The network for 'rna phosphodiester bond hydrolysis endonucleolytic' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rna phosphodiester bond hydrolysis endonucleolytic

The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
EIF2C2eukaryotic translation initiation factor 2C, 20.606
EIF2C1eukaryotic translation initiation factor 2C, 10.242
EIF2C3eukaryotic translation initiation factor 2C, 30.136
TNRC6Atrinucleotide repeat containing 6A0.095
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.064
PABPC1poly(A) binding protein, cytoplasmic 10.061
FTSJ3FtsJ homolog 3 (E. coli)0.049
EIF2C4eukaryotic translation initiation factor 2C, 40.045
SYVN1synovial apoptosis inhibitor 1, synoviolin0.036
TNRC6Ctrinucleotide repeat containing 6C0.028
TNRC6Btrinucleotide repeat containing 6B0.022
RPP40ribonuclease P/MRP 40kDa subunit0.021
DICER1dicer 1, ribonuclease type III0.020
TGS1trimethylguanosine synthase 10.019
NUFIP1nuclear fragile X mental retardation protein interacting protein 10.015
UPF1UPF1 regulator of nonsense transcripts homolog (yeast)0.015
C10orf2chromosome 10 open reading frame 20.012
BMS1BMS1 homolog, ribosome assembly protein (yeast)0.012
CHAF1Achromatin assembly factor 1, subunit A (p150)0.011
PPANpeter pan homolog (Drosophila)0.011
IPO8importin 80.011
TARBP2TAR (HIV-1) RNA binding protein 20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.721
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.462
Mybbp1aMYB binding protein (P160) 1a0.309
Grwd1glutamate-rich WD repeat containing 10.224
Noc4lnucleolar complex associated 4 homolog (S. cerevisiae)0.178
Nop2NOP2 nucleolar protein homolog (yeast)0.165
Trim32tripartite motif-containing 320.161
Eedembryonic ectoderm development0.159
Smad4MAD homolog 4 (Drosophila)0.149
Ppanpeter pan homolog (Drosophila)0.134
Ddx6DEAD (Asp-Glu-Ala-Asp) box polypeptide 60.114
Pwp2PWP2 periodic tryptophan protein homolog (yeast)0.109
Atrataxia telangiectasia and Rad3 related0.106
Gnl3guanine nucleotide binding protein-like 3 (nucleolar)0.079
Pprc1peroxisome proliferative activated receptor, gamma, coactivator-related 10.073
Fam203afamily with sequence similarity 203, member A0.065
Utp20UTP20, small subunit (SSU) processome component, homolog (yeast)0.054
Smyd5SET and MYND domain containing 50.053
Wdr43WD repeat domain 430.051
Rrp12ribosomal RNA processing 12 homolog (S. cerevisiae)0.050
Ftsj3FtsJ homolog 3 (E. coli)0.049
Trim25tripartite motif-containing 250.047
Tex10testis expressed gene 100.043
Nubp1nucleotide binding protein 10.041
Tnrc6ctrinucleotide repeat containing 6C0.040
Nolc1nucleolar and coiled-body phosphoprotein 10.036
Ddx21DEAD (Asp-Glu-Ala-Asp) box polypeptide 210.035
Pus1pseudouridine synthase 10.033
Rrp1bribosomal RNA processing 1 homolog B (S. cerevisiae)0.033
Pdcd11programmed cell death 110.032
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.029
Ifit1interferon-induced protein with tetratricopeptide repeats 10.028
Rrs1RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)0.028
Dph2DPH2 homolog (S. cerevisiae)0.027
Rbm34RNA binding motif protein 340.027
Heatr1HEAT repeat containing 10.027
Ccdc86coiled-coil domain containing 860.026
Eftud2elongation factor Tu GTP binding domain containing 20.025
Akap9A kinase (PRKA) anchor protein (yotiao) 90.024
Rrp15ribosomal RNA processing 15 homolog (S. cerevisiae)0.024
Tbrg4transforming growth factor beta regulated gene 40.024
Elac2elaC homolog 2 (E. coli)0.024
TcrdT-cell receptor delta chain0.023
Nop56NOP56 ribonucleoprotein homolog (yeast)0.023
Gar1GAR1 ribonucleoprotein homolog (yeast)0.023
Polr1bpolymerase (RNA) I polypeptide B0.022
Srmspermidine synthase0.022
Polr3apolymerase (RNA) III (DNA directed) polypeptide A0.021
Nufip1nuclear fragile X mental retardation protein interacting protein 10.021
Wdr3WD repeat domain 30.021
TcrbT-cell receptor beta chain0.020
Rbm19RNA binding motif protein 190.020
Droshadrosha, ribonuclease type III0.019
Safbscaffold attachment factor B0.019
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.019
Dis3DIS3 mitotic control homolog (S. cerevisiae)0.019
Xpo5exportin 50.018
Rtp4receptor transporter protein 40.018
Pus7lpseudouridylate synthase 7 homolog (S. cerevisiae)-like0.018
YrdcyrdC domain containing (E.coli)0.018
Mogsmannosyl-oligosaccharide glucosidase0.018
2610027L16RikRIKEN cDNA 2610027L16 gene0.018
Ddx51DEAD (Asp-Glu-Ala-Asp) box polypeptide 510.018
Apcadenomatosis polyposis coli0.017
Dkc1dyskeratosis congenita 1, dyskerin homolog (human)0.017
Usp18ubiquitin specific peptidase 180.017
Nsun5NOL1/NOP2/Sun domain family, member 50.016
Ikzf1IKAROS family zinc finger 10.016
Foxp3forkhead box P30.016
D19Bwg1357eDNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed0.016
Ighimmunoglobulin heavy chain complex0.016
Byslbystin-like0.016
Ercc3excision repair cross-complementing rodent repair deficiency, complementation group 30.015
Ddx20DEAD (Asp-Glu-Ala-Asp) box polypeptide 200.015
Taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor0.015
Nsun2NOL1/NOP2/Sun domain family member 20.015
Imp4IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)0.015
Oasl22'-5' oligoadenylate synthetase-like 20.014
Aenapoptosis enhancing nuclease0.014
Ddx39DEAD (Asp-Glu-Ala-Asp) box polypeptide 390.014
Mettl1methyltransferase like 10.014
Tnrc6btrinucleotide repeat containing 6b0.014
Rcl1RNA terminal phosphate cyclase-like 10.014
Rfc2replication factor C (activator 1) 20.014
Pdcd2programmed cell death 20.014
Tsr1TSR1, 20S rRNA accumulation, homolog (yeast)0.014
Nip7nuclear import 7 homolog (S. cerevisiae)0.013
Ipo4importin 40.013
Oas1a2'-5' oligoadenylate synthetase 1A0.013
Dcaf13DDB1 and CUL4 associated factor 130.013
Ifi44interferon-induced protein 440.013
1810008A18RikRIKEN cDNA 1810008A18 gene0.013
Isg20l2interferon stimulated exonuclease gene 20-like 20.013
Ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.012
Isg15ISG15 ubiquitin-like modifier0.012
Ptpn11protein tyrosine phosphatase, non-receptor type 110.012
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.012
Chd4chromodomain helicase DNA binding protein 40.012
Wdr46WD repeat domain 460.012
Irf7interferon regulatory factor 70.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
ECM16Ecm16p0.796
ENP1Enp1p0.775
BFR2Bfr2p0.748
SOF1Sof1p0.733
FAF1Faf1p0.693
UTP18Utp18p0.638
CBF5Cbf5p0.589
NOP14Nop14p0.512
DBP7Dbp7p0.503
UTP11Utp11p0.499
DIP2Dip2p0.469
KRR1Krr1p0.441
UTP8Utp8p0.420
UTP25Utp25p0.417
MRD1Mrd1p0.390
SLX9Slx9p0.377
MPP10Mpp10p0.317
IMP3Imp3p0.295
NOC2Noc2p0.292
UTP10Utp10p0.292
UTP4Utp4p0.292
UTP23Utp23p0.246
NOB1Nob1p0.245
UTP30Utp30p0.243
RRP14Rrp14p0.236
ENP2Enp2p0.231
UTP21Utp21p0.223
BUD21Bud21p0.204
GAR1Gar1p0.203
RPS21ARps21ap0.202
RPS4ARps4ap0.176
IMP4Imp4p0.176
NAN1Nan1p0.168
TRM112Trm112p0.165
NUC1Nuc1p0.157
RIX1Rix1p0.144
BMS1Bms1p0.140
RRP3Rrp3p0.139
EFG1Efg1p0.136
NSA2Nsa2p0.134
RPS28BRps28bp0.131
SGD1Sgd1p0.131
NOP1Nop1p0.128
NOC4Noc4p0.121
RPS29ARps29ap0.113
UBP10Ubp10p0.108
FYV7Fyv7p0.105
LRP1Lrp1p0.104
RRN3Rrn3p0.102
ESF2Esf2p0.100
EBP2Ebp2p0.099
UTP14Utp14p0.097
PRS2Prs2p0.096
RPS17ARps17ap0.095
RIX7Rix7p0.093
BCD1Bcd1p0.092
RPS18BRps18bp0.091
PWP2Pwp2p0.091
NOP10Nop10p0.089
UTP13Utp13p0.085
NOP6Nop6p0.085
RRN7Rrn7p0.082
KRE33Kre33p0.081
UTP20Utp20p0.080
RET1Ret1p0.079
MPE1Mpe1p0.077
RNH203Rnh203p0.073
UTP15Utp15p0.071
DRS1Drs1p0.071
PXR1Pxr1p0.069
PNO1Pno1p0.069
RPL22ARpl22ap0.067
ROK1Rok1p0.067
GRC3Grc3p0.065
RPS30ARps30ap0.065
RIO1Rio1p0.065
CMS1Cms1p0.062
NUP82Nup82p0.062
RRP36Rrp36p0.062
POL30Pol30p0.061
RLP7Rlp7p0.061
UAF30Uaf30p0.060
NAF1Naf1p0.060
YHB1Yhb1p0.060
PRS1Prs1p0.059
EMG1Emg1p0.058
TRL1Trl1p0.058
UTP5Utp5p0.056
RRP7Rrp7p0.055
DHR2Dhr2p0.055
UTP9Utp9p0.055
NUP85Nup85p0.055
YJR129Chypothetical protein0.055
NUP157Nup157p0.052
RPL23BRpl23bp0.052
SRD1Srd1p0.052
TMA23Tma23p0.051
MTR3Mtr3p0.051
CCT8Cct8p0.051
CUP1-1Cup1-1p0.050