The network for 'signal transduction in response to dna damage' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

signal transduction in response to dna damage

A cascade of processes induced by the detection of DNA damage within a cell.

NameDescriptionProbabilityFunc Analog Organism
TP53tumor protein p531.000
BRCA1breast cancer 1, early onset1.000
RB1retinoblastoma 10.987
CREBBPCREB binding protein0.986
EP300E1A binding protein p3000.986
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.975
MDM2Mdm2 p53 binding protein homolog (mouse)0.967
MAPK8mitogen-activated protein kinase 80.929
CASP8caspase 8, apoptosis-related cysteine peptidase0.925
MAPK14mitogen-activated protein kinase 140.923
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.878
CASP3caspase 3, apoptosis-related cysteine peptidase0.832
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.826
H2AFXH2A histone family, member X0.807
MDC1mediator of DNA-damage checkpoint 10.806
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.803
ATMataxia telangiectasia mutated0.798
CHEK2CHK2 checkpoint homolog (S. pombe)0.752
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.750
E2F7E2F transcription factor 70.748
GSK3Bglycogen synthase kinase 3 beta0.728
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.686
PAX3paired box 30.681
RAD50RAD50 homolog (S. cerevisiae)0.677
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.645
BCAS2breast carcinoma amplified sequence 20.634
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.605
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.604
XIAPX-linked inhibitor of apoptosis0.568
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.567
TWIST1twist homolog 1 (Drosophila)0.557
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.532
E2F8E2F transcription factor 80.511
SIRT1sirtuin 10.496
WRNWerner syndrome, RecQ helicase-like0.484
HNRNPMheterogeneous nuclear ribonucleoprotein M0.443
CDK2cyclin-dependent kinase 20.409
POU5F1POU class 5 homeobox 10.404
UHRF2ubiquitin-like with PHD and ring finger domains 20.374
FANCD2Fanconi anemia, complementation group D20.372
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.367
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.354
CCNE1cyclin E10.342
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.330
MAPK1mitogen-activated protein kinase 10.329
PGK1phosphoglycerate kinase 10.323
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.321
PARP1poly (ADP-ribose) polymerase 10.317
IER3immediate early response 30.313
DDAH2dimethylarginine dimethylaminohydrolase 20.313
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.302
CFLARCASP8 and FADD-like apoptosis regulator0.297
RAD18RAD18 homolog (S. cerevisiae)0.281
CREB1cAMP responsive element binding protein 10.277
TP53BP1tumor protein p53 binding protein 10.273
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.271
APAF1apoptotic peptidase activating factor 10.266
CDC25Acell division cycle 25 homolog A (S. pombe)0.265
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.256
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.256
MAP2K4mitogen-activated protein kinase kinase 40.246
GADD45GIP1growth arrest and DNA-damage-inducible, gamma interacting protein 10.240
SMAD7SMAD family member 70.231
FASFas (TNF receptor superfamily, member 6)0.229
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.226
SETD7SET domain containing (lysine methyltransferase) 70.223
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.216
BCL3B-cell CLL/lymphoma 30.215
SMAD3SMAD family member 30.213
OTUB1OTU domain, ubiquitin aldehyde binding 10.209
DAXXdeath-domain associated protein0.208
MYH7Bmyosin, heavy chain 7B, cardiac muscle, beta0.205
MAPK3mitogen-activated protein kinase 30.201
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.193
NCOA3nuclear receptor coactivator 30.186
PPFIA1protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 10.175
BCL2B-cell CLL/lymphoma 20.168
SMAD2SMAD family member 20.166
CDK11Bcyclin-dependent kinase 11B0.166
CHEK1CHK1 checkpoint homolog (S. pombe)0.163
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.162
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.154
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.152
RUNX1runt-related transcription factor 10.150
BCL2L11BCL2-like 11 (apoptosis facilitator)0.150
KAT2BK(lysine) acetyltransferase 2B0.149
H3F3CH3 histone, family 3C0.147
TK1thymidine kinase 1, soluble0.145
MAP3K8mitogen-activated protein kinase kinase kinase 80.144
COASYCoA synthase0.143
DUSP1dual specificity phosphatase 10.139
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.137
SKP2S-phase kinase-associated protein 2 (p45)0.137
CCND3cyclin D30.133
IFI16interferon, gamma-inducible protein 160.132
SETD8SET domain containing (lysine methyltransferase) 80.132
EPRSglutamyl-prolyl-tRNA synthetase0.130
SMURF1SMAD specific E3 ubiquitin protein ligase 10.129
RASSF5Ras association (RalGDS/AF-6) domain family member 50.125
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
p53CG33336 gene product from transcript CG33336-RB0.773
imdimmune deficiency0.481
rad50CG6339 gene product from transcript CG6339-RD0.429
mei-9meiotic 90.324
IswiImitation SWI0.163
mus101mutagen-sensitive 1010.148
CtBPC-terminal Binding Protein0.142
Adf1Adh transcription factor 10.133
Akt1CG4006 gene product from transcript CG4006-RA0.128
MTF-1Metal response element-binding Transcription Factor-10.103
mus201mutagen-sensitive 2010.100
AGO2Argonaute 20.099
mus205mutagen-sensitive 2050.090
CG4699CG4699 gene product from transcript CG4699-RJ0.082
ird5immune response deficient 50.077
CG5524CG5524 gene product from transcript CG5524-RA0.074
l(1)G0007lethal (1) G00070.073
RASSF8CG5053 gene product from transcript CG5053-RA0.068
tefutelomere fusion0.068
Sin3ACG8815 gene product from transcript CG8815-RC0.067
Vap-33-1CG5014 gene product from transcript CG5014-RB0.065
RicRas which interacts with Calmodulin0.059
mei-41meiotic 410.058
Cdc42CG12530 gene product from transcript CG12530-RA0.057
weeCG4488 gene product from transcript CG4488-RA0.055
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.054
debcldeath executioner Bcl-2 homologue0.052
CG10107CG10107 gene product from transcript CG10107-RA0.052
BG4CG12297 gene product from transcript CG12297-RA0.049
RecQ5homolog of RecQ0.049
Dcp-1Death caspase-10.046
wbwing blister0.046
zfh1Zn finger homeodomain 10.041
p38bCG7393 gene product from transcript CG7393-RA0.041
Pi3K92ECG4141 gene product from transcript CG4141-RB0.041
Brca2Breast cancer 2, early onset homolog0.040
nbsCG6754 gene product from transcript CG6754-RC0.039
Hr4CG16902 gene product from transcript CG16902-RC0.039
Mpk2CG5475 gene product from transcript CG5475-RB0.038
CG32685CG32685 gene product from transcript CG32685-RC0.038
Smg5CG8954 gene product from transcript CG8954-RA0.038
DNApol-etaCG7143 gene product from transcript CG7143-RA0.038
Atg6Autophagy-specific gene 60.037
Top3alphaTopoisomerase 3alpha0.037
GATAdCG5034 gene product from transcript CG5034-RA0.037
Dcp2Decapping protein 20.036
ird1immune response deficient 10.036
ari-2ariadne 20.036
lidlittle imaginal discs0.035
CG6015CG6015 gene product from transcript CG6015-RA0.035
Rac2CG8556 gene product from transcript CG8556-RA0.035
Bap60Brahma associated protein 60kD0.034
X11LCG5675 gene product from transcript CG5675-RB0.034
Atg18Autophagy-specific gene 180.033
TBPHCG10327 gene product from transcript CG10327-RC0.033
cwoclockwork orange0.033
mus304mutagen-sensitive 3040.033
S6kRPS6-p70-protein kinase0.032
crolcrooked legs0.032
mus308mutagen-sensitive 3080.032
CG9821CG9821 gene product from transcript CG9821-RB0.032
CG10462CG10462 gene product from transcript CG10462-RB0.031
CG5794CG5794 gene product from transcript CG5794-RB0.031
CG9772CG9772 gene product from transcript CG9772-RB0.030
Tfb5CG42373 gene product from transcript CG42373-RB0.029
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.029
NFATNFAT homolog0.029
Sema-1aCG18405 gene product from transcript CG18405-RD0.029
slp1sloppy paired 10.028
CG14023CG14023 gene product from transcript CG14023-RB0.028
CkIalphaCasein kinase Ialpha0.028
CG17002CG17002 gene product from transcript CG17002-RB0.028
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mdm2transformed mouse 3T3 cell double minute 20.863
Trp53transformation related protein 530.812
Rb1retinoblastoma 10.477
Ptenphosphatase and tensin homolog0.440
Mdm4transformed mouse 3T3 cell double minute 40.231
Brca1breast cancer 10.201
Kitkit oncogene0.148
Cdkn1bcyclin-dependent kinase inhibitor 1B0.063
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.062
Apcadenomatosis polyposis coli0.061
Kitlkit ligand0.061
Mecp2methyl CpG binding protein 20.052
Trp73transformation related protein 730.048
En1engrailed 10.038
Cyldcylindromatosis (turban tumor syndrome)0.038
DaxxFas death domain-associated protein0.035
Abl1c-abl oncogene 1, non-receptor tyrosine kinase0.034
Smc1astructural maintenance of chromosomes 1A0.032
Dok1docking protein 10.030
Atmataxia telangiectasia mutated homolog (human)0.028
Rararetinoic acid receptor, alpha0.028
Smarcd1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.027
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.025
Enahenabled homolog (Drosophila)0.025
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.025
Mmp9matrix metallopeptidase 90.025
Smc3structural maintenace of chromosomes 30.024
Thbs1thrombospondin 10.024
Trp63transformation related protein 630.023
Mybl2myeloblastosis oncogene-like 20.023
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.021
Tgfb1transforming growth factor, beta 10.020
Socs1suppressor of cytokine signaling 10.020
Itgb1integrin beta 1 (fibronectin receptor beta)0.020
Ptpn11protein tyrosine phosphatase, non-receptor type 110.020
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.019
Mcl1myeloid cell leukemia sequence 10.019
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.019
Smad3MAD homolog 3 (Drosophila)0.019
Icam1intercellular adhesion molecule 10.018
Arid1bAT rich interactive domain 1B (SWI-like)0.018
Ddx46DEAD (Asp-Glu-Ala-Asp) box polypeptide 460.017
Mapk8mitogen-activated protein kinase 80.017
Ep300E1A binding protein p3000.017
Ttc4tetratricopeptide repeat domain 40.016
CblCasitas B-lineage lymphoma0.015
S1pr2sphingosine-1-phosphate receptor 20.015
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.015
Tcf7l2transcription factor 7-like 2, T-cell specific, HMG-box0.015
Hprthypoxanthine guanine phosphoribosyl transferase0.015
Gli3GLI-Kruppel family member GLI30.015
Kdm2blysine (K)-specific demethylase 2B0.015
Slc12a2solute carrier family 12, member 20.014
Gtse1G two S phase expressed protein 10.014
Ccnd1cyclin D10.014
Jak3Janus kinase 30.014
Cdkn2acyclin-dependent kinase inhibitor 2A0.014
Ctnnb1catenin (cadherin associated protein), beta 10.013
Stat6signal transducer and activator of transcription 60.013
Meox2mesenchyme homeobox 20.013
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.013
E2f1E2F transcription factor 10.013
Arandrogen receptor0.013
Notch1Notch gene homolog 1 (Drosophila)0.013
Snai1snail homolog 1 (Drosophila)0.013
Chst8carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 80.013
Fgfr1fibroblast growth factor receptor 10.013
Gm3258predicted gene 32580.013
Taf4aTAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor0.013
Stat3signal transducer and activator of transcription 30.012
Hif1ahypoxia inducible factor 1, alpha subunit0.012
H2-Aahistocompatibility 2, class II antigen A, alpha0.012
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.012
Hcfc1host cell factor C10.012
Atxn1ataxin 10.012
Ikbkapinhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein0.012
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.012
Arntlaryl hydrocarbon receptor nuclear translocator-like0.012
Rargretinoic acid receptor, gamma0.012
Socs3suppressor of cytokine signaling 30.012
Rbl1retinoblastoma-like 1 (p107)0.012
Terf1telomeric repeat binding factor 10.012
Rnf2ring finger protein 20.011
Smad4MAD homolog 4 (Drosophila)0.011
Tnftumor necrosis factor0.011
Mapk11mitogen-activated protein kinase 110.011
Adam17a disintegrin and metallopeptidase domain 170.011
Vangl2vang-like 2 (van gogh, Drosophila)0.011
Gata3GATA binding protein 30.011
Rnf8ring finger protein 80.011
Il21rinterleukin 21 receptor0.011
2500003M10RikRIKEN cDNA 2500003M10 gene0.011
Psmc5protease (prosome, macropain) 26S subunit, ATPase 50.011
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.011
Pax2paired box gene 20.011
Hipk1homeodomain interacting protein kinase 10.011
Huwe1HECT, UBA and WWE domain containing 10.011
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism