The network for 'directional locomotion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

directional locomotion

Self-propelled movement of a cell or organism from one location to another along an axis.

NameDescriptionProbabilityFunc Analog Organism
DLG4discs, large homolog 4 (Drosophila)1.000
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.999
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.980
CTNNBIP1catenin, beta interacting protein 10.932
WDYHV1WDYHV motif containing 10.845
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.799
TRIOtriple functional domain (PTPRF interacting)0.735
APCadenomatous polyposis coli0.694
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.646
DMDdystrophin0.601
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.518
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.483
DLGAP1discs, large (Drosophila) homolog-associated protein 10.385
CTNND1catenin (cadherin-associated protein), delta 10.365
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.357
DSPdesmoplakin0.250
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.237
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.228
NLGN1neuroligin 10.152
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.149
SPRR2Asmall proline-rich protein 2A0.118
DAG1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.111
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.103
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.097
UTRNutrophin0.081
GRIP1glutamate receptor interacting protein 10.068
DTNAdystrobrevin, alpha0.068
ING5inhibitor of growth family, member 50.063
SFNstratifin0.048
PKP2plakophilin 20.042
DSG2desmoglein 20.038
NSFN-ethylmaleimide-sensitive factor0.033
CRIPTcysteine-rich PDZ-binding protein0.031
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.027
PKP3plakophilin 30.026
APPamyloid beta (A4) precursor protein0.024
UBE2R2ubiquitin-conjugating enzyme E2R 20.023
SH3BP2SH3-domain binding protein 20.022
DLG3discs, large homolog 3 (Drosophila)0.019
PCBD1pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha0.018
HSD17B14hydroxysteroid (17-beta) dehydrogenase 140.018
STX12syntaxin 120.017
TCF4transcription factor 40.016
GRIK2glutamate receptor, ionotropic, kainate 20.014
RABAC1Rab acceptor 1 (prenylated)0.014
ZFYVE9zinc finger, FYVE domain containing 90.014
BAI1brain-specific angiogenesis inhibitor 10.013
PIAS2protein inhibitor of activated STAT, 20.013
RAC3ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)0.013
BLNKB-cell linker0.012
BTRCbeta-transducin repeat containing0.012
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.012
EZRezrin0.012
GRIA1glutamate receptor, ionotropic, AMPA 10.012
MARK2MAP/microtubule affinity-regulating kinase 20.011
SPRY2sprouty homolog 2 (Drosophila)0.011
RHOAras homolog gene family, member A0.011
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.011
PTPRNprotein tyrosine phosphatase, receptor type, N0.010
PLECplectin0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
slo-1Protein SLO-10.705
stn-1Protein STN-10.702
ace-2Protein ACE-20.695
egl-15Protein EGL-150.445
dyb-1Protein DYB-10.254
hsp-12.2Protein HSP-12.20.204
egl-36Protein EGL-360.196
dyc-1Protein DYC-10.155
glr-4Protein GLR-40.120
cpn-3Protein CPN-30.118
rig-6Protein RIG-60.115
egl-23Protein EGL-230.109
dbl-1Protein DBL-10.107
T25F10.6Protein T25F10.60.079
tnt-2Protein TNT-20.066
F55C12.5Protein F55C12.50.066
eor-1Protein EOR-10.063
ZK1321.4Protein ZK1321.40.062
unc-27Protein UNC-270.059
F37H8.5Protein F37H8.50.054
unc-54Protein UNC-540.053
ace-4Protein ACE-40.050
lin-29Protein LIN-290.047
frm-3Protein FRM-30.045
CELE_F25E5.4Protein F25E5.40.043
CELE_M04F3.5Protein M04F3.50.043
vab-8Protein VAB-80.043
unc-73Protein UNC-730.042
glr-5Protein GLR-50.042
unc-9Protein UNC-90.040
F14D12.1Protein F14D12.10.040
Y48C3A.5Protein Y48C3A.50.038
myo-3Protein MYO-30.036
egl-30Protein EGL-300.036
trim-9Protein TRIM-90.036
ccz-1Protein CCZ-10.036
syg-1Protein SYG-10.035
max-1Protein MAX-10.034
F26E4.3Protein F26E4.30.034
unc-13Protein UNC-130.033
rhgf-2Protein RHGF-20.033
C30F12.1Protein C30F12.10.032
unc-15Protein UNC-150.031
gck-2Protein GCK-20.031
lin-18Protein LIN-180.030
sas-4Protein SAS-40.029
F21C10.7Protein F21C10.70.029
F25H2.7Protein F25H2.70.028
cwn-2Protein CWN-20.026
ast-1Protein AST-10.026
pat-10Protein PAT-100.026
mlc-2Protein MLC-20.024
pdfr-1Protein PDFR-10.024
glr-1Protein GLR-10.023
Y57A10B.1Protein Y57A10B.10.022
F58F9.7Protein F58F9.70.022
ape-1Protein APE-10.021
arrd-26Protein ARRD-260.021
unc-41Protein UNC-410.021
F54C8.4Protein F54C8.40.020
gpd-3Protein GPD-30.020
K10C3.4Protein K10C3.40.020
cpna-5Protein CPNA-50.020
pitp-1Protein PITP-10.020
K03E5.2Protein K03E5.20.020
hhat-2Protein HHAT-20.020
inx-5Protein INX-50.019
lin-11Protein LIN-110.019
srh-235Protein SRH-2350.018
cpna-1Protein CPNA-10.018
acs-7Protein ACS-70.018
ing-3Protein ING-30.018
dop-1Protein DOP-10.018
dys-1Protein DYS-10.018
ets-4Protein ETS-40.018
R57.1Protein R57.10.017
plc-1Protein PLC-10.017
T22D1.1Protein T22D1.10.017
W01F3.1Protein W01F3.10.017
lec-4Protein LEC-40.017
acr-15Protein ACR-150.017
tag-273Protein TAG-2730.016
csq-1Protein CSQ-10.016
R11D1.1Protein R11D1.10.016
kcnl-2Protein KCNL-20.016
dhs-20Protein DHS-200.016
tre-4Protein TRE-40.015
T03G6.3Protein T03G6.30.015
sgca-1Protein SGCA-10.015
ketn-1Protein KETN-10.015
exp-2Protein EXP-20.015
mup-2Protein MUP-20.015
emb-9Protein EMB-90.015
ZK1058.9Protein ZK1058.90.015
egl-2Protein EGL-20.014
F27C1.13Protein F27C1.130.014
ist-1Protein IST-10.014
srj-14Protein SRJ-140.014
col-43Protein COL-430.014
nlt-1Protein NLT-10.014
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gria2aglutamate receptor, ionotropic, AMPA 2a0.998
gria1aglutamate receptor, ionotropic, AMPA 1a0.990
gria3bglutamate receptor, ionotrophic, AMPA 3b0.989
gria3aglutamate receptor, ionotropic, AMPA 3a0.974
gria4aglutamate receptor, ionotropic, AMPA 4a0.964
gria4bglutamate receptor, ionotropic, AMPA 4b0.925
tnni1altroponin I, skeletal, slow like0.698
gria1bglutamate receptor, ionotropic, AMPA 1b0.548
smyhc2slow myosin heavy chain 20.518
sncgbsynuclein, gamma b (breast cancer-specific protein 1)0.225
tnni1btroponin I, skeletal, slow b0.218
gria2bglutamate receptor, ionotropic, AMPA 2b0.173
dag1dystroglycan 10.158
tnnc1btroponin C type 1b (slow)0.149
tnni2a.4troponin I, skeletal, fast 2a.40.138
pvalb1parvalbumin 10.131
cadm2bcell adhesion molecule 2b0.129
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.122
leprleptin receptor0.109
mmp15amatrix metallopeptidase 15a0.105
flot1bflotillin 1b0.094
tpm2tropomyosin 2 (beta)0.073
muskmuscle, skeletal, receptor tyrosine kinase0.069
hhatlbhedgehog acyltransferase-like, b0.062
grmaglutamate receptor, metabotropic a0.059
fxr2fragile X mental retardation, autosomal homolog 20.055
casz1castor zinc finger 10.054
ampd1adenosine monophosphate deaminase 1 (isoform M)0.051
smyhc1slow myosin heavy chain 10.051
zgc:66286zgc:662860.050
stmn2bstathmin-like 2b0.049
zgc:91999zgc:919990.049
chrndcholinergic receptor, nicotinic, delta polypeptide0.048
sc:d0319sc:d03190.047
smyhc3slow myosin heavy chain 30.046
si:ch211-191i18.3si:ch211-191i18.30.045
slc17a8solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 80.044
myom1amyomesin 1a (skelemin)0.044
gperG protein-coupled estrogen receptor 10.044
il1rapl1binterleukin 1 receptor accessory protein-like 1b0.041
zgc:65890zgc:658900.039
zdhhc8bzinc finger, DHHC-type containing 8b0.037
fxr1fragile X mental retardation, autosomal homolog 10.037
btg1B-cell translocation gene 10.036
gphn2gephyrin20.036
asb2bankyrin repeat and SOCS box-containing 2b0.036
tnnt3btroponin T3b, skeletal, fast0.035
eno2enolase 20.034
cyfip2cytoplasmic FMR1 interacting protein 20.032
plxna3plexin A30.031
lamb2laminin, beta 2 (laminin S)0.031
trpv1transient receptor potential cation channel subfamily V member 10.030
penkaproenkephalin a0.030
LOC569768metabotropic glutamate receptor 8-like0.029
cav3caveolin 30.029
camkvbCaM kinase-like vesicle-associated b0.029
unc45bunc-45 homolog B (C. elegans)0.028
wu:fj52c07wu:fj52c070.028
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.028
actn3bactinin alpha 3b0.028
im:6895682im:68956820.028
ugp2bUDP-glucose pyrophosphorylase 2b0.028
wu:fi18a01wu:fi18a010.028
stac3SH3 and cysteine rich domain 30.027
plxna4plexin A40.027
slc17a6bsolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6b0.027
LOC799480hypothetical protein LOC7994800.027
pvalb3parvalbumin 30.026
zgc:66156zgc:661560.026
nrxn2aneurexin 2a0.026
atg12ATG12 autophagy related 12 homolog (S. cerevisiae)0.024
cadm1acell adhesion molecule 1a0.024
dync1h1dynein, cytoplasmic 1, heavy chain 10.023
LOC559201similar to Neuromedin-K receptor (NKR) (Neurokinin B receptor) (NK-3 receptor) (NK-3R) (Tachykinin receptor 3)0.023
etv1ets variant gene 10.023
smyd1bSET and MYND domain containing 1b0.023
dpysl4dihydropyrimidinase-like 40.022
zgc:136894zgc:1368940.022
jph2junctophilin 20.022
LOC100007758novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)0.021
zgc:114164zgc:1141640.021
trpc5transient receptor potential cation channel, subfamily C, member 50.021
myoz1amyozenin 1a0.021
zgc:100829zgc:1008290.021
nr4a2anuclear receptor subfamily 4, group A, member 2a0.021
cacna1dacalcium channel, voltage-dependent, L type, alpha 1D subunit, a0.021
trpm2transient receptor potential cation channel, subfamily M, member 20.021
si:ch1073-186e1.1si:ch1073-186e1.10.021
pkm2bpyruvate kinase, muscle, b0.020
jam2ajunctional adhesion molecule 2a0.020
tpm1tropomyosin 1 (alpha)0.020
lamc1laminin, gamma 10.020
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.020
tnni2a.3troponin I, skeletal, fast 2a.30.020
tnnt1troponin T1, skeletal, slow0.020
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.020
acbd4acyl-CoA binding domain containing 40.020
slc17a6asolute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6a0.019
iclp1invariant chain-like protein 10.019
tnnt3atroponin T3a, skeletal, fast0.019
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
armarmadillo0.043
CG9548CG9548 gene product from transcript CG9548-RA0.018
aopanterior open0.015
MadMothers against dpp0.013
Aos1CG12276 gene product from transcript CG12276-RA0.013
Rpb5CG11979 gene product from transcript CG11979-RA0.013
HHairless0.012
SmFSmall ribonucleoprotein particle protein SmF0.011
hoiphoi-polloi0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)1.000
Dlg4discs, large homolog 4 (Drosophila)1.000
Gria2glutamate receptor, ionotropic, AMPA2 (alpha 2)1.000
Dmddystrophin, muscular dystrophy0.997
Cacng2calcium channel, voltage-dependent, gamma subunit 20.891
Gria1glutamate receptor, ionotropic, AMPA1 (alpha 1)0.868
Ptpn11protein tyrosine phosphatase, non-receptor type 110.842
Cox6a2cytochrome c oxidase, subunit VI a, polypeptide 20.823
Dtnadystrobrevin alpha0.701
Gria3glutamate receptor, ionotropic, AMPA3 (alpha 3)0.544
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.512
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.464
InadlInaD-like (Drosophila)0.445
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.400
Apcadenomatosis polyposis coli0.398
Nos1nitric oxide synthase 1, neuronal0.385
Mybpc3myosin binding protein C, cardiac0.325
Drd2dopamine receptor D20.297
Gria4glutamate receptor, ionotropic, AMPA4 (alpha 4)0.294
Grin2aglutamate receptor, ionotropic, NMDA2A (epsilon 1)0.293
Plp1proteolipid protein (myelin) 10.293
Grip1glutamate receptor interacting protein 10.293
Grin2cglutamate receptor, ionotropic, NMDA2C (epsilon 3)0.292
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.267
Emx1empty spiracles homolog 1 (Drosophila)0.261
Dlg2discs, large homolog 2 (Drosophila)0.258
Exoc4exocyst complex component 40.226
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.223
Thtyrosine hydroxylase0.203
Gsk3bglycogen synthase kinase 3 beta0.198
Akap6A kinase (PRKA) anchor protein 60.191
Hif1ahypoxia inducible factor 1, alpha subunit0.185
Sgcasarcoglycan, alpha (dystrophin-associated glycoprotein)0.172
Grik2glutamate receptor, ionotropic, kainate 2 (beta 2)0.162
Arcactivity regulated cytoskeletal-associated protein0.159
Atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.137
Plcb1phospholipase C, beta 10.136
Mdm2transformed mouse 3T3 cell double minute 20.120
Nf1neurofibromatosis 10.114
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.111
Rac1RAS-related C3 botulinum substrate 10.096
Tff3trefoil factor 3, intestinal0.096
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.092
Nf2neurofibromatosis 20.088
Sgcgsarcoglycan, gamma (dystrophin-associated glycoprotein)0.087
Cntnap1contactin associated protein-like 10.086
Syt1synaptotagmin I0.086
Inpp5jinositol polyphosphate 5-phosphatase J0.086
Doc2bdouble C2, beta0.082
Itga7integrin alpha 70.082
Dyrk1bdual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b0.081
Smad3MAD homolog 3 (Drosophila)0.081
Syn2synapsin II0.081
Adam22a disintegrin and metallopeptidase domain 220.078
Kcnk3potassium channel, subfamily K, member 30.077
Ctnna1catenin (cadherin associated protein), alpha 10.076
Ctnnd1catenin (cadherin associated protein), delta 10.075
Prox1prospero-related homeobox 10.074
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.073
Nrcamneuron-glia-CAM-related cell adhesion molecule0.071
Cxadrcoxsackie virus and adenovirus receptor0.070
Grin2dglutamate receptor, ionotropic, NMDA2D (epsilon 4)0.070
Appamyloid beta (A4) precursor protein0.068
Shc3src homology 2 domain-containing transforming protein C30.067
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.067
Ppfia4protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 40.065
Dlgap1discs, large (Drosophila) homolog-associated protein 10.064
Numbnumb gene homolog (Drosophila)0.064
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.063
Mark4MAP/microtubule affinity-regulating kinase 40.063
Nefmneurofilament, medium polypeptide0.062
Grb2growth factor receptor bound protein 20.061
Cntn1contactin 10.060
Chrm1cholinergic receptor, muscarinic 1, CNS0.060
Dag1dystroglycan 10.058
Prm2protamine 20.058
Gabra3gamma-aminobutyric acid (GABA) A receptor, subunit alpha 30.057
Sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.056
Stx1bsyntaxin 1B0.056
Psen1presenilin 10.054
Vsnl1visinin-like 10.054
Rab18RAB18, member RAS oncogene family0.054
Slnsarcolipin0.053
Hspa12aheat shock protein 12A0.052
Vmn2r1vomeronasal 2, receptor 10.052
Cnr1cannabinoid receptor 1 (brain)0.052
Slc1a2solute carrier family 1 (glial high affinity glutamate transporter), member 20.052
Citcitron0.051
NapbN-ethylmaleimide sensitive fusion protein attachment protein beta0.051
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.049
Cpne6copine VI0.048
Sh3kbp1SH3-domain kinase binding protein 10.048
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.048
Gfapglial fibrillary acidic protein0.047
Gab2growth factor receptor bound protein 2-associated protein 20.047
B3galt1UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 10.047
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.046
Egfrepidermal growth factor receptor0.046
Gja1gap junction protein, alpha 10.046
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.046
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism