osr1odd-skipped related 1 (Drosophila)0.191
lef1lymphocyte enhancer binding factor 10.188
msxcmuscle segment homeobox C0.182
fgf3fibroblast growth factor 30.181
foxn4forkhead box N40.176
nrarpanotch-regulated ankyrin repeat protein a0.174
nkx2.3NK2 transcription factor related 30.171
sfrp1asecreted frizzled-related protein 1a0.168
mab21l2mab-21-like 20.166
axin2axin 2 (conductin, axil)0.165
wnt11rwingless-type MMTV integration site family, member 11, related0.161
lmo4aLIM domain only 4a0.155
foxa3forkhead box A30.145
sox11bSRY-box containing gene 11b0.144
notch3notch homolog 30.141
gata6GATA-binding protein 60.140
tbx20T-box 200.137
sparcsecreted acidic cysteine rich glycoprotein0.132
cdh2cadherin 2, neuronal0.132
frem3Fras1 related extracellular matrix 30.124
dlx3bdistal-less homeobox gene 3b0.115
has2hyaluronan synthase 20.105
eya1eyes absent homolog 10.105
wnt3wingless-type MMTV integration site family, member 30.100
nkx2.1aNK2 homeobox 1a0.100
plcg1phospholipase C, gamma 10.098
fgf17fibroblast growth factor 170.097
epha4beph receptor A4b0.097
wnt4awingless-type MMTV integration site family, member 4a0.097
aplnraapelin receptor a0.096
ptch1patched 10.095
fn1fibronectin 10.094
rargaretinoic acid receptor gamma a0.089
igf1rbinsulin-like growth factor 1b receptor0.088
lhx1bLIM homeobox 1b0.086
wnt5bwingless-type MMTV integration site family, member 5b0.086
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.085
itga3bintegrin, alpha 3b0.082
hmx4H6 family homeobox 40.080
hoxc4ahomeo box C4a0.080
crb2acrumbs homolog 2a0.078
hhiphedgehog interacting protein0.077
bmp1abone morphogenetic protein 1a0.077
hoxc8ahomeo box C8a0.077
tgfbitransforming growth factor, beta-induced0.077
runx2arunt-related transcription factor 2a0.075
jag1bjagged 1b0.075
vcanbversican b0.074
rasl11bRAS-like, family 11, member B0.074
nkx3.2NK3 homeobox 20.073
sox2SRY-box containing gene 20.072
rtcd1RNA terminal phosphate cyclase domain 10.072
wif1wnt inhibitory factor 10.071
gyltl1bglycosyltransferase-like 1b0.071
tgfb1atransforming growth factor, beta 1a0.071
grem2gremlin 2, cysteine knot superfamily0.070
p4ha2procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 20.069
metmet proto-oncogene (hepatocyte growth factor receptor)0.067
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.066
wnt3awingless-type MMTV integration site family, member 3A0.066
tfap2ctranscription factor AP-2 gamma (activating enhancer binding protein 2 gamma)0.066
notch1anotch homolog 1a0.066
pax9paired box gene 90.064
tfectranscription factor EC0.064
dlx2adistal-less homeobox gene 2a0.064
znf703zinc finger protein 7030.062
prkciprotein kinase C, iota0.062
sfrp5secreted frizzled-related protein 50.061
smad7MAD, mothers against decapentaplegic homolog 7 (Drosophila)0.060
sox1aSRY-box containing gene 1a0.060
vgll4lvestigial like 4 like0.060
spry4sprouty (Drosophila) homolog 40.059
tp63tumor protein p630.058
fgf10afibroblast growth factor 10a0.058
ephb4beph receptor B4b0.056
msxemuscle segment homeobox E0.056
tbx2aT-box gene 2a0.056
hoxa2bhomeo box A2b0.054
evx1even-skipped homeobox 10.053
neurod4neurogenic differentiation 40.053
cx43.4connexin 43.40.053
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI30.999
Efnb2ephrin B20.998
Fgfr2fibroblast growth factor receptor 20.996
Tgfb2transforming growth factor, beta 20.996
Foxc1forkhead box C10.974
Ephb2Eph receptor B20.962
Gli2GLI-Kruppel family member GLI20.958
Ctnnb1catenin (cadherin associated protein), beta 10.956
Pax3paired box gene 30.947
Bmp4bone morphogenetic protein 40.946
Jag1jagged 10.933
Pitx2paired-like homeodomain transcription factor 20.924
Hand1heart and neural crest derivatives expressed transcript 10.904
Msx1homeobox, msh-like 10.901
Pbx1pre B-cell leukemia transcription factor 10.883
Efnb1ephrin B10.881
Tcfap2atranscription factor AP-2, alpha0.880
Pax6paired box gene 60.877
Hand2heart and neural crest derivatives expressed transcript 20.875
Sfrp2secreted frizzled-related protein 20.862
Snai1snail homolog 1 (Drosophila)0.862
Prrx1paired related homeobox 10.829
Gdnfglial cell line derived neurotrophic factor0.812
Notch1Notch gene homolog 1 (Drosophila)0.802
Smad3MAD homolog 3 (Drosophila)0.798
Prrx2paired related homeobox 20.790
Foxc2forkhead box C20.788
Tbx3T-box 30.788
Rargretinoic acid receptor, gamma0.785
Smad4MAD homolog 4 (Drosophila)0.783
Gata4GATA binding protein 40.779
Runx2runt related transcription factor 20.769
Foxa2forkhead box A20.747
Neurod1neurogenic differentiation 10.739
Fgf8fibroblast growth factor 80.730
Ascl1achaete-scute complex homolog 1 (Drosophila)0.721
Tgfbr2transforming growth factor, beta receptor II0.718
Msx2homeobox, msh-like 20.712
Hoxa1homeobox A10.705
Hoxd13homeobox D130.702
Tcf21transcription factor 210.697
Ptf1apancreas specific transcription factor, 1a0.676
Sox11SRY-box containing gene 110.670
Gas1growth arrest specific 10.663
Vangl2vang-like 2 (van gogh, Drosophila)0.649
Foxg1forkhead box G10.647
Bmp7bone morphogenetic protein 70.644
Smad6MAD homolog 6 (Drosophila)0.644
Hic1hypermethylated in cancer 10.643
Crb2crumbs homolog 2 (Drosophila)0.633
Hey2hairy/enhancer-of-split related with YRPW motif 20.625
Twist2twist homolog 2 (Drosophila)0.618
Ror2receptor tyrosine kinase-like orphan receptor 20.612
Tbx1T-box 10.605
Otx2orthodenticle homolog 2 (Drosophila)0.596
Foxh1forkhead box H10.594
Ephb3Eph receptor B30.592
Fgfr1fibroblast growth factor receptor 10.574
Wnt5awingless-related MMTV integration site 5A0.527
Eya1eyes absent 1 homolog (Drosophila)0.524
Dlx5distal-less homeobox 50.501
Lef1lymphoid enhancer binding factor 10.500
Hoxd11homeobox D110.500
Dab1disabled homolog 1 (Drosophila)0.492
Neurog2neurogenin 20.478
Gata6GATA binding protein 60.461
Smad1MAD homolog 1 (Drosophila)0.450
Psen1presenilin 10.439
Pax9paired box gene 90.432
Rspo2R-spondin 2 homolog (Xenopus laevis)0.425
Yap1yes-associated protein 10.419
Axin1axin 10.414
Ptk7PTK7 protein tyrosine kinase 70.409
Pax2paired box gene 20.406
Ntf3neurotrophin 30.402
Smosmoothened homolog (Drosophila)0.402
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.382
Col2a1collagen, type II, alpha 10.381
Atoh7atonal homolog 7 (Drosophila)0.373
Tlx3T-cell leukemia, homeobox 30.373
Meox2mesenchyme homeobox 20.366
Gpc3glypican 30.359
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.354
Emx1empty spiracles homolog 1 (Drosophila)0.350
Bnc1basonuclin 10.350
Epha4Eph receptor A40.345
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.338
Vegfavascular endothelial growth factor A0.336
Hoxa13homeobox A130.332
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.322
Sox2SRY-box containing gene 20.315
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.314
Hes1hairy and enhancer of split 1 (Drosophila)0.310
Zic3zinc finger protein of the cerebellum 30.303
Hspg2perlecan (heparan sulfate proteoglycan 2)0.300
Fzd2frizzled homolog 2 (Drosophila)0.298
Acvr1activin A receptor, type 10.295
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.531
Col5a1collagen, type V, alpha 10.222
Col1a2collagen, type I, alpha 20.066
Col4a1collagen, type IV, alpha 10.058
Tomm20translocase of outer mitochondrial membrane 20 homolog (yeast)0.047
RragaRas-related GTP binding A0.041
Loxlysyl oxidase0.039
Col12a1collagen, type XII, alpha 10.038
Lamc1laminin, gamma 10.037
Col5a2collagen, type V, alpha 20.036
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.033
Fbln2fibulin 20.033
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.032
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.030
Slit3slit homolog 3 (Drosophila)0.027
Pmepa1prostate transmembrane protein, androgen induced 10.026
Loxl1lysyl oxidase-like 10.026
Bmp1bone morphogenetic protein 10.025
C1dC1D nuclear receptor co-repressor0.025
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.024
Fstl1follistatin-like 10.022
Efnb1ephrin B10.022
Tcf3transcription factor 30.022
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 10.021
Ltbp4latent transforming growth factor beta binding protein 40.021
Col18a1collagen, type XVIII, alpha 10.020
Col14a1collagen, type XIV, alpha 10.020
Timp2TIMP metallopeptidase inhibitor 20.020
Flt1FMS-related tyrosine kinase 10.020
Sox13SRY (sex determining region Y)-box 130.020
Dchs1dachsous 1 (Drosophila)0.020
Fgfr1Fibroblast growth factor receptor 10.018
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.017
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.017
Acta2smooth muscle alpha-actin0.017
RestRE1-silencing transcription factor0.017
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.017
Fbn1fibrillin 10.016
Tln1talin 10.016
Metmet proto-oncogene0.016
Mmp23matrix metallopeptidase 230.016
Col6a2collagen, type VI, alpha 20.016
Elk3ELK3, ETS-domain protein0.016
Plekhg2pleckstrin homology domain containing, family G (with RhoGef domain) member 20.015
Col4a2collagen, type IV, alpha 20.015
Pim1pim-1 oncogene0.015
Nr2f2nuclear receptor subfamily 2, group F, member 20.014
Olfml2bolfactomedin-like 2B0.014
Pcolceprocollagen C-endopeptidase enhancer0.014
Ece1endothelin converting enzyme 10.014
VapaVAMP (vesicle-associated membrane protein)-associated protein A0.014
Col1a1collagen, type I, alpha 10.014
Igfbp5insulin-like growth factor binding protein 50.014
Fam38afamily with sequence similarity 38, member A0.014
Scgb1a1secretoglobin, family 1A, member 1 (uteroglobin)0.014
RGD1309188similar to hypothetical protein BC0118330.014
Has2hyaluronan synthase 20.013
S1pr2sphingosine-1-phosphate receptor 20.013
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.013
Figfc-fos induced growth factor0.013
Uoxurate oxidase0.013
Tcfe2atranscription factor E2a0.013
Mrfap1Mof4 family associated protein 10.013
Crtapcartilage associated protein0.013
Postnperiostin, osteoblast specific factor0.013
Stat6signal transducer and activator of transcription 60.013
Onecut1one cut homeobox 10.013
Mfap4microfibrillar-associated protein 40.013
Ncor2nuclear receptor co-repressor 20.013
Ier5limmediate early response 5-like0.013
Wdr77WD repeat domain 770.013
Fn1fibronectin 10.013
Unc13dunc-13 homolog D (C. elegans)0.013
Tcf4transcription factor 40.012
Ecm1extracellular matrix protein 10.012
Smad7SMAD family member 70.012
Aebp1AE binding protein 10.012
Tgfbr2transforming growth factor, beta receptor II0.012
Wisp2WNT1 inducible signaling pathway protein 20.012
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.012
Lmcd1LIM and cysteine-rich domains 10.012
Scarf2scavenger receptor class F, member 20.012
Vash2vasohibin 20.012
Pdk4pyruvate dehydrogenase kinase, isozyme 40.012
Sbk1SH3-binding domain kinase 10.012
Fapfibroblast activation protein, alpha0.012
Ppp2r2aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform0.012
Pear1platelet endothelial aggregation receptor 10.011
Fbxo22F-box protein 220.011
Epas1endothelial PAS domain protein 10.011
Tgfb1i1transforming growth factor beta 1 induced transcript 10.011
Gpc3glypican 30.011
Col15a1collagen, type XV, alpha 10.011
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.011
Slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.011
Col9a1collagen, type IX, alpha 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism