The network for 'positive regulation of t cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of t cell proliferation

Any process that activates or increases the rate or extent of T cell proliferation.

NameDescriptionProbabilityFunc Analog Organism
LCKlymphocyte-specific protein tyrosine kinase0.995
IL1Binterleukin 1, beta0.956
SYKspleen tyrosine kinase0.909
CTLA4cytotoxic T-lymphocyte-associated protein 40.886
ICAM1intercellular adhesion molecule 10.885
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.882
CCR5chemokine (C-C motif) receptor 50.860
CD86CD86 molecule0.847
CD80CD80 molecule0.833
CD2CD2 molecule0.761
IL1R1interleukin 1 receptor, type I0.759
CCL4chemokine (C-C motif) ligand 40.735
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.729
CXCL9chemokine (C-X-C motif) ligand 90.726
CD247CD247 molecule0.682
PTPN6protein tyrosine phosphatase, non-receptor type 60.680
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.644
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.638
IL8interleukin 80.624
CCL5chemokine (C-C motif) ligand 50.569
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.565
HLA-DQB1major histocompatibility complex, class II, DQ beta 10.526
IL4Rinterleukin 4 receptor0.456
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.447
HLA-DMAmajor histocompatibility complex, class II, DM alpha0.412
HLA-DMBmajor histocompatibility complex, class II, DM beta0.399
CD40CD40 molecule, TNF receptor superfamily member 50.398
LST1leukocyte specific transcript 10.393
CFLARCASP8 and FADD-like apoptosis regulator0.390
CXCL2chemokine (C-X-C motif) ligand 20.366
EGFRepidermal growth factor receptor0.364
LCP2lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)0.352
HCKhemopoietic cell kinase0.332
BIRC3baculoviral IAP repeat containing 30.327
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.300
TRAF1TNF receptor-associated factor 10.294
IFNGinterferon, gamma0.293
HLA-DRB1major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 10.281
SOCS3suppressor of cytokine signaling 30.251
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.249
IL10interleukin 100.247
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.246
CCL20chemokine (C-C motif) ligand 200.242
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.241
IGF2insulin-like growth factor 2 (somatomedin A)0.238
CXCL10chemokine (C-X-C motif) ligand 100.237
CD1CCD1c molecule0.231
CCR7chemokine (C-C motif) receptor 70.230
CASP8caspase 8, apoptosis-related cysteine peptidase0.226
TNFAIP3tumor necrosis factor, alpha-induced protein 30.225
CCR1chemokine (C-C motif) receptor 10.223
IL2RGinterleukin 2 receptor, gamma0.217
CXCL3chemokine (C-X-C motif) ligand 30.217
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.214
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.211
CXCL13chemokine (C-X-C motif) ligand 130.206
GRB2growth factor receptor-bound protein 20.199
SH3BP2SH3-domain binding protein 20.192
NR4A1nuclear receptor subfamily 4, group A, member 10.190
BCL10B-cell CLL/lymphoma 100.190
IDEinsulin-degrading enzyme0.189
CCL13chemokine (C-C motif) ligand 130.187
CCL22chemokine (C-C motif) ligand 220.186
GRAP2GRB2-related adaptor protein 20.178
CCL2chemokine (C-C motif) ligand 20.174
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.174
IL6interleukin 6 (interferon, beta 2)0.169
TAB2TGF-beta activated kinase 1/MAP3K7 binding protein 20.169
DPP4dipeptidyl-peptidase 40.165
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.164
JAK1Janus kinase 10.158
TNFRSF9tumor necrosis factor receptor superfamily, member 90.156
HLA-DPB1major histocompatibility complex, class II, DP beta 10.146
HLA-DRB4major histocompatibility complex, class II, DR beta 40.137
SPTBspectrin, beta, erythrocytic0.136
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.134
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.134
PLCG1phospholipase C, gamma 10.132
CD52CD52 molecule0.131
STAT4signal transducer and activator of transcription 40.129
IL2RBinterleukin 2 receptor, beta0.129
CD33CD33 molecule0.128
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.125
CD1BCD1b molecule0.123
PTPN1protein tyrosine phosphatase, non-receptor type 10.122
IL1R2interleukin 1 receptor, type II0.121
LAIR1leukocyte-associated immunoglobulin-like receptor 10.120
NLRP3NLR family, pyrin domain containing 30.119
IL6Rinterleukin 6 receptor0.115
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.113
INSRinsulin receptor0.110
RGS19regulator of G-protein signaling 190.110
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.110
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.107
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.103
MEFVMediterranean fever0.097
SH2D1ASH2 domain containing 1A0.097
CCR4chemokine (C-C motif) receptor 40.096
SIGLEC7sialic acid binding Ig-like lectin 70.095
CD28CD28 molecule0.091
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lyz2lysozyme 20.999
Tnftumor necrosis factor0.989
Rnf2ring finger protein 20.988
Ifnginterferon gamma0.987
FasFas (TNF receptor superfamily member 6)0.984
Ccr2chemokine (C-C motif) receptor 20.984
Ccl2chemokine (C-C motif) ligand 20.965
Tnfaip3tumor necrosis factor, alpha-induced protein 30.958
Cd247CD247 antigen0.949
Il10interleukin 100.943
Foxp3forkhead box P30.942
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.910
Pdcd1programmed cell death 10.898
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.898
Cd40CD40 antigen0.869
Tlr4toll-like receptor 40.867
Cd44CD44 antigen0.864
Il4interleukin 40.863
Mmp9matrix metallopeptidase 90.856
RybpRING1 and YY1 binding protein0.825
Icosinducible T-cell co-stimulator0.792
Stat3signal transducer and activator of transcription 30.790
Csf1colony stimulating factor 1 (macrophage)0.779
Batfbasic leucine zipper transcription factor, ATF-like0.729
Tgfb1transforming growth factor, beta 10.719
Stat5asignal transducer and activator of transcription 5A0.717
Cd28CD28 antigen0.716
FynFyn proto-oncogene0.705
Sh2d2aSH2 domain protein 2A0.693
Il1r1interleukin 1 receptor, type I0.679
Nos2nitric oxide synthase 2, inducible0.676
Cd6CD6 antigen0.665
Il2rbinterleukin 2 receptor, beta chain0.629
Nckap1lNCK associated protein 1 like0.617
Nck2non-catalytic region of tyrosine kinase adaptor protein 20.614
FaslFas ligand (TNF superfamily, member 6)0.593
Ccr7chemokine (C-C motif) receptor 70.587
Efnb2ephrin B20.583
Cd5CD5 antigen0.581
Cd19CD19 antigen0.581
Ptgs2prostaglandin-endoperoxide synthase 20.577
Ptprcprotein tyrosine phosphatase, receptor type, C0.562
Leprleptin receptor0.561
Myd88myeloid differentiation primary response gene 880.551
Lcklymphocyte protein tyrosine kinase0.526
Casp4caspase 4, apoptosis-related cysteine peptidase0.510
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.510
Ccr1chemokine (C-C motif) receptor 10.508
Il1binterleukin 1 beta0.505
Stat5bsignal transducer and activator of transcription 5B0.494
Cd7CD7 antigen0.489
Foxn1forkhead box N10.479
Ubdubiquitin D0.474
Il6interleukin 60.468
Sfpi1SFFV proviral integration 10.433
Casp1caspase 10.430
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.414
Clec4nC-type lectin domain family 4, member n0.410
Nlrp3NLR family, pyrin domain containing 30.410
Prf1perforin 1 (pore forming protein)0.408
Tbx21T-box 210.404
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.394
Il12binterleukin 12b0.385
Inpp5dinositol polyphosphate-5-phosphatase D0.372
Casp8caspase 80.369
Socs1suppressor of cytokine signaling 10.346
Gzmkgranzyme K0.344
Cd4CD4 antigen0.322
Itgb2integrin beta 20.321
Ctla4cytotoxic T-lymphocyte-associated protein 40.315
Dok2docking protein 20.309
Itgalintegrin alpha L0.309
Snai1snail homolog 1 (Drosophila)0.307
Fgfr2fibroblast growth factor receptor 20.299
Smad3MAD homolog 3 (Drosophila)0.289
Ccl17chemokine (C-C motif) ligand 170.280
Ccl3chemokine (C-C motif) ligand 30.278
Cd8b1CD8 antigen, beta chain 10.275
Tlr2toll-like receptor 20.275
ItkIL2-inducible T-cell kinase0.273
Itgb1integrin beta 1 (fibronectin receptor beta)0.270
Klrg1killer cell lectin-like receptor subfamily G, member 10.267
Pnp2purine-nucleoside phosphorylase 20.263
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.262
Cd80CD80 antigen0.259
Rag1recombination activating gene 10.252
Il27rainterleukin 27 receptor, alpha0.247
Cd3eCD3 antigen, epsilon polypeptide0.247
Ccl22chemokine (C-C motif) ligand 220.246
Ctnnb1catenin (cadherin associated protein), beta 10.245
Gpr132G protein-coupled receptor 1320.242
Il4rainterleukin 4 receptor, alpha0.241
Il2rainterleukin 2 receptor, alpha chain0.238
Cd86CD86 antigen0.238
Il10rainterleukin 10 receptor, alpha0.226
Ikzf1IKAROS family zinc finger 10.226
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.223
Ccl7chemokine (C-C motif) ligand 70.213
Nos3nitric oxide synthase 3, endothelial cell0.211
Ror2receptor tyrosine kinase-like orphan receptor 20.207
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Casp1caspase 10.040
Cd37CD37 molecule0.039
Aldh6a1aldehyde dehydrogenase 6 family, member A10.037
RT1-BaRT1 class II, locus Ba0.033
Cd247Cd247 molecule0.028
Cd53Cd53 molecule0.025
Ptprcprotein tyrosine phosphatase, receptor type, C0.024
TcrbT-cell receptor beta chain0.023
Xcl1chemokine (C motif) ligand 10.019
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.019
Il1binterleukin 1 beta0.018
Cd5Cd5 molecule0.017
Ugt8UDP glycosyltransferase 80.016
RT1-DaRT1 class II, locus Da0.015
Il7rinterleukin 7 receptor0.015
Vom2r27vomeronasal 2 receptor, 270.015
Il2rbinterleukin 2 receptor, beta0.014
Ptprqprotein tyrosine phosphatase, receptor type, Q0.014
Scp2sterol carrier protein 20.014
Nkg7natural killer cell group 7 sequence0.013
Itgb7integrin, beta 70.013
Gzmkgranzyme K0.012
Cd44Cd44 molecule0.012
Hckhemopoietic cell kinase0.011
Fcgr2aFc fragment of IgG, low affinity IIa, receptor (CD32)0.011
Psgb1pregnancy-specific beta 1-glycoprotein0.011
Laptm5lysosomal protein transmembrane 50.011
Maoamonoamine oxidase A0.010
RT1-DMbRT1 class II, locus DMb0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism