The network for 'dna dependent dna replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna dependent dna replication

A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

NameDescriptionProbabilityFunc Analog Organism
MCM2minichromosome maintenance complex component 21.000
RPA1replication protein A1, 70kDa1.000
MCM7minichromosome maintenance complex component 71.000
MCM3minichromosome maintenance complex component 31.000
MCM6minichromosome maintenance complex component 61.000
MCM4minichromosome maintenance complex component 41.000
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.999
CDK2cyclin-dependent kinase 20.998
BRCA1breast cancer 1, early onset0.998
ORC1origin recognition complex, subunit 10.997
MCM5minichromosome maintenance complex component 50.997
GINS2GINS complex subunit 2 (Psf2 homolog)0.994
SSRP1structure specific recognition protein 10.991
RFC2replication factor C (activator 1) 2, 40kDa0.990
CDC45cell division cycle 45 homolog (S. cerevisiae)0.987
BLMBloom syndrome, RecQ helicase-like0.986
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.983
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.981
SMC1Astructural maintenance of chromosomes 1A0.979
RPA2replication protein A2, 32kDa0.978
MMS22LMMS22-like, DNA repair protein0.976
MCM10minichromosome maintenance complex component 100.967
CCNE1cyclin E10.965
RPA3replication protein A3, 14kDa0.959
ORC2origin recognition complex, subunit 20.959
CDC6cell division cycle 6 homolog (S. cerevisiae)0.952
POLE3polymerase (DNA directed), epsilon 3 (p17 subunit)0.950
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.934
RFC4replication factor C (activator 1) 4, 37kDa0.920
RFC3replication factor C (activator 1) 3, 38kDa0.901
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.900
PARP1poly (ADP-ribose) polymerase 10.891
FEN1flap structure-specific endonuclease 10.874
RFC5replication factor C (activator 1) 5, 36.5kDa0.871
CDC7cell division cycle 7 homolog (S. cerevisiae)0.868
E2F7E2F transcription factor 70.854
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.841
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.827
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.818
ORC3origin recognition complex, subunit 30.789
CHAF1Achromatin assembly factor 1, subunit A (p150)0.777
E2F1E2F transcription factor 10.756
E2F8E2F transcription factor 80.749
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.747
CSNK2A1casein kinase 2, alpha 1 polypeptide0.728
APITD1apoptosis-inducing, TAF9-like domain 10.720
BMPR1Abone morphogenetic protein receptor, type IA0.694
RMI1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)0.692
CHEK1CHK1 checkpoint homolog (S. pombe)0.683
RFC1replication factor C (activator 1) 1, 145kDa0.676
PCNAproliferating cell nuclear antigen0.669
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.662
FANCAFanconi anemia, complementation group A0.656
ORC5origin recognition complex, subunit 50.638
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.628
ORC6origin recognition complex, subunit 60.624
WAPALwings apart-like homolog (Drosophila)0.617
CHEK2CHK2 checkpoint homolog (S. pombe)0.581
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.565
FANCMFanconi anemia, complementation group M0.554
YY1YY1 transcription factor0.526
POLEpolymerase (DNA directed), epsilon0.520
TOP2Atopoisomerase (DNA) II alpha 170kDa0.513
PRIM1primase, DNA, polypeptide 1 (49kDa)0.504
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.485
MSH6mutS homolog 6 (E. coli)0.484
GINS4GINS complex subunit 4 (Sld5 homolog)0.479
SMC3structural maintenance of chromosomes 30.448
MAPK14mitogen-activated protein kinase 140.431
TOPBP1topoisomerase (DNA) II binding protein 10.430
FANCGFanconi anemia, complementation group G0.426
RAD21RAD21 homolog (S. pombe)0.421
MDC1mediator of DNA-damage checkpoint 10.418
GINS3GINS complex subunit 3 (Psf3 homolog)0.405
ATF2activating transcription factor 20.395
CCNE2cyclin E20.390
UNGuracil-DNA glycosylase0.386
BRCA2breast cancer 2, early onset0.377
GINS1GINS complex subunit 1 (Psf1 homolog)0.348
CCNB2cyclin B20.328
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.293
SKP2S-phase kinase-associated protein 2 (p45)0.292
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.292
H2AFXH2A histone family, member X0.285
CDK4cyclin-dependent kinase 40.283
NBNnibrin0.282
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 50.280
CNOT10CCR4-NOT transcription complex, subunit 100.271
RB1retinoblastoma 10.268
CDT1chromatin licensing and DNA replication factor 10.259
UHRF2ubiquitin-like with PHD and ring finger domains 20.256
SMC2structural maintenance of chromosomes 20.256
PRIM2primase, DNA, polypeptide 2 (58kDa)0.240
RAD50RAD50 homolog (S. cerevisiae)0.237
TMPOthymopoietin0.235
ARRB1arrestin, beta 10.222
RBBP4retinoblastoma binding protein 40.220
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.210
PDS5BPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.210
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.208
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mcm-2Protein MCM-20.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Mcm2Minichromosome maintenance 20.972
RfC4Replication factor C subunit 40.909
Orc2Origin recognition complex subunit 20.793
Mcm6Minichromosome maintenance 60.569
CDC45LCG3658 gene product from transcript CG3658-RA0.568
mus209mutagen-sensitive 2090.383
hdhumpty dumpty0.379
RPA2Replication protein A20.211
dpadisc proliferation abnormal0.208
mus101mutagen-sensitive 1010.201
Ndc80CG9938 gene product from transcript CG9938-RA0.177
RfC38Replication factor C 38kD subunit0.156
mus304mutagen-sensitive 3040.144
BubR1Bub1-related kinase0.140
Mcm5Minichromosome maintenance 50.138
Psf1CG9187 gene product from transcript CG9187-RA0.128
rad50CG6339 gene product from transcript CG6339-RD0.121
tostosca0.120
CG9576CG9576 gene product from transcript CG9576-RA0.116
SlbpStem-loop binding protein0.110
CG8142CG8142 gene product from transcript CG8142-RA0.108
DNApol-alpha73DNA polymerase alpha 73kD0.108
CG13350CG13350 gene product from transcript CG13350-RA0.102
RfC3Replication factor C subunit 30.101
tldtolloid0.096
Klp61FKinesin-like protein at 61F0.090
mus301mutagen-sensitive 3010.090
hayhaywire0.086
DNApol-alpha50DNA polymerase alpha 50kD0.085
DNApol-alpha60DNA polymerase alpha 60kD0.079
cicubitus interruptus0.071
CG5524CG5524 gene product from transcript CG5524-RA0.070
cavcaravaggio0.063
Orc1Origin recognition complex subunit 10.060
ash1absent, small, or homeotic discs 10.053
CG3430CG3430 gene product from transcript CG3430-RA0.053
Mcm10Sensitized chromosome inheritance modifier 190.051
Mcm3Minichromosome maintenance 30.050
PcafCG4107 gene product from transcript CG4107-RA0.049
WRNexoWRN exonuclease0.047
CG4933CG4933 gene product from transcript CG4933-RA0.047
mei-38meiotic 380.046
Pole2CG10489 gene product from transcript CG10489-RA0.046
cdc2cCG10498 gene product from transcript CG10498-RC0.045
Orc5Origin recognition complex subunit 50.045
mus205mutagen-sensitive 2050.045
RnrSRibonucleoside diphosphate reductase small subunit0.045
asf1anti-silencing factor 10.044
auraurora0.042
CG8247CG8247 gene product from transcript CG8247-RB0.042
RnrLRibonucleoside diphosphate reductase large subunit0.041
bskbasket0.040
Cdk4Cyclin-dependent kinase 40.039
mre11meiotic recombination 110.038
RecQ5homolog of RecQ0.038
Pp1-87BProtein phosphatase 1 at 87B0.038
CG2199CG2199 gene product from transcript CG2199-RB0.038
esgescargot0.038
Fen1Flap endonuclease 10.038
Psf2CG18013 gene product from transcript CG18013-RA0.037
SseSeparase0.036
CTCFCG8591 gene product from transcript CG8591-RA0.035
CG3358CG3358 gene product from transcript CG3358-RA0.035
SceSex combs extra0.033
frufruitless0.033
latlatheo0.032
CG33332CG33332 gene product from transcript CG33332-RA0.032
mei-9meiotic 90.031
cidcentromere identifier0.030
DetDeterin0.029
piwiCG6122 gene product from transcript CG6122-RA0.028
CG7544CG7544 gene product from transcript CG7544-RA0.028
GgaCG3002 gene product from transcript CG3002-RB0.028
rodrough deal0.028
Atac1ATAC component 10.027
Ets97DEts at 97D0.026
RecQ4CG7487 gene product from transcript CG7487-RA0.026
escextra sexcombs0.026
CG4980CG4980 gene product from transcript CG4980-RA0.026
CycCCyclin C0.025
DMAP1CG11132 gene product from transcript CG11132-RA0.025
tefutelomere fusion0.025
MCPH1Microcephalin0.024
dapdacapo0.024
CG3407CG3407 gene product from transcript CG3407-RA0.024
CG9945CG9945 gene product from transcript CG9945-RB0.024
His2AvHistone H2A variant0.024
HipHopHP1-HOAP-interacting protein0.023
Mcm7Minichromosome maintenance 70.023
ph-dpolyhomeotic distal0.023
Rab23CG2108 gene product from transcript CG2108-RA0.022
MRG15CG6363 gene product from transcript CG6363-RA0.022
CG10267CG10267 gene product from transcript CG10267-RB0.022
DNApol-deltaDNA-polymerase-delta0.022
IrbpInverted repeat-binding protein0.022
spn-Aspindle A0.022
Fcp1CG12252 gene product from transcript CG12252-RA0.022
NiPp1Nuclear inhibitor of Protein phosphatase 10.022
CG10336CG10336 gene product from transcript CG10336-RC0.021
poloCG12306 gene product from transcript CG12306-RA0.021
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cdt1chromatin licensing and DNA replication factor 10.999
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.999
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.999
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.996
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.996
Prim1DNA primase, p49 subunit0.975
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.974
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.907
Brca2breast cancer 20.901
Timelesstimeless homolog (Drosophila)0.873
Tipintimeless interacting protein0.862
Mapk14mitogen-activated protein kinase 140.772
Smc1astructural maintenance of chromosomes 1A0.689
Lig1ligase I, DNA, ATP-dependent0.641
Brca1breast cancer 10.618
Mecp2methyl CpG binding protein 20.561
Rfc2replication factor C (activator 1) 20.556
Pola1polymerase (DNA directed), alpha 10.546
Rfc5replication factor C (activator 1) 50.495
Cdk4cyclin-dependent kinase 40.477
Rpa1replication protein A10.448
Nup85nucleoporin 850.435
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.426
Rad51ap1RAD51 associated protein 10.411
Gmnngeminin0.376
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.330
Rfc4replication factor C (activator 1) 40.327
Rrm2ribonucleotide reductase M20.319
Polepolymerase (DNA directed), epsilon0.309
Cdca5cell division cycle associated 50.298
Prim2DNA primase, p58 subunit0.293
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.292
Rfc1replication factor C (activator 1) 10.291
Rpa2replication protein A20.287
Wdhd1WD repeat and HMG-box DNA binding protein 10.275
Ezh2enhancer of zeste homolog 2 (Drosophila)0.257
Ncaphnon-SMC condensin I complex, subunit H0.236
Tcf19transcription factor 190.229
Cdc45cell division cycle 45 homolog (S. cerevisiae)0.228
Atmataxia telangiectasia mutated homolog (human)0.218
Hellshelicase, lymphoid specific0.216
Smc3structural maintenace of chromosomes 30.204
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.201
Pcnaproliferating cell nuclear antigen0.182
Rad51RAD51 homolog (S. cerevisiae)0.174
Orc2origin recognition complex, subunit 20.174
Rad21RAD21 homolog (S. pombe)0.167
Orc6origin recognition complex, subunit 60.152
Chek1checkpoint kinase 1 homolog (S. pombe)0.152
Atf2activating transcription factor 20.145
Gins4GINS complex subunit 4 (Sld5 homolog)0.144
Hdac1histone deacetylase 10.141
E2f1E2F transcription factor 10.140
Fen1flap structure specific endonuclease 10.135
Aurkbaurora kinase B0.130
Cdk2cyclin-dependent kinase 20.129
Nup107nucleoporin 1070.122
Ccne1cyclin E10.121
Rrm1ribonucleotide reductase M10.113
Pds5aPDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)0.108
Cks1bCDC28 protein kinase 1b0.107
Rad50RAD50 homolog (S. cerevisiae)0.104
Nbnnibrin0.101
Cdk1cyclin-dependent kinase 10.099
Mlh1mutL homolog 1 (E. coli)0.094
Dhfrdihydrofolate reductase0.093
Rabep1rabaptin, RAB GTPase binding effector protein 10.090
Parp1poly (ADP-ribose) polymerase family, member 10.088
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.088
Dnmt1DNA methyltransferase (cytosine-5) 10.087
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.087
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.086
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.085
Msh2mutS homolog 2 (E. coli)0.084
Ccnfcyclin F0.082
Exo1exonuclease 10.081
Vrk1vaccinia related kinase 10.080
Dtymkdeoxythymidylate kinase0.080
Incenpinner centromere protein0.080
Orc1origin recognition complex, subunit 10.079
Mybl2myeloblastosis oncogene-like 20.077
RecqlRecQ protein-like0.077
Gins1GINS complex subunit 1 (Psf1 homolog)0.076
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.076
Rpgrip1lRpgrip1-like0.075
Cdca7lcell division cycle associated 7 like0.075
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.075
Sass6spindle assembly 6 homolog (C. elegans)0.073
Crkv-crk sarcoma virus CT10 oncogene homolog (avian)0.072
Pola2polymerase (DNA directed), alpha 20.071
Tk1thymidine kinase 10.070
Nudt1nudix (nucleoside diphosphate linked moiety X)-type motif 10.069
Cdca7cell division cycle associated 70.067
Haus6HAUS augmin-like complex, subunit 60.064
Unguracil DNA glycosylase0.062
Pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.059
Mapk11mitogen-activated protein kinase 110.058
Nvlnuclear VCP-like0.057
Orc5origin recognition complex, subunit 50.057
Hmbshydroxymethylbilane synthase0.056
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Mcm6minichromosome maintenance complex component 60.134
Tubg1tubulin, gamma 10.037
Top2atopoisomerase (DNA) II alpha0.030
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.016
Mcm2minichromosome maintenance complex component 20.014
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.011
Mcm5minichromosome maintenance complex component 50.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
MCM2Mcm2p0.999
ORC2Orc2p0.997
POL1Pol1p0.997
MRC1Mrc1p0.997
CDC45Cdc45p0.996
SLD5Sld5p0.994
MCM4Mcm4p0.994
POL2Pol2p0.986
PSF1Psf1p0.979
DPB2Dpb2p0.978
POL12Pol12p0.973
ORC1Orc1p0.973
MCM5Mcm5p0.967
POL32Pol32p0.962
MCM7Mcm7p0.953
CTF4Ctf4p0.941
TOF1Tof1p0.935
CTF18Ctf18p0.912
RFC5Rfc5p0.897
MCM10Mcm10p0.882
MCM3Mcm3p0.872
DIA2Dia2p0.870
ORC3Orc3p0.849
RFA1Rfa1p0.842
DBF4Dbf4p0.822
PRI2Pri2p0.807
CLB5Clb5p0.804
MCM6Mcm6p0.795
ORC6Orc6p0.793
SMC6Smc6p0.764
RAD53Rad53p0.687
SDS3Sds3p0.668
RFC4Rfc4p0.661
RFC1Rfc1p0.656
DPB11Dpb11p0.650
DPB4Dpb4p0.636
POL30Pol30p0.605
RAD24Rad24p0.588
CDC14Cdc14p0.542
RLF2Rlf2p0.542
RFC2Rfc2p0.541
RFA2Rfa2p0.514
PDS1Pds1p0.509
CHL1Chl1p0.508
RAD27Rad27p0.482
MEC1Mec1p0.481
SRS2Srs2p0.473
RRM3Rrm3p0.446
IES3Ies3p0.430
MDN1Mdn1p0.413
RAD59Rad59p0.392
PAP2Pap2p0.392
POL3Pol3p0.389
POB3Pob3p0.365
SLD2Sld2p0.352
FKH1Fkh1p0.352
POL31Pol31p0.351
SNT1Snt1p0.345
PHO23Pho23p0.334
HST1Hst1p0.323
CHD1Chd1p0.316
PRI1Pri1p0.306
SIP1Sip1p0.296
RAD5Rad5p0.285
ARP4Arp4p0.282
MOT1Mot1p0.280
TAH11Tah11p0.277
RSC58Rsc58p0.273
HAT1Hat1p0.264
RAD1Rad1p0.258
ORC4Orc4p0.255
HST3Hst3p0.254
CDC6Cdc6p0.251
CDC8Cdc8p0.250
RIX1Rix1p0.249
RAD52Rad52p0.244
RAD9Rad9p0.244
BIR1Bir1p0.242
NPA3Npa3p0.238
HSL1Hsl1p0.235
RSC2Rsc2p0.234
RSC9Rsc9p0.232
TOR2Tor2p0.229
SMC4Smc4p0.227
MGM101Mgm101p0.211
CSM3Csm3p0.206
DNA2Dna2p0.205
SGV1Sgv1p0.203
YLR257Whypothetical protein0.202
SET3Set3p0.198
SWI1Swi1p0.197
ESS1Ess1p0.196
MMS1Mms1p0.193
GRR1Grr1p0.193
MSH6Msh6p0.191
SPT16Spt16p0.191
ORC5Orc5p0.191
RAD30Rad30p0.186
HOS4Hos4p0.185
CDC9Cdc9p0.184