The network for 'positive regulation of mitotic cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of mitotic cell cycle

Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.

NameDescriptionProbabilityFunc Analog Organism
CDK2cyclin-dependent kinase 21.000
RB1retinoblastoma 10.998
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.988
CCNA2cyclin A20.978
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.971
EGFRepidermal growth factor receptor0.962
NOTCH1notch 10.961
INSRinsulin receptor0.954
PTPN1protein tyrosine phosphatase, non-receptor type 10.921
JAK2Janus kinase 20.910
PLK1polo-like kinase 10.844
JAG1jagged 10.821
CCNE1cyclin E10.819
E2F1E2F transcription factor 10.814
CDC6cell division cycle 6 homolog (S. cerevisiae)0.791
SKP2S-phase kinase-associated protein 2 (p45)0.766
RBL1retinoblastoma-like 1 (p107)0.759
CDC20cell division cycle 20 homolog (S. cerevisiae)0.736
CCND1cyclin D10.709
CDC25Acell division cycle 25 homolog A (S. pombe)0.701
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.700
CDC27cell division cycle 27 homolog (S. cerevisiae)0.672
PRKCAprotein kinase C, alpha0.642
ORC1origin recognition complex, subunit 10.626
BRCA1breast cancer 1, early onset0.609
CDK6cyclin-dependent kinase 60.585
C19orf39chromosome 19 open reading frame 390.571
WAPALwings apart-like homolog (Drosophila)0.571
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.564
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.531
IGF1Rinsulin-like growth factor 1 receptor0.529
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.528
CDK1cyclin-dependent kinase 10.521
HDAC1histone deacetylase 10.510
ACTN2actinin, alpha 20.492
GRB10growth factor receptor-bound protein 100.474
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.470
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.466
ARHGAP10Rho GTPase activating protein 100.456
CDC5LCDC5 cell division cycle 5-like (S. pombe)0.453
IRS1insulin receptor substrate 10.399
BRCA2breast cancer 2, early onset0.398
EP300E1A binding protein p3000.394
CDT1chromatin licensing and DNA replication factor 10.386
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.376
CAV1caveolin 1, caveolae protein, 22kDa0.374
CDKN3cyclin-dependent kinase inhibitor 30.363
APBB1amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)0.362
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.359
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.352
RAD51L3RAD51-like 3 (S. cerevisiae)0.347
MYBL2v-myb myeloblastosis viral oncogene homolog (avian)-like 20.343
CCND3cyclin D30.329
CLSPNclaspin0.323
PTPN11protein tyrosine phosphatase, non-receptor type 110.282
CHEK1CHK1 checkpoint homolog (S. pombe)0.280
CHAF1Achromatin assembly factor 1, subunit A (p150)0.279
H2AFXH2A histone family, member X0.279
CKS1BCDC28 protein kinase regulatory subunit 1B0.277
MDM2Mdm2 p53 binding protein homolog (mouse)0.265
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.248
VHLvon Hippel-Lindau tumor suppressor0.241
RAD51L1RAD51-like 1 (S. cerevisiae)0.237
CCNB2cyclin B20.231
IL1R1interleukin 1 receptor, type I0.230
CCT4chaperonin containing TCP1, subunit 4 (delta)0.227
CD80CD80 molecule0.226
EIF4EBP1eukaryotic translation initiation factor 4E binding protein 10.222
CNOT2CCR4-NOT transcription complex, subunit 20.219
ORC2origin recognition complex, subunit 20.205
FUBP1far upstream element (FUSE) binding protein 10.199
CDC26cell division cycle 26 homolog (S. cerevisiae)0.191
FOXM1forkhead box M10.190
SMC3structural maintenance of chromosomes 30.189
EIF4EBP3eukaryotic translation initiation factor 4E binding protein 30.188
POU5F1POU class 5 homeobox 10.188
CCNFcyclin F0.181
CCNB1cyclin B10.172
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.172
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.170
NCOR2nuclear receptor corepressor 20.163
PCGF2polycomb group ring finger 20.162
GRAP2GRB2-related adaptor protein 20.158
CCNE2cyclin E20.155
E2F4E2F transcription factor 4, p107/p130-binding0.152
CDC23cell division cycle 23 homolog (S. cerevisiae)0.150
CDC7cell division cycle 7 homolog (S. cerevisiae)0.146
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 30.140
SPENspen homolog, transcriptional regulator (Drosophila)0.139
HIPK2homeodomain interacting protein kinase 20.139
BLMBloom syndrome, RecQ helicase-like0.135
IL1RAPinterleukin 1 receptor accessory protein0.135
IARSisoleucyl-tRNA synthetase0.133
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.125
LIN9lin-9 homolog (C. elegans)0.124
ORC3origin recognition complex, subunit 30.124
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.123
MBNL1muscleblind-like (Drosophila)0.122
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.117
ANAPC4anaphase promoting complex subunit 40.116
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycECyclin E0.976
dapdacapo0.866
Akt1CG4006 gene product from transcript CG4006-RA0.866
CycBCyclin B0.846
HLHmgammaE(spl) region transcript mgamma0.664
Rho1CG8416 gene product from transcript CG8416-RB0.622
MadMothers against dpp0.555
aspabnormal spindle0.545
PtenCG5671 gene product from transcript CG5671-RB0.513
ChroChromator0.491
HLHmbetaE(spl) region transcript mbeta0.403
HLHm5E(spl) region transcript m50.393
hpohippo0.361
jubAjuba LIM protein0.333
cidcentromere identifier0.315
Kmn1kinetochore Mis12-Ndc80 network component 10.313
HLHmdeltaE(spl) region transcript mdelta0.298
HLHm7E(spl) region transcript m70.287
CycACyclin A0.267
dmdiminutive0.254
Psf2CG18013 gene product from transcript CG18013-RA0.229
Cks30ACyclin-dependent kinase subunit 30A0.212
E(spl)Enhancer of split0.181
spn-Bspindle B0.169
emcextra macrochaetae0.166
hthhomothorax0.165
ctpcut up0.156
twstwins0.147
malphaE(spl) region transcript malpha0.126
poloCG12306 gene product from transcript CG12306-RA0.125
pimpimples0.124
rolsrolling pebbles0.122
drkdownstream of receptor kinase0.119
ncdnon-claret disjunctional0.117
bratbrain tumor0.117
spispitz0.115
Su(H)Suppressor of Hairless0.112
Ras85DRas oncogene at 85D0.109
Vsx2CG33980 gene product from transcript CG33980-RA0.109
EgfrEpidermal growth factor receptor0.095
Mcm6Minichromosome maintenance 60.093
RbfRetinoblastoma-family protein0.093
jumujumeau0.092
Orc6Origin recognition complex subunit 60.091
smosmoothened0.088
dcodiscs overgrown0.088
orboo18 RNA-binding protein0.085
dupdouble parked0.083
tkvthickveins0.083
binbiniou0.077
DetDeterin0.076
gammaTub37Cgamma-Tubulin at 37C0.073
mus301mutagen-sensitive 3010.071
idaimaginal discs arrested0.071
HLHm3E(spl) region transcript m30.070
Top1Topoisomerase 10.070
knrlknirps-like0.070
InRInsulin-like receptor0.069
ari-1ariadne0.069
bazbazooka0.069
shnschnurri0.068
NNotch0.068
CG9772CG9772 gene product from transcript CG9772-RB0.068
nejnejire0.067
dadaughterless0.067
Fas2Fasciclin 20.065
Cks85ACyclin-dependent kinase subunit 85A0.065
hdhumpty dumpty0.065
osaCG7467 gene product from transcript CG7467-RD0.064
egeagle0.062
SMC2CG10212 gene product from transcript CG10212-RA0.058
Fs(2)KetFemale sterile (2) Ketel0.058
ranshiCG9793 gene product from transcript CG9793-RA0.057
smt3CG4494 gene product from transcript CG4494-RA0.056
elavembryonic lethal abnormal vision0.056
Top2Topoisomerase 20.056
cactcactus0.056
ash2absent, small, or homeotic discs 20.054
stgstring0.051
CG14937CG14937 gene product from transcript CG14937-RA0.051
enaenabled0.048
wdbwiderborst0.048
panpangolin0.048
hephhephaestus0.048
waplwings apart-like0.047
vflvielfaltig0.047
foxoforkhead box, sub-group O0.046
e(y)3enhancer of yellow 30.045
CG42629CG42629 gene product from transcript CG42629-RB0.045
Cul-5Cullin-50.045
Cap-GCG34438 gene product from transcript CG34438-RF0.044
Stat92ESignal-transducer and activator of transcription protein at 92E0.044
l(2)gllethal (2) giant larvae0.042
Mcm2Minichromosome maintenance 20.042
babobaboon0.040
cdc2cCG10498 gene product from transcript CG10498-RC0.040
lmglemming0.039
ImpIGF-II mRNA-binding protein0.039
Rya-r44FRyanodine receptor 44F0.039
Mcm10Sensitized chromosome inheritance modifier 190.039
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.996
Emx1empty spiracles homolog 1 (Drosophila)0.893
Ctnnb1catenin (cadherin associated protein), beta 10.878
Shhsonic hedgehog0.869
Apcadenomatosis polyposis coli0.866
Notch1Notch gene homolog 1 (Drosophila)0.857
Mdm2transformed mouse 3T3 cell double minute 20.847
Gli3GLI-Kruppel family member GLI30.828
Cdk4cyclin-dependent kinase 40.780
Ccne1cyclin E10.770
Cdkn1bcyclin-dependent kinase inhibitor 1B0.765
Notch2Notch gene homolog 2 (Drosophila)0.762
Ccnb1cyclin B10.754
Neurod1neurogenic differentiation 10.742
En1engrailed 10.729
Sox2SRY-box containing gene 20.714
Flt4FMS-like tyrosine kinase 40.706
Cdc25ccell division cycle 25 homolog C (S. pombe)0.701
CblCasitas B-lineage lymphoma0.666
Nognoggin0.665
Nos3nitric oxide synthase 3, endothelial cell0.629
Stat5bsignal transducer and activator of transcription 5B0.577
Itgb1integrin beta 1 (fibronectin receptor beta)0.565
Ascl1achaete-scute complex homolog 1 (Drosophila)0.544
Gsk3bglycogen synthase kinase 3 beta0.530
Cdk1cyclin-dependent kinase 10.527
Kif20akinesin family member 20A0.520
Psen1presenilin 10.503
Hoxa13homeobox A130.495
Fgfr1fibroblast growth factor receptor 10.452
Irf9interferon regulatory factor 90.442
Brca1breast cancer 10.432
Rb1retinoblastoma 10.432
Hes1hairy and enhancer of split 1 (Drosophila)0.426
Col1a1collagen, type I, alpha 10.409
Grb10growth factor receptor bound protein 100.394
Grb2growth factor receptor bound protein 20.388
Kdrkinase insert domain protein receptor0.386
Hdac1histone deacetylase 10.376
Lyz2lysozyme 20.371
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.371
Zeb1zinc finger E-box binding homeobox 10.367
Cdkn2acyclin-dependent kinase inhibitor 2A0.362
Ptenphosphatase and tensin homolog0.352
Ptf1apancreas specific transcription factor, 1a0.352
Onecut1one cut domain, family member 10.331
Ccna2cyclin A20.327
Neurog2neurogenin 20.319
Fgfr2fibroblast growth factor receptor 20.315
Hoxa1homeobox A10.309
Lhx3LIM homeobox protein 30.309
Pax3paired box gene 30.303
Twist2twist homolog 2 (Drosophila)0.299
Jag2jagged 20.292
Tgfb2transforming growth factor, beta 20.288
Fgf15fibroblast growth factor 150.288
Chd7chromodomain helicase DNA binding protein 70.286
Prf1perforin 1 (pore forming protein)0.281
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.274
Cdk2cyclin-dependent kinase 20.274
Gab1growth factor receptor bound protein 2-associated protein 10.272
Cd19CD19 antigen0.267
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.266
Insm1insulinoma-associated 10.258
Vegfavascular endothelial growth factor A0.256
Gli2GLI-Kruppel family member GLI20.255
Prnpprion protein0.244
Dysfdysferlin0.240
Gdnfglial cell line derived neurotrophic factor0.239
Sgol1shugoshin-like 1 (S. pombe)0.229
Leprleptin receptor0.229
Stag1stromal antigen 10.225
Igf2rinsulin-like growth factor 2 receptor0.216
Meox2mesenchyme homeobox 20.215
Prc1protein regulator of cytokinesis 10.206
Prrx2paired related homeobox 20.206
Mis18bp1MIS18 binding protein 10.199
Cdc25bcell division cycle 25 homolog B (S. pombe)0.199
Wnt3awingless-related MMTV integration site 3A0.199
Lama5laminin, alpha 50.195
Pax6paired box gene 60.191
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.187
Dab1disabled homolog 1 (Drosophila)0.184
Mdm4transformed mouse 3T3 cell double minute 40.180
Otx2orthodenticle homolog 2 (Drosophila)0.179
Pou5f1POU domain, class 5, transcription factor 10.178
Stat3signal transducer and activator of transcription 30.178
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.173
Mbd3methyl-CpG binding domain protein 30.172
Hoxd11homeobox D110.159
Jak2Janus kinase 20.159
Ptk7PTK7 protein tyrosine kinase 70.157
Inpp5dinositol polyphosphate-5-phosphatase D0.153
Ccnb2cyclin B20.153
Pax9paired box gene 90.152
Appamyloid beta (A4) precursor protein0.151
Kif4kinesin family member 40.150
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.147
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.145
Foxc1forkhead box C10.144
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rps27aribosomal protein S27a0.059
Rps14ribosomal protein S140.058
Rps6ribosomal protein S60.054
Rpl36aribosomal protein L36a0.043
Rpl9ribosomal protein L90.042
Rps20ribosomal protein S200.040
Rps3ribosomal protein S30.030
Rplp1ribosomal protein, large, P10.029
Nacanascent polypeptide-associated complex alpha subunit0.024
Rps21ribosomal protein S210.014
Rpl26ribosomal protein L260.012
Rpl27ribosomal protein L270.012
LOC100359498ribosomal protein L35a-like0.012
Rpl31ribosomal protein L310.011
Uba52ubiquitin A-52 residue ribosomal protein fusion product 10.011
Rpl18aribosomal protein L18A0.011
Rps17ribosomal protein S170.011
Rpl35ribosomal protein L350.011
Rps12ribosomal protein S120.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CDC28Cdc28p0.314
CKS1Cks1p0.299
CLB3Clb3p0.137
DCC1Dcc1p0.108
CDC55Cdc55p0.104
CDC20Cdc20p0.095
CLB2Clb2p0.085
HSL1Hsl1p0.076
CLB1Clb1p0.072
CLB5Clb5p0.061
CLN2Cln2p0.047
CDH1Cdh1p0.042
CTF18Ctf18p0.042
CLB6Clb6p0.039
CDC27Cdc27p0.038
PSP2Psp2p0.035
RLM1Rlm1p0.034
PKH1Pkh1p0.033
NSE4Nse4p0.031
CDC16Cdc16p0.030
NUP157Nup157p0.029
CLB4Clb4p0.029
APP1App1p0.027
CLN1Cln1p0.026
RAD55Rad55p0.026
SWE1Swe1p0.026
SLD5Sld5p0.024
GID7Gid7p0.024
PSF1Psf1p0.024
APC2Apc2p0.023
BUB1Bub1p0.023
PDS1Pds1p0.022
PSF2Psf2p0.022
ACM1Acm1p0.021
BCK1Bck1p0.021
DED1Ded1p0.021
PPH21Pph21p0.021
KDX1Kdx1p0.021
MMS21Mms21p0.020
NSE1Nse1p0.020
CDC40Cdc40p0.019
DPB2Dpb2p0.019
BNR1Bnr1p0.019
MAD3Mad3p0.018
CDC26Cdc26p0.018
MCM10Mcm10p0.017
CDC6Cdc6p0.017
SIF2Sif2p0.017
PKH2Pkh2p0.017
MKK2Mkk2p0.017
CDC14Cdc14p0.017
IML1Iml1p0.016
MAD2Mad2p0.016
YNR014Whypothetical protein0.016
CMK1Cmk1p0.016
RUP1Rup1p0.016
ULA1Ula1p0.015
CHA1Cha1p0.015
GYL1Gyl1p0.015
CYR1Cyr1p0.015
YJU2Yju2p0.015
CDC23Cdc23p0.015
CAK1Cak1p0.014
DSE3Dse3p0.014
CTF4Ctf4p0.014
BUB3Bub3p0.014
SUB2Sub2p0.014
ARP10Arp10p0.014
FYV10Fyv10p0.014
KRE29Kre29p0.014
YBR296C-Ahypothetical protein0.013
CDC15Cdc15p0.013
BCK2Bck2p0.013
MDN1Mdn1p0.013
VID24Vid24p0.013
CDC48Cdc48p0.013
HOS2Hos2p0.013
GPB2Gpb2p0.013
YOR223Whypothetical protein0.013
MTH1Mth1p0.013
YMR086Whypothetical protein0.013
MCM4Mcm4p0.013
MND2Mnd2p0.013
PPR1Ppr1p0.013
PKC1Pkc1p0.013
PPQ1Ppq1p0.013
YPL277Chypothetical protein0.013
HIR1Hir1p0.013
SRD1Srd1p0.012
ESF1Esf1p0.012
TRK1Trk1p0.012
YLR264C-Ahypothetical protein0.012
RAD28Rad28p0.012
PSF3Psf3p0.012
CTI6Cti6p0.012
BRE4Bre4p0.012
TAM41Tam41p0.012
IRE1Ire1p0.012
ZPS1Zps1p0.011
DIA2Dia2p0.011