The network for 'positive regulation of peptidase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of peptidase activity

Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 20.999
CASP8caspase 8, apoptosis-related cysteine peptidase0.999
CASP3caspase 3, apoptosis-related cysteine peptidase0.981
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.979
MDM2Mdm2 p53 binding protein homolog (mouse)0.979
XIAPX-linked inhibitor of apoptosis0.974
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.972
BCL2L1BCL2-like 10.969
CASP10caspase 10, apoptosis-related cysteine peptidase0.956
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.954
CREBBPCREB binding protein0.954
SMAD3SMAD family member 30.948
SMAD4SMAD family member 40.938
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.937
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.924
FASFas (TNF receptor superfamily, member 6)0.916
BAXBCL2-associated X protein0.916
BCL2L11BCL2-like 11 (apoptosis facilitator)0.915
FADDFas (TNFRSF6)-associated via death domain0.913
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.897
CASP9caspase 9, apoptosis-related cysteine peptidase0.891
SMAD2SMAD family member 20.883
SMAD7SMAD family member 70.881
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.877
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.876
SMAD1SMAD family member 10.870
POU5F1POU class 5 homeobox 10.868
CASP2caspase 2, apoptosis-related cysteine peptidase0.866
PYCARDPYD and CARD domain containing0.863
CFLARCASP8 and FADD-like apoptosis regulator0.863
CAV1caveolin 1, caveolae protein, 22kDa0.862
BIDBH3 interacting domain death agonist0.845
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.824
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.800
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.793
SMURF2SMAD specific E3 ubiquitin protein ligase 20.783
PSMD13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.758
SP1Sp1 transcription factor0.728
S100BS100 calcium binding protein B0.718
PSMC4proteasome (prosome, macropain) 26S subunit, ATPase, 40.703
UCHL5ubiquitin carboxyl-terminal hydrolase L50.689
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.681
PSME3proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)0.672
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.651
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.631
BCAP31B-cell receptor-associated protein 310.622
S100A6S100 calcium binding protein A60.603
APAF1apoptotic peptidase activating factor 10.601
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.594
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.559
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.554
PSME2proteasome (prosome, macropain) activator subunit 2 (PA28 beta)0.550
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.535
SOCS1suppressor of cytokine signaling 10.511
ESR1estrogen receptor 10.504
HSPA9heat shock 70kDa protein 9 (mortalin)0.495
ANXA2annexin A20.480
PSMD3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.444
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.438
EIF3Leukaryotic translation initiation factor 3, subunit L0.421
PSMD14proteasome (prosome, macropain) 26S subunit, non-ATPase, 140.411
TP53BP2tumor protein p53 binding protein, 20.401
RB1retinoblastoma 10.398
SMN1survival of motor neuron 1, telomeric0.395
PTPN12protein tyrosine phosphatase, non-receptor type 120.389
CTGFconnective tissue growth factor0.386
SKILSKI-like oncogene0.369
SQSTM1sequestosome 10.353
RAD23BRAD23 homolog B (S. cerevisiae)0.347
PTMAprothymosin, alpha0.341
RXRAretinoid X receptor, alpha0.338
CARD11caspase recruitment domain family, member 110.334
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.334
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.334
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.334
S100A4S100 calcium binding protein A40.332
FHfumarate hydratase0.319
FMR1fragile X mental retardation 10.316
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 30.307
HCKhemopoietic cell kinase0.306
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.298
PSME1proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)0.298
VDAC1voltage-dependent anion channel 10.298
BADBCL2-associated agonist of cell death0.288
EPAS1endothelial PAS domain protein 10.287
FASLGFas ligand (TNF superfamily, member 6)0.277
MDM4Mdm4 p53 binding protein homolog (mouse)0.276
NCK1NCK adaptor protein 10.276
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.275
ENGendoglin0.275
BMP2bone morphogenetic protein 20.271
COL4A1collagen, type IV, alpha 10.271
CHEK2CHK2 checkpoint homolog (S. pombe)0.268
PIAS4protein inhibitor of activated STAT, 40.262
ARandrogen receptor0.260
TBK1TANK-binding kinase 10.256
PSMB8proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)0.251
FN1fibronectin 10.246
GAS7growth arrest-specific 70.235
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.235
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
B0001.5Protein B0001.50.014
syp-1Protein SYP-10.011
C18B2.3Protein C18B2.30.011
T09B4.8Protein T09B4.80.010
F56A6.4Protein F56A6.40.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bcl2B-cell leukemia/lymphoma 20.129
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.115
bidaBH3 interacting domain death agonist0.068
bcl2l1bcl2-like 10.064
sulf1sulfatase 10.062
baxabcl2-associated X protein, a0.055
wnt9awingless-type MMTV integration site family, member 9A0.052
adipor1badiponectin receptor 1b0.048
stc1lstanniocalcin 1, like0.045
wif1wnt inhibitory factor 10.045
ef1aelongation factor 1-alpha0.042
col5a2lcollagen, type V, alpha 2-like0.038
badBCL2-antagonist of cell death0.036
mcl1amyeloid cell leukemia sequence 1a0.036
mcl1bmyeloid cell leukemia sequence 1b0.034
kdrlkinase insert domain receptor like0.033
LOC567131calcitonin gene-related peptide type 1 receptor-like0.032
tfe3btranscription factor binding to IGHM enhancer 3b0.032
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.031
wt1bwilms tumor 1b0.030
wnt2bbwingless-type MMTV integration site family, member 2Bb0.029
tnfsf10ltumor necrosis factor (ligand) superfamily, member 10 like0.027
fn1fibronectin 10.027
fstl1bfollistatin-like 1b0.023
hbae1hemoglobin alpha embryonic-10.023
ighzimmunoglobulin heavy constant zeta0.022
mmp14amatrix metalloproteinase 14a (membrane-inserted)0.022
ism1isthmin 10.022
psmc1bproteasome (prosome, macropain) 26S subunit, ATPase, 1b0.022
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.021
hmgb2ahigh-mobility group box 2a0.021
cmybtranscription factor cmyb0.021
ctgfconnective tissue growth factor0.020
terttelomerase reverse transcriptase0.020
immtinner membrane protein, mitochondrial (mitofilin)0.019
ahcyS-adenosylhomocysteine hydrolase0.019
vegfabvascular endothelial growth factor Ab0.019
caspacaspase a0.018
bbc3BCL2 binding component 30.018
egr1early growth response 10.017
eporerythropoietin receptor0.017
polbpolymerase (DNA directed), beta0.017
loxl2blysyl oxidase-like 2b0.017
il1binterleukin 1, beta and interleukin 1, beta0.016
cntfrciliary neurotrophic factor receptor0.016
capns1bcalpain, small subunit 1 b0.016
si:rp71-39b20.7si:rp71-39b20.70.016
nphs2nephrosis 2, idiopathic, steroid-resistant (podocin)0.016
ighmimmunoglobulin heavy constant mu and immunoglobulin heavy constant mu0.016
gata3GATA-binding protein 30.015
mycbp2MYC binding protein 20.015
gata1aGATA binding protein 1a0.015
wnt11rwingless-type MMTV integration site family, member 11, related0.015
prrx1apaired related homeobox 1a0.015
tgfbr2transforming growth factor, beta receptor II0.014
col12a1collagen, type XII, alpha 10.014
ext1bexostoses (multiple) 1b0.014
psmg2proteasome (prosome, macropain) assembly chaperone 20.014
psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.014
hmgb3bhigh-mobility group box 3b0.013
tnfrsfatumor necrosis factor receptor superfamily, member a0.013
lmx1aLIM homeobox transcription factor 1, alpha0.013
psme2proteasome activator subunit 20.013
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.013
trpv4transient receptor potential cation channel, subfamily V, member 40.013
sdcbpsyndecan binding protein (syntenin)0.013
plxnb2aplexin b2a0.012
psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.012
gata5GATA-binding protein 50.012
foxn1forkhead box N10.012
psmb2proteasome (prosome, macropain) subunit, beta type, 20.012
p4ha1bprolyl 4-hydroxylase, alpha polypeptide I b0.012
has2hyaluronan synthase 20.012
tlr9toll-like receptor 90.012
fzd7bfrizzled homolog 7b0.011
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.011
rdh10bretinol dehydrogenase 10b0.011
ntd5ntl-dependent gene 50.011
cldngclaudin g0.011
si:ch211-212m21.5si:ch211-212m21.50.011
pccbpropionyl Coenzyme A carboxylase, beta polypeptide0.011
foxn4forkhead box N40.011
caluacalumenin a0.011
irf6interferon regulatory factor 60.011
timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.011
plxna3plexin A30.011
myod1myogenic differentiation 10.011
emp2epithelial membrane protein 20.011
ikzf1IKAROS family zinc finger 1 (Ikaros)0.011
tmem106atransmembrane protein 106A0.011
prim1primase polypeptide 10.011
phlda2pleckstrin homology-like domain, family A, member 20.010
olfml3bolfactomedin-like 3b0.010
ighz2immunoglobulin heavy constant zeta20.010
mmp2matrix metalloproteinase 20.010
lap3leucine aminopeptidase 30.010
trpv6transient receptor potential cation channel, subfamily V, member 60.010
cyt1type I cytokeratin, enveloping layer0.010
bmf1Bcl2 modifying factor 10.010
blmhbleomycin hydrolase0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
ththread0.923
hbshibris0.789
grimCG4345 gene product from transcript CG4345-RA0.788
Rpt1CG1341 gene product from transcript CG1341-RA0.779
rstroughest0.713
imdimmune deficiency0.670
Dcp-1Death caspase-10.564
NcNedd2-like caspase0.490
Tbp-1Tat-binding protein-10.487
PliPellino0.430
Eip74EFEcdysone-induced protein 74EF0.389
eygeyegone0.374
bchsblue cheese0.374
Pros26.4Proteasome 26S subunit subunit 4 ATPase0.369
Rac1CG2248 gene product from transcript CG2248-RA0.365
AGO2Argonaute 20.365
yuriyuri gagarin0.363
jarjaguar0.339
Cyt-c-dCytochrome c distal0.334
RASSF8CG5053 gene product from transcript CG5053-RA0.331
CG9772CG9772 gene product from transcript CG9772-RB0.317
scribscribbled0.312
CG9894CG9894 gene product from transcript CG9894-RB0.301
kirrekin of irre0.287
Rpt4CG3455 gene product from transcript CG3455-RA0.272
His3.3AHistone H3.3A0.263
p53CG33336 gene product from transcript CG33336-RB0.252
X11LCG5675 gene product from transcript CG5675-RB0.249
drprdraper0.246
WWrinkled0.237
Traf4TNF-receptor-associated factor 40.231
CG1103CG1103 gene product from transcript CG1103-RA0.227
betaTub85Dbeta-Tubulin at 85D0.220
Rpn6Proteasome p44.5 subunit0.220
ranCG1404 gene product from transcript CG1404-RB0.209
Vrp1Verprolin 10.194
CG5384CG5384 gene product from transcript CG5384-RA0.174
Rpt3CG16916 gene product from transcript CG16916-RA0.171
CctgammaCG8977 gene product from transcript CG8977-RC0.168
roboroundabout0.146
Hr38Hormone receptor-like in 380.144
alphalphabet0.142
fs(2)ltoPP43female sterile (2) ltoPP430.141
wtswarts0.139
lmglemming0.132
dmtdalmatian0.121
Eip93FCG18389 gene product from transcript CG18389-RB0.120
Sox14Sox box protein 140.120
XNPCG4548 gene product from transcript CG4548-RA0.120
Akt1CG4006 gene product from transcript CG4006-RA0.115
stanstarry night0.115
trioCG18214 gene product from transcript CG18214-RA0.115
Mov34CG3416 gene product from transcript CG3416-RA0.113
Mcm3Minichromosome maintenance 30.112
spag4sperm-associated antigen 40.111
ArkApaf-1-related-killer0.110
Gef26CG9491 gene product from transcript CG9491-RB0.108
Pi3K92ECG4141 gene product from transcript CG4141-RB0.106
Dcr-2Dicer-20.104
pr-set7CG3307 gene product from transcript CG3307-RC0.101
Roc1bCG16988 gene product from transcript CG16988-RA0.100
SmoxSmad on X0.100
loqsloquacious0.097
msnmisshapen0.094
PakPAK-kinase0.093
Cdc42CG12530 gene product from transcript CG12530-RA0.092
CG12016CG12016 gene product from transcript CG12016-RA0.090
bskbasket0.089
swmsecond mitotic wave missing0.089
CadNCadherin-N0.087
ph-dpolyhomeotic distal0.086
Rpn3Regulatory particle non-ATPase 30.086
Iap2Inhibitor of apoptosis 20.083
Df31Decondensation factor 310.081
rinrasputin0.080
CG5355CG5355 gene product from transcript CG5355-RA0.079
CG4747CG4747 gene product from transcript CG4747-RB0.078
Rpn11CG18174 gene product from transcript CG18174-RA0.078
Pros45CG1489 gene product from transcript CG1489-RA0.078
snssticks and stones0.078
cln3CG5582 gene product from transcript CG5582-RA0.078
DreddDeath related ced-3/Nedd2-like protein0.078
IceCG7788 gene product from transcript CG7788-RA0.076
edlETS-domain lacking0.074
aopanterior open0.074
Sep4Septin 40.073
eastenhanced adult sensory threshold0.071
Toll-6CG7250 gene product from transcript CG7250-RA0.070
RnrLRibonucleoside diphosphate reductase large subunit0.070
carcarnation0.069
Prosbeta3Proteasome beta3 subunit0.069
Rpn1CG7762 gene product from transcript CG7762-RA0.069
tadrtorn and diminished rhabdomeres0.067
CG34110CG34110 gene product from transcript CG34110-RC0.067
Toll-7CG8595 gene product from transcript CG8595-RA0.066
Chrac-14CG13399 gene product from transcript CG13399-RA0.066
Rpn9CG10230 gene product from transcript CG10230-RB0.066
His3.3BHistone H3.3B0.065
Trxr-1Thioredoxin reductase-10.064
CG10638CG10638 gene product from transcript CG10638-RA0.063
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 531.000
Casp4caspase 4, apoptosis-related cysteine peptidase0.998
BaxBCL2-associated X protein0.980
Bcl2B-cell leukemia/lymphoma 20.963
Tnftumor necrosis factor0.944
PycardPYD and CARD domain containing0.901
Il10interleukin 100.873
Cd44CD44 antigen0.872
Stat5asignal transducer and activator of transcription 5A0.868
Foxn1forkhead box N10.827
Casp1caspase 10.821
SkilSKI-like0.815
Lyz2lysozyme 20.800
Gbp5guanylate binding protein 50.799
Sfrp2secreted frizzled-related protein 20.762
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.759
Psme1proteasome (prosome, macropain) 28 subunit, alpha0.747
Cav1caveolin 1, caveolae protein0.741
Psme2proteasome (prosome, macropain) 28 subunit, beta0.705
Tlr4toll-like receptor 40.701
S100a9S100 calcium binding protein A9 (calgranulin B)0.658
Ptch2patched homolog 20.646
Ptprcprotein tyrosine phosphatase, receptor type, C0.607
Npm1nucleophosmin 10.586
Mcl1myeloid cell leukemia sequence 10.566
Ctgfconnective tissue growth factor0.556
Wt1Wilms tumor 1 homolog0.547
Map3k14mitogen-activated protein kinase kinase kinase 140.520
Ptrfpolymerase I and transcript release factor0.486
Il1r1interleukin 1 receptor, type I0.466
Bcl2l1BCL2-like 10.462
Stat5bsignal transducer and activator of transcription 5B0.454
Rararetinoic acid receptor, alpha0.454
Sfrp1secreted frizzled-related protein 10.429
Ltalymphotoxin A0.426
Irf1interferon regulatory factor 10.422
Thbs1thrombospondin 10.419
Tgfb1transforming growth factor, beta 10.418
Socs1suppressor of cytokine signaling 10.409
Wnt3awingless-related MMTV integration site 3A0.402
Irf9interferon regulatory factor 90.398
Trp73transformation related protein 730.397
S100a8S100 calcium binding protein A8 (calgranulin A)0.396
Cycscytochrome c, somatic0.394
Gli2GLI-Kruppel family member GLI20.385
Htthuntingtin0.344
Slit3slit homolog 3 (Drosophila)0.338
Socs3suppressor of cytokine signaling 30.333
Ccr1chemokine (C-C motif) receptor 10.310
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.306
Ptgs2prostaglandin-endoperoxide synthase 20.299
Pax2paired box gene 20.285
Ikbkbinhibitor of kappaB kinase beta0.265
NmiN-myc (and STAT) interactor0.263
Ltbp2latent transforming growth factor beta binding protein 20.258
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.251
Leprleptin receptor0.249
Fstl1follistatin-like 10.245
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.239
Arandrogen receptor0.238
Esr2estrogen receptor 2 (beta)0.232
Gdnfglial cell line derived neurotrophic factor0.227
Il6stinterleukin 6 signal transducer0.223
Ldlrlow density lipoprotein receptor0.219
Lifleukemia inhibitory factor0.218
Spg21spastic paraplegia 21 homolog (human)0.212
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.200
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.199
Mdm2transformed mouse 3T3 cell double minute 20.199
Ikzf1IKAROS family zinc finger 10.196
Hoxc6homeobox C60.196
Thbs2thrombospondin 20.187
Pax8paired box gene 80.185
Htra3HtrA serine peptidase 30.183
FasFas (TNF receptor superfamily member 6)0.183
Hbb-b1hemoglobin, beta adult major chain0.182
Vegfavascular endothelial growth factor A0.182
Il15interleukin 150.177
Nos3nitric oxide synthase 3, endothelial cell0.175
Adam17a disintegrin and metallopeptidase domain 170.172
Mmp11matrix metallopeptidase 110.169
Dkk1dickkopf homolog 1 (Xenopus laevis)0.164
Hspe1heat shock protein 1 (chaperonin 10)0.162
Wnt5awingless-related MMTV integration site 5A0.161
Wnt10bwingless related MMTV integration site 10b0.159
Pecam1platelet/endothelial cell adhesion molecule 10.154
Stat1signal transducer and activator of transcription 10.154
Il7interleukin 70.154
Fgf18fibroblast growth factor 180.154
Mdm4transformed mouse 3T3 cell double minute 40.153
TapbpTAP binding protein0.153
Mapk14mitogen-activated protein kinase 140.153
Nbl1neuroblastoma, suppression of tumorigenicity 10.152
FaddFas (TNFRSF6)-associated via death domain0.152
Ifnginterferon gamma0.150
Coro1bcoronin, actin binding protein 1B0.149
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.149
Casp7caspase 70.147
Nlrp3NLR family, pyrin domain containing 30.145
Exoc6exocyst complex component 60.138
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
S100a8S100 calcium binding protein A80.012
Jak1Janus kinase 10.011
C1rcomplement component 1, r subcomponent0.011
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism