The network for 'regulation of protein secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of protein secretion

Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.994
SHC1SHC (Src homology 2 domain containing) transforming protein 10.977
ANXA1annexin A10.968
TEKTEK tyrosine kinase, endothelial0.953
TAL1T-cell acute lymphocytic leukemia 10.920
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.908
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.899
BTN3A2butyrophilin, subfamily 3, member A20.897
BTN3A3butyrophilin, subfamily 3, member A30.803
CD80CD80 molecule0.749
SMN1survival of motor neuron 1, telomeric0.744
LATlinker for activation of T cells0.741
ENO1enolase 1, (alpha)0.738
IL1R1interleukin 1 receptor, type I0.736
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.732
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.729
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.721
CAV1caveolin 1, caveolae protein, 22kDa0.719
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.701
TRAF1TNF receptor-associated factor 10.677
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.665
FGAfibrinogen alpha chain0.652
PILRApaired immunoglobin-like type 2 receptor alpha0.649
APOEapolipoprotein E0.622
NLRC4NLR family, CARD domain containing 40.619
ANGangiogenin, ribonuclease, RNase A family, 50.619
CCL4chemokine (C-C motif) ligand 40.615
LRP1low density lipoprotein receptor-related protein 10.605
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.593
FGBfibrinogen beta chain0.580
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.569
APPamyloid beta (A4) precursor protein0.564
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.563
BTN3A1butyrophilin, subfamily 3, member A10.563
ABI2abl-interactor 20.543
AXLAXL receptor tyrosine kinase0.538
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.526
IL1RNinterleukin 1 receptor antagonist0.484
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.481
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.463
CTLA4cytotoxic T-lymphocyte-associated protein 40.446
FASFas (TNF receptor superfamily, member 6)0.431
MPDZmultiple PDZ domain protein0.400
ITKIL2-inducible T-cell kinase0.399
ANGPT2angiopoietin 20.396
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.379
RNASE4ribonuclease, RNase A family, 40.378
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.367
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.350
IFI16interferon, gamma-inducible protein 160.344
FSTL1follistatin-like 10.344
CCR2chemokine (C-C motif) receptor 20.339
CDH5cadherin 5, type 2 (vascular endothelium)0.337
TRIM22tripartite motif containing 220.326
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.323
CASP4caspase 4, apoptosis-related cysteine peptidase0.322
NLRP3NLR family, pyrin domain containing 30.319
IL10RAinterleukin 10 receptor, alpha0.312
CRPC-reactive protein, pentraxin-related0.306
NRP1neuropilin 10.305
S100A10S100 calcium binding protein A100.287
IL10interleukin 100.285
CCL2chemokine (C-C motif) ligand 20.282
IDEinsulin-degrading enzyme0.282
DRD2dopamine receptor D20.277
TLR2toll-like receptor 20.261
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.261
CCR1chemokine (C-C motif) receptor 10.258
HLA-DRB5major histocompatibility complex, class II, DR beta 50.256
HCKhemopoietic cell kinase0.253
IL1Binterleukin 1, beta0.240
FGGfibrinogen gamma chain0.238
ADORA2Aadenosine A2a receptor0.237
ANXA2annexin A20.234
C19orf50chromosome 19 open reading frame 500.233
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.221
TRIM39tripartite motif containing 390.218
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.218
COL4A1collagen, type IV, alpha 10.215
HK3hexokinase 3 (white cell)0.214
HLA-DMBmajor histocompatibility complex, class II, DM beta0.209
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.206
HLA-Gmajor histocompatibility complex, class I, G0.205
CD86CD86 molecule0.203
LILRA2leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 20.203
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.202
HLA-DRB4major histocompatibility complex, class II, DR beta 40.200
SIGLEC7sialic acid binding Ig-like lectin 70.187
SOS1son of sevenless homolog 1 (Drosophila)0.186
IL4interleukin 40.183
SP100SP100 nuclear antigen0.180
CSF2RAcolony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)0.177
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.173
KLRD1killer cell lectin-like receptor subfamily D, member 10.167
BTN2A2butyrophilin, subfamily 2, member A20.164
SP110SP110 nuclear body protein0.163
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cupCG11181 gene product from transcript CG11181-RB0.216
Cg25CCollagen type IV0.210
Pvf1PDGF- and VEGF-related factor 10.202
Drep-2DNA fragmentation factor-related protein 20.182
trioCG18214 gene product from transcript CG18214-RA0.141
sogshort gastrulation0.121
BG4CG12297 gene product from transcript CG12297-RA0.119
mewmultiple edematous wings0.107
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.085
CHOp24CG3564 gene product from transcript CG3564-RA0.071
fs(1)K10female sterile (1) K100.069
imdimmune deficiency0.060
Atg13Autophagy-specific gene 130.051
Dcp-1Death caspase-10.045
EloAElongin A0.044
myoglianinCG1838 gene product from transcript CG1838-RD0.040
Myo10Aunconventional myosin class XV0.038
Sema-1aCG18405 gene product from transcript CG18405-RD0.032
OsbpOxysterol binding protein0.031
G-oalpha47AG protein oalpha 47A0.028
CG9536CG9536 gene product from transcript CG9536-RB0.028
zfh1Zn finger homeodomain 10.027
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.027
stcshuttle craft0.026
ManfMesencephalic astrocyte-derived neurotrophic factor0.024
CG9053CG9053 gene product from transcript CG9053-RA0.024
PvrPDGF- and VEGF-receptor related0.024
deltaCOPdelta-coatomer protein0.023
Wnt2Wnt oncogene analog 20.023
SdhASuccinate dehydrogenase A0.023
CG12187CG12187 gene product from transcript CG12187-RA0.022
gcmglial cells missing0.022
Atg4Autophagy-specific gene 40.022
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.021
CG5382CG5382 gene product from transcript CG5382-RB0.021
Octbeta2RCG33976 gene product from transcript CG33976-RA0.019
Gef26CG9491 gene product from transcript CG9491-RB0.019
Eip74EFEcdysone-induced protein 74EF0.019
fkhfork head0.019
Smg5CG8954 gene product from transcript CG8954-RA0.019
Hip14Huntingtin-interacting protein 140.018
Tfb5CG42373 gene product from transcript CG42373-RB0.018
fasfaint sausage0.018
pex16peroxin 160.018
trpmltransient receptor potential mucolipin0.016
reporeversed polarity0.015
GlcAT-PCG6207 gene product from transcript CG6207-RC0.015
CG5027CG5027 gene product from transcript CG5027-RA0.014
RpS20Ribosomal protein S200.014
scfsupercoiling factor0.014
Drep-1DNA fragmentation factor-related protein 10.014
betaCopbeta-coatomer protein0.014
CG9063CG9063 gene product from transcript CG9063-RA0.013
TbhTyramine beta hydroxylase0.013
form3formin 30.012
CG9904CG9904 gene product from transcript CG9904-RA0.012
LanALaminin A0.012
SrpRbetaSignal recognition particle receptor beta0.011
Atg9Autophagy-specific gene 90.011
HLH54FCG5005 gene product from transcript CG5005-RA0.011
NPFR1neuropeptide F receptor0.011
piwiCG6122 gene product from transcript CG6122-RA0.011
P58IPKCG8286 gene product from transcript CG8286-RA0.011
TRAMCG11642 gene product from transcript CG11642-RB0.011
OdsHOds-site homeobox0.010
oa2octopamine receptor 20.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.934
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.918
Ccr2chemokine (C-C motif) receptor 20.834
Cd40CD40 antigen0.829
Il1binterleukin 1 beta0.826
C3ar1complement component 3a receptor 10.825
Cd28CD28 antigen0.822
Pax8paired box gene 80.794
Tlr4toll-like receptor 40.767
Leprleptin receptor0.754
Ccl2chemokine (C-C motif) ligand 20.729
Casp4caspase 4, apoptosis-related cysteine peptidase0.702
Pdcd1programmed cell death 10.678
Csf1rcolony stimulating factor 1 receptor0.653
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.653
Msr1macrophage scavenger receptor 10.637
Ccr1chemokine (C-C motif) receptor 10.613
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.608
Gpr33G protein-coupled receptor 330.596
Emr1EGF-like module containing, mucin-like, hormone receptor-like sequence 10.593
Ifnginterferon gamma0.574
Il10interleukin 100.533
Map3k14mitogen-activated protein kinase kinase kinase 140.521
Ltalymphotoxin A0.519
Csf1colony stimulating factor 1 (macrophage)0.509
Ccl22chemokine (C-C motif) ligand 220.502
Ccl6chemokine (C-C motif) ligand 60.500
MefvMediterranean fever0.494
Agtr1aangiotensin II receptor, type 1a0.488
Socs1suppressor of cytokine signaling 10.484
Clec4nC-type lectin domain family 4, member n0.480
Ccl9chemokine (C-C motif) ligand 90.470
Itgaxintegrin alpha X0.453
Hcn4hyperpolarization-activated, cyclic nucleotide-gated K+ 40.447
Tlr7toll-like receptor 70.436
Pcdh12protocadherin 120.428
Il1rninterleukin 1 receptor antagonist0.426
Folr2folate receptor 2 (fetal)0.426
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.422
Ren1renin 1 structural0.421
Nos2nitric oxide synthase 2, inducible0.415
Ccl8chemokine (C-C motif) ligand 80.405
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.399
Cxcr5chemokine (C-X-C motif) receptor 50.393
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.387
Lyz2lysozyme 20.380
Pdcd1lg2programmed cell death 1 ligand 20.377
Cybbcytochrome b-245, beta polypeptide0.374
Clec7aC-type lectin domain family 7, member a0.372
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.371
C1qbcomplement component 1, q subcomponent, beta polypeptide0.371
Dkk1dickkopf homolog 1 (Xenopus laevis)0.369
Fgf21fibroblast growth factor 210.369
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.368
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.367
Cd160CD160 antigen0.358
Fcgr1Fc receptor, IgG, high affinity I0.353
Mmp12matrix metallopeptidase 120.353
Ccr5chemokine (C-C motif) receptor 50.347
Il12rb2interleukin 12 receptor, beta 20.337
Il6stinterleukin 6 signal transducer0.329
Cd86CD86 antigen0.325
Siglec1sialic acid binding Ig-like lectin 1, sialoadhesin0.320
Il1rl1interleukin 1 receptor-like 10.316
Htr75-hydroxytryptamine (serotonin) receptor 70.315
Sfpi1SFFV proviral integration 10.315
Trpm1transient receptor potential cation channel, subfamily M, member 10.306
Ptgirprostaglandin I receptor (IP)0.306
C5ar1complement component 5a receptor 10.304
FasFas (TNF receptor superfamily member 6)0.299
Il4interleukin 40.289
Il2rbinterleukin 2 receptor, beta chain0.287
Lair1leukocyte-associated Ig-like receptor 10.287
Cyp2b19cytochrome P450, family 2, subfamily b, polypeptide 190.285
Klk6kallikrein related-peptidase 60.277
Sh2d2aSH2 domain protein 2A0.277
Ltblymphotoxin B0.275
Il18rapinterleukin 18 receptor accessory protein0.275
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.275
AF251705cDNA sequence AF2517050.270
Relreticuloendotheliosis oncogene0.269
Klrg1killer cell lectin-like receptor subfamily G, member 10.267
Cxcl13chemokine (C-X-C motif) ligand 130.267
Has2hyaluronan synthase 20.266
Sfrp4secreted frizzled-related protein 40.265
Fgf7fibroblast growth factor 70.262
Cd4CD4 antigen0.260
Atp4bATPase, H+/K+ exchanging, beta polypeptide0.259
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.257
Cd80CD80 antigen0.249
Xcl1chemokine (C motif) ligand 10.247
Ccl7chemokine (C-C motif) ligand 70.247
Ccl24chemokine (C-C motif) ligand 240.245
Nlrp3NLR family, pyrin domain containing 30.241
Itgb2lintegrin beta 2-like0.237
Apoeapolipoprotein E0.234
Atp7aATPase, Cu++ transporting, alpha polypeptide0.233
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.463
Il1binterleukin 1 beta0.257
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.257
Cxcl10chemokine (C-X-C motif) ligand 100.137
Pla2g4aphospholipase A2, group IVA (cytosolic, calcium-dependent)0.136
S1pr2sphingosine-1-phosphate receptor 20.124
Adora2aadenosine A2a receptor0.122
Ccr2chemokine (C-C motif) receptor 20.085
Cd247Cd247 molecule0.079
Arl11ADP-ribosylation factor-like 110.077
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.077
Arpc1bactin related protein 2/3 complex, subunit 1B0.076
Plauplasminogen activator, urokinase0.070
Tlr4toll-like receptor 40.066
Stat6signal transducer and activator of transcription 60.065
Ubbubiquitin B0.065
Ptprcprotein tyrosine phosphatase, receptor type, C0.064
Cd44Cd44 molecule0.063
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.060
Ccl3chemokine (C-C motif) ligand 30.060
Ccl4chemokine (C-C motif) ligand 40.059
Bdkrb2bradykinin receptor B20.059
Egfrepidermal growth factor receptor0.058
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.057
Ccl2chemokine (C-C motif) ligand 20.056
Il1r1interleukin 1 receptor, type I0.055
Il4interleukin 40.054
S100a10S100 calcium binding protein A100.054
Mc5rmelanocortin 5 receptor0.054
Prrx1paired related homeobox 10.047
Olr1082olfactory receptor 10820.047
Msx2msh homeobox 20.046
Casp1caspase 10.046
Olr1500olfactory receptor 15000.044
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.043
Mca32mast cell antigen 320.043
Ltbp2latent transforming growth factor beta binding protein 20.043
Rnf4ring finger protein 40.042
Gfi1growth factor independent 1 transcription repressor0.041
Ctsccathepsin C0.041
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.041
Ceacam10carcinoembryonic antigen-related cell adhesion molecule 100.040
Rab1bRAB1B, member RAS oncogene family0.040
Cmklr1chemokine-like receptor 10.039
Map3k8mitogen-activated protein kinase kinase kinase 80.038
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.038
Gzmkgranzyme K0.037
siat7Dalpha-2,6-sialyltransferase ST6GalNAc IV0.037
Iappislet amyloid polypeptide0.037
Il8rbinterleukin 8 receptor, beta0.036
Dnah1dynein, axonemal, heavy chain 10.036
Has2hyaluronan synthase 20.036
Slc34a1solute carrier family 34 (sodium phosphate), member 10.035
Olfml2bolfactomedin-like 2B0.035
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.035
Matkmegakaryocyte-associated tyrosine kinase0.034
Sec24dSEC24 family, member D (S. cerevisiae)0.034
Sirpasignal-regulatory protein alpha0.034
Il2rbinterleukin 2 receptor, beta0.034
Insrrinsulin receptor-related receptor0.034
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.033
Ptger2prostaglandin E receptor 2 (subtype EP2)0.033
Ceacam3carcinoembryonic antigen-related cell adhesion molecule 30.033
Ctsecathepsin E0.032
Nat1N-acetyltransferase 10.032
Ptafrplatelet-activating factor receptor0.031
Reg3aregenerating islet-derived 3 alpha0.031
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.030
Adam17ADAM metallopeptidase domain 170.030
Cskc-src tyrosine kinase0.029
Icam1intercellular adhesion molecule 10.029
Svs1seminal vesicle secretory protein 10.029
Ripk3receptor-interacting serine-threonine kinase 30.029
Fgfr1Fibroblast growth factor receptor 10.029
Cxcl2chemokine (C-X-C motif) ligand 20.029
Anpepalanyl (membrane) aminopeptidase0.028
Klrb1akiller cell lectin-like receptor subfamily B, member 1A0.028
Aqp5aquaporin 50.028
Casp3caspase 30.028
Cxcr3chemokine (C-X-C motif) receptor 30.028
Il2rginterleukin 2 receptor, gamma0.027
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.027
LOC619574hypothetical protein LOC6195740.027
Dock8dedicator of cytokinesis 80.027
Cd38CD38 molecule0.027
Gfapglial fibrillary acidic protein0.027
Tnfrsf11btumor necrosis factor receptor superfamily, member 11b0.026
Anxa4annexin A40.026
Csn1s1casein alpha s10.026
Itgamintegrin, alpha M0.026
Csrnp2cysteine-serine-rich nuclear protein 20.026
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.025
Glt25d1glycosyltransferase 25 domain containing 10.025
Hckhemopoietic cell kinase0.025
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism