The network for 'positive regulation of ossification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of ossification

Any process that activates or increases the frequency, rate or extent of bone formation.

NameDescriptionProbabilityFunc Analog Organism
SMAD7SMAD family member 70.990
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.986
BMPR1Abone morphogenetic protein receptor, type IA0.946
SMAD2SMAD family member 20.915
POU3F2POU class 3 homeobox 20.900
FSTL1follistatin-like 10.893
FGFR1fibroblast growth factor receptor 10.882
JUPjunction plakoglobin0.858
FKBP1AFK506 binding protein 1A, 12kDa0.808
BMP2bone morphogenetic protein 20.732
NOTCH1notch 10.592
IFITM1interferon induced transmembrane protein 1 (9-27)0.551
SKIv-ski sarcoma viral oncogene homolog (avian)0.544
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.520
TGFB3transforming growth factor, beta 30.519
PAX3paired box 30.490
FBLN1fibulin 10.459
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.451
TM4SF1transmembrane 4 L six family member 10.432
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.373
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.364
FGFR2fibroblast growth factor receptor 20.324
SMAD5SMAD family member 50.308
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.306
CYR61cysteine-rich, angiogenic inducer, 610.305
RXRAretinoid X receptor, alpha0.285
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.256
MDM2Mdm2 p53 binding protein homolog (mouse)0.238
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.237
IFITM2interferon induced transmembrane protein 2 (1-8D)0.234
TJP1tight junction protein 1 (zona occludens 1)0.231
BMP4bone morphogenetic protein 40.223
ZFYVE9zinc finger, FYVE domain containing 90.219
SNIP1Smad nuclear interacting protein 10.210
FZD1frizzled homolog 1 (Drosophila)0.189
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.186
WWP2WW domain containing E3 ubiquitin protein ligase 20.185
NOTCH3notch 30.180
IFITM3interferon induced transmembrane protein 3 (1-8U)0.175
PMLpromyelocytic leukemia0.168
KRT5keratin 50.135
WWOXWW domain containing oxidoreductase0.132
SMAD4SMAD family member 40.132
IGF2Rinsulin-like growth factor 2 receptor0.131
NUCB1nucleobindin 10.129
MSX1msh homeobox 10.129
LRRK2leucine-rich repeat kinase 20.122
CTGFconnective tissue growth factor0.121
MEOX2mesenchyme homeobox 20.115
TGFB2transforming growth factor, beta 20.111
FOXD3forkhead box D30.106
ZHX1zinc fingers and homeoboxes 10.104
WNT1wingless-type MMTV integration site family, member 10.102
PRKG1protein kinase, cGMP-dependent, type I0.101
INHBBinhibin, beta B0.100
JAK1Janus kinase 10.100
SMAD9SMAD family member 90.100
FGF18fibroblast growth factor 180.099
TCF4transcription factor 40.098
FZD8frizzled homolog 8 (Drosophila)0.096
EPAS1endothelial PAS domain protein 10.096
PARVAparvin, alpha0.095
SMAD6SMAD family member 60.093
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.085
PTPN12protein tyrosine phosphatase, non-receptor type 120.083
JUNjun proto-oncogene0.082
TGFB1transforming growth factor, beta 10.080
NCK2NCK adaptor protein 20.079
GAS1growth arrest-specific 10.077
ARRDC3arrestin domain containing 30.075
SFRP1secreted frizzled-related protein 10.075
HMGA1high mobility group AT-hook 10.074
COL11A2collagen, type XI, alpha 20.074
EP300E1A binding protein p3000.074
NEDD4neural precursor cell expressed, developmentally down-regulated 40.073
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.072
COL2A1collagen, type II, alpha 10.071
SATB2SATB homeobox 20.071
MYH9myosin, heavy chain 9, non-muscle0.068
TGFBR1transforming growth factor, beta receptor 10.068
SOX9SRY (sex determining region Y)-box 90.068
POU5F1POU class 5 homeobox 10.067
AXIN1axin 10.067
GFI1Bgrowth factor independent 1B transcription repressor0.067
STAT4signal transducer and activator of transcription 40.066
BMP7bone morphogenetic protein 70.065
FZD7frizzled homolog 7 (Drosophila)0.065
SOX7SRY (sex determining region Y)-box 70.065
VKORC1vitamin K epoxide reductase complex, subunit 10.064
PRKAR1Aprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)0.063
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.063
DDR2discoidin domain receptor tyrosine kinase 20.063
SMAD1SMAD family member 10.063
MAGI3membrane associated guanylate kinase, WW and PDZ domain containing 30.061
SHC1SHC (Src homology 2 domain containing) transforming protein 10.060
BST2bone marrow stromal cell antigen 20.059
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.997
Msx1homeobox, msh-like 10.992
Gli3GLI-Kruppel family member GLI30.992
Shhsonic hedgehog0.991
Tgfb2transforming growth factor, beta 20.988
Pthlhparathyroid hormone-like peptide0.960
Runx2runt related transcription factor 20.938
Trp53transformation related protein 530.937
Gli2GLI-Kruppel family member GLI20.929
Bmp4bone morphogenetic protein 40.909
Pax3paired box gene 30.907
Fgfr1fibroblast growth factor receptor 10.905
Fgf8fibroblast growth factor 80.897
Meox2mesenchyme homeobox 20.895
Fgfr3fibroblast growth factor receptor 30.884
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.860
Foxc1forkhead box C10.858
Csf1colony stimulating factor 1 (macrophage)0.843
Prrx1paired related homeobox 10.828
Bmp7bone morphogenetic protein 70.814
Prrx2paired related homeobox 20.799
Ror2receptor tyrosine kinase-like orphan receptor 20.793
Notch1Notch gene homolog 1 (Drosophila)0.745
Nos3nitric oxide synthase 3, endothelial cell0.710
Sfrp2secreted frizzled-related protein 20.689
Hand1heart and neural crest derivatives expressed transcript 10.639
Sox9SRY-box containing gene 90.639
Tbx3T-box 30.620
Ppargperoxisome proliferator activated receptor gamma0.605
Hoxd13homeobox D130.585
Zeb1zinc finger E-box binding homeobox 10.581
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.566
Jag1jagged 10.532
Pax2paired box gene 20.526
Tbx2T-box 20.525
Gpc3glypican 30.484
Dkk1dickkopf homolog 1 (Xenopus laevis)0.483
Smosmoothened homolog (Drosophila)0.475
Bmp2bone morphogenetic protein 20.464
Col1a1collagen, type I, alpha 10.462
Id1inhibitor of DNA binding 10.431
Alx4aristaless-like homeobox 40.431
Adrb1adrenergic receptor, beta 10.420
Hes1hairy and enhancer of split 1 (Drosophila)0.409
Axin1axin 10.406
Smad4MAD homolog 4 (Drosophila)0.405
Zfpm2zinc finger protein, multitype 20.402
Msx2homeobox, msh-like 20.401
Col2a1collagen, type II, alpha 10.399
Tcf4transcription factor 40.394
Fgf18fibroblast growth factor 180.371
Ntf3neurotrophin 30.371
FosFBJ osteosarcoma oncogene0.361
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.353
Lrp6low density lipoprotein receptor-related protein 60.351
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.350
Hoxd11homeobox D110.348
Hey2hairy/enhancer-of-split related with YRPW motif 20.347
Pou3f3POU domain, class 3, transcription factor 30.331
Pax8paired box gene 80.330
Hand2heart and neural crest derivatives expressed transcript 20.312
Ptch1patched homolog 10.311
Ptenphosphatase and tensin homolog0.310
Smad6MAD homolog 6 (Drosophila)0.310
Mndalmyeloid nuclear differentiation antigen like0.309
Id3inhibitor of DNA binding 30.304
Fzd1frizzled homolog 1 (Drosophila)0.294
Pax9paired box gene 90.286
Wnt3awingless-related MMTV integration site 3A0.285
Lhx1LIM homeobox protein 10.283
Rspo2R-spondin 2 homolog (Xenopus laevis)0.277
Fgf3fibroblast growth factor 30.266
Wnt5awingless-related MMTV integration site 5A0.260
Fgf10fibroblast growth factor 100.257
Lrp2low density lipoprotein receptor-related protein 20.250
Tgfbr1transforming growth factor, beta receptor I0.249
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.248
Npr3natriuretic peptide receptor 30.248
Foxc2forkhead box C20.246
Gata4GATA binding protein 40.245
Phexphosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)0.244
Neurog3neurogenin 30.241
Mapk8mitogen-activated protein kinase 80.225
Wnt4wingless-related MMTV integration site 40.223
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.222
Smad2MAD homolog 2 (Drosophila)0.214
Emx2empty spiracles homolog 2 (Drosophila)0.208
Tbx15T-box 150.207
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.200
Hspg2perlecan (heparan sulfate proteoglycan 2)0.197
Twist2twist homolog 2 (Drosophila)0.195
Zic3zinc finger protein of the cerebellum 30.192
Twist1twist homolog 1 (Drosophila)0.189
Ptpn11protein tyrosine phosphatase, non-receptor type 110.186
Rargretinoic acid receptor, gamma0.179
Rxraretinoid X receptor alpha0.179
Retret proto-oncogene0.178
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.120
Edn1endothelin 10.037
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.037
Nr1d2nuclear receptor subfamily 1, group D, member 20.032
Myh9myosin, heavy chain 9, non-muscle0.028
Jak2Janus kinase 20.027
Ptpn14protein tyrosine phosphatase, non-receptor type 140.025
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.024
Nedd4neural precursor cell expressed, developmentally down-regulated 40.024
Lamc1laminin, gamma 10.023
Ptpn1protein tyrosine phosphatase, non-receptor type 10.020
Pax8paired box 80.019
Iqgap1IQ motif containing GTPase activating protein 10.018
Adrb1adrenergic, beta-1-, receptor0.018
Btg2BTG family, member 20.018
Metmet proto-oncogene0.018
Hdgfl1hepatoma derived growth factor-like 10.018
Jak1Janus kinase 10.018
Emp1epithelial membrane protein 10.017
Stat3signal transducer and activator of transcription 30.016
DbpD site of albumin promoter (albumin D-box) binding protein0.016
Nfianuclear factor I/A0.016
Flt1FMS-related tyrosine kinase 10.016
Kcnh7potassium voltage-gated channel, subfamily H (eag-related), member 70.016
Ptprhprotein tyrosine phosphatase, receptor type, H0.015
Phkg1phosphorylase kinase, gamma 10.015
Htr2c5-hydroxytryptamine (serotonin) receptor 2C0.015
Cald1caldesmon 10.015
Smad7SMAD family member 70.014
Jdp2Jun dimerization protein 20.014
Actn4actinin alpha 40.014
Timp3TIMP metallopeptidase inhibitor 30.013
Smad1SMAD family member 10.013
Col12a1collagen, type XII, alpha 10.013
Bcl2B-cell CLL/lymphoma 20.013
Il6rinterleukin 6 receptor0.013
Cd14CD14 molecule0.013
Ier3immediate early response 30.012
Igfbp5insulin-like growth factor binding protein 50.012
Notch3Notch homolog 3 (Drosophila)0.012
Syt8synaptotagmin VIII0.012
Lrfn2leucine rich repeat and fibronectin type III domain containing 20.011
Foxd3forkhead box D30.011
Kcnk12potassium channel, subfamily K, member 120.011
Ggcxgamma-glutamyl carboxylase0.011
Zic1Zic family member 1 (odd-paired homolog, Drosophila)0.010
Zfp36l2zinc finger protein 36, C3H type-like 20.010
Cd40lgCD40 ligand0.010
Lmnalamin A0.010
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.010
Actn1actinin, alpha 10.010
Ece1endothelin converting enzyme 10.010
Sp1Sp1 transcription factor0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism